Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0021 | 0.0021 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0597 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3194 | 0.3194 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3194 | 0.3194 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2331 | 0.3374 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0021 | 0.0021 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3194 | 0.3194 |
Brugia malayi | RNA binding protein | 0.007 | 0.3194 | 0.4624 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.3445 | 0.3445 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2331 | 0.2331 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.3445 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.3194 | 0.4624 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.6907 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0021 | 0.0021 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3194 | 0.3194 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0021 | 0.0021 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0597 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0597 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.3445 | 0.3445 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.121 | 0.121 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.3194 | 0.4624 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.3194 | 0.3194 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.3194 | 0.4624 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0021 | 0.0021 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0021 | 0.0021 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2234 | 0.3234 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.6907 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.3445 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2331 | 0.2331 |
Brugia malayi | hypothetical protein | 0.0074 | 0.3445 | 0.4987 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0597 | 0.0865 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2234 | 0.3234 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.3194 | 0.3194 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.3445 | 0.3445 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.3194 | 0.4624 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2331 | 0.2331 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0021 | 0.0031 |
Brugia malayi | hypothetical protein | 0.0017 | 0.003 | 0.0044 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2331 | 0.2331 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0597 | 0.0865 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2331 | 0.2331 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.3445 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0597 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0021 | 0.0021 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0021 | 0.0031 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0597 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0021 | 0.0031 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2331 | 0.2331 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0597 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2331 | 0.2331 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.3445 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0597 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.3445 | 0.3445 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0597 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.121 | 0.1751 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2234 | 0.3234 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.6907 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0021 | 0.0021 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2234 | 0.3234 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.3194 | 0.3194 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.121 | 0.1751 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2331 | 0.3374 |
Brugia malayi | TAR-binding protein | 0.007 | 0.3194 | 0.4624 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0021 | 0.0031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 53 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 47.1 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.