Detailed information for compound 1297396

Basic information

Technical information
  • TDR Targets ID: 1297396
  • Name: [(amino-pyridin-4-ylmethylidene)amino] 2-(4-c hlorophenyl)acetate
  • MW: 289.717 | Formula: C14H12ClN3O2
  • H donors: 1 H acceptors: 2 LogP: 2.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccc(cc1)Cl)ONC(=N)c1ccncc1
  • InChi: 1S/C14H12ClN3O2/c15-12-3-1-10(2-4-12)9-13(19)20-18-14(16)11-5-7-17-8-6-11/h1-8H,9H2,(H2,16,18)
  • InChiKey: UQWBKYAGKHCUKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [[amino-(4-pyridyl)methylene]amino] 2-(4-chlorophenyl)acetate
  • 2-(4-chlorophenyl)acetic acid [[amino-(4-pyridyl)methylene]amino] ester
  • [(amino-pyridin-4-yl-methylidene)amino] 2-(4-chlorophenyl)ethanoate
  • STK111146
  • CBMicro_034459
  • BIM-0034310.P001
  • MLS000516286
  • SMR000372918

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0018 0.0035 0.0005
Schistosoma mansoni importin beta-1 0.0031 0.0177 0.0414
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0112 0.0546
Loa Loa (eye worm) hypothetical protein 0.0082 0.074 0.2117
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0086 0.0246
Loa Loa (eye worm) beta-lactamase 0.0082 0.074 0.2117
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0192 0.0549
Brugia malayi hypothetical protein 0.0056 0.045 0.1443
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.074 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0192 0.0549
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0035 0.01
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0084 0.7514
Echinococcus granulosus Smad4 0.0018 0.0035 0.0082
Echinococcus multilocularis lamin 0.0033 0.0192 0.0186
Onchocerca volvulus Huntingtin homolog 0.0135 0.1317 0.5906
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Entamoeba histolytica hypothetical protein 0.0157 0.1565 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0465 0.133
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.074 0.1198
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0076 0.0122
Echinococcus granulosus snurportin 1 0.0333 0.3496 1
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0076 0.0069
Brugia malayi beta-lactamase 0.0082 0.074 0.2433
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0033 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.074 0.1198
Brugia malayi RNA, U transporter 1 0.0089 0.0809 0.2668
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0096
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.045 0.5574
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0033 0.0027
Brugia malayi hypothetical protein 0.0157 0.1565 0.5242
Echinococcus multilocularis expressed protein 0.0037 0.0245 0.0239
Loa Loa (eye worm) hypothetical protein 0.0082 0.074 0.2117
Schistosoma mansoni DNA polymerase eta 0.0022 0.0076 0.0122
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.074 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0076 0.0122
Onchocerca volvulus 0.0053 0.0418 0.1185
Brugia malayi beta-lactamase family protein 0.0082 0.074 0.2433
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0033 0.0027
Leishmania major importin beta-1 subunit, putative 0.0025 0.0112 0.0546
Loa Loa (eye worm) hypothetical protein 0.0206 0.2097 0.5997
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.074 0.2041
Loa Loa (eye worm) TAR-binding protein 0.0284 0.2963 0.8475
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.074 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0086 0.004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0035 0.0082
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.074 0.0734
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0177 0.1419
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0084 0.0014
Brugia malayi Importin beta-1 subunit 0.0031 0.0177 0.0515
Schistosoma mansoni lamin 0.0033 0.0192 0.0458
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.074 0.2102
Loa Loa (eye worm) hypothetical protein 0.0082 0.074 0.2117
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0019
Echinococcus granulosus tar DNA binding protein 0.0284 0.2963 0.8472
Loa Loa (eye worm) MH2 domain-containing protein 0.0269 0.2789 0.7978
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0076 0.017
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0112 0.0546
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.074 1
Loa Loa (eye worm) Smad1 0.0018 0.0035 0.01
Schistosoma mansoni lamin 0.0033 0.0192 0.0458
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0236 0.2315
Schistosoma mansoni tar DNA-binding protein 0.0284 0.2963 0.846
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.045 1
Leishmania major GTP-binding protein, putative 0.0023 0.0086 0.0159
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0076 0.0069
Echinococcus multilocularis GPCR, family 2 0.0018 0.0033 0.0027
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0245 0.0701
Entamoeba histolytica hypothetical protein 0.0157 0.1565 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0054 0.0433 0.2397
Schistosoma mansoni hypothetical protein 0.0053 0.0418 0.111
Schistosoma mansoni ap endonuclease 0.0023 0.0084 0.0145
Loa Loa (eye worm) transcription factor SMAD2 0.0269 0.2789 0.7978
Loa Loa (eye worm) hypothetical protein 0.0054 0.0433 0.1238
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0033 0.0077
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0526 0.5626 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0084 0.0119
Brugia malayi Smad1 0.0018 0.0035 0.0032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0033 0.0096
Brugia malayi MH2 domain containing protein 0.0269 0.2789 0.9408
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0245 0.2552
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0084 0.0197
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0054 0.0433 0.5373
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0033 0.0077
Echinococcus multilocularis lamin dm0 0.0033 0.0192 0.0186
Echinococcus multilocularis sentrin specific protease 1 0.0054 0.0433 0.0426
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0086 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0157 0.1565 0.4424
Schistosoma mansoni Smad4 0.0018 0.0035 0.0005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0076 0.0216
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0206 0.2097 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0033 0.0027
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0086 0.1158
Trichomonas vaginalis ran, putative 0.0023 0.0086 0.0159
Trichomonas vaginalis rotamase, putative 0.0037 0.0236 0.2406
Loa Loa (eye worm) hypothetical protein 0.0082 0.074 0.2117
Onchocerca volvulus 0.0082 0.074 0.2878
Echinococcus granulosus GPCR family 2 0.0018 0.0033 0.0077
Echinococcus granulosus sentrin specific protease 1 0.0054 0.0433 0.1221
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0112 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.074 1
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.074 1
Mycobacterium tuberculosis Conserved protein 0.0082 0.074 0.1198
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0236 0.2406
Loa Loa (eye worm) hypothetical protein 0.0039 0.0265 0.0759
Echinococcus granulosus expressed protein 0.0037 0.0245 0.0684
Entamoeba histolytica hypothetical protein 0.0157 0.1565 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0035 0.0028
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0054 0.0433 0.1153
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0076 0.1015
Schistosoma mansoni hypothetical protein 0.0157 0.1565 0.4424
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0236 0.2406
Entamoeba histolytica hypothetical protein 0.0157 0.1565 1
Trichomonas vaginalis esterase, putative 0.0082 0.074 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0465 0.1496
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.011 0.0103
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.3496 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0236 0.3177
Entamoeba histolytica hypothetical protein 0.0025 0.0112 0.0243
Onchocerca volvulus 0.0082 0.074 0.2878
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0084 0.0119
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0086 0.0159
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0084 0.0119
Schistosoma mansoni hypothetical protein 0.0025 0.011 0.0221
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0084 0.0239
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0086 0.0159
Schistosoma mansoni tar DNA-binding protein 0.0284 0.2963 0.846
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0084 0.0221
Mycobacterium ulcerans hypothetical protein 0.0082 0.074 1
Schistosoma mansoni ran 0.0023 0.0086 0.0152
Echinococcus granulosus lamin dm0 0.0033 0.0192 0.0531
Loa Loa (eye worm) hypothetical protein 0.0082 0.074 0.2117
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0076 0.0198
Brugia malayi RNA binding protein 0.0284 0.2963 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Brugia malayi hypothetical protein 0.026 0.2697 0.9094
Plasmodium vivax importin-beta 2, putative 0.0031 0.0177 0.1419
Schistosoma mansoni tar DNA-binding protein 0.0284 0.2963 0.846
Brugia malayi N-terminal motif family protein 0.0206 0.2097 0.7051
Schistosoma mansoni ran 0.0023 0.0086 0.0152
Loa Loa (eye worm) hypothetical protein 0.0082 0.074 0.2117
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0177 0.2382
Brugia malayi MH2 domain containing protein 0.0018 0.0035 0.0032
Echinococcus granulosus importin subunit beta 1 0.0031 0.0177 0.0488
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0192 0.0566
Plasmodium vivax sentrin-specific protease 1, putative 0.0054 0.0433 0.5317
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0465 0.133
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.045 0.6071
Echinococcus granulosus smad 0.0018 0.0035 0.0082
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0054 0.0433 0.1153
Mycobacterium tuberculosis Conserved protein 0.0082 0.074 0.1198
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.045 1
Trypanosoma brucei unspecified product 0.0022 0.0076 0.1015
Schistosoma mansoni hypothetical protein 0.0039 0.0265 0.067
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.045 0.5627
Brugia malayi hypothetical protein 0.0036 0.0231 0.07
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0084 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.074 1
Mycobacterium ulcerans lipase LipD 0.0082 0.074 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.074 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0236 0.1074
Schistosoma mansoni smad1 5 8 and 0.0018 0.0035 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.074 1
Brugia malayi TAR-binding protein 0.0284 0.2963 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0076 0.1015
Mycobacterium leprae conserved hypothetical protein 0.0082 0.074 0.5
Mycobacterium tuberculosis Conserved protein 0.0082 0.074 0.1198
Leishmania major hypothetical protein, conserved 0.0082 0.074 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.045 0.1286
Echinococcus granulosus dna polymerase eta 0.0022 0.0076 0.0198
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0035 0.01
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0086 0.004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0086 0.0228
Echinococcus multilocularis musashi 0.0033 0.0192 0.0186
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0177 0.017
Brugia malayi intermediate filament protein 0.0033 0.0192 0.0566
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0284 0.2963 0.8475
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0465 0.1496
Entamoeba histolytica Ran family GTPase 0.0023 0.0086 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Brugia malayi MH1 domain containing protein 0.0018 0.0035 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0185 0.053
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0076 0.017
Echinococcus granulosus survival motor neuron protein 1 0.026 0.2697 0.7709
Echinococcus granulosus dna polymerase kappa 0.0022 0.0076 0.0198
Mycobacterium leprae Probable lipase LipE 0.0082 0.074 0.5
Loa Loa (eye worm) hypothetical protein 0.0135 0.1317 0.3767
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0054 0.0433 0.5317
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0418 0.1335
Loa Loa (eye worm) hypothetical protein 0.026 0.2697 0.7713
Schistosoma mansoni rotamase 0.0037 0.0245 0.0612
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0084 0.5
Loa Loa (eye worm) RNA binding protein 0.0284 0.2963 0.8475
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0076 0.1015
Echinococcus multilocularis snurportin 1 0.0333 0.3496 0.3492
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.074 0.2041
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0086 0.0072
Brugia malayi beta-lactamase family protein 0.0082 0.074 0.2433
Echinococcus multilocularis tar DNA binding protein 0.0284 0.2963 0.2958
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0035 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.074 0.1198
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0084 0.0053
Echinococcus granulosus intermediate filament protein 0.0033 0.0192 0.0531
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0084 0.0119
Plasmodium vivax hypothetical protein, conserved 0.0082 0.074 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.074 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0026 0.0073
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0084 0.1122
Onchocerca volvulus Huntingtin homolog 0.0135 0.1317 0.5906
Plasmodium falciparum importin beta, putative 0.0031 0.0177 0.2546
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0265 0.0816
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0157 0.1565 0.156
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0076 0.1015
Schistosoma mansoni survival motor neuron protein 0.0053 0.0418 0.111
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.074 0.2433
Plasmodium falciparum sentrin-specific protease 1 0.0054 0.0433 0.9539
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.074 0.1198
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.074 0.1198
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.045 0.5627
Echinococcus multilocularis Smad4 0.0018 0.0035 0.0028
Trichomonas vaginalis rotamase, putative 0.0037 0.0245 0.2552
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0236 0.2406
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.074 0.1198
Loa Loa (eye worm) hypothetical protein 0.0022 0.0076 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Schistosoma mansoni intermediate filament proteins 0.0033 0.0192 0.0458
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0054 0.0433 0.1386
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0084 0.0119
Brugia malayi MH2 domain containing protein 0.0018 0.0035 0.0032
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.074 0.1198
Echinococcus granulosus lamin 0.0033 0.0192 0.0531
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0245 0.0748
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0084 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0505
Schistosoma mansoni tar DNA-binding protein 0.0284 0.2963 0.846
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0086 1
Brugia malayi hypothetical protein 0.0135 0.1317 0.4396
Brugia malayi RNA recognition motif domain containing protein 0.0284 0.2963 1
Schistosoma mansoni hypothetical protein 0.0333 0.3496 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0076 0.1015
Onchocerca volvulus 0.0082 0.074 0.2878
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.045 0.5574
Toxoplasma gondii ABC1 family protein 0.0082 0.074 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0035 0.0005
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0177 0.2382
Loa Loa (eye worm) hypothetical protein 0.0135 0.1317 0.3767
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.011 0.0296
Schistosoma mansoni tar DNA-binding protein 0.0284 0.2963 0.846
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0192 0.0549
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.074 0.2117
Echinococcus multilocularis dna polymerase eta 0.0022 0.0076 0.0069
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0035 0.0082
Mycobacterium ulcerans beta-lactamase 0.0082 0.074 1
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.2697 0.2692
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0086 0.0206
Leishmania major hypothetical protein, conserved 0.0056 0.045 0.5627
Echinococcus multilocularis smad 0.0018 0.0035 0.0028
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0084 0.0119
Schistosoma mansoni ap endonuclease 0.0023 0.0084 0.0145
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0157 0.1565 0.4467
Schistosoma mansoni smad 0.0018 0.0035 0.0005
Schistosoma mansoni smad1 5 8 and 0.0018 0.0035 0.0005
Brugia malayi MH1 domain containing protein 0.0018 0.0035 0.0032
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0112 0.0546

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0398 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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