Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0224 | 0.0546 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2786 | 0.6798 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2786 | 0.7369 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.3781 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0224 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.4758 | 0.4758 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.2786 | 0.2786 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2786 | 0.7369 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.4098 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1884 | 0.1276 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2786 | 0.7369 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0487 | 0.1188 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0317 | 0.0317 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1674 | 0.4427 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0487 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2269 | 0.2269 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 1 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.3781 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.014 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2786 | 0.7369 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2786 | 0.6798 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.189 | 0.189 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0317 | 0.0774 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0487 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.21 | 0.21 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1674 | 0.4427 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.2786 | 0.2246 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0054 | 0.0054 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.5137 | 0.4773 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2786 | 0.6798 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0224 | 0.0592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.