TDR Targets

Basic information

Technical information

TDR Targets ID: 1299407
Name: N-(1,3-benzothiazol-2-yl)-2-[1-(4-fluoropheny l)tetrazol-5-yl]sulfanylacetamide
MW: 386.427 | Formula: C16H11FN6OS2
H donors: 1 H acceptors: 5 LogP: 3.86 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)n1nnnc1SCC(=O)Nc1nc2c(s1)cccc2
InChi: 1S/C16H11FN6OS2/c17-10-5-7-11(8-6-10)23-16(20-21-22-23)25-9-14(24)19-15-18-12-3-1-2-4-13(12)26-15/h1-8H,9H2,(H,18,19,24)
InChiKey: WHXTXNXYLQHYDO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(1,3-benzothiazol-2-yl)-2-[1-(4-fluorophenyl)tetrazol-5-yl]sulfanyl-acetamide
N-(1,3-benzothiazol-2-yl)-2-[[1-(4-fluorophenyl)-5-tetrazolyl]thio]acetamide
N-(1,3-benzothiazol-2-yl)-2-[[1-(4-fluorophenyl)tetrazol-5-yl]thio]acetamide
N-(1,3-benzothiazol-2-yl)-2-[[1-(4-fluorophenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]ethanamide
BAS 04455819
N-Benzothiazol-2-yl-2-[1-(4-fluoro-phenyl)-1H-tetrazol-5-ylsulfanyl]-acetamide
MLS000067756
ZINC00783298
SMR000122375

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed), eta	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma brucei gambiense	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus granulosus	dna polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Toxoplasma gondii	ImpB/MucB/SamB family protein	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania infantum	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Brugia malayi	ImpB/MucB/SamB family protein	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania infantum	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Candida albicans	similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions	Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus multilocularis	dna polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma cruzi	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K03509 DNA polymerase eta subunit, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma japonicum	ko:K03509 DNA polymerase eta subunit, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Candida albicans	similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions	Get druggable targets OG5_128521	All targets in OG5_128521
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Neospora caninum	Pc21g17280 protein, related	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania braziliensis	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania major	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma cruzi	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma mansoni	DNA polymerase eta	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania braziliensis	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma congolense	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Cryptosporidium parvum	DinB/family X-type DNA polymerase	Get druggable targets OG5_128521	All targets in OG5_128521
Leishmania mexicana		Get druggable targets OG5_128521	All targets in OG5_128521
Trypanosoma brucei	DNA polymerase eta, putative	Get druggable targets OG5_128521	All targets in OG5_128521
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable lipase LipD	0.0071	0.1258	0.1212
Schistosoma mansoni	DNA polymerase eta	0.0054	0.0862	0.3132
Echinococcus granulosus	dro:myosuppressin receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0052	0.0001
Leishmania major	hypothetical protein, conserved	0.0071	0.1258	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.1258	0.4277
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	G protein coupled receptor 139	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0052	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0052	0.0001
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.1258	0.1943
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.626	1
Brugia malayi	neuropeptide F receptor	0.0018	0.0052	0.0001
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.626	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0889	0.3235
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0051	0.5
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0022	0.0143	0.0148
Echinococcus granulosus	BC026374 protein S09 family	0.0022	0.0143	0.0354
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0052	0.0001
Brugia malayi	follicle stimulating hormone receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0143	0.0354
Schistosoma mansoni	amine GPCR	0.0018	0.0052	0.0001
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0052	0.0001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Trypanosoma cruzi	DNA polymerase eta, putative	0.0054	0.0862	0.6722
Echinococcus multilocularis	neuropeptide receptor A26	0.0018	0.0052	0.0001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Trypanosoma brucei	DNA polymerase eta, putative	0.0054	0.0862	0.6856
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0052	0.0001
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0164	0.0436
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	somatostatin receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1146	0.4229
Echinococcus granulosus	7tm_1 domain containing protein	0.0018	0.0052	0.0001
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0164	0.0935
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0071	0.1258	0.1212
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1258	0.4659
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0143	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1258	0.4659
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0052	0.0001
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	sex peptide receptor	0.0018	0.0052	0.0001
Treponema pallidum	fructose-bisphosphate aldolase	0.0292	0.626	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1258	0.4659
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0889	0.3235
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1258	0.4659
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1258	0.4659
Echinococcus granulosus	g-protein coupled receptor	0.0018	0.0052	0.0001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus granulosus	orexin receptor type 2	0.0018	0.0052	0.0001
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0132	0.264	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	beta-lactamase	0.0071	0.1258	0.4659
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0051	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	Dopamine receptor protein 1	0.0018	0.0052	0.0001
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Echinococcus granulosus	acetylcholinesterase	0.0132	0.264	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0143	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	opsin-like receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0164	0.0436
Brugia malayi	Serotonin receptor	0.0018	0.0052	0.0001
Brugia malayi	Carboxylesterase family protein	0.0132	0.264	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0498	0.3699
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0164	0.0436
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.2872	0.2835
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0018	0.0052	0.0001
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1258	0.1943
Brugia malayi	G-protein coupled receptor	0.0018	0.0052	0.0001
Onchocerca volvulus		0.0071	0.1258	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0018	0.0052	0.0001
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0052	0.0001
Brugia malayi	G protein-coupled receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0889	0.3235
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1258	0.1212
Schistosoma mansoni	myosin xvIII	0.0018	0.0052	0.0001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0052	0.0001
Echinococcus granulosus	dna polymerase eta	0.0054	0.0862	0.3132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0052	0.0001
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	putative neuropeptide receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	TYRA-2 protein	0.0018	0.0052	0.0001
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	neuropeptide s receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	para nitrobenzyl esterase	0.0022	0.0143	0.0354
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0164	0.04
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0164	0.0935
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0164	0.0182
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0052	0.0001
Brugia malayi	beta-lactamase family protein	0.0071	0.1258	0.4659
Brugia malayi	neuropeptide F receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0143	0.0092
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1258	0.1943
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0143	0.0354
Brugia malayi	RE15519p	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1258	0.4659
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0164	0.0113
Brugia malayi	sulfakinin receptor protein	0.0018	0.0052	0.0001
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0018	0.0052	0.0001
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0164	0.1305
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0164	0.0436
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	allatostatin A receptor	0.0018	0.0052	0.0001
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0052	0.0001
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.1258	0.4277
Loa Loa (eye worm)	hypothetical protein	0.0132	0.264	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0018	0.0052	0.0001
Brugia malayi	ORL1-like opioid receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	serotonin receptor	0.0018	0.0052	0.0001
Leishmania major	DNA polymerase eta, putative	0.0038	0.0498	0.3699
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0018	0.0052	0.0001
Echinococcus granulosus	neuroligin	0.0022	0.0143	0.0354
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0018	0.0052	0.0001
Schistosoma mansoni	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0052	0.0001
Brugia malayi	Melibiase family protein	0.0067	0.1146	0.4229
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0052	0.0001
Mycobacterium ulcerans	lipase LipD	0.0071	0.1258	0.4277
Echinococcus multilocularis	sex peptide receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0052	0.0001
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0018	0.0052	0.0001
Brugia malayi	hypothetical protein	0.0022	0.0143	0.0354
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0018	0.0052	0.0001
Echinococcus multilocularis	dro:myosuppressin receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	G protein coupled receptor 139	0.0018	0.0052	0.0001
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Toxoplasma gondii	melibiase subfamily protein	0.01	0.1901	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.626	1
Mycobacterium ulcerans	beta-lactamase	0.0071	0.1258	0.4277
Mycobacterium ulcerans	carboxylesterase, LipT	0.0022	0.0143	0.0325
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Loa Loa (eye worm)	acetylcholinesterase 1	0.0132	0.264	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0292	0.626	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0018	0.0052	0.0001
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0018	0.0052	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.1258	0.1943
Echinococcus multilocularis	somatostatin receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0143	0.0354
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0164	0.0935
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.1258	0.4659
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0018	0.0052	0.0001
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0018	0.0052	0.0001
Onchocerca volvulus		0.0022	0.0143	0.0759
Echinococcus multilocularis	carboxylesterase 5A	0.0132	0.264	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.1258	0.4659
Echinococcus granulosus	neuropeptide s receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0862	0.3132
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	carboxylesterase	0.0022	0.0143	0.0354
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1258	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.1146	0.4229
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0018	0.0052	0.0001
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0889	0.3235
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1258	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1258	0.1943
Echinococcus granulosus	7TM GPCR rhodopsin	0.0018	0.0052	0.0001
Echinococcus granulosus	fmrfamide receptor	0.0018	0.0052	0.0001
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.626	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0018	0.0052	0.0001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0889	0.3235
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0052	0.0001
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0018	0.0052	0.0001
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1901	0.7145
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0164	0.0182
Schistosoma mansoni	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0051	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.1258	1
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0052	0.0001
Onchocerca volvulus		0.0022	0.0143	0.0759
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0143	0.0354
Mycobacterium tuberculosis	Probable hydrolase	0.0071	0.1258	0.1212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Onchocerca volvulus		0.0022	0.0143	0.0759
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Onchocerca volvulus		0.0071	0.1258	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0018	0.0052	0.0001
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0022	0.0143	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Mycobacterium ulcerans	hypothetical protein	0.0071	0.1258	0.4277
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Echinococcus granulosus	neuropeptide receptor A26	0.0018	0.0052	0.0001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0889	0.3235
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.01	0.1901	0.7145
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Trichomonas vaginalis	spcc417.12 protein, putative	0.0022	0.0143	0.0148
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.1146	0.4229
Brugia malayi	ImpB/MucB/SamB family protein	0.0054	0.0862	0.3132
Brugia malayi	G protein-coupled receptor F59B2.13	0.0018	0.0052	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.1258	0.4659
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.626	1
Loa Loa (eye worm)	hypothetical protein	0.0132	0.264	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0018	0.0052	0.0001
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Onchocerca volvulus		0.0022	0.0143	0.0759
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.1258	0.4659
Schistosoma mansoni	growth hormone secretagogue receptor	0.0018	0.0052	0.0001
Onchocerca volvulus		0.0022	0.0143	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0143	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0052	0.0001
Leishmania major	DNA polymerase eta, putative	0.0054	0.0862	0.6722
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0022	0.0143	0.0092
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.2872	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Brugia malayi	Carboxylesterase family protein	0.0022	0.0143	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	histamine h1 receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0889	0.3235
Brugia malayi	Dopamine receptor	0.0018	0.0052	0.0001
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0022	0.0143	0.0092
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Echinococcus granulosus	carboxylesterase 5A	0.0132	0.264	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	beta-lactamase family protein	0.0071	0.1258	0.4659
Echinococcus multilocularis	orexin receptor type 2	0.0018	0.0052	0.0001
Echinococcus granulosus	neuropeptide FF receptor 2	0.0018	0.0052	0.0001
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.1258	0.4659
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0164	0.04
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	Dopamine receptor protein 2	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0067	0.1146	0.1763
Echinococcus multilocularis	allatostatin A receptor	0.0018	0.0052	0.0001
Brugia malayi	AKH receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	amine GPCR	0.0018	0.0052	0.0001
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0022	0.0143	0.0354
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0052	0.0001
Trichomonas vaginalis	esterase, putative	0.0071	0.1258	0.1943
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	acetylcholinesterase	0.0022	0.0143	0.0354
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.626	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0071	0.1258	0.1212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0143	0.0354
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Echinococcus granulosus	acetylcholinesterase	0.0132	0.264	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0052	0.0001
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0164	0.0182
Echinococcus multilocularis	neuroligin	0.0022	0.0143	0.0354
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.01	0.1901	0.7145
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0052	0.0001
Brugia malayi	Carboxylesterase family protein	0.0022	0.0143	0.0354
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0164	0.0935
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0018	0.0052	0.0001
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.1258	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0018	0.0052	0.0001
Mycobacterium tuberculosis	Probable esterase LipL	0.0071	0.1258	0.1212
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0052	0.0001
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0164	0.1305
Trypanosoma brucei	unspecified product	0.0023	0.0164	0.1305
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0164	0.0935
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.01	0.1901	0.7145
Schistosoma mansoni	neuropeptide f receptor 76f	0.0018	0.0052	0.0001
Echinococcus granulosus	serotonin receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	amine GPCR	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	carboxylesterase	0.0132	0.264	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0018	0.0052	0.0001
Brugia malayi	GnHR receptor homolog	0.0018	0.0052	0.0001
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	serotonin receptor	0.0018	0.0052	0.0001
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0038	0.0498	0.2412
Brugia malayi	Serotonin receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0164	0.0436
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0164	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	hypothetical protein	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0164	0.0436
Echinococcus multilocularis	g-protein coupled receptor	0.0018	0.0052	0.0001
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.626	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	G-protein coupled receptor	0.0018	0.0052	0.0001
Loa Loa (eye worm)	melatonin receptor type 1A	0.0018	0.0052	0.0001
Schistosoma mansoni	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.264	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0052	0.0001
Brugia malayi	Carboxylesterase family protein	0.0132	0.264	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0143	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Schistosoma mansoni	adenoreceptor	0.0018	0.0052	0.0001
Onchocerca volvulus		0.0071	0.1258	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0022	0.0143	0.0354
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.626	1
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.264	1
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.2872	1
Schistosoma mansoni	opsin-like receptor	0.0018	0.0052	0.0001
Brugia malayi	putative neuropeptide receptor NPR1	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.626	1
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1258	0.1212
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0052	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0052	0.0001
Toxoplasma gondii	ABC1 family protein	0.0071	0.1258	0.6521
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0164	0.0113
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0889	0.3235
Echinococcus multilocularis	dna polymerase eta	0.0054	0.0862	0.3132
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0018	0.0052	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0052	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0001
Echinococcus multilocularis	para nitrobenzyl esterase	0.0022	0.0143	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0143	0.0354
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1901	0.7145
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1901	0.7145
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0018	0.0052	0.0001
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0052	0.0001
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0164	0.1305
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0052	0.0001
Brugia malayi	Melatonin receptor type 1A	0.0018	0.0052	0.0001
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.1258	0.4659
Brugia malayi	larval opioid receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	amine GPCR	0.0018	0.0052	0.0001
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0164	0.0436
Schistosoma mansoni	amine GPCR	0.0018	0.0052	0.0001
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0071	0.1258	0.1212
Brugia malayi	beta-lactamase	0.0071	0.1258	0.4659
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0071	0.1258	0.1212
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.01	0.1901	0.7145
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0164	0.1305
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0164	0.0935
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0018	0.0052	0.0001
Brugia malayi	Carboxylesterase family protein	0.0022	0.0143	0.0354
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0022	0.0143	0.0354
Schistosoma mansoni	opsin-like receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	BC026374 protein (S09 family)	0.0022	0.0143	0.0354
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0052	0.0001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0889	0.3235
Schistosoma mansoni	gliotactin	0.0022	0.0143	0.0354
Echinococcus granulosus	hypothetical protein	0.0018	0.0052	0.0001
Brugia malayi	Carboxylesterase family protein	0.0022	0.0143	0.0354
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1258	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0022	0.0143	0.0354
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0164	0.0182
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.626	1
Brugia malayi	hypothetical protein	0.0018	0.0052	0.0001

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1420797

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1299407