TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 335.357 | Formula: C19H17N3O3
H donors: 2 H acceptors: 3 LogP: 3.76 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: C=CCn1c(O)c(c2c1cccc2)N=NC(=O)C(c1ccccc1)O
InChi: 1S/C19H17N3O3/c1-2-12-22-15-11-7-6-10-14(15)16(19(22)25)20-21-18(24)17(23)13-8-4-3-5-9-13/h2-11,17,23,25H,1,12H2
InChiKey: OXFGKGFCCWTXIV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0055	0.0087
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0045	0.0072
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0296	0.0338
Brugia malayi	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0296	0.0472
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0614	0.0978
Loa Loa (eye worm)	patched family protein	0.0012	0.0119	0.0136
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0465	0.3386
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0465	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0092	0.0105
Echinococcus multilocularis	snurportin 1	0.0306	0.6285	1
Brugia malayi	Pre-SET motif family protein	0.0061	0.1141	0.1301
Echinococcus multilocularis	Smad4	0.0009	0.0045	0.0072
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Entamoeba histolytica	Ran family GTPase	0.0021	0.0307	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Brugia malayi	nuclear receptor RXR	0.001	0.0068	0.0077
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2575	0.4096
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.6285	0.7167
Brugia malayi	nuclear receptor NHR-67	0.001	0.0068	0.0077
Brugia malayi	ecdysone receptor	0.001	0.0068	0.0077
Loa Loa (eye worm)	TAR-binding protein	0.0129	0.2575	0.2936
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.1742	0.1986
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0296	0.0338
Echinococcus multilocularis	protein patched	0.0086	0.1672	0.266
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.1141	0.1816
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0068	0.0077
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0296	0.0338
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0296	0.0338
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0296	0.0472
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0055	0.0087
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	0.2522	0.2875
Brugia malayi	RNA binding protein	0.0129	0.2575	0.2936
Echinococcus multilocularis	smad	0.0009	0.0045	0.0072
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0086	0.1672	0.1906
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0055	0.0087
Schistosoma mansoni	hypothetical protein	0.0049	0.0889	0.1414
Echinococcus granulosus	Smad4	0.0009	0.0045	0.0072
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0188	0.03
Brugia malayi	MAP kinase sur-1	0.0054	0.0998	0.1138
Loa Loa (eye worm)	DR-78	0.001	0.0068	0.0077
Brugia malayi	RNA, U transporter 1	0.0082	0.1574	0.1795
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0045	0.0072
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0068	0.0108
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0998	0.0998
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0296	0.0338
Schistosoma mansoni	hypothetical protein	0.0049	0.0889	0.1414
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0307	0.1832
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0998	0.1588
Onchocerca volvulus		0.0012	0.0119	0.0119
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0614	0.0978
Mycobacterium ulcerans	glutaminase	0.0267	0.5469	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0296	0.0472
Brugia malayi	CHE-14 protein	0.0086	0.1672	0.1906
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0092	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Schistosoma mansoni	hypothetical protein	0.0036	0.0614	0.0978
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0296	0.0338
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0296	0.0338
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1742	0.2772
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0068	0.0077
Brugia malayi	TAR-binding protein	0.0129	0.2575	0.2936
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0068	0.0077
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0296	0.0472
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	0.2522	0.2875
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0425	0.877	1
Schistosoma mansoni	coup transcription factor	0.0021	0.0296	0.0472
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0061	0.1141	0.1816
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0068	0.0108
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0068	0.0108
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0045	0.0051
Schistosoma mansoni	Smad4	0.0009	0.0045	0.0072
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0068	0.0077
Onchocerca volvulus		0.0009	0.0055	0.0055
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0055	0.0087
Onchocerca volvulus		0.0012	0.0119	0.0119
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1742	0.2772
Schistosoma mansoni	hypothetical protein	0.0174	0.3505	0.5576
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0055	0.0087
Loa Loa (eye worm)	patched family protein	0.0012	0.0119	0.0136
Brugia malayi	Patched related family protein 4	0.0012	0.0119	0.0136
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0068	0.0077
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0998	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0998	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0201	0.4077	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0055	0.0062
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0889	0.1414
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0055	0.0087
Trichomonas vaginalis	glutaminase, putative	0.0267	0.5469	0.5469
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0296	0.0472
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Brugia malayi	hypothetical protein	0.0012	0.0119	0.0136
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0296	0.0338
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0465	0.3779
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0188	0.03
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Brugia malayi	Patched related family protein 10	0.0012	0.0119	0.0136
Leishmania major	GTP-binding protein, putative	0.0021	0.0307	0.1461
Brugia malayi	hypothetical protein	0.001	0.0068	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0201	0.4077	0.4649
Schistosoma mansoni	nuclear receptor	0.001	0.0068	0.0108
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0296	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0092	0.0105
Schistosoma mansoni	dishevelled	0.0009	0.0055	0.0087
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0068	0.0108
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0889	0.1014
Schistosoma mansoni	ran	0.0021	0.0307	0.0488
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0055	0.0087
Brugia malayi	hypothetical protein	0.0036	0.0614	0.0701
Brugia malayi	latrophilin 2 splice variant baaae	0.0106	0.2078	0.237
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0296	0.0338
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0296	0.0338
Brugia malayi	tailless protein	0.001	0.0068	0.0077
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0092	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0465	0.074
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0998	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0296	0.0338
Brugia malayi	MH2 domain containing protein	0.0009	0.0045	0.0051
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0092	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus granulosus	histone lysine methyltransferase setb	0.0061	0.1141	0.1816
Toxoplasma gondii	hypothetical protein	0.0012	0.0119	0.0594
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.1742	0.2772
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0296	0.0472
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0059	0.1094	0.1741
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0889	0.1414
Echinococcus granulosus	geminin	0.0174	0.3505	0.5576
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0092	0.0105
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0068	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0296	0.0338
Trypanosoma brucei	protein kinase, putative	0.0054	0.0998	1
Brugia malayi	steroid hormone receptor	0.0021	0.0296	0.0338
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2575	0.4096
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0068	0.0077
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0998	0.8683
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0068	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0296	0.0472
Schistosoma mansoni	hypothetical protein	0.0174	0.3505	0.5576
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0352	0.0352
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Brugia malayi	nuclear hormone receptor	0.0021	0.0296	0.0338
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0296	0.0338
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0092	0.0147
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0296	0.0338
Echinococcus multilocularis	muscleblind protein	0.018	0.3645	0.5799
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0188	0.1228
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0188	0.03
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0296	0.0472
Schistosoma mansoni	dep domain containing protein	0.0009	0.0055	0.0087
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Brugia malayi	nuclear receptor RXR	0.0011	0.0092	0.0105
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0465	0.074
Echinococcus granulosus	tar DNA binding protein	0.0129	0.2575	0.4096
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0296	0.0338
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0092	0.0105
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0188	0.0674
Schistosoma mansoni	hypothetical protein	0.0083	0.1607	0.2556
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0055	0.0087
Echinococcus granulosus	expressed conserved protein	0.0189	0.3821	0.608
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0296	0.0472
Brugia malayi	hypothetical protein	0.0011	0.0092	0.0105
Onchocerca volvulus		0.0012	0.0119	0.0119
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0296	0.0472
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0998	0.1138
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0055	0.0062
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2575	0.4096
Brugia malayi	nuclear receptor NHR-88	0.001	0.0068	0.0077
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.0998	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.1742	0.1986
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0296	0.0338
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0352	0.3523
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3103	0.3539
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0296	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	glutaminase	0.0267	0.5469	0.6237
Loa Loa (eye worm)	patched family protein	0.0012	0.0119	0.0136
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0188	0.03
Brugia malayi	MH2 domain containing protein	0.0127	0.2522	0.2875
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0889	0.1414
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0465	0.0531
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0055	0.0087
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0296	0.0338
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0352	0.0352
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0296	0.0472
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0155	0.3103	0.3539
Echinococcus granulosus	Niemann Pick C1 protein	0.0287	0.5885	0.9363
Loa Loa (eye worm)	hypothetical protein	0.0309	0.633	0.7218
Schistosoma mansoni	glutaminase	0.0267	0.5469	0.8702
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0055	0.0087
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0296	0.0472
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Brugia malayi	hypothetical protein	0.0011	0.0092	0.0105
Loa Loa (eye worm)	patched family protein	0.0012	0.0119	0.0136
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0188	0.1991
Brugia malayi	Smad1	0.0009	0.0045	0.0051
Brugia malayi	Muscleblind-like protein	0.018	0.3645	0.4156
Echinococcus granulosus	GPCR family 2	0.0049	0.0889	0.1414
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0068	0.0108
Onchocerca volvulus		0.0012	0.0119	0.0119
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0068	0.0108
Toxoplasma gondii	patched family protein	0.0012	0.0119	0.0594
Loa Loa (eye worm)	RNA binding protein	0.0129	0.2575	0.2936
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0055	0.0087
Brugia malayi	conserved hypotetical protein	0.001	0.0068	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0055	0.0055
Toxoplasma gondii	patched family protein	0.0012	0.0119	0.0594
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0061	0.1141	1
Brugia malayi	hypothetical protein	0.001	0.0068	0.0077
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0296	0.0338
Onchocerca volvulus		0.0309	0.633	0.633
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0307	0.1461
Schistosoma mansoni	hypothetical protein	0.0083	0.1607	0.2556
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0188	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.1742	0.2772
Onchocerca volvulus		0.001	0.0068	0.0068
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0155	0.3103	0.3539
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0188	0.03
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0061	0.1141	0.1816
Giardia lamblia	Kinase, CMGC MAPK	0.0054	0.0998	1
Schistosoma mansoni	hypothetical protein	0.0083	0.1607	0.2556
Brugia malayi	hypothetical protein	0.0012	0.0119	0.0136
Schistosoma mansoni	importin beta-1	0.0029	0.0465	0.074
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0045	0.0072
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0188	0.03
Schistosoma mansoni	smad	0.0009	0.0045	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0296	0.0338
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0068	0.0068
Entamoeba histolytica	hypothetical protein	0.0036	0.0614	0.1507
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0155	0.3103	0.3539
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0188	0.03
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0307	0.035
Brugia malayi	nuclear hormone receptor	0.001	0.0068	0.0077
Echinococcus multilocularis	muscleblind protein 1	0.018	0.3645	0.5799
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.1141	0.1816
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0188	0.1886
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0296	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0296	0.0296
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0055	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2078	0.237
Onchocerca volvulus	Protein patched homolog	0.0012	0.0119	0.0119
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0296	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1672	0.1906
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Entamoeba histolytica	hypothetical protein	0.0036	0.0614	0.1507
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0307	0.0488
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0296	0.0338
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0068	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0055	0.0062
Brugia malayi	Patched related family protein 12	0.0012	0.0119	0.0136
Onchocerca volvulus		0.0061	0.1141	0.1141
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0068	0.0108
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0068	0.0068
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0296	0.0472
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0068	0.0108
Brugia malayi	Importin beta-1 subunit	0.0029	0.0465	0.0531
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0614	0.0978
Brugia malayi	glutaminase DH11.1	0.0267	0.5469	0.6237
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0296	0.0338
Brugia malayi	hypothetical protein	0.0009	0.0055	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1141	0.1301
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0296	0.0338
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0296	0.0472
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0465	0.3422
Brugia malayi	RNA recognition motif domain containing protein	0.0129	0.2575	0.2936
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2575	0.4096
Brugia malayi	protein C24B5.3	0.0012	0.0119	0.0136
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0068	0.0108
Schistosoma mansoni	dishevelled	0.0009	0.0055	0.0087
Schistosoma mansoni	hypothetical protein	0.0306	0.6285	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0201	0.4077	0.6486
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0296	0.0338
Echinococcus granulosus	smad	0.0009	0.0045	0.0072
Schistosoma mansoni	hypothetical protein	0.0106	0.2078	0.3307
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0068	0.0108
Echinococcus granulosus	snurportin 1	0.0306	0.6285	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0086	0.1672	0.266
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0296	0.0338
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0296	0.0472
Brugia malayi	hypothetical protein	0.0012	0.0119	0.0136
Schistosoma mansoni	hypothetical protein	0.0083	0.1607	0.2556
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0352	0.2017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0092	0.0105
Echinococcus multilocularis	tar DNA binding protein	0.0129	0.2575	0.4096
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0307	0.3072
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0055	0.0087
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0307	0.3072
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0129	0.2575	0.2936
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.0998	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0092	0.0105
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0188	0.1886
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0296	0.0338
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0092	0.0105
Echinococcus multilocularis	expressed conserved protein	0.0189	0.3821	0.608
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0889	0.1414
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.1742	0.2772
Schistosoma mansoni	zinc finger protein	0.001	0.0068	0.0108
Echinococcus multilocularis	protein dispatched 1	0.0098	0.1927	0.3066
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0068	0.0077
Brugia malayi	protein C24B5.3	0.0012	0.0119	0.0136
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0188	0.1228
Brugia malayi	MH1 domain containing protein	0.0009	0.0045	0.0051
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0998	0.0998
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0296	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0055	0.0062
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0045	0.0051
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0998	0.1588
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0296	0.0472
Brugia malayi	MH2 domain containing protein	0.0009	0.0045	0.0051
Loa Loa (eye worm)	hypothetical protein	0.018	0.3645	0.4156
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Brugia malayi	ecdysteroid receptor	0.0021	0.0296	0.0338
Toxoplasma gondii	patched family protein	0.0012	0.0119	0.0594
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0188	0.0215
Brugia malayi	N-terminal motif family protein	0.0185	0.3742	0.4268
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0296	0.0338
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0296	0.0472
Loa Loa (eye worm)	Smad1	0.0009	0.0045	0.0051
Onchocerca volvulus		0.001	0.0068	0.0068
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0068	0.0077
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0296	0.0472
Trichomonas vaginalis	set domain proteins, putative	0.0484	1	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.0998	1
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0188	0.0215
Onchocerca volvulus		0.0012	0.0119	0.0119
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0296	0.0338
Schistosoma mansoni	ran	0.0021	0.0307	0.0488
Onchocerca volvulus		0.0012	0.0119	0.0119
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0204	0.4142	0.659
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0889	0.1414
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0045	0.0072
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0307	0.035
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0998	0.0998
Toxoplasma gondii	patched family protein	0.0012	0.0119	0.0594
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0307	0.5411
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0045	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Entamoeba histolytica	hypothetical protein	0.0036	0.0614	0.1507
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0296	0.0472
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0296	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0045	0.0072
Loa Loa (eye worm)	hypothetical protein	0.018	0.3645	0.4156
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0889	0.1014
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0998	0.0998
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0998	0.1588
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0296	0.0472
Brugia malayi	Niemann-Pick C1 protein precursor	0.0201	0.4077	0.4649
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0055	0.0087
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0068	0.0108
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0188	0.0215
Plasmodium falciparum	importin beta, putative	0.0029	0.0465	1
Trichomonas vaginalis	ran, putative	0.0021	0.0307	0.0307
Brugia malayi	hypothetical protein	0.0009	0.0055	0.0062
Onchocerca volvulus	Protein patched homolog	0.0012	0.0119	0.0119
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.0998	1
Plasmodium vivax	SET domain protein, putative	0.0061	0.1141	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.1141	0.1816
Loa Loa (eye worm)	patched family protein	0.0012	0.0119	0.0136
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0055	0.0062
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0045	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0055	0.0062
Schistosoma mansoni	nuclear receptor	0.001	0.0068	0.0108
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0296	0.0338
Brugia malayi	Myosin head containing protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	glutaminase 2	0.0267	0.5469	0.6237
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0296	0.0472
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2575	0.4096
Entamoeba histolytica	hypothetical protein	0.0036	0.0614	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0296	0.0338
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0307	0.2318
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.1742	0.2772
Brugia malayi	hypothetical protein	0.0309	0.633	0.7218
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0068	0.0108
Brugia malayi	DIX domain containing protein	0.0009	0.0055	0.0062
Echinococcus multilocularis	Niemann Pick C1 protein	0.0201	0.4077	0.6486
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0296	0.0472
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0352	0.0352
Echinococcus multilocularis	Niemann Pick C1 protein	0.0287	0.5885	0.9363
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0055	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0185	0.3742	0.4268
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0296	0.0472
Schistosoma mansoni	patched 1	0.0086	0.1672	0.266
Entamoeba histolytica	hypothetical protein	0.0023	0.0352	0.0863
Brugia malayi	MH1 domain containing protein	0.0009	0.0045	0.0051
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0061	0.1141	0.1816
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0068	0.0108
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0045	0.0072
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0296	0.0296
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0889	0.1014
Brugia malayi	Pre-SET motif family protein	0.0425	0.877	1
Onchocerca volvulus		0.0012	0.0119	0.0119
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0296	0.0296
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0068	0.0108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.1742	0.2772
Onchocerca volvulus		0.0021	0.0296	0.0296
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0296	0.0338
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0296	0.0472
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0068	0.0108
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0307	0.0488
Brugia malayi	Patched protein homolog 1	0.0012	0.0119	0.0136
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0296	0.0472
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.1672	0.1672
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2079	0.237
Echinococcus multilocularis	sterol regulatory element binding protein	0.0086	0.1672	0.266
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Schistosoma mansoni	hypothetical protein	0.0049	0.0889	0.1414
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.0998	1
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0889	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0185	0.3742	0.3742
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.001	0.0068	0.0077
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0296	0.0338
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0998	0.1588
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0296	0.0338
Schistosoma mansoni	hypothetical protein	0.0049	0.0889	0.1414
Echinococcus granulosus	muscleblind protein	0.018	0.3645	0.5799
Echinococcus multilocularis	geminin	0.0174	0.3505	0.5576
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0092	0.0147
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Brugia malayi	Patched family protein	0.0012	0.0119	0.0136
Echinococcus granulosus	Protein patched homolog 1	0.0086	0.1672	0.266

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.2213 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	15.8489 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1420070

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1300540