Detailed information for compound 1296419

Basic information

Technical information
  • TDR Targets ID: 1296419
  • Name: (2-oxo-1H-pyridin-3-yl) N-phenylcarbamate
  • MW: 230.219 | Formula: C12H10N2O3
  • H donors: 2 H acceptors: 3 LogP: 1.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Oc1cccnc1O)Nc1ccccc1
  • InChi: 1S/C12H10N2O3/c15-11-10(7-4-8-13-11)17-12(16)14-9-5-2-1-3-6-9/h1-8H,(H,13,15)(H,14,16)
  • InChiKey: YCCPWEQZQVZXOB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-phenylcarbamic acid (2-oxo-1H-pyridin-3-yl) ester
  • N-phenylcarbamic acid (2-keto-1H-pyridin-3-yl) ester
  • 71848-07-2
  • 2(1H)-Pyridinone, 3-[[(phenylamino)carbonyl]oxy]-
  • NSC277806
  • SMR000528856
  • MLS000766249

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Oryctolagus cuniculus Fructose-bisphosphate aldolase A Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens glyceraldehyde-3-phosphate dehydrogenase Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium yoelii Fructose-bisphosphate aldolase class-I Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium knowlesi fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense fructose-bisphosphate aldolase, glycosomal putative Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus fructose bisphosphate aldolase class I Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Fructose-bisphosphate aldolase (EC 4.1.2.13), related Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 Get druggable targets OG5_127143 All targets in OG5_127143
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Babesia bovis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01623 fructose-bisphosphate aldolase, class I [EC4.1.2.13A], putative Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni fructose 16-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi fructose-bisphosphate aldolase 1 Get druggable targets OG5_127143 All targets in OG5_127143
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania braziliensis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Theileria parva fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis fructose bisphosphate aldolase class I Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium hominis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni fructose 16-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Babesia bovis glyceraldehyde-3-phosphate dehydrogenase protein Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum fructose-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative glyceraldehyde-3-phosphate dehydrogenase 293 aa 259 aa 28.2 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Onchocerca volvulus Fructose-bisphosphate aldolase A   364 aa 357 aa 69.5 %
Onchocerca volvulus Ubiquitin-40S ribosomal protein S27a homolog Fructose-bisphosphate aldolase A   364 aa 338 aa 53.0 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glucosidase, putative 0.0044 0.0881 0.298
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0082 0.2009 0.6996
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.1364 0.2171
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1175 0.3974
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0156 0.0119
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1573 0.1594
Schistosoma mansoni hypothetical protein 0.0321 0.9044 1
Onchocerca volvulus 0.0036 0.0657 0.0733
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0157 0.0201
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0157 0.053
Echinococcus granulosus geminin 0.0168 0.4547 0.7893
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0157 0.053
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2009 0.6795
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1573 0.2696
Trypanosoma brucei polo-like protein kinase 0.0114 0.2957 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1369 0.1869
Loa Loa (eye worm) hypothetical protein 0.0041 0.0807 0.1059
Echinococcus multilocularis geminin 0.0168 0.4547 0.7893
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0028 0.0428 0.0601
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0157 0.0002
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0082 0.2009 0.6996
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0157 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0931 0.1394
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.1261 0.1714
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.2828 0.9565
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.2554 0.3579
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0074
Loa Loa (eye worm) RecQ helicase 0.0026 0.0354 0.0404
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0881 0.298
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2957 0.2957
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0156 0.0119
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0881 0.1304
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.1573 0.1594
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0881 0.298
Giardia lamblia Kinase, PLK 0.0114 0.2957 0.2019
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0881 0.0881
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0881 0.1166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0931 0.1394
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0881 0.0881
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2009 0.6795
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0931 0.1394
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0881 0.0881
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.2554 0.2699
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1369 0.1869
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0881 0.0881
Onchocerca volvulus 0.0286 0.8028 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2957 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1364 0.1862
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2957 0.3152
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0157 0.053
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0028 0.0427 0.0427
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2009 0.3332
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2009 0.2009
Loa Loa (eye worm) hypothetical protein 0.006 0.1369 0.1869
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2009 0.3332
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.2009 0.6934
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.011 0.2828 0.4804
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2957 0.2957
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.1364 0.2171
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.1364 0.1862
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2009 0.3332
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.1573 0.2547
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.2009 0.2793
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0074 0.0074
Brugia malayi mbt repeat family protein 0.0053 0.1149 0.1551
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.1149 0.1117
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.1149 0.1117
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2957 0.2957
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0041 0.0807 0.0733
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2009 0.2086
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.1149 0.1784
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.5395 0.9416
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2957 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.4677 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0881 0.0881
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0807 0.1059
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0054 0.1175 0.3974
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0354 0.0354
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.572 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2009 0.2086
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0657 0.0901
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.011 0.2828 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1177 0.1592
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0157 0.053
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2957 0.2957
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0082 0.2009 0.3723
Echinococcus granulosus bloom syndrome protein 0.0026 0.0354 0.0356
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2957 0.3625
Brugia malayi mbt repeat family protein 0.0053 0.1149 0.1551
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2009 0.6795
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2009 0.6795
Brugia malayi isocitrate dehydrogenase 0.0019 0.0157 0.012
Plasmodium vivax SET domain protein, putative 0.0036 0.0657 0.2018
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0881 0.1304
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1177 0.1177
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2009 0.6795
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0931 0.1394
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0157 0.0001
Plasmodium falciparum fructose-bisphosphate aldolase 0.011 0.2828 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0881 0.0881
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2957 0.4161
Loa Loa (eye worm) MBCTL1 0.006 0.1364 0.1862
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.011 0.2828 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0074
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2009 0.6795
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0074 0.0074
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0074 0.0074
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.2009 1
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.011 0.2828 0.3975
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.011 0.2828 0.4804
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7004 1
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0427 0.1443
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2009 0.2086
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0194 0.0043
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2009 0.3332
Loa Loa (eye worm) hypothetical protein 0.0019 0.0156 0.0119
Onchocerca volvulus 0.0053 0.1149 0.1352
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.2828 0.9565
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0427 0.1011
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0881 0.2859
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.5395 0.7678
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2009 0.6989
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0931 0.1237
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2957 0.2957
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.011 0.2828 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0427 0.1192
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.1573 0.5319
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.011 0.2828 0.3975
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0074
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0618 0.0831
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1175 0.3974
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0157 0.0002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.4677 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.6795
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0881 0.0881
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1259 0.1259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0931 0.0872
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0427 0.1443
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.2009
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0074 0.0249
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.011 0.2828 0.4804
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.572 1
Schistosoma mansoni hypothetical protein 0.0168 0.4547 0.4941
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0657 0.0901
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1175 0.3974
Brugia malayi fructose-bisphosphate aldolase 1 0.011 0.2828 0.3975
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0931 0.1237
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0025 0.0342 0.1158
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.011 0.2828 0.3007
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.1573 0.5395
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.1573 0.3133
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.1364 0.1359
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0025 0.0342 0.1158
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2957 0.5035
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0025 0.0342 0.1158
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0881 0.298
Onchocerca volvulus 0.0114 0.2949 0.3615
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.1149 0.1784
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0074 0.0074
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0262 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0657 0.0564
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1177 0.1177
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.1573 0.2547
Schistosoma mansoni kinase 0.0058 0.1303 0.1291
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0157 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1259 0.1259
Entamoeba histolytica hypothetical protein 0.0028 0.0427 0.0427
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.2828 0.9565
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0082 0.2009 0.1653
Loa Loa (eye worm) hypothetical protein 0.01 0.2554 0.3579
Loa Loa (eye worm) hypothetical protein 0.0021 0.02 0.0183
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.2009 0.0945
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2957 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0931 0.0872
Schistosoma mansoni alpha-glucosidase 0.0169 0.4587 0.4986
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.011 0.2828 0.4804
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0082 0.2009 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0157 0.0179
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.1149 0.1784
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.2554 0.4311
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.5395 0.9416
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.011 0.2828 0.4804
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.1149 0.1784
Brugia malayi Pre-SET motif family protein 0.0036 0.0657 0.0842
Brugia malayi Pre-SET motif family protein 0.0251 0.7004 1
Schistosoma mansoni hypothetical protein 0.0168 0.4547 0.4941
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0657 0.0564
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0427 0.1192
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0074 0.0249
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.011 0.2828 0.4804
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1177 0.1835
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1369 0.1869
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0157 0.012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0931 0.0872
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0074 0.0249
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0074 0.0074
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0881 0.0881
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0881 0.0881
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2957 0.2957
Loa Loa (eye worm) hypothetical protein 0.0036 0.0657 0.0842
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2957 0.4161
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.2009
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0157 0.0201
Loa Loa (eye worm) hypothetical protein 0.0053 0.1149 0.1551
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2009 0.2086
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0157 0.053
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.2828 0.9565
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0427 0.1172
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.1364 0.2171
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.2009
Brugia malayi fructose-bisphosphate aldolase 2 0.011 0.2828 0.3975
Schistosoma mansoni alpha glucosidase 0.0044 0.0881 0.0816
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.011 0.2828 0.3007
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.1364 0.2171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.6795
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0028 0.0428 0.0004
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1177 0.1592
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0028 0.0427 0.051
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.6795
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1573 0.2696
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0157 0.0002
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0082 0.2009 0.6795
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.5395 0.9416
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.2009
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.1149 0.1352
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.1149 0.1551
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0657 0.0564
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0881 0.1166
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0881 0.0881
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1177 0.1592
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2009 0.6795
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.6795
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.011 0.2828 0.4804
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0354 0.0356
Onchocerca volvulus 0.01 0.2554 0.3119
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0157 0.0002
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0025 0.0342 0.0388
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0074 0.0249
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.011 0.2828 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.5395 0.7678
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.1573 0.2696
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2957 0.2957
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2009 0.2009
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.1261 0.1714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0657 0.0564
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.4677 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2957 0.5035
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.2554 0.4311
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0025 0.0342 0.1158
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2957 0.2957
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0025 0.0342 0.1158
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.1149 0.1117
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0156 0.0119
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0427 0.0597
Leishmania major fructose-1,6-bisphosphate aldolase 0.011 0.2828 0.9565
Echinococcus granulosus fructose bisphosphate aldolase class I 0.011 0.2828 0.4804
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1177 0.1835
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0657 0.0901
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0881 0.0881
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0157 0.0002
Schistosoma mansoni alpha-glucosidase 0.0169 0.4587 0.4986
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2009 0.2009
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0354 0.0404
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.2828 0.9565
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8028 0.8028
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2009 0.2009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0657 0.2036

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2309 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Primary screen confirmation. (Class of assay: confirmatory) [Related pubchem assays: 2451, 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 0.73 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Rabbit FBPA Selectivity. (Class of assay: confirmatory) [Related pubchem assays: 2451, 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 1.4092 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 2.5902 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen confirmation. (Class of assay: confirmatory) [Related pubchem assays: 2451, 2472, 2464 ] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.8445 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.003 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 20.9696 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) [Related pubchem assays: 1490 (qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)), 1819 (Probe Development Summary of Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6294 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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