Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0039 | 0.6619 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.6619 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.2726 | 0.2818 |
Echinococcus granulosus | lamin | 0.0027 | 0.3556 | 0.5373 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2726 | 0.2818 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.1198 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.2726 | 0.2818 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2726 | 0.245 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3556 | 0.3556 |
Brugia malayi | hypothetical protein | 0.0034 | 0.528 | 0.5101 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1198 | 0.1198 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.2726 | 0.2818 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.3556 | 0.3556 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.343 | 0.343 |
Onchocerca volvulus | 0.0027 | 0.3556 | 1 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.3556 | 0.3312 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1198 | 0.1198 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0365 | 0.0365 |
Onchocerca volvulus | 0.0027 | 0.3556 | 1 | |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.6619 | 0.6159 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2726 | 0.245 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.3556 | 0.5373 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.2726 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2726 | 0.2818 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.2726 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.3556 | 0.5373 |
Echinococcus multilocularis | lamin | 0.0027 | 0.3556 | 0.5373 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.6619 | 0.5352 |
Schistosoma mansoni | lamin | 0.0027 | 0.3556 | 0.2272 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.3556 | 0.3312 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0039 | 0.6619 | 0.5 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.2656 | 0.4012 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.2726 | 0.2818 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.6619 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.6619 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.6619 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.6619 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.2726 | 0.313 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1198 | 0.1198 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.1198 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2726 | 0.2726 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.6619 | 0.6159 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.6619 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2726 | 0.2818 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.2726 | 0.2818 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.3556 | 0.3556 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.2726 | 0.313 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.6619 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.3556 | 0.2272 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.6619 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1198 | 0.1198 |
Echinococcus multilocularis | musashi | 0.0027 | 0.3556 | 0.5373 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.2656 | 0.4012 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1198 | 0.1198 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2726 | 0.2726 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.6619 | 0.6619 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2726 | 0.2726 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2726 | 0.245 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0039 | 0.6619 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.3556 | 0.2272 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.3556 | 0.5373 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0039 | 0.6619 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.6619 | 0.6491 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (ADMET) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (ADMET) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.