Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.22 | 0.22 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0465 | 0.0679 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0283 | 0.0242 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4009 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1975 | 0.1975 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4009 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1742 | 0.4076 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.506 | 0.506 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0465 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2383 | 0.2383 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.4351 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.5468 | 0.5132 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1742 | 0.4076 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1968 | 0.1372 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0465 | 0.0739 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0283 | 0.0283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7079 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.