Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0083 | 0.0677 | 0.0795 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.5551 | 0.6979 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.1876 | 0.2584 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0233 | 0.4962 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0195 | 0.3898 | 0.7714 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0208 | 0.4268 | 0.8509 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.006 | 0.0005 | 0.0007 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0233 | 0.4962 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0253 | 0.5551 | 0.9613 |
Brugia malayi | TAR-binding protein | 0.0253 | 0.5551 | 0.9613 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.1371 | 0.1888 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0233 | 0.4962 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0208 | 0.4268 | 0.8509 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0233 | 0.4962 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0253 | 0.5551 | 0.7646 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0271 | 0.034 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0337 | 0.7954 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.5551 | 0.6979 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0233 | 0.4962 | 0.854 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.119 | 0.1673 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0107 | 0.1371 | 0.2003 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0233 | 0.4962 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.119 | 0.1639 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.007 | 0.0307 | 0.0609 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0195 | 0.3898 | 0.7714 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.5551 | 0.6979 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0233 | 0.4962 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.5551 | 0.6979 |
Schistosoma mansoni | tar DNA-binding protein | 0.0253 | 0.5551 | 0.6979 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0222 | 0.466 | 0.9352 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0337 | 0.7954 | 0.7629 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0253 | 0.5551 | 0.7646 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.007 | 0.0307 | 0.5 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0171 | 0.3204 | 0.5 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.007 | 0.0307 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0271 | 0.0373 |
Echinococcus granulosus | tar DNA binding protein | 0.0253 | 0.5551 | 0.4844 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.026 | 0.5764 | 0.7939 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.119 | 0.1673 |
Brugia malayi | RNA binding protein | 0.0253 | 0.5551 | 0.9613 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0104 | 0.1278 | 0.1833 |
Echinococcus multilocularis | tar DNA binding protein | 0.0253 | 0.5551 | 0.4844 |
Loa Loa (eye worm) | RNA binding protein | 0.0253 | 0.5551 | 0.7646 |
Brugia malayi | MH2 domain containing protein | 0.026 | 0.5764 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.026 | 0.5764 | 0.7939 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0313 | 0.726 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.119 | 0.1639 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.007 | 0.0307 | 0.0386 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0337 | 0.7954 | 0.7629 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 251.1886 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.