Detailed information for compound 1294917

Basic information

Technical information
  • TDR Targets ID: 1294917
  • Name: N-(2,5-dimethoxyphenyl)-3-[(3-methyl-2-oxo-1, 3-benzoxazol-6-yl)sulfonylamino]propanamide
  • MW: 435.451 | Formula: C19H21N3O7S
  • H donors: 2 H acceptors: 4 LogP: 1.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)CCNS(=O)(=O)c1ccc2c(c1)oc(=O)n2C)OC
  • InChi: 1S/C19H21N3O7S/c1-22-15-6-5-13(11-17(15)29-19(22)24)30(25,26)20-9-8-18(23)21-14-10-12(27-2)4-7-16(14)28-3/h4-7,10-11,20H,8-9H2,1-3H3,(H,21,23)
  • InChiKey: OTCFLNHSFYXTKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dimethoxyphenyl)-3-[(2-keto-3-methyl-1,3-benzoxazol-6-yl)sulfonylamino]propionamide
  • SMR000132327
  • MLS000521919
  • C697-0989
  • NCGC00111989-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0043 0.1271 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.1271 0.2499
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.1896 0.5757
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.3125 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1271 0.3601
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0732 0.2329
Schistosoma mansoni hypothetical protein 0.0029 0.0717 0.2296
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1271 0.4047
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.3125 1
Schistosoma mansoni DNA helicase recq5 0.0012 0.0097 0.0312
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.3125 0.6141
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1271 0.3601
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0717 0.3784
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1852 0.364
Schistosoma mansoni jumonji domain containing protein 0.0074 0.2425 0.776
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.1896 0.3726
Trypanosoma brucei polo-like protein kinase 0.0093 0.3125 1
Brugia malayi beta-lactamase family protein 0.0043 0.1271 0.4047
Schistosoma mansoni hypothetical protein 0.0035 0.0967 0.3094
Mycobacterium ulcerans lipase LipD 0.0043 0.1271 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.1479 0.2906
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0097 0.0514
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0967 0.2855
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.3125 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1271 0.3601
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.3142 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.1135 0.3407
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1381 0.3979
Loa Loa (eye worm) hypothetical protein 0.0043 0.1271 0.2499
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.3125 0.9945
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.3125 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0942 0.3013
Brugia malayi beta-lactamase 0.0043 0.1271 0.4047
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1271 0.3601
Onchocerca volvulus 0.0043 0.1271 0.2302
Leishmania major hypothetical protein, conserved 0.0043 0.1271 0.3601
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0717 0.141
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.1896 0.5757
Trichomonas vaginalis CMGC family protein kinase 0.006 0.1896 0.5757
Brugia malayi jmjC domain containing protein 0.0035 0.0942 0.2997
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0717 0.2036
Toxoplasma gondii ABC1 family protein 0.0043 0.1271 0.6707
Loa Loa (eye worm) beta-lactamase 0.0043 0.1271 0.2499
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0967 0.3094
Loa Loa (eye worm) RecQ helicase 0.0029 0.0732 0.1438
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0967 0.2855
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1271 0.3856
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0097 0.031
Giardia lamblia Kinase, CMGC MAPK 0.006 0.1896 0.594
Echinococcus granulosus peregrin 0.0029 0.0717 0.2036
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.3125 1
Entamoeba histolytica hypothetical protein 0.0035 0.0967 0.2549
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1381 0.3979
Echinococcus multilocularis jumonji domain containing protein 0.004 0.1135 0.3407
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.1896 0.6067
Brugia malayi jmjC domain containing protein 0.0094 0.3142 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.3125 1
Trypanosoma brucei protein kinase, putative 0.006 0.1896 0.6067
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1271 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1271 0.4069
Brugia malayi beta-lactamase family protein 0.0043 0.1271 0.4047
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0942 0.2773
Trichomonas vaginalis esterase, putative 0.0043 0.1271 0.3601
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.1896 0.5757
Entamoeba histolytica hypothetical protein 0.0035 0.0967 0.2549
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1271 0.3856
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0942 0.1851
Entamoeba histolytica hypothetical protein 0.0035 0.0967 0.2549
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.3142 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0373 0.1969
Mycobacterium ulcerans beta-lactamase 0.0043 0.1271 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1271 0.5
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.1896 0.5907
Giardia lamblia Kinase, PLK 0.0093 0.3125 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.1271 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1271 0.4069
Loa Loa (eye worm) hypothetical protein 0.0043 0.1271 0.2499
Loa Loa (eye worm) hypothetical protein 0.0043 0.1271 0.2499
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.06 0.8371
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0504 0.1614
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0732 0.1737
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0382 0.3004
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.1896 0.5907
Brugia malayi Bromodomain containing protein 0.0029 0.0717 0.2283
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.1896 0.5757
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.3125 1
Trichomonas vaginalis CMGC family protein kinase 0.006 0.1896 0.5757
Giardia lamblia PHD finger protein 15 0.0029 0.0717 0.2048
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.3125 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.1896 0.5757
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.3125 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1271 1
Trichomonas vaginalis CMGC family protein kinase 0.006 0.1896 0.5757
Plasmodium falciparum phd finger protein, putative 0.0029 0.0717 1
Entamoeba histolytica hypothetical protein 0.0035 0.0967 0.2549
Brugia malayi hypothetical protein 0.0035 0.0967 0.3077
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.3125 0.9943
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1271 0.3601
Onchocerca volvulus 0.0043 0.1271 0.2302
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0097 0.0514
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1271 0.3601
Mycobacterium leprae conserved hypothetical protein 0.0043 0.1271 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.3125 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.1896 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.3125 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.3125 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.1896 0.5757
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1271 0.3601
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0942 0.3013
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0717 0.3784
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0732 0.1737
Loa Loa (eye worm) hypothetical protein 0.0146 0.5088 1
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.1896 0.5907
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.3125 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0097 0.1359
Loa Loa (eye worm) hypothetical protein 0.0029 0.0717 0.141
Brugia malayi PHD-finger family protein 0.0029 0.0717 0.2283
Schistosoma mansoni kinase 0.0048 0.1427 0.4566
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0717 0.2036
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0097 0.031
Brugia malayi MAP kinase sur-1 0.006 0.1896 0.6034
Schistosoma mansoni serine/threonine protein kinase 0.006 0.1896 0.6067
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0229 0.0732
Echinococcus multilocularis peregrin 0.0029 0.0717 0.2036
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0717 0.2296
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.3125 0.9943
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0192
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0097 0.0192
Schistosoma mansoni DNA helicase recq1 0.0012 0.0097 0.0312
Onchocerca volvulus 0.0043 0.1271 0.2302
Loa Loa (eye worm) hypothetical protein 0.0043 0.1271 0.2499
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1271 0.2499
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0732 0.2083
Echinococcus granulosus bloom syndrome protein 0.0029 0.0732 0.2083
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0717 0.5642
Trichomonas vaginalis CMGC family protein kinase 0.006 0.1896 0.5757
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1271 0.4069
Loa Loa (eye worm) hypothetical protein 0.0043 0.1271 0.2499
Echinococcus granulosus mitogen activated protein kinase 0.006 0.1896 0.5907
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0942 0.2773

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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