Detailed information for compound 1295608

Basic information

Technical information
  • TDR Targets ID: 1295608
  • Name: 1-[2-(4-methoxyphenyl)-3,4-dimethylpyrazolo[3 ,4-d]pyridazin-7-yl]-N-[(2-methylphenyl)methy l]piperidine-4-carboxamide
  • MW: 484.593 | Formula: C28H32N6O2
  • H donors: 1 H acceptors: 4 LogP: 4.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1nc2c(c1C)c(C)nnc2N1CCC(CC1)C(=O)NCc1ccccc1C
  • InChi: 1S/C28H32N6O2/c1-18-7-5-6-8-22(18)17-29-28(35)21-13-15-33(16-14-21)27-26-25(19(2)30-31-27)20(3)34(32-26)23-9-11-24(36-4)12-10-23/h5-12,21H,13-17H2,1-4H3,(H,29,35)
  • InChiKey: WMKRAHFYBKHHRF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[2-(4-methoxyphenyl)-3,4-dimethyl-pyrazolo[3,4-d]pyridazin-7-yl]-N-[(2-methylphenyl)methyl]piperidine-4-carboxamide
  • 1-[2-(4-methoxyphenyl)-3,4-dimethyl-7-pyrazolo[3,4-d]pyridazinyl]-N-[(2-methylphenyl)methyl]-4-piperidinecarboxamide
  • 1-[2-(4-methoxyphenyl)-3,4-dimethyl-pyrazolo[3,4-d]pyridazin-7-yl]-N-(2-methylbenzyl)isonipecotamide
  • E859-0836
  • NCGC00126013-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 2, group E, member 3 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens nuclear receptor corepressor 2 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens peroxisome proliferator-activated receptor gamma No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi photoreceptor-specific nuclear receptor Get druggable targets OG5_135311 All targets in OG5_135311
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus nuclear receptor co repressor related ncor Get druggable targets OG5_131772 All targets in OG5_131772
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135311 All targets in OG5_135311
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis nuclear receptor co repressor related (ncor) Get druggable targets OG5_131772 All targets in OG5_131772
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Brugia malayi Nuclear hormone receptor family member nhr-49 nuclear receptor subfamily 2, group E, member 3 410 aa 384 aa 28.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0636 0.0636
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.003 0.025
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.1881 0.4923
Trypanosoma brucei heat shock protein, putative 0.0034 0.0245 0.5363
Brugia malayi MH2 domain containing protein 0.0144 0.1778 0.4238
Brugia malayi nuclear receptor NHR-88 0.0032 0.0212 0.0504
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0245 0.0592
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0212 0.0212
Brugia malayi hypothetical protein 0.0182 0.2314 0.5514
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0245 0.5363
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Brugia malayi heat shock protein 90 0.0034 0.0245 0.0584
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0628 0.2776
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.1083 0.5399
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0059 0.0137
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0628 0.0628
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0212 0.0504
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0228 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0212 0.0212
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0212 0.0212
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0228 0.0543
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0212 0.0212
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.1083 1
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Schistosoma mansoni hypothetical protein 0.0033 0.0228 0.0228
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0333 0.4414 0.4414
Plasmodium falciparum thioredoxin reductase 0.0049 0.0455 0.4184
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0212 0.0504
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0636 0.0636
Echinococcus granulosus GPCR family 2 0.0033 0.0228 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.4099 1
Schistosoma mansoni hypothetical protein 0.0205 0.2623 0.2623
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0212 0.0212
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0228 0.0543
Loa Loa (eye worm) glutaminase 0.029 0.3818 0.9099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0212 0.0504
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0245 0.5363
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0212 0.0212
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0317 0.4196 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0212 0.0504
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1232 0.2936
Giardia lamblia Fructose-bisphosphate aldolase 0.031 0.4099 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0212 0.0504
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.003 0.025
Toxoplasma gondii thioredoxin reductase 0.0049 0.0455 0.4184
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0245 0.0592
Plasmodium falciparum glutathione reductase 0.0049 0.0455 0.4184
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0132 0.2855
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0228 0.0228
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0003 0.0003
Loa Loa (eye worm) glutaminase 2 0.029 0.3818 0.9099
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0212 0.0212
Schistosoma mansoni endoplasmin 0.0034 0.0245 0.0245
Trypanosoma brucei heat shock protein, putative 0.0034 0.0245 0.5363
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Onchocerca volvulus 0.0182 0.2314 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.003 0.0597
Brugia malayi steroid hormone receptor 0.0032 0.0212 0.0504
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0212 0.0212
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0245 0.5363
Treponema pallidum heat shock protein 90 0.0027 0.0147 0.0352
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0212 0.0212
Echinococcus granulosus heat shock protein 90 0.0034 0.0245 0.0245
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.003
Trichomonas vaginalis glutaminase, putative 0.029 0.3818 0.9315
Echinococcus multilocularis endoplasmin 0.0027 0.0147 0.0147
Echinococcus granulosus tumor protein p63 0.0408 0.5467 0.5467
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0212 0.0504
Echinococcus granulosus heat shock protein 90 0.0027 0.0147 0.0147
Trypanosoma brucei heat shock protein, putative 0.0034 0.0245 0.5363
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0504
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0205 0.2623 0.2623
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0147 0.0352
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0132 0.1194
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0212 0.0212
Toxoplasma gondii hypothetical protein 0.0033 0.0218 0.1991
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.1881 1
Trypanosoma brucei heat shock protein, putative 0.0034 0.0245 0.5363
Schistosoma mansoni hypothetical protein 0.0033 0.0228 0.0228
Schistosoma mansoni heat shock protein 0.0034 0.0245 0.0245
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0147 0.0352
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1083 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0003 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0636 0.0636
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0245 0.2244
Echinococcus granulosus geminin 0.0205 0.2623 0.2623
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0048 0.0993
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0228 0.0228
Trypanosoma brucei heat shock protein, putative 0.0034 0.0245 0.5363
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1341 0.7125
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0132 0.2855
Brugia malayi ecdysteroid receptor 0.0032 0.0212 0.0504
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1232 0.2936
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0212 0.0212
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0628 0.3331
Echinococcus multilocularis heat shock protein 90 0.0027 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.4099 1
Brugia malayi jmjC domain containing protein 0.0062 0.0636 0.1514
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1083 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0212 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.4099 1
Brugia malayi glutaminase DH11.1 0.029 0.3818 0.9099
Plasmodium falciparum endoplasmin, putative 0.0021 0.0059 0.0519
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1083 0.2832
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0245 0.2244
Loa Loa (eye worm) hypothetical protein 0.0105 0.1232 0.2936
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.003 0.003
Echinococcus multilocularis GPCR, family 2 0.0033 0.0228 0.0228
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0212 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.4099 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0212 0.0212
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0455 1
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0245 0.5363
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0245 0.5363
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0212 0.0504
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.003 0.025
Plasmodium vivax glutathione reductase, putative 0.0049 0.0455 0.4184
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0218 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0212 0.0504
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Brugia malayi jmjC domain containing protein 0.0062 0.0636 0.1514
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0228 0.0228
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.1083 0.1083
Schistosoma mansoni hypothetical protein 0.0033 0.0228 0.0228
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0218 0.1991
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.003 0.0071
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0147 0.3191
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0003 0.0003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0455 0.2407
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0212 0.0212
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1778 0.4238
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1517 0.8063
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0245 0.5363
Echinococcus granulosus endoplasmin 0.0027 0.0147 0.0147
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0147 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0212 0.0504
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0628 0.3331
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0455 0.0455
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0132 0.1194
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0455 0.4184
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1083 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1341 0.7125
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0636 0.1514
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0132 0.1194
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0333 0.4414 0.4414
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.006 0.0598 0.1425
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0212 0.0504
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.003 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1232 0.2936
Loa Loa (eye worm) hypothetical protein 0.0182 0.2314 0.5514
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0245 0.0584
Giardia lamblia Grp94/Hsp90 0.0027 0.0147 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0212 0.0504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.4099 1
Mycobacterium tuberculosis Probable reductase 0.0113 0.1341 0.7125
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0218 0.0525
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0212 0.0212
Treponema pallidum fructose-bisphosphate aldolase 0.031 0.4099 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0317 0.4196 1
Schistosoma mansoni coup transcription factor 0.0032 0.0212 0.0212
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Plasmodium falciparum heat shock protein 90 0.0034 0.0245 0.2244
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0132 0.2855
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1083 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.003 0.0071
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0228 0.0543
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.4099 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1517 0.8063
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0147 0.0768
Brugia malayi hypothetical protein 0.0017 0.0001 0.0003
Plasmodium vivax endoplasmin, putative 0.0034 0.0245 0.2244
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0767 0.1828
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.1083 0.1083
Brugia malayi Thioredoxin reductase 0.0049 0.0455 0.1084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0212 0.0504
Loa Loa (eye worm) endoplasmin 0.0034 0.0245 0.0584
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0504
Echinococcus multilocularis geminin 0.0205 0.2623 0.2623
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0636 0.0636
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0147 0.0352
Brugia malayi Probable ClpP-like protease 0.0094 0.1083 0.2581
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0212 0.0504
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Loa Loa (eye worm) hypothetical protein 0.0033 0.0228 0.0543
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0132 0.1194
Brugia malayi hypothetical protein 0.0026 0.0132 0.0314
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0147 0.0352
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.1881 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0504
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0504
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0212 0.0212
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1517 0.7901
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0212 0.0504
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0218 0.1991
Leishmania major hypothetical protein, conserved 0.0026 0.0132 0.2855
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0212 0.0504
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1341 0.7125
Trypanosoma brucei heat shock protein, putative 0.0034 0.0245 0.5363
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0212 0.0212
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1778 0.4238
Echinococcus granulosus heat shock protein 0.0034 0.0245 0.0245
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0212 0.0212
Brugia malayi glutathione reductase 0.0049 0.0455 0.1084
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0597
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0598 0.0598
Schistosoma mansoni hypothetical protein 0.0072 0.0767 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0212 0.0504
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0245 0.5363
Echinococcus multilocularis heat shock protein 90 0.0034 0.0245 0.0245
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0212 0.0212
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0212 0.0212
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1083 0.2638
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0147 0.0378
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0245 0.2244
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0212 0.0212
Schistosoma mansoni glutaminase 0.029 0.3818 0.3818
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0212 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0212 0.0504
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0059 0.0137
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0147 0.3191
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0212 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.4099 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.003 0.0597
Echinococcus multilocularis heat shock protein 0.0034 0.0245 0.0245
Mycobacterium ulcerans glutaminase 0.029 0.3818 1
Schistosoma mansoni endoplasmin 0.0034 0.0245 0.0245
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1517 0.8063
Loa Loa (eye worm) hypothetical protein 0.0072 0.0767 0.1828
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0212 0.0504
Echinococcus multilocularis tumor protein p63 0.0408 0.5467 0.5467
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.1083 0.1083
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.1083 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1341 0.7125
Brugia malayi Endoplasmin precursor 0.0034 0.0245 0.0584
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0212 0.0504
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0212 0.0504
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0636 0.0636
Brugia malayi nuclear hormone receptor 0.0032 0.0212 0.0504
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.4099 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0245 0.5363
Loa Loa (eye worm) glutathione reductase 0.0049 0.0455 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0212 0.0504
Trypanosoma brucei heat shock protein, putative 0.0034 0.0245 0.5363
Leishmania major trypanothione reductase 0.0049 0.0455 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0504
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.003 0.0144
Onchocerca volvulus 0.006 0.0598 0.1838
Trypanosoma brucei heat shock protein, putative 0.0034 0.0245 0.5363
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0147 0.1335
Schistosoma mansoni heat shock protein 0.0034 0.0245 0.0245
Brugia malayi Isocitrate dehydrogenase 0.0019 0.003 0.0071
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0094 0.1083 0.2581
Schistosoma mansoni hypothetical protein 0.0033 0.0228 0.0228
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1083 0.2832
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0147 0.3191
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0212 0.0212
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0628 0.0628
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0455 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0212 0.0504
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1083 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1341 0.6886
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1341 0.7125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.4099 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.0314
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0212 0.0504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.4099 1
Trypanosoma brucei trypanothione reductase 0.0049 0.0455 1
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0212 0.0212
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.003 0.025
Leishmania major heat shock protein 83-1 0.0034 0.0245 0.5363
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0212 0.0212
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.003 0.0597

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.436 um PUBCHEM_BIOASSAY: Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2). (Class of assay: confirmatory) [Related pubchem assays: 2379 (Confirmation (NR2E3 agonists in quadruplicate)), 2759 (Dose response counterscreen (PPARg and NCOR2 interaction agonists in triplicate)), 2758 (Dose response (NR2E3 agonists in quadruplicate)), 2325 (Summary (NR2E3 agonists)), 2300 (Primary screen (NR2E3 agonists in singlicate))] ChEMBL. No reference
IC50 (functional) = 2.011 um PUBCHEM_BIOASSAY: TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists. (Class of assay: confirmatory) [Related pubchem assays: 2379 (Confirmation (NR2E3 agonists in quadruplicate)), 2759 (Dose response counterscreen (PPARg and NCOR2 interaction agonists in triplicate)), 2758 (Dose response (NR2E3 agonists in quadruplicate)), 2325 (Summary (NR2E3 agonists)), 2300 (Primary screen (NR2E3 agonists in singlicate))] ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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