TDR Targets

Basic information

Technical information

TDR Targets ID: 1299203
Name: 5-bromo-N-(thiophen-2-ylmethyl)furan-2-carbox amide
MW: 286.145 | Formula: C10H8BrNO2S
H donors: 1 H acceptors: 1 LogP: 2.83 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(o1)C(=O)NCc1cccs1
InChi: 1S/C10H8BrNO2S/c11-9-4-3-8(14-9)10(13)12-6-7-2-1-5-15-7/h1-5H,6H2,(H,12,13)
InChiKey: MAAURARLZNEXJA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-bromo-N-(2-thienylmethyl)furan-2-carboxamide
5-bromo-N-(2-thienylmethyl)-2-furancarboxamide
5-bromo-N-(2-thienylmethyl)-2-furamide
MLS000680663
SMR000272240
ZINC00475232
IVK/9174309

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0117	0.3388
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0292	0.8492
Echinococcus granulosus	dna polymerase kappa	0.002	0.0117	0.0298
Brugia malayi	RNA binding protein	0.0064	0.0629	0.2209
Brugia malayi	Ets-domain containing protein	0.0074	0.0754	0.265
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0292	0.0814
Onchocerca volvulus	Bile acid receptor homolog	0.0018	0.0092	0.2881
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0292	0.1026
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0018	0.0092	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0292	0.1026
Schistosoma mansoni	ap endonuclease	0.0038	0.0324	0.0829
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0092	0.0321
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0292	0.8971
Onchocerca volvulus		0.0035	0.0292	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0321
Trypanosoma cruzi	small ubiquitin protein, putative	0.0031	0.0243	0.7178
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0292	0.1026
Echinococcus granulosus	sentrin specific protease 1	0.0013	0.0037	0.0093
Echinococcus granulosus	GA binding protein alpha chain	0.0074	0.0754	0.1927
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0092	0.0321
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Plasmodium vivax	metacaspase 1, putative	0.0027	0.0197	0.5563
Echinococcus multilocularis	protein C ets 2	0.0011	0.0011	0.0011
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0197	0.5563
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0092	0.0321
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0292	0.1026
Echinococcus multilocularis	ETS domain containing protein Elk 1	0.0011	0.0011	0.0011
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0018	0.0092	0.0234
Schistosoma mansoni	hypothetical protein	0.0344	0.3914	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0243	0.7414
Trypanosoma cruzi	metacaspase 5, putative	0.0027	0.0197	0.5563
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0324	0.0829
Plasmodium vivax	hypothetical protein, conserved	0.0027	0.0197	0.5563
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0128
Brugia malayi	Cell death protein 3 precursor	0.0027	0.0197	0.0691
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0011	0.0011	0.0011
Echinococcus multilocularis	caspase	0.01	0.105	0.105
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Onchocerca volvulus	Cell death protein 3 homolog	0.0027	0.0197	0.6614
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0074	0.0754	0.265
Schistosoma mansoni	ets-related	0.0226	0.2524	0.6449
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0324	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0186	0.3549
Onchocerca volvulus		0.0026	0.0186	0.6238
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0092	0.0234
Echinococcus multilocularis	ewsr:fli fusion protein type	0.0011	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0321
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0148	0.1619	0.4136
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0466	0.1636
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0186	0.3549
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0324	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Echinococcus granulosus	nuclear receptor co repressor related ncor	0.0275	0.3101	0.7922
Trypanosoma cruzi	small ubiquitin protein, putative	0.0031	0.0243	0.7178
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0186	0.037
Schistosoma mansoni	retinoic acid receptor RXR	0.0018	0.0092	0.0234
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0292	0.8971
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0292	0.0746
Brugia malayi	beta-lactamase family protein	0.0035	0.0292	0.1026
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0018	0.0092	0.0321
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0197	0.5933
Trypanosoma brucei	Metacaspase-4	0.0027	0.0197	0.5563
Loa Loa (eye worm)	hypothetical protein	0.0019	0.011	0.0386
Plasmodium falciparum	small ubiquitin-related modifier	0.0031	0.0243	0.7178
Echinococcus multilocularis	GA binding protein alpha chain	0.0074	0.0754	0.0754
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0292	0.0814
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0292	0.0814
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0186	0.0654
Echinococcus multilocularis	expressed conserved protein	0.0135	0.1468	0.1468
Echinococcus multilocularis	ETS transcription factor Elf 2	0.0011	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0039
Echinococcus multilocularis	ecdysone induced protein 78C	0.0018	0.0092	0.0092
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0117	0.041
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0018	0.0092	0.2881
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0289
Giardia lamblia	Sentrin	0.0031	0.0243	0.7178
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0018	0.0092	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0321
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0292	0.0814
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0197	0.5563
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0018	0.0092	0.0092
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0117	0.0661
Entamoeba histolytica	ubiquitin like protein	0.0031	0.0243	0.1447
Schistosoma mansoni	hypothetical protein	0.0011	0.0011	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0037	0.0128
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0018	0.0092	0.0234
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0292	0.0814
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0186	0.1092
Echinococcus granulosus	geminin	0.0344	0.3914	1
Schistosoma mansoni	DNA polymerase eta	0.002	0.0117	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0321
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1572	0.5522
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0117	0.0316
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0018	0.0092	0.0321
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0018	0.0092	0.0321
Schistosoma mansoni	caspase-3 (C14 family)	0.01	0.105	0.2683
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.011	0.2552
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0027	0.0197	0.0691
Loa Loa (eye worm)	D-ets-2 protein	0.0011	0.0011	0.0039
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0197	0.5563
Onchocerca volvulus		0.0035	0.0292	1
Echinococcus granulosus	caspase 3	0.0073	0.0739	0.1887
Schistosoma mansoni	caspase-7 (C14 family)	0.0027	0.0197	0.0502
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0117	0.0117
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0292	0.8877
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0027	0.0197	0.0502
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.0092	0.0321
Brugia malayi	Ubiquitin-like protein SMT3	0.0031	0.0243	0.0854
Schistosoma mansoni	polyomavirus enhancer activator 3 pea3	0.0011	0.0011	0.0029
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0324	0.1952
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0018	0.0092	0.0092
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0013	0.0037	0.0093
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0324	0.5
Echinococcus multilocularis	caspase 2	0.0027	0.0197	0.0197
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Echinococcus granulosus	caspase	0.01	0.105	0.2683
Echinococcus multilocularis	FTZ F1 alpha	0.0018	0.0092	0.0092
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0163
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0466	0.119
Trypanosoma brucei	unspecified product	0.002	0.0117	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0186	0.0654
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0019	0.011	0.0386
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0629	0.1606
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0292	0.8492
Trypanosoma brucei	unspecified product	0.0014	0.0045	0.0289
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0117	0.041
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0292	0.1026
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0197	0.5933
Brugia malayi	hypothetical protein	0.0011	0.001	0.0036
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0186	0.3549
Schistosoma mansoni	ets-related	0.0011	0.0011	0.0029
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0324	0.1139
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0324	1
Loa Loa (eye worm)	fli-1 protein	0.0226	0.2524	0.8867
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0197	0.0691
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0466	0.0466
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0018	0.0092	0.0321
Echinococcus granulosus	ETS transcription factor Elf 1	0.0011	0.0011	0.0029
Echinococcus granulosus	expressed conserved protein	0.0135	0.1468	0.3749
Loa Loa (eye worm)	hypothetical protein	0.0253	0.2847	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0186	0.3549
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0092	0.0234
Trypanosoma brucei	metacaspase	0.0027	0.0197	0.5563
Brugia malayi	steroid hormone receptor	0.0018	0.0092	0.0321
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0629	0.2209
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0117	0.2787
Trichomonas vaginalis	Sentrin-specific protease, putative	0.0013	0.0037	0.0834
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0013	0.0037	0.0093
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0031	0.0243	0.7178
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0197	0.5563
Echinococcus granulosus	sentrin specific protease 7	0.0148	0.1619	0.4136
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0292	0.0746
Echinococcus multilocularis	ETS transcription factor Elf 1	0.0011	0.0011	0.0011
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0197	0.5563
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0186	0.3549
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0011	0.0011	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0292	0.1026
Brugia malayi	Steroid receptor seven-up type 2	0.0018	0.0092	0.0321
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0027	0.0197	0.5563
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0324	0.1139
Trypanosoma brucei	metacaspase MCA3	0.0027	0.0197	0.5563
Loa Loa (eye worm)	DNA-binding protein D-ETS-3	0.0011	0.0011	0.0039
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Brugia malayi	Ets-domain containing protein	0.0011	0.0011	0.0039
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0018	0.0092	0.0234
Trypanosoma cruzi	metacaspase, putative	0.0027	0.0197	0.5563
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0018	0.0092	0.0234
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0324	1
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0163
Trypanosoma brucei	small ubiquitin-related modifier	0.0031	0.0243	0.7178
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0629	0.1606
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Echinococcus multilocularis	caspase 3	0.0073	0.0739	0.0739
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0117	0.0117
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0018	0.0092	0.0321
Trichomonas vaginalis	esterase, putative	0.0035	0.0292	0.8971
Echinococcus granulosus	ecdysone induced protein 78C	0.0018	0.0092	0.0234
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0292	0.8877
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0292	0.8971
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0186	0.3549
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0019	0.011	0.0386
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0292	0.8971
Brugia malayi	TAR-binding protein	0.0064	0.0629	0.2209
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0128
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0324	1
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0292	0.8877
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.011	0.0051
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0117	0.2787
Echinococcus granulosus	ewsr:fli fusion protein type	0.0011	0.0011	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0292	0.1026
Schistosoma mansoni	coup transcription factor	0.0018	0.0092	0.0234
Giardia lamblia	DINP protein human, muc B family	0.002	0.0117	0.2787
Schistosoma mansoni	hypothetical protein	0.0344	0.3914	1
Echinococcus multilocularis	ETS transcription factor Elf 5	0.0011	0.0011	0.0011
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0292	0.0292
Schistosoma mansoni	gabp alpha	0.0074	0.0754	0.1927
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.0092	0.0234
Loa Loa (eye worm)	Ulp1 protease	0.0013	0.0037	0.0128
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0018	0.0092	0.0321
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0466	0.119
Schistosoma mansoni	ets	0.0011	0.0011	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0321
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.011	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0186	0.5195
Brugia malayi	MH2 domain containing protein	0.0144	0.1572	0.5522
Echinococcus multilocularis	nuclear receptor co repressor related (ncor)	0.0275	0.3101	0.3101
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.2485	1
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0629	0.0629
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0197	0.5933
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0186	0.0654
Schistosoma mansoni	elf1	0.0011	0.0011	0.0029
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0117	0.3388
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.0092	0.0321
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.011	0.2552
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0324	1
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0031	0.0243	0.0621
Plasmodium falciparum	metacaspase-like protein	0.0027	0.0197	0.5563
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0629	0.2209
Echinococcus granulosus	ubiquitin	0.0011	0.001	0.0026
Echinococcus multilocularis	sentrin specific protease 7	0.0148	0.1619	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0197	0.0691
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0092	0.0234
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0092	0.0321
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0292	0.0814
Onchocerca volvulus		0.0013	0.0037	0.093
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0466	0.119
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0324	1
Echinococcus granulosus	caspase 8	0.0027	0.0197	0.0502
Brugia malayi	nuclear hormone receptor	0.0018	0.0092	0.0321
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0117	0.008
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0186	0.0654
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.01	0.105	0.2683
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0292	0.0814
Echinococcus granulosus	FTZ F1 alpha	0.0018	0.0092	0.0234
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0018	0.0092	0.0321
Echinococcus granulosus	caspase 2	0.0027	0.0197	0.0502
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0037	0.0834
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0117	0.0316
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0466	0.0466
Echinococcus multilocularis	ubiquitin	0.0011	0.001	0.001
Trichomonas vaginalis	sentrin/sumo-specific protease, senp8, putative	0.0013	0.0037	0.0834
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0117	0.2787
Brugia malayi	beta-lactamase family protein	0.0035	0.0292	0.1026
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0117	0.0298
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0019	0.011	0.0386
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0018	0.0092	0.0092
Trypanosoma cruzi	metacaspase 5, putative	0.0027	0.0197	0.5563
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0186	0.3549
Echinococcus multilocularis	sentrin specific protease 8	0.0013	0.0037	0.0037
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0186	0.037
Brugia malayi	Ets-domain containing protein	0.0074	0.0754	0.265
Trypanosoma brucei	metacaspase 5, putative	0.0027	0.0197	0.5563
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0628	0.2207
Leishmania major	metacaspase, putative	0.0027	0.0197	0.5563
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0117	0.0298
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0018	0.0092	0.0321
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0018	0.0092	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0321
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0292	0.0814
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0629	0.1606
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0117	0.041
Brugia malayi	beta-lactamase	0.0035	0.0292	0.1026
Loa Loa (eye worm)	ets-domain-containing protein	0.0011	0.0011	0.0039
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.0092	0.0234
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0092	0.0092
Onchocerca volvulus		0.0035	0.0292	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0629	0.2209
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0128
Loa Loa (eye worm)	steroid hormone receptor	0.0018	0.0092	0.0321
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0324	0.5
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0292	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0289
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0018	0.0092	0.0092
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0292	0.8971
Leishmania major	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Trypanosoma brucei	unspecified product	0.0014	0.0045	0.0289
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0018	0.0092	0.0234
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0163
Leishmania major	DNA polymerase eta, putative	0.002	0.0117	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0039
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0018	0.0092	0.0234
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0292	0.8877
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0186	0.1092
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0031	0.0243	0.7178
Loa Loa (eye worm)	SMO-1 protein	0.0031	0.0243	0.0854
Echinococcus granulosus	ETS transcription factor Elf 2	0.0011	0.0011	0.0029
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Toxoplasma gondii	exonuclease III APE	0.0038	0.0324	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0186	0.0654
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0289
Echinococcus granulosus	ETS domain containing protein Elk 1	0.0011	0.0011	0.0029
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.01	0.105	0.105
Echinococcus multilocularis	ets variant gene 4	0.0011	0.0011	0.0011
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0163
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0117	0.2787
Brugia malayi	transcription factor E74 isoform	0.0011	0.0011	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0197	0.5933
Brugia malayi	DNA-binding protein D-ETS-3	0.0011	0.0011	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0092	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0019	0.011	0.0386
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0018	0.0092	0.0234
Echinococcus granulosus	dna polymerase eta	0.002	0.0117	0.0298
Brugia malayi	nuclear receptor NHR-88	0.0018	0.0092	0.0321
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0117	0.2787
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0292	0.0814
Schistosoma mansoni	caspase-7 (C14 family)	0.01	0.105	0.2683
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.0092	0.0092
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0292	0.8492
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0148	0.1619	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0186	0.0654
Leishmania major	small ubiquitin protein, putative	0.0031	0.0243	0.7178
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0324	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0018	0.0092	0.0234
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0629	0.1606
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0018	0.0092	0.0092
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0018	0.0092	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0037	0.0128
Echinococcus granulosus	protein C ets 2	0.0011	0.0011	0.0029
Loa Loa (eye worm)	Ulp1 protease	0.0013	0.0037	0.0128
Echinococcus multilocularis	dna polymerase eta	0.002	0.0117	0.0117
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0466	0.119
Echinococcus multilocularis	geminin	0.0344	0.3914	0.3914
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0292	0.1026
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0186	0.5195
Plasmodium falciparum	metacaspase 1	0.0027	0.0197	0.5563
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0186	0.3549
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0031	0.0243	0.0243
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0629	0.1606
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.0036
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0324	0.0949
Onchocerca volvulus		0.0012	0.0028	0.0628
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1572	0.5522
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0013	0.0037	0.0128
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Echinococcus multilocularis	sentrin specific protease 1	0.0013	0.0037	0.0037
Schistosoma mansoni	ap endonuclease	0.0038	0.0324	0.0829
Brugia malayi	ecdysteroid receptor	0.0018	0.0092	0.0321
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.041
Echinococcus granulosus	ETS transcription factor Elf 2	0.0011	0.0011	0.0029
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0292	0.8492
Leishmania major	hypothetical protein, conserved	0.0035	0.0292	0.8877
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0018	0.0092	0.0234
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0117	0.008
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0292	0.0746
Echinococcus granulosus	Small ubiquitin modifier 2	0.0031	0.0243	0.0621
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0117	0.2787
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0292	0.0814
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0292	1
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0013	0.0037	0.0834
Onchocerca volvulus	Protein ultraspiracle homolog	0.0018	0.0092	0.2881
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0324	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.0092	0.0321
Mycobacterium ulcerans	lipase LipD	0.0035	0.0292	0.8492
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0466	0.119
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0027	0.0197	0.5933
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0466	0.1636
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0629	0.2209
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0324	0.0324
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0037	0.0128
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0013	0.0037	0.0093
Toxoplasma gondii	ABC1 family protein	0.0035	0.0292	0.8877
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0324	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.2787
Schistosoma mansoni	hypothetical protein	0.0011	0.0011	0.0029
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0117	0.0298
Onchocerca volvulus		0.0018	0.0092	0.2881
Echinococcus granulosus	ETS transcription factor Elf 5	0.0011	0.0011	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0018	0.0092	0.0321
Brugia malayi	Fli-1 protein	0.0226	0.2524	0.8867
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0629	0.1606
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0197	0.5933
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0197	0.5933
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0018	0.0092	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0292	0.1026
Brugia malayi	photoreceptor-specific nuclear receptor	0.0253	0.2847	1
Echinococcus granulosus	sentrin specific protease 8	0.0013	0.0037	0.0093
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0018	0.0092	0.0234
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0186	0.5195
Schistosoma mansoni	RAR-like nuclear receptor	0.0018	0.0092	0.0234
Echinococcus multilocularis	caspase 8	0.0027	0.0197	0.0197
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0018	0.0092	0.0234
Trypanosoma brucei	metacaspase MCA2	0.0027	0.0197	0.5563
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0186	0.1092
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.0092	0.0234

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3264 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.5849 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1409301

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1299203