TDR Targets

Basic information

Technical information

TDR Targets ID: 1299685
Name: N-(4-ethoxyphenyl)-1,3-benzothiazole-6-sulfon amide
MW: 334.413 | Formula: C15H14N2O3S2
H donors: 1 H acceptors: 3 LogP: 3.24 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)NS(=O)(=O)c1ccc2c(c1)scn2
InChi: 1S/C15H14N2O3S2/c1-2-20-12-5-3-11(4-6-12)17-22(18,19)13-7-8-14-15(9-13)21-10-16-14/h3-10,17H,2H2,1H3
InChiKey: MNQDHXALIYRFFY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

SMR000300945
MLS000663368
AG-205/41004735
ZINC00969983

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	pyruvate kinase, muscle	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium vivax	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania donovani	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Theileria parva	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium falciparum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium hominis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium knowlesi	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei gambiense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Cryptosporidium parvum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase-PB	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium berghei	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma brucei	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Trichomonas vaginalis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	pyruvate kinase 2, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	Pyruvate kinase, muscle isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Toxoplasma gondii	pyruvate kinase PyK1	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania major	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Trypanosoma congolense	pyruvate kinase 1, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium leprae	Probable pyruvate kinase PykA	Get druggable targets OG5_126685	All targets in OG5_126685
Plasmodium yoelii	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania braziliensis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus granulosus	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Mycobacterium ulcerans	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania infantum	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Leishmania mexicana	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126685	All targets in OG5_126685
Entamoeba histolytica	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma japonicum	ko:K00873 pyruvate kinase [EC2.7.1.40], putative	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus	Pyruvate kinase homolog	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Giardia lamblia	Pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Echinococcus multilocularis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Chlamydia trachomatis	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Neospora caninum	Pyruvate kinase (EC 2.7.1.40), related	Get druggable targets OG5_126685	All targets in OG5_126685
Loa Loa (eye worm)	pyruvate kinase	Get druggable targets OG5_126685	All targets in OG5_126685
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Pyruvate kinase isozyme R, putative	Get druggable targets OG5_126685	All targets in OG5_126685
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	Pyruvate kinase, M2 isozyme	Get druggable targets OG5_126685	All targets in OG5_126685
Babesia bovis	pyruvate kinase, putative	Get druggable targets OG5_126685	All targets in OG5_126685

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyruvate kinase	pyruvate kinase, muscle	605 aa	521 aa	34.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	neuropeptide receptor A26	0.0069	0.8512	0.8388
Schistosoma mansoni	neuropeptide F-like receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.8512	0.8388
Echinococcus granulosus	somatostatin receptor	0.0069	0.8512	0.8011
Brugia malayi	RE15519p	0.0069	0.8512	0.8011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.8512	0.8011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Echinococcus granulosus	biogenic amine 5HT receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0069	0.8512	0.8388
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.8512	0.8388
Echinococcus granulosus	7TM GPCR rhodopsin	0.0069	0.8512	0.8011
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	TYRA-2 protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Onchocerca volvulus		0.0069	0.8512	1
Schistosoma mansoni	opsin-like receptor	0.0069	0.8512	0.8011
Mycobacterium leprae	Probable pyruvate kinase PykA	0.004	0.2518	0.5
Trichomonas vaginalis	pyruvate kinase, putative	0.004	0.2518	0.5
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Brugia malayi	putative neuropeptide receptor	0.0069	0.8512	0.8011
Onchocerca volvulus		0.0069	0.8512	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0069	0.8512	0.8388
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.8512	0.8388
Leishmania major	pyruvate kinase	0.004	0.2518	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0069	0.8512	0.8388
Trypanosoma cruzi	pyruvate kinase 2, putative	0.004	0.2518	0.5
Echinococcus multilocularis	sex peptide receptor	0.0069	0.8512	0.8388
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0069	0.8512	0.8011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.8512	0.8011
Brugia malayi	AKH receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	neuropeptide receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	biogenic amine 5HT receptor	0.0069	0.8512	0.8011
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Onchocerca volvulus		0.0069	0.8512	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	biogenic amine receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0069	0.8512	0.8011
Entamoeba histolytica	pyruvate kinase, putative	0.0028	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	neuropeptides capa receptor	0.0069	0.8512	0.8388
Brugia malayi	Dopamine receptor protein 2	0.0069	0.8512	0.8011
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	neuropeptide F-like receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.8512	0.8388
Schistosoma mansoni	neuropeptide receptor	0.0069	0.8512	0.8011
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0069	0.8512	0.8011
Echinococcus granulosus	orexin receptor type 2	0.0069	0.8512	0.8011
Trypanosoma brucei	pyruvate kinase 1	0.004	0.2518	0.5
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.004	0.2518	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Brugia malayi	larval opioid receptor	0.0069	0.8512	0.8011
Brugia malayi	G protein-coupled receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.8512	0.8388
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Plasmodium vivax	pyruvate kinase, putative	0.004	0.2518	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0069	0.8512	0.8011
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0069	0.8512	0.8388
Schistosoma mansoni	opsin-like receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	neuropeptide receptor A26	0.0069	0.8512	0.8011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.8512	0.8388
Echinococcus granulosus	g protein coupled receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	histamine h1 receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	g protein coupled receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.8512	0.8011
Echinococcus granulosus	g-protein coupled receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.8512	0.8388
Schistosoma mansoni	neuropeptide receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	pyruvate kinase	0.004	0.2518	0.2518
Onchocerca volvulus		0.0069	0.8512	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0069	0.8512	0.8388
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus granulosus	g protein coupled receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus granulosus	neuropeptide receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.8512	0.8388
Onchocerca volvulus		0.0069	0.8512	1
Brugia malayi	follicle stimulating hormone receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus granulosus	sex peptide receptor	0.0069	0.8512	0.8011
Onchocerca volvulus		0.0069	0.8512	1
Giardia lamblia	Pyruvate kinase	0.004	0.2518	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.8512	0.8011
Schistosoma mansoni	hypothetical protein	0.0069	0.8512	0.8011
Onchocerca volvulus		0.0069	0.8512	1
Mycobacterium ulcerans	pyruvate kinase	0.004	0.2518	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	pyruvate kinase	0.004	0.2518	0.1899
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Brugia malayi	ORL1-like opioid receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0069	0.8512	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	melatonin receptor type 1A	0.0069	0.8512	0.8512
Loa Loa (eye worm)	G-protein coupled receptor	0.0069	0.8512	0.8512
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0069	0.8512	0.8388
Echinococcus granulosus	dro:myosuppressin receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.8512	0.8011
Onchocerca volvulus		0.0069	0.8512	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	orexin receptor type 2	0.0069	0.8512	0.8388
Schistosoma mansoni	myosin xvIII	0.0069	0.8512	0.8011
Loa Loa (eye worm)	pyruvate kinase	0.004	0.2518	0.2518
Schistosoma mansoni	amine GPCR	0.0069	0.8512	0.8011
Echinococcus granulosus	neuropeptide Y receptor	0.0069	0.8512	0.8011
Brugia malayi	Melatonin receptor type 1A	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.004	0.2518	0.2518
Echinococcus granulosus	allatostatin A receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0069	0.8512	0.8388
Onchocerca volvulus		0.0069	0.8512	1
Trypanosoma brucei	pyruvate kinase 1, putative	0.004	0.2518	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.8512	0.8388
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0069	0.8512	0.8512
Echinococcus granulosus	7tm_1 domain containing protein	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.8512	0.8011
Loa Loa (eye worm)	RNA binding protein	0.0076	1	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	hypothetical protein	0.0069	0.8512	0.8011
Chlamydia trachomatis	pyruvate kinase	0.004	0.2518	0.5
Schistosoma mansoni	amine GPCR	0.0069	0.8512	0.8011
Schistosoma mansoni	adenoreceptor	0.0069	0.8512	0.8011
Echinococcus granulosus	neuropeptide s receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	amine GPCR	0.0069	0.8512	0.8011
Brugia malayi	neuropeptide F receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.8512	0.8011
Plasmodium falciparum	pyruvate kinase	0.004	0.2518	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0069	0.8512	0.8011
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0069	0.8512	0.8011
Brugia malayi	Serotonin receptor	0.0069	0.8512	0.8011
Onchocerca volvulus		0.0069	0.8512	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0069	0.8512	0.8512
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0069	0.8512	0.8388
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Brugia malayi	RNA recognition motif domain containing protein	0.0076	1	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	pyruvate kinase	0.004	0.2518	0.1899
Echinococcus granulosus	neuropeptides capa receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0069	0.8512	0.8388
Echinococcus granulosus	neuropeptide receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	hypothetical protein	0.0069	0.8512	0.8011
Echinococcus multilocularis	neuropeptides capa receptor	0.0069	0.8512	0.8388
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0069	0.8512	0.8011
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0069	0.8512	0.8388
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Brugia malayi	G-protein coupled receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	TAR-binding protein	0.0076	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0069	0.8512	0.8011
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.8512	0.8011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Echinococcus granulosus	neuropeptide Y receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	biogenic amine receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	pyruvate kinase	0.004	0.2518	0.2518
Schistosoma mansoni	opsin-like receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	fmrfamide receptor	0.0069	0.8512	0.8388
Echinococcus multilocularis	serotonin receptor	0.0069	0.8512	0.8388
Brugia malayi	putative neuropeptide receptor NPR1	0.0069	0.8512	0.8011
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0069	0.8512	0.8512
Toxoplasma gondii	pyruvate kinase PyK1	0.004	0.2518	0.5
Onchocerca volvulus		0.0069	0.8512	1
Onchocerca volvulus		0.0069	0.8512	1
Echinococcus multilocularis	tar DNA binding protein	0.0076	1	1
Onchocerca volvulus		0.0069	0.8512	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0069	0.8512	0.8011
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.8512	0.8388
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0069	0.8512	0.8011
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0069	0.8512	0.8011
Brugia malayi	neuropeptide F receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	serotonin receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0069	0.8512	0.8388
Echinococcus granulosus	neuropeptides capa receptor	0.0069	0.8512	0.8011
Brugia malayi	TAR-binding protein	0.0076	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0069	0.8512	0.8512
Echinococcus multilocularis	g-protein coupled receptor	0.0069	0.8512	0.8388
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.8512	0.8388
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0069	0.8512	0.8011
Onchocerca volvulus		0.0069	0.8512	1
Brugia malayi	Dopamine receptor	0.0069	0.8512	0.8011
Onchocerca volvulus		0.0069	0.8512	1
Echinococcus granulosus	tar DNA binding protein	0.0076	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0069	0.8512	0.8388
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.8512	0.8388
Trichomonas vaginalis	pyruvate kinase, putative	0.004	0.2518	0.5
Brugia malayi	Dopamine receptor protein 1	0.0069	0.8512	0.8011
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.8512	0.8388
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0069	0.8512	0.8011
Leishmania major	pyruvate kinase	0.004	0.2518	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0069	0.8512	0.8011
Echinococcus multilocularis	dro:myosuppressin receptor	0.0069	0.8512	0.8388
Onchocerca volvulus		0.0069	0.8512	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	neuropeptide F receptor	0.0069	0.8512	0.8512
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0069	0.8512	0.8388
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0069	0.8512	0.8512
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.8512	0.8011
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0069	0.8512	0.8512
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0069	0.8512	0.8388
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0069	0.8512	0.8011
Brugia malayi	sulfakinin receptor protein	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Trypanosoma cruzi	pyruvate kinase 2, putative	0.004	0.2518	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0069	0.8512	0.8011
Brugia malayi	GnHR receptor homolog	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Brugia malayi	Serotonin receptor	0.0069	0.8512	0.8011
Brugia malayi	G-protein coupled receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.8512	0.8011
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Schistosoma mansoni	amine GPCR	0.0069	0.8512	0.8011
Echinococcus granulosus	hypothetical protein	0.0069	0.8512	0.8011
Echinococcus multilocularis	neuropeptide receptor	0.0069	0.8512	0.8388
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0069	0.8512	0.8388
Echinococcus granulosus	G protein coupled receptor 139	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	fmrfamide receptor	0.0069	0.8512	0.8388
Schistosoma mansoni	hypothetical protein	0.0069	0.8512	0.8011
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Schistosoma mansoni	neuropeptide receptor	0.0069	0.8512	0.8011
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0069	0.8512	0.8388
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0069	0.8512	0.8388
Loa Loa (eye worm)	hypothetical protein	0.0069	0.8512	0.8512
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0069	0.8512	1
Echinococcus multilocularis	serotonin receptor	0.0069	0.8512	0.8388
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.8512	0.8011
Schistosoma mansoni	amine GPCR	0.0069	0.8512	0.8011
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0069	0.8512	0.8011
Brugia malayi	G protein-coupled receptor F59B2.13	0.0069	0.8512	0.8011
Echinococcus multilocularis	neuropeptide s receptor	0.0069	0.8512	0.8388
Echinococcus multilocularis	neuropeptide Y receptor	0.0069	0.8512	0.8388
Echinococcus multilocularis	somatostatin receptor	0.0069	0.8512	0.8388
Onchocerca volvulus		0.0069	0.8512	1
Echinococcus granulosus	fmrfamide receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0069	0.8512	0.8011
Brugia malayi	hypothetical protein	0.0069	0.8512	0.8011
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0069	0.8512	0.8512
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0069	0.8512	0.8011
Schistosoma mansoni	biogenic amine receptor	0.0069	0.8512	0.8011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.8512	0.8011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.8512	0.8011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.8512	0.8388

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1422578

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1299685