Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.333 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2098 | 0.2098 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.1414 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1281 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.333 | 0.333 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.333 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.333 | 0.333 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.333 | 0.333 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2098 | 0.2098 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.2385 | 0.7163 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2098 | 0.2098 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.333 | 1 |
Brugia malayi | RNA binding protein | 0.0068 | 0.333 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1281 | 0.1281 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1281 | 0.3848 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.333 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.2385 | 0.7163 |
Brugia malayi | hypothetical protein | 0.0039 | 0.1414 | 0.4247 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.2098 | 0.63 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1414 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.1414 | 0.1414 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.2385 | 0.7163 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2098 | 0.2098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.333 | 0.333 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.333 | 0.333 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1414 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.333 | 0.333 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.2098 | 0.63 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2098 | 0.2098 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2385 | 0.7163 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2098 | 0.2098 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1414 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.333 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2098 | 0.2098 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1414 | 0.1414 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.1414 | 0.1414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.333 | 0.333 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1414 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 112.2018 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.