Detailed information for compound 1300472

Basic information

Technical information
  • TDR Targets ID: 1300472
  • Name: 2-(2-hydroxyethylsulfanyl)-2-phenyl-N-[3-(tri fluoromethyl)phenyl]acetamide
  • MW: 355.375 | Formula: C17H16F3NO2S
  • H donors: 2 H acceptors: 2 LogP: 3.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCSC(c1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F
  • InChi: 1S/C17H16F3NO2S/c18-17(19,20)13-7-4-8-14(11-13)21-16(23)15(24-10-9-22)12-5-2-1-3-6-12/h1-8,11,15,22H,9-10H2,(H,21,23)
  • InChiKey: DEYBSHNAFKGIAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-hydroxyethylthio)-2-phenyl-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-(2-hydroxyethylsulfanyl)-2-phenyl-N-[3-(trifluoromethyl)phenyl]ethanamide
  • MLS000394482
  • SMR000261904
  • T0509-9378
  • IDI1_007213
  • Enamine_003570

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0021 0.0021
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0043 0.0043
Brugia malayi Pre-SET motif family protein 0.0064 0.0662 0.1248
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0457 0.0859
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0251 0.0251
Leishmania major GTP-binding protein, putative 0.0044 0.0424 0.4095
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0102 0.15
Schistosoma mansoni nuclear hormone receptor 0.003 0.0251 0.0251
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0049 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0372 0.4961
Echinococcus granulosus dna polymerase eta 0.0082 0.088 0.088
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0999 0.0999
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0049 0.0454
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.058 0.5796
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0528 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0662 0.0662
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0387 0.05
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0329 0.3265
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0387 0.0387
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.011 0.1065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0444 0.528 0.528
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0102 0.0992
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0102 0.15
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.058 0.5796
Schistosoma mansoni nuclear receptor 0.0014 0.0059 0.0059
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0329 0.3265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0528 0.0685
Schistosoma mansoni cpg binding protein 0.003 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0043
Loa Loa (eye worm) hypothetical protein 0.0071 0.0745 0.0968
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.107 0.3481
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.058 0.058
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0059 0.0105
Mycobacterium leprae Probable lipase LipE 0.004 0.0372 0.3452
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.0323
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.0323
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.058 0.5796
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0613 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0745 1
Brugia malayi nuclear receptor RXR 0.0016 0.0079 0.0144
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0745 0.1406
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0139 0.0227
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.048
Brugia malayi Pre-SET motif family protein 0.0441 0.5244 0.9932
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0413 0.0684
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0049 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0428 0.0804
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0372 0.048
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0999 0.1664
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0372 0.11
Schistosoma mansoni DNA polymerase eta 0.0082 0.088 0.088
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.048 0.048
Brugia malayi RNA recognition motif domain containing protein 0.0252 0.2943 0.5571
Loa Loa (eye worm) hypothetical protein 0.0071 0.0745 0.0968
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4737 0.4737
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0049 0.0244
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0059 0.0093
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0424 0.0796
Loa Loa (eye worm) hypothetical protein 0.0101 0.1118 0.1453
Onchocerca volvulus 0.0027 0.0209 0.0344
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0139 0.0308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0616 0.6156
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0139 0.1362
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0413 0.6214
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.0323
Echinococcus granulosus translational activator gcn1 0.0011 0.0025 0.0025
Leishmania major importin beta-1 subunit, putative 0.0049 0.0478 0.4655
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0251 0.0469
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0049 0.0738
Plasmodium falciparum glutathione reductase 0.0013 0.0049 0.0738
Echinococcus multilocularis dna polymerase kappa 0.0057 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.0323
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0387 0.0387
Onchocerca volvulus 0.0027 0.0209 0.0344
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.011 0.0207
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Echinococcus multilocularis neuropeptide s receptor 0.0455 0.5413 0.5413
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0372 0.0372
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0049 0.0049
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0139 0.1828
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0021 0.0022
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0478 0.4771
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.0323
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0251 0.0251
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0251 0.0414
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0745 0.7398
Leishmania major DNA polymerase eta, putative 0.0082 0.088 0.8781
Schistosoma mansoni ran 0.0044 0.0424 0.0424
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0025 0.0327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0049 0.0454
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0562 0.0562
Brugia malayi polk-prov protein 0.0018 0.0102 0.0187
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0059 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Schistosoma mansoni transcription factor LCR-F1 0.0444 0.528 0.528
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0251 0.0323
Brugia malayi nuclear receptor NHR-88 0.003 0.0251 0.0469
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0329 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0102 0.1612
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0282 0.2614
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0745 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0139 0.1828
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0049 0.061
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0139 0.0227
Echinococcus multilocularis lamin 0.0027 0.0209 0.0209
Brugia malayi ecdysone receptor 0.0014 0.0059 0.0105
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0139 0.1362
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0139 0.0139
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0354 0.0456
Echinococcus granulosus importin subunit beta 1 0.006 0.0616 0.0616
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0139 0.1272
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0079 0.0099
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.00000054962
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0102 0.0992
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0104 0.0189
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0049 0.0687
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.058 0.5796
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.048 0.048
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.036 0.036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0662 0.0662
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0372 0.11
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0354 0.1039
Onchocerca volvulus 0.0021 0.0139 0.0227
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0444 0.528 0.528
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0251 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0251 0.0469
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0139 0.0308
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.1687 0.3191
Schistosoma mansoni intermediate filament proteins 0.0027 0.0209 0.0209
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0251 0.0251
Echinococcus granulosus snurportin 1 0.0641 0.7671 0.7671
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0251 0.0251
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1624 0.1624
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0228 0.0292
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0329 0.4936
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0049 0.0454
Loa Loa (eye worm) hypothetical protein 0.0049 0.048 0.0621
Brugia malayi tailless protein 0.0014 0.0059 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.011 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0372 0.3698
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0372 0.0615
Leishmania major DNA polymerase kappa, putative 0.0018 0.0102 0.0793
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0049 0.0076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.1687 0.2196
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0428 0.0428
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0372 0.3698
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.0177
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0139 0.1362
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0613 0.6035
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0139 0.1828
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0099 0.0171
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0059 0.0105
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0059 0.0059
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0251 0.0251
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.2268 0.2268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0424 0.6858
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0049 0.0454
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0354 0.5316
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.5244 0.6835
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0139 0.1172
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.036 0.036
Echinococcus granulosus tumor protein p63 0.0664 0.7945 0.7945
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.011 0.0201
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0059 0.0059
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.011 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0204 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0251 0.0469
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0251 0.0251
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0049 0.0738
Brugia malayi mbt repeat family protein 0.0049 0.048 0.0903
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0369 0.5962
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0059 0.0059
Echinococcus granulosus lamin dm0 0.0027 0.0209 0.0209
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0951 0.8887
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0251 0.0251
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.2982 1
Schistosoma mansoni hypothetical protein 0.004 0.0369 0.0369
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0662 0.0662
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2943 0.2943
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.048 0.0621
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0251 0.0251
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0251 0.0251
Brugia malayi nuclear receptor NHR-88 0.0014 0.0059 0.0105
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0613 0.9253
Echinococcus granulosus GPCR family 2 0.0047 0.0457 0.0457
Onchocerca volvulus 0.0014 0.0059 0.0093
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0059 0.0093
Plasmodium vivax importin-beta 2, putative 0.006 0.0616 0.9307
Echinococcus granulosus cpg binding protein 0.003 0.0247 0.0247
Brugia malayi Thioredoxin reductase 0.0038 0.0354 0.0663
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0049 0.0244
Brugia malayi intermediate filament protein 0.0027 0.0209 0.039
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0079 0.0079
Onchocerca volvulus 0.0064 0.0662 0.1101
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Echinococcus granulosus dnaJ subfamily B 0.04 0.4737 0.4737
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0102 0.0992
Trichomonas vaginalis hypothetical protein 0.0011 0.0025 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Leishmania major DNA polymerase kappa, putative 0.0057 0.058 0.5703
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0099 0.0957
Echinococcus multilocularis protein dispatched 1 0.0047 0.0457 0.0457
Echinococcus multilocularis importin subunit beta 1 0.006 0.0616 0.0616
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0251 0.0469
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.048
Loa Loa (eye worm) hypothetical protein 0.0056 0.0562 0.0728
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0139 0.1828
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0139 0.1828
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0059 0.0072
Loa Loa (eye worm) hypothetical protein 0.0148 0.1687 0.2196
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0372 0.0615
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0064 0.0662 0.0859
Mycobacterium ulcerans hypothetical protein 0.004 0.0372 0.4961
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0139 0.0257
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0951 0.3076
Giardia lamblia DINP protein human, muc B family 0.0057 0.058 0.5796
Entamoeba histolytica hypothetical protein 0.0444 0.528 1
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0251 0.0251
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0099 0.018
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0049 0.0076
Schistosoma mansoni ran 0.0044 0.0424 0.0424
Mycobacterium leprae conserved hypothetical protein 0.004 0.0372 0.3452
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1674 0.1674
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0059 0.0059
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0059 0.0072
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0139 0.2059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0428 0.0428
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0102 0.0992
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0139 0.0308
Onchocerca volvulus 0.0021 0.0139 0.0227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0139 0.0257
Schistosoma mansoni DNA ligase IV 0.001 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0745 1
Onchocerca volvulus 0.0028 0.0228 0.0375
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0102 0.0992
Schistosoma mansoni nuclear receptor 0.0014 0.0059 0.0059
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1674 0.3166
Schistosoma mansoni hypothetical protein 0.0047 0.0457 0.0457
Plasmodium falciparum glutathione reductase 0.0038 0.0354 0.5712
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0562 0.1058
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0413 0.6214
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0139 0.1828
Schistosoma mansoni lamin 0.0027 0.0209 0.0209
Echinococcus multilocularis tumor protein p63 0.0664 0.7945 0.7945
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0616 0.9307
Schistosoma mansoni ap endonuclease 0.0018 0.011 0.011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.058 0.5703
Loa Loa (eye worm) RNA binding protein 0.0252 0.2943 0.3834
Giardia lamblia DNA damage repair protein 0.0018 0.0102 0.0992
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0745 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0071 0.0745 0.0968
Loa Loa (eye worm) hypothetical protein 0.0016 0.0079 0.0099
Mycobacterium ulcerans beta-lactamase 0.004 0.0372 0.4961
Trypanosoma brucei trypanothione reductase 0.0038 0.0354 0.3516
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0493 0.1516
Plasmodium falciparum transportin 0.0011 0.0025 0.0351
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.011 0.011
Mycobacterium tuberculosis Conserved protein 0.004 0.0372 0.11
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.048
Loa Loa (eye worm) DR-78 0.0014 0.0059 0.0072
Entamoeba histolytica Ran family GTPase 0.0044 0.0424 0.0796
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0099 0.0124
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0951 0.3076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0493 0.1516
Brugia malayi CHE-14 protein 0.0041 0.0387 0.0726
Echinococcus multilocularis transportin 1 0.0011 0.0025 0.0025
Echinococcus multilocularis translational activator gcn1 0.0011 0.0025 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0493 0.1516
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0745 0.6958
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.088 0.1661
Schistosoma mansoni thyroid hormone receptor 0.003 0.0251 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0102 0.0992
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0252 0.2943 0.3834
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0493 0.1516
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0139 0.2213
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0457 0.0859
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.011 0.1609
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0049 0.0862
Mycobacterium ulcerans hypothetical protein 0.0018 0.0102 0.1331
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0102 0.0992
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0616 0.6156
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0059 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0369 0.3671
Leishmania major DNA polymerase eta, putative 0.0042 0.0402 0.3872
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0049 0.0454
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0049 0.0244
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0478 0.0794
Brugia malayi hypothetical protein 0.0014 0.0059 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0139 0.1828
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0662 1
Schistosoma mansoni cpg binding protein 0.0028 0.0228 0.0228
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.058 0.1093
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0329 0.0329
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0139 0.2059
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0528 0.7972
Loa Loa (eye worm) acetyltransferase 0.0147 0.1674 0.2179
Plasmodium vivax hypothetical protein, conserved 0.004 0.0372 0.559
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0251 0.0251
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0049 0.0049
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0102 0.0992
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0413 0.6214
Onchocerca volvulus 0.0014 0.0059 0.0093
Onchocerca volvulus 0.004 0.0372 0.0615
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.006 0.0073
Brugia malayi steroid hormone receptor 0.003 0.0251 0.0469
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2943 0.2943
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0079 0.0144
Echinococcus granulosus geminin 0.0533 0.6352 0.6352
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0251 0.0469
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0745 0.1406
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0951 0.3076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0251 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0251 0.0469
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0424 0.4222
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.011 0.1065
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0139 0.1272
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0562 0.0562
Echinococcus multilocularis nibrin 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0047 0.0457 0.0457
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0626 0.0626
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0372 0.0372
Brugia malayi hypothetical protein 0.0444 0.528 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.005 0.0499 0.0646
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0372 0.4961
Loa Loa (eye worm) glutathione reductase 0.0038 0.0354 0.0456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0662 0.0662
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0004 0.00000062286
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0049 0.0454
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.058 0.5796
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0387 0.0387
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0251 0.0469
Brugia malayi kap beta 3 protein 0.0011 0.0025 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0387 0.0641
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0251 0.0251
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0139 0.0257
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0638 0.0638
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0613 0.0613
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0372 0.11
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0079 0.0079
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0999 0.1886
Onchocerca volvulus 0.0021 0.0139 0.0227
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.048
Echinococcus multilocularis snurportin 1 0.0641 0.7671 0.7671
Loa Loa (eye worm) hypothetical protein 0.0016 0.0079 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2943 0.2943
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0428 0.0554
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0457 0.0591
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0528 0.7075
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0478 0.0794
Loa Loa (eye worm) hypothetical protein 0.0053 0.0528 0.0685
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2943 0.2943
Schistosoma mansoni hypothetical protein 0.004 0.0369 0.0369
Echinococcus multilocularis expressed conserved protein 0.009 0.0981 0.0981
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1051 0.1051
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1674 0.1674
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0251 0.0469
Echinococcus granulosus FTZ F1 alpha 0.003 0.0251 0.0251
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0139 0.0257
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.011 0.1065
Brugia malayi mbt repeat family protein 0.0049 0.048 0.0903
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.0323
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0369 0.0692
Mycobacterium tuberculosis Probable reductase 0.0088 0.0951 0.3076
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0099 0.1447
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0745 0.7398
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0139 0.1828
Trypanosoma brucei unspecified product 0.0039 0.0365 0.3634
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0011 0.0025 0.0216
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0049 0.0454
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0099 0.1447
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0613 0.0613
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0251 0.0323
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0251 0.0414
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0099 0.0957
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0021 0.0021
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0999 0.0999
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0049 0.0687
Brugia malayi RNA, U transporter 1 0.0171 0.196 0.3709
Schistosoma mansoni hypothetical protein 0.0641 0.7671 0.7671
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0004 0.00000054962
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.107 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0049 0.0454
Plasmodium vivax transportin, putative 0.0011 0.0025 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.058 0.7775
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0049 0.061
Trichomonas vaginalis set domain proteins, putative 0.0502 0.5983 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0533 0.6352 0.6352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0251 0.0323
Echinococcus granulosus nibrin 0.001 0.0004 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0613 0.1923
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0049 0.0086
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1051 0.1985
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0251 0.0251
Entamoeba histolytica hypothetical protein 0.0444 0.528 1
Plasmodium falciparum importin beta, putative 0.006 0.0616 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0209 0.0268
Brugia malayi CXXC zinc finger family protein 0.0028 0.0228 0.0425
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0372 0.11
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0613 0.0613
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.9474 0.9474
Entamoeba histolytica HEAT repeat domain containing protein 0.0011 0.0025 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0251 0.0469
Schistosoma mansoni importin beta-1 0.006 0.0616 0.0616
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0251 0.0251
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0999 0.1664
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.011 0.0177
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0329 0.0329
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0329 0.3116
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0424 0.4222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.058 0.5796
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0139 0.1362
Trypanosoma brucei polo-like protein kinase 0.0092 0.0999 1
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1551 0.1551
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0437 0.0726
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0999 0.1664
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0745 0.7398
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0059 0.0059
Toxoplasma gondii exonuclease III APE 0.0018 0.011 0.1609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0528 0.1635
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0251 0.0251
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0139 0.2059
Plasmodium vivax glutathione reductase, putative 0.0038 0.0354 0.5316
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.1067 0.1067
Toxoplasma gondii ABC1 family protein 0.004 0.0372 0.559
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0079 0.0144
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0745 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0251 0.0323
Schistosoma mansoni ap endonuclease 0.0018 0.011 0.011
Trypanosoma brucei DNA polymerase eta, putative 0.0082 0.088 0.8808
Brugia malayi nuclear hormone receptor 0.003 0.0251 0.0469
Schistosoma mansoni hypothetical protein 0.0301 0.3536 0.3536
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0604 0.9126
Plasmodium falciparum thioredoxin reductase 0.0013 0.0049 0.0738
Echinococcus multilocularis dna polymerase eta 0.0082 0.088 0.088
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0139 0.1828
Brugia malayi hypothetical protein 0.0016 0.0079 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0251 0.0251
Schistosoma mansoni thyroid hormone receptor 0.003 0.0251 0.0251
Plasmodium falciparum thioredoxin reductase 0.0038 0.0354 0.5712
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0457 0.0457
Entamoeba histolytica hypothetical protein 0.0444 0.528 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0053 0.0528 0.0685
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0457 0.0457
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0049 0.0454
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.048 0.048
Brugia malayi beta-lactamase 0.004 0.0372 0.0697
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0139 0.1172
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0329 0.0543
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.048 0.048
Onchocerca volvulus 0.004 0.0372 0.0615
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0139 0.0308
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0745 0.1406
Trypanosoma brucei unspecified product 0.0057 0.058 0.5796
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0424 0.6383
Brugia malayi nuclear hormone receptor 0.0014 0.0059 0.0105
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.048 0.048
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0745 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0424 0.6383
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0059 0.0105
Loa Loa (eye worm) hypothetical protein 0.0041 0.0387 0.05
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0049 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Loa Loa (eye worm) beta-lactamase 0.004 0.0372 0.048
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.048 0.0797
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0099 0.0099
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0099 0.0957
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0424 0.4222
Schistosoma mansoni hypothetical protein 0.04 0.4737 0.4737
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0251 0.0469
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0251 0.0251
Echinococcus granulosus replication factor c subunit 1 0.001 0.0004 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0745 0.6958
Loa Loa (eye worm) hypothetical protein 0.0082 0.088 0.1143
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0019 0.003
Brugia malayi isocitrate dehydrogenase 0.0017 0.0099 0.018
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0329 0.4381
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0999 0.1664
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0251 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0428 0.0428
Echinococcus granulosus dna polymerase kappa 0.0057 0.058 0.058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0099 0.0099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0099 0.0099
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0745 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0251 0.0469
Echinococcus granulosus expressed conserved protein 0.009 0.0981 0.0981
Onchocerca volvulus 0.0502 0.5983 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0365 0.3634
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0251 0.0251
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0613 0.8212
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0424 0.0548
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.2268 0.2268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0662 0.0662
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.058 0.058
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0099 0.0099
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0641 0.7671 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0251 0.0251
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0025 0.0028
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.011 0.1065
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0099 0.0757
Schistosoma mansoni hypothetical protein 0.0047 0.0457 0.0457
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1051 0.1985
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0139 0.0139
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.058 0.0965
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0139 0.1828
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.058 0.1812
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0102 0.0102
Toxoplasma gondii thioredoxin reductase 0.0038 0.0354 0.5316
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0139 0.0308
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0613 0.8212
Mycobacterium tuberculosis Conserved protein 0.004 0.0372 0.11
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0099 0.0099
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0999 0.1298
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0251 0.0469
Schistosoma mansoni kinase 0.0047 0.0452 0.0452
Schistosoma mansoni topbp1 0.001 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2943 0.2943
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0745 0.1406
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0562 0.0562
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0139 0.1828
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.00000054962
Brugia malayi nuclear receptor RXR 0.0014 0.0059 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0079 0.0099
Schistosoma mansoni hypothetical protein 0.0444 0.528 0.528
Brugia malayi hypothetical protein 0.0014 0.0059 0.0105
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.048
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0006 0.0004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0251 0.0251
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0457 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0102 0.0992
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0139 0.1362
Brugia malayi beta-lactamase family protein 0.004 0.0372 0.0697
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0329 0.0616
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0102 0.15
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.011 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0745 0.2375
Schistosoma mansoni hypothetical protein 0.004 0.0369 0.0369
Onchocerca volvulus 0.004 0.0372 0.0615
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0102 0.0992
Entamoeba histolytica hypothetical protein 0.0049 0.0478 0.09
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0999 1
Echinococcus multilocularis protein patched 0.0041 0.0387 0.0387
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0562 0.0562
Echinococcus multilocularis importin 5 0.0011 0.0025 0.0025
Schistosoma mansoni cpg binding protein 0.003 0.0247 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0251 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0365 0.3634
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0006 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0252 0.2943 0.3834
Schistosoma mansoni hypothetical protein 0.0101 0.1118 0.1118
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0999 0.1886
Loa Loa (eye worm) hypothetical protein 0.0047 0.0457 0.0591
Brugia malayi conserved hypotetical protein 0.0014 0.0059 0.0105
Echinococcus multilocularis GPCR, family 2 0.0047 0.0457 0.0457
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0049 0.0454
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0999 0.1664
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.058 0.0965
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0999 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0662 0.0662
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0209 0.0268
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0528 0.8566
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0282 0.0796
Treponema pallidum NADH oxidase 0.0013 0.0049 0.4268
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0424 0.0424
Giardia lamblia Kinase, PLK 0.0092 0.0999 1
Echinococcus granulosus lamin 0.0027 0.0209 0.0209
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0102 0.0992
Echinococcus multilocularis musashi 0.0027 0.0209 0.0209
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0372 0.0372
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.1118 0.2112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0096 0.1051 0.1366
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0139 0.1828
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0354 0.3516
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0059 0.0059
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0139 0.0177
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0139 0.0308
Leishmania major hypothetical protein, conserved 0.004 0.0372 0.3558
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0457 0.0457
Onchocerca volvulus 0.0021 0.0139 0.0227
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0059 0.0072
Schistosoma mansoni hypothetical protein 0.0047 0.0457 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0999 0.1664
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0329 0.0543
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0099 0.0099
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.048 0.048
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0099 0.1554
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0402 0.4004
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0043 0.0043
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0059 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0372 0.0615
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0049 0.0454
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0059 0.0059
Onchocerca volvulus 0.0049 0.048 0.0797
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0372 0.11
Loa Loa (eye worm) hypothetical protein 0.0097 0.1067 0.1386
Loa Loa (eye worm) hypothetical protein 0.006 0.0616 0.0799
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0129
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.048 0.048
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0951 0.3076
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.011 0.0177
Brugia malayi ecdysteroid receptor 0.003 0.0251 0.0469
Schistosoma mansoni lamin 0.0027 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0016 0.0079 0.0099
Echinococcus granulosus neuropeptide receptor A26 0.0455 0.5413 0.5413
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0049 0.061
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0613 0.8212
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0099 0.0957
Brugia malayi RNA binding protein 0.0252 0.2943 0.5571
Schistosoma mansoni inositol monophosphatase 0.0036 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.0177
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0099 0.1447
Plasmodium vivax SET domain protein, putative 0.0064 0.0662 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.0323
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0049 0.1391
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0251 0.0251
Mycobacterium ulcerans lipase LipD 0.004 0.0372 0.4961
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.058 0.5796
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0139 0.0308
Echinococcus multilocularis neuropeptide receptor A26 0.0455 0.5413 0.5413
Echinococcus multilocularis geminin 0.0533 0.6352 0.6352
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1551 0.1551
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0139 0.1828
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.058 0.0752
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0139 0.0257
Schistosoma mansoni zinc finger protein 0.0014 0.0059 0.0059
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0012 0.0037 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0365 0.3634
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0478 0.0794
Onchocerca volvulus 0.0071 0.0745 0.1241
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0662 0.0662
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0049 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0139 0.0308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Schistosoma mansoni coup transcription factor 0.003 0.0251 0.0251
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0372 0.11
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0413 0.0684
Echinococcus multilocularis lamin dm0 0.0027 0.0209 0.0209
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1069 0.1069
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0139 0.0308
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0999 0.0999
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0372 0.3698
Echinococcus granulosus tar DNA binding protein 0.0252 0.2943 0.2943
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0372 0.0697
Trichomonas vaginalis esterase, putative 0.004 0.0372 0.0615
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0209 0.0268
Schistosoma mansoni patched 1 0.0041 0.0387 0.0387
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0029 0.0252
Leishmania major trypanothione reductase 0.0038 0.0354 0.3373
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0372 0.11
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0745 0.1406
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0139 0.1172
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0059 0.0059
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0209 0.039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.011 0.0138
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0251 0.0251
Echinococcus granulosus importin 5 0.0011 0.0025 0.0025
Mycobacterium tuberculosis Conserved protein 0.004 0.0372 0.11
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0025 0.0028
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.058 0.1093
Brugia malayi TAR-binding protein 0.0252 0.2943 0.5571
Loa Loa (eye worm) hypothetical protein 0.0053 0.0528 0.0685
Leishmania major DNA damage repair protein, putative 0.0018 0.0102 0.0793
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0372 0.0615
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0079 0.0079
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0999 1
Schistosoma mansoni hypothetical protein 0.004 0.0369 0.0369
Echinococcus granulosus neuropeptide s receptor 0.0455 0.5413 0.5413
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0139 0.1828
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0079 0.0099
Echinococcus multilocularis tar DNA binding protein 0.0252 0.2943 0.2943
Trypanosoma brucei unspecified product 0.0039 0.0365 0.3634
Onchocerca volvulus 0.0097 0.1067 0.1778
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0999 0.1664
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.058 0.5796
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0251 0.0469
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0251 0.0469
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.0323
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.011 0.326
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0329 0.3265
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0139 0.0257
Brugia malayi beta-lactamase family protein 0.004 0.0372 0.0697
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0251 0.0469
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0139 0.1362
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0413 0.0413
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0251 0.0323
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.107 0.3481
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.058 0.1812
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0004 0.0000049921
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0004 0.0004
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0139 0.0308
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.006 0.0107
Entamoeba histolytica hypothetical protein 0.0444 0.528 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0059 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0745 0.1406
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0402 0.6053
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.011 0.0867
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0139 0.1828
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0059 0.0059
Schistosoma mansoni inositol monophosphatase 0.0036 0.0329 0.0329
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0059 0.0059
Loa Loa (eye worm) inositol-1 0.0036 0.0329 0.0424
Schistosoma mansoni topbp1 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0528 0.0685
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0049 0.1391
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0329 0.0543
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0139 0.1828
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0139 0.2059
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0059 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0372 0.0615
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0139 0.0257
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0049 0.0687
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.058 0.7775
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0424 0.0424
Trichomonas vaginalis ran, putative 0.0044 0.0424 0.0703
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0059 0.0059
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0059 0.0105
Echinococcus multilocularis cpg binding protein 0.003 0.0247 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0251 0.0323
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.058 0.058
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0099 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0139 0.1828
Schistosoma mansoni hypothetical protein 0.0533 0.6352 0.6352
Echinococcus granulosus transportin 1 0.0011 0.0025 0.0025
Brugia malayi Inositol-1 0.0036 0.0329 0.0616
Schistosoma mansoni importin-beta 2 0.0011 0.0025 0.0025
Brugia malayi glutathione reductase 0.0038 0.0354 0.0663
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0049 0.0687
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.107 0.3481
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0372 0.0372
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0139 0.0308
Brugia malayi Importin beta-1 subunit 0.006 0.0616 0.1161
Brugia malayi hypothetical protein 0.0016 0.0079 0.0144
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.1687 0.3191
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0025 0.0327
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0424 0.4222
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1051 0.1051
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0139 0.0177
Onchocerca volvulus 0.003 0.0251 0.0414
Mycobacterium ulcerans hypothetical protein 0.0071 0.0745 1
Loa Loa (eye worm) oxidoreductase 0.0021 0.0139 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0999 0.1664
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0049 0.0454
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0437 0.0726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0251 0.0323
Brugia malayi nuclear receptor NHR-67 0.0014 0.0059 0.0105
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.088 0.8808
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0562 0.0562
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.011 0.1428
Loa Loa (eye worm) MBCTL1 0.0056 0.0562 0.0728
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0139 0.1272
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0951 0.3076
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0745 0.2375
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.011 0.1729

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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