Detailed information for compound 1295141

Basic information

Technical information
  • TDR Targets ID: 1295141
  • Name: 4-chloro-N-[3-oxo-3-[4-(phenylmethyl)piperazi n-1-yl]propyl]benzenesulfonamide
  • MW: 421.941 | Formula: C20H24ClN3O3S
  • H donors: 1 H acceptors: 3 LogP: 2.25 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C20H24ClN3O3S/c21-18-6-8-19(9-7-18)28(26,27)22-11-10-20(25)24-14-12-23(13-15-24)16-17-4-2-1-3-5-17/h1-9,22H,10-16H2
  • InChiKey: REUMRHNMZVZSCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-[3-oxo-3-[4-(phenylmethyl)-1-piperazinyl]propyl]benzenesulfonamide
  • N-[3-[4-(benzyl)piperazin-1-yl]-3-keto-propyl]-4-chloro-benzenesulfonamide
  • ST5328966
  • MLS000522095
  • SMR000132503
  • EU-0097547

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0058 0.0382 0.0564
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0755 0.1113
Echinococcus multilocularis cysteine protease 0.0112 0.0831 0.1226
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0493
Loa Loa (eye worm) hypothetical protein 0.0078 0.0548 0.2038
Loa Loa (eye worm) beta-lactamase 0.0189 0.1477 0.5494
Trypanosoma cruzi cysteine proteinase, putative 0.0062 0.0416 0.1481
Plasmodium vivax hypothetical protein, conserved 0.0189 0.1477 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0475 0.1766
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2284 0.3368
Brugia malayi Cathepsin L-like precursor 0.0078 0.0548 0.2038
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0755 0.4825
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0081 0.012
Trypanosoma cruzi cysteine protease, putative 0.0062 0.0416 0.1481
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0755 0.1113
Onchocerca volvulus 0.0112 0.0831 0.5196
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0233 0.1085
Entamoeba histolytica cysteine proteinase 2 0.0062 0.0416 0.4458
Schistosoma mansoni cathepsin S (C01 family) 0.0028 0.0132 0.0195
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0132 0.0195
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.008 0.0118
Mycobacterium ulcerans lipase LipD 0.0189 0.1477 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0663 0.0978
Schistosoma mansoni ran 0.0022 0.0081 0.012
Entamoeba histolytica hypothetical protein 0.0037 0.0202 0.1603
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0132 0.0365
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0112 0.0831 0.1226
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0703 0.1036
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0703 0.1036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0493
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0028 0.0132 0.0365
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0245 0.1943 0.1799
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.022 0.1737 0.159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Brugia malayi cathepsin L-like cysteine proteinase 0.0028 0.0132 0.0493
Plasmodium vivax unspecified product 0.0028 0.0132 0.0365
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.1775 0.6601
Trypanosoma brucei trypanothione reductase 0.0097 0.0703 0.4683
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0416 0.4458
Echinococcus granulosus microtubule associated protein 2 0.0823 0.6781 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0132 0.068
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0189 0.1477 0.1325
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0189 0.1477 0.1325
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0831 1
Leishmania major trypanothione reductase 0.0097 0.0703 0.4683
Schistosoma mansoni cathepsin C 0.0028 0.0132 0.0195
Brugia malayi cathepsin L precursor 0.0028 0.0132 0.0493
Plasmodium falciparum thioredoxin reductase 0.0097 0.0703 0.8287
Brugia malayi cathepsin F-like cysteine proteinase 0.0034 0.0179 0.0664
Echinococcus granulosus cathepsin l cysteine peptidase 0.0112 0.0831 0.1226
Brugia malayi cathepsin B-like cysteine proteinase 0.0334 0.2688 1
Plasmodium falciparum serine repeat antigen 3 0.0028 0.0132 0.068
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0755 0.4825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0175 0.0579
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0028 0.0132 0.0195
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0228
Giardia lamblia Cathepsin L-like protease 0.0028 0.0132 0.0606
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0286 0.0422
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.2596 0.9655
Toxoplasma gondii preprocathepsin c precursor, putative 0.0028 0.0132 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Echinococcus granulosus beta LACTamase domain containing family member 0.0189 0.1477 0.2178
Echinococcus multilocularis beta LACTamase domain containing family member 0.0189 0.1477 0.2178
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0755 0.5042
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0035 0.0052
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0548 0.0808
Brugia malayi mbt repeat family protein 0.0047 0.0286 0.1065
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0175 0.0671
Trichomonas vaginalis penicillin-binding protein, putative 0.0189 0.1477 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0175 0.1113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0175 0.0579
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0175 0.0671
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0132 0.0493
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0148 0.0479
Brugia malayi follicle stimulating hormone receptor 0.0225 0.1775 0.6601
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Mycobacterium tuberculosis Probable lipase LipD 0.0189 0.1477 0.1325
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0422 0.0622
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0703 0.4452
Trypanosoma cruzi cruzipain precursor, putative 0.0034 0.0179 0.0592
Mycobacterium ulcerans esterase/lipase LipP 0.0189 0.1477 1
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0548 0.6222
Schistosoma mansoni hypothetical protein 0.0284 0.2272 0.335
Brugia malayi MH2 domain containing protein 0.0124 0.0931 0.3462
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0663 0.0978
Treponema pallidum NADH oxidase 0.0033 0.0175 0.5
Brugia malayi PHD-finger family protein 0.0024 0.0099 0.037
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0028 0.0132 0.068
Mycobacterium tuberculosis Conserved protein 0.0189 0.1477 0.1325
Loa Loa (eye worm) hypothetical protein 0.0038 0.021 0.078
Trypanosoma cruzi major cysteine proteinase, putative 0.0028 0.0132 0.0419
Echinococcus granulosus cathepsin L 0.0062 0.0416 0.0613
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0931 0.3462
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0028 0.0132 0.0365
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.034 0.0502
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0175 0.0579
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0703 0.2557
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0175 0.0671
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0755 0.5042
Plasmodium falciparum thioredoxin reductase 0.0033 0.0175 0.1249
Echinococcus multilocularis zinc finger protein 0.0019 0.0056 0.0082
Brugia malayi Bromodomain containing protein 0.0073 0.051 0.1896
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0175 0.1061
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.0132 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0416 0.2713
Entamoeba histolytica hypothetical protein 0.0028 0.0132 0.068
Giardia lamblia Cathepsin L precursor 0.0028 0.0132 0.0606
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0175 0.0579
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.2688 0.3965
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0034 0.0179 0.0664
Mycobacterium tuberculosis Probable hydrolase 0.0189 0.1477 0.1325
Loa Loa (eye worm) hypothetical protein 0.0047 0.0286 0.1065
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0703 0.2614
Onchocerca volvulus 0.0112 0.0831 0.5196
Entamoeba histolytica hypothetical protein 0.0037 0.0202 0.1603
Giardia lamblia Cathepsin B precursor 0.0028 0.0132 0.0606
Toxoplasma gondii ABC1 family protein 0.0189 0.1477 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0493
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0416 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Schistosoma mansoni survival motor neuron protein 0.0058 0.0382 0.0564
Loa Loa (eye worm) hypothetical protein 0.0189 0.1477 0.5494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0663 0.0978
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0755 0.2752
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.1477 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0334 0.2688 0.3965
Giardia lamblia Cathepsin B precursor 0.0123 0.0923 1
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0028 0.0132 0.0365
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0189 0.1477 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0123 0.0923 0.6196
Onchocerca volvulus Cathepsin L homolog 0.0112 0.0831 0.5196
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0257 0.0955
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0035 0.0052
Loa Loa (eye worm) fibroinase 0.0112 0.0831 0.3091
Echinococcus multilocularis importin subunit beta 1 0.003 0.0148 0.0219
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0286 0.1065
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0416 0.1481
Loa Loa (eye worm) hypothetical protein 0.0189 0.1477 0.5494
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0384 0.0567
Echinococcus granulosus snurportin 1 0.0323 0.2596 0.3828
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0078 0.0548 0.1976
Echinococcus granulosus cathepsin l1 0.0112 0.0831 0.1226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0132 0.0365
Brugia malayi Thioredoxin reductase 0.0097 0.0703 0.2614
Giardia lamblia Cathepsin B precursor 0.0028 0.0132 0.0606
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0831 0.3038
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.1477 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0703 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0028 0.0132 0.0365
Plasmodium falciparum serine repeat antigen 5 0.0028 0.0132 0.068
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0416 0.4458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0132 0.0365
Toxoplasma gondii cathepsin B 0.0123 0.0923 0.603
Schistosoma mansoni hypothetical protein 0.034 0.2738 0.4037
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0286 0.0422
Brugia malayi cathepsin Z-like cysteine proteinase 0.0028 0.0132 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0422 0.1896
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0123 0.0923 0.6196
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0028 0.0132 0.068
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0422 0.0251
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0028 0.0132 0.0195
Toxoplasma gondii cathepsin CPL 0.0112 0.0831 0.5372
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0028 0.0132 0.0365
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Brugia malayi Cathepsin L-like precursor 0.0112 0.0831 0.3091
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.022 0.1737 0.159
Echinococcus multilocularis microtubule associated protein 2 0.0823 0.6781 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0081 0.012
Leishmania major GTP-binding protein, putative 0.0022 0.0081 0.0418
Loa Loa (eye worm) hypothetical protein 0.0286 0.2284 0.8494
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0112 0.0831 1
Giardia lamblia Cysteine protease 0.0028 0.0132 0.0606
Loa Loa (eye worm) hypothetical protein 0.0038 0.0209 0.0777
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0286 0.0422
Leishmania major cathepsin L-like protease 0.0112 0.0831 0.5565
Loa Loa (eye worm) hypothetical protein 0.0034 0.0179 0.0664
Schistosoma mansoni cathepsin B (C01 family) 0.0028 0.0132 0.0195
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0228
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0035 0.0052
Echinococcus granulosus cathepsin b 0.0334 0.2688 0.3965
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0175 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0132 0.0365
Onchocerca volvulus 0.0189 0.1477 1
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0931 0.3462
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0112 0.0831 0.5372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0416 0.2395
Mycobacterium tuberculosis Putative ferredoxin reductase 0.022 0.1737 0.159
Plasmodium vivax importin-beta 2, putative 0.003 0.0148 0.0479
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.019 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0548 0.3342
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0384 0.0567
Schistosoma mansoni zinc finger protein 0.0015 0.0021 0.003
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.008 0.0118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0202 0.0297
Giardia lamblia Cysteine protease 0.0028 0.0132 0.0606
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0035 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0132 0.0365
Mycobacterium tuberculosis Probable esterase LipL 0.0189 0.1477 0.1325
Loa Loa (eye worm) hypothetical protein 0.0034 0.0179 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0132 0.0365
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0257 0.0379
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0245 0.1943 1
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.004 0.0149
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.034 0.0502
Schistosoma mansoni hypothetical protein 0.0037 0.0202 0.0297
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0175 0.1061
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.008 0.0118
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0233 0.1085
Entamoeba histolytica cysteine protease, putative 0.0028 0.0132 0.068
Giardia lamblia Hypothetical protein 0.0028 0.0132 0.0606
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0028 0.0132 0.0365
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0418
Entamoeba histolytica cysteine protease, putative 0.0112 0.0831 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0179 0.0664
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0175 0.1061
Entamoeba histolytica cysteine protease, putative 0.0028 0.0132 0.068
Brugia malayi cathepsin F-like cysteine proteinase 0.0028 0.0132 0.0493
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.01 0.0299
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0028 0.0132 0.0606
Plasmodium vivax unspecified product 0.0062 0.0416 0.2395
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0028 0.0132 0.0195
Mycobacterium tuberculosis Probable dehydrogenase 0.022 0.1737 0.159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0132 0.0365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0028 0.0132 0.0365
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0175 0.0671
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0416 0.4458
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0493
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0755 0.4825
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0548 0.3342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0132 0.0365
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0303
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0422 0.1896
Plasmodium falciparum importin beta, putative 0.003 0.0148 0.0891
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0132 0.0493
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0175 0.1061
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0112 0.0831 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.2688 0.3965
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0028 0.0132 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0334 0.2688 0.3965
Mycobacterium ulcerans hypothetical protein 0.0189 0.1477 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0112 0.0831 0.1226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0132 0.0365
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0112 0.0831 0.3091
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.1477 0.5459
Brugia malayi fibroinase precursor 0.0028 0.0132 0.0493
Brugia malayi hypothetical protein 0.0037 0.0202 0.075
Schistosoma mansoni hypothetical protein 0.002 0.0064 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0132 0.0365
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0755 0.2752
Brugia malayi Cathepsin L-like precursor 0.0112 0.0831 0.3091
Mycobacterium ulcerans beta-lactamase 0.0189 0.1477 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0663 0.0978
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0028 0.0132 0.0365
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0416 0.0613
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0175 0.1249
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0148 0.0876
Brugia malayi RNA, U transporter 1 0.0086 0.0615 0.2286
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Echinococcus multilocularis cathepsin b 0.0334 0.2688 0.3965
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0028 0.0132 0.0195
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Schistosoma mansoni microtubule-associated protein tau 0.0823 0.6781 1
Echinococcus granulosus cathepsin L cysteine protease 0.0062 0.0416 0.0613
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0148 0.0876
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0493
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0831 0.3038
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0028 0.0132 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0028 0.0132 0.0493
Brugia malayi glutathione reductase 0.0097 0.0703 0.2614
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0175 0.0579
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0132 0.0493
Leishmania major cysteine peptidase A (CPA) 0.0112 0.0831 0.5565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.022 0.1737 0.159
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0132 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0123 0.0923 0.603
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0175 0.0258
Plasmodium vivax serine-repeat antigen (SERA) 0.0028 0.0132 0.0365
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.1436 0.2117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.013
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Giardia lamblia Cathepsin L precursor 0.0028 0.0132 0.0606
Leishmania major cathepsin L-like protease 0.0112 0.0831 0.5565
Plasmodium falciparum serine repeat antigen 7 0.0028 0.0132 0.068
Brugia malayi Cathepsin L-like precursor 0.0112 0.0831 0.3091
Giardia lamblia Cathepsin L precursor 0.0028 0.0132 0.0606
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0286 0.0422
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0422 0.0622
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0035 0.0052
Echinococcus granulosus cathepsin L 0.0028 0.0132 0.0195
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.034 0.0502
Echinococcus multilocularis cathepsin L 0.0028 0.0132 0.0195
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.1436 0.2117
Toxoplasma gondii cathepsin CPC2 0.0028 0.0132 0.0365
Brugia malayi Cathepsin L-like precursor 0.0112 0.0831 0.3091
Trypanosoma brucei hypothetical protein, conserved 0.0189 0.1477 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0257 0.0955
Brugia malayi Cathepsin L-like precursor 0.0112 0.0831 0.3091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0416 0.2713
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0755 0.4825
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0422 0.0622
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Echinococcus multilocularis cathepsin b 0.0334 0.2688 0.3965
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0028 0.0132 0.068
Echinococcus granulosus importin subunit beta 1 0.003 0.0148 0.0219
Giardia lamblia Cathepsin L precursor 0.0028 0.0132 0.0606
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0175 0.0579
Loa Loa (eye worm) hypothetical protein 0.0078 0.0548 0.2038
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0175 0.0579
Toxoplasma gondii thioredoxin reductase 0.0097 0.0703 0.4452
Plasmodium falciparum serine repeat antigen 8 0.0028 0.0132 0.068
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0416 0.4458
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.029 0.0428
Brugia malayi beta-lactamase family protein 0.0189 0.1477 0.5494
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0175 0.1061
Entamoeba histolytica cysteine protease, putative 0.0028 0.0132 0.068
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0286 0.1144
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0755 0.1113
Trypanosoma brucei protein kinase, putative 0.0103 0.0755 0.5042
Plasmodium falciparum cysteine proteinase falcipain 1 0.0062 0.0416 0.4458
Entamoeba histolytica cysteine proteinase 1, putative 0.0062 0.0416 0.4458
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0422 0.1896
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0755 0.8002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0132 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0132 0.0365
Trichomonas vaginalis esterase, putative 0.0189 0.1477 1
Schistosoma mansoni ran 0.0022 0.0081 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0663 0.0978
Leishmania major cathepsin L-like protease 0.0112 0.0831 0.5565
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0382 0.1422
Plasmodium falciparum serine repeat antigen 4 0.0028 0.0132 0.068
Onchocerca volvulus Cathepsin L homolog 0.0112 0.0831 0.5196
Plasmodium vivax vivapain-1 0.0062 0.0416 0.2395
Entamoeba histolytica cysteine protease, putative 0.0028 0.0132 0.068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0175 0.0579
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0303
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Brugia malayi mbt repeat family protein 0.0047 0.0286 0.1065
Leishmania major cathepsin L-like protease 0.0112 0.0831 0.5565
Plasmodium vivax vivapain-3 0.0062 0.0416 0.2395
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0175 0.1061
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Leishmania major importin beta-1 subunit, putative 0.0025 0.01 0.0548
Onchocerca volvulus 0.0078 0.0548 0.309
Mycobacterium tuberculosis Probable reductase 0.022 0.1737 0.159
Brugia malayi beta-lactamase family protein 0.0189 0.1477 0.5494
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.034 0.0502
Loa Loa (eye worm) hypothetical protein 0.0042 0.0245 0.091
Echinococcus multilocularis cathepsin L cysteine protease 0.0112 0.0831 0.1226
Schistosoma mansoni hypothetical protein 0.0323 0.2596 0.3828
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0035 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0755 0.2808
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0132 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0028 0.0132 0.0365
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0831 1
Loa Loa (eye worm) cysteine protease 0.0112 0.0831 0.3091
Trypanosoma cruzi major cysteine proteinase, putative 0.0028 0.0132 0.0419
Onchocerca volvulus 0.0112 0.0831 0.5196
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0202 0.0297
Echinococcus granulosus geminin 0.034 0.2738 0.4037
Plasmodium falciparum serine repeat antigen 1 0.0028 0.0132 0.068
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0064 0.0239
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0175 0.1061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Trichomonas vaginalis importin beta-1, putative 0.0025 0.01 0.0136
Trichomonas vaginalis D-aminoacylase, putative 0.0189 0.1477 1
Plasmodium vivax vivapain-2 0.0112 0.0831 0.5372
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0831 0.3038
Loa Loa (eye worm) cathepsin B 0.0123 0.0923 0.3433
Entamoeba histolytica hypothetical protein 0.0037 0.0202 0.1603
Mycobacterium tuberculosis Conserved protein 0.0189 0.1477 0.1325
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0175 0.0258
Onchocerca volvulus 0.0047 0.0286 0.1144
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0132 0.0365
Plasmodium falciparum glutathione reductase 0.0033 0.0175 0.1249
Loa Loa (eye worm) hypothetical protein 0.0078 0.0548 0.2038
Schistosoma mansoni cathepsin s 0.0034 0.0179 0.0263
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0286 0.0422
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0175 0.0671
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0175 0.1061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0189 0.1477 0.2178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0663 0.0978
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0189 0.1477 0.2178
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.034 0.1266
Brugia malayi cathepsin L-like precursor 0.0078 0.0548 0.2038
Brugia malayi cathepsin Z-like cysteine proteinase 0.0028 0.0132 0.0493
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0101 0.0375
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0334 0.2688 1
Plasmodium falciparum serine repeat antigen 9 0.0028 0.0132 0.068
Echinococcus granulosus cysteine protease 0.0062 0.0416 0.0613
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0123 0.0923 0.3382
Onchocerca volvulus 0.0189 0.1477 1
Entamoeba histolytica cysteine protease, putative 0.0062 0.0416 0.4458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0175 0.1249
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0035 0.0052
Echinococcus multilocularis geminin 0.034 0.2738 0.4037
Plasmodium vivax unspecified product 0.0034 0.0179 0.0696
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0132 0.0365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0663 0.0978
Leishmania major cathepsin L-like protease 0.0112 0.0831 0.5565
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.034 0.0502
Leishmania major cathepsin L-like protease 0.0112 0.0831 0.5565
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0132 0.0195
Schistosoma mansoni cathepsin F (C01 family) 0.0112 0.0831 0.1226
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0123 0.0923 0.1361
Loa Loa (eye worm) glutathione reductase 0.0097 0.0703 0.2614
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.01 0.0136
Schistosoma mansoni hypothetical protein 0.034 0.2738 0.4037
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0755 0.2752
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0831 0.5372
Giardia lamblia Cathepsin B precursor 0.0028 0.0132 0.0606
Entamoeba histolytica cysteine protease, putative 0.0028 0.0132 0.068
Brugia malayi Bromodomain containing protein 0.0038 0.0209 0.0778
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0028 0.0132 0.0365
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0101 0.0375
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0286 0.0422
Plasmodium falciparum serine repeat antigen 2 0.0028 0.0132 0.068
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.022 0.1737 0.5586
Plasmodium falciparum cysteine proteinase falcipain 3 0.0112 0.0831 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1477 0.5494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Leishmania major hypothetical protein, conserved 0.0189 0.1477 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0132 0.0365
Echinococcus granulosus cathepsin L cysteine proteinase 0.0112 0.0831 0.1226
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0028 0.0132 0.0493
Onchocerca volvulus 0.0189 0.1477 1
Echinococcus granulosus cathepsin l1 0.0078 0.0548 0.0808
Brugia malayi beta-lactamase 0.0189 0.1477 0.5494
Brugia malayi Importin beta-1 subunit 0.003 0.0148 0.0551
Plasmodium falciparum glutathione reductase 0.0097 0.0703 0.8287
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0755 0.4825
Loa Loa (eye worm) MBCTL1 0.0053 0.034 0.1266
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0179 0.0664
Mycobacterium tuberculosis Probable lipase LipE 0.0189 0.1477 0.1325
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0202 0.0297
Giardia lamblia Cathepsin L precursor 0.0028 0.0132 0.0606
Entamoeba histolytica hypothetical protein 0.0025 0.01 0.0253
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0175 0.0651
Brugia malayi Cathepsin L-like precursor 0.0078 0.0548 0.2038
Schistosoma mansoni hypothetical protein 0.0015 0.0021 0.003
Loa Loa (eye worm) hypothetical protein 0.0334 0.2688 1
Trypanosoma cruzi cruzipain precursor, putative 0.0112 0.0831 0.3038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0112 0.0831 0.5372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2284 0.3368
Mycobacterium tuberculosis Conserved protein 0.0189 0.1477 0.1325
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0245 0.1943 0.1799
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0551
Giardia lamblia Cathepsin L precursor 0.0028 0.0132 0.0606
Loa Loa (eye worm) hypothetical protein 0.0189 0.1477 0.5494
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0416 0.1546
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0189 0.1477 0.1325
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0755 0.5042
Giardia lamblia Cathepsin B precursor 0.0123 0.0923 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0179 0.0664
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0416 0.1546
Brugia malayi Cathepsin L-like cysteine proteinase 0.0078 0.0548 0.2038
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0831 0.3091
Entamoeba histolytica hypothetical protein 0.0037 0.0202 0.1603
Onchocerca volvulus 0.0112 0.0831 0.5196
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0422 0.244
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0175 0.0579
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0189 0.1477 0.5494
Schistosoma mansoni zinc finger protein 0.0019 0.0056 0.0082
Giardia lamblia Cysteine protease 0.0028 0.0132 0.0606
Schistosoma mansoni cathepsin F (C01 family) 0.0112 0.0831 0.1226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0028 0.0132 0.0365
Loa Loa (eye worm) hypothetical protein 0.0053 0.034 0.1266
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0755 0.2752
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0286 0.0422
Brugia malayi MAP kinase sur-1 0.0103 0.0755 0.2808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0062 0.0416 0.2395
Echinococcus multilocularis snurportin 1 0.0323 0.2596 0.3828
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0132 0.0195
Giardia lamblia Cathepsin B precursor 0.0123 0.0923 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0062 0.0416 0.1481
Brugia malayi hypothetical protein 0.0286 0.2284 0.8494
Onchocerca volvulus 0.0058 0.0382 0.1859
Giardia lamblia Hypothetical protein 0.0028 0.0132 0.0606
Giardia lamblia Cathepsin B precursor 0.0028 0.0132 0.0606
Giardia lamblia Cathepsin B precursor 0.0028 0.0132 0.0606
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0179 0.0592
Giardia lamblia Encystation-specific protease 0.0028 0.0132 0.0606
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.029 0.0428
Onchocerca volvulus 0.0112 0.0831 0.5196
Trypanosoma cruzi cysteine proteinase, putative 0.0062 0.0416 0.1481
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0663 0.2467
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0132 0.0195
Schistosoma mansoni bromodomain containing protein 0.0062 0.0414 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0831 0.5372
Schistosoma mansoni importin beta-1 0.003 0.0148 0.0219
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0663 0.2467
Echinococcus multilocularis cathepsin L cysteine protease 0.0112 0.0831 0.1226
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0175 0.5
Leishmania major cathepsin L-like protease 0.0112 0.0831 0.5565
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0189 0.1477 0.5494
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0257 0.0379
Loa Loa (eye worm) hypothetical protein 0.0189 0.1477 0.5494
Plasmodium vivax glutathione reductase, putative 0.0097 0.0703 0.4452
Plasmodium vivax serine-repeat antigen (SERA) 0.0028 0.0132 0.0365
Loa Loa (eye worm) hypothetical protein 0.0112 0.0831 0.3091
Echinococcus multilocularis cysteine protease 0.0112 0.0831 0.1226
Toxoplasma gondii cathepsin CPC1 0.0028 0.0132 0.0365
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.019 0.028
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0755 0.1113
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0112 0.0831 0.3091
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0422 0.2756
Giardia lamblia Cathepsin L-like protease 0.0028 0.0132 0.0606
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.0132 0.0606
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0755 0.1113
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0028 0.0132 0.0365
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0831 0.3038
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0175 0.0671
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0175 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0229 0.0852
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0416 0.0613
Echinococcus multilocularis cathepsin L 0.0062 0.0416 0.0613
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.0132 0.0606
Trichomonas vaginalis penicillin-binding protein, putative 0.0189 0.1477 1
Plasmodium vivax vivapain-2 0.0112 0.0831 0.5372
Leishmania major cathepsin L-like protease 0.0112 0.0831 0.5565
Plasmodium falciparum serine repeat antigen 6 0.0028 0.0132 0.068
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0028 0.0132 0.0365
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0175 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.01 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.1477 0.5459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0132 0.0365
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0028 0.0132 0.0365
Mycobacterium tuberculosis Probable oxidoreductase 0.0245 0.1943 0.1799
Loa Loa (eye worm) ctsf protein 0.0112 0.0831 0.3091
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0035 0.0052
Brugia malayi Cathepsin L-like precursor 0.0112 0.0831 0.3091
Echinococcus granulosus cathepsin b 0.0334 0.2688 0.3965
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0422 0.0622
Echinococcus granulosus zinc finger protein 0.0019 0.0056 0.0082
Giardia lamblia Cysteine protease 0.0028 0.0132 0.0606
Onchocerca volvulus Cathepsin F homolog 0.0112 0.0831 0.5196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0831 0.5565
Onchocerca volvulus 0.0112 0.0831 0.5196
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0493
Onchocerca volvulus 0.0112 0.0831 0.5196
Loa Loa (eye worm) hypothetical protein 0.0189 0.1477 0.5494

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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