Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.2865 | 0.28 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0106 | 0.4733 | 0.4685 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0242 | 0.0153 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0808 | 0.1707 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.1364 | 0.2882 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0808 | 0.1707 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.2861 | 0.2796 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3308 | 0.6988 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.2865 | 0.6054 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0106 | 0.4733 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0419 | 0.0332 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0808 | 0.0724 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0776 | 0.1639 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0242 | 0.0153 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0808 | 0.1707 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0106 | 0.4733 | 0.4685 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0808 | 0.1707 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0808 | 0.0724 |
Schistosoma mansoni | lamin | 0.0033 | 0.0808 | 0.0724 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2865 | 0.28 |
Echinococcus granulosus | lamin | 0.0033 | 0.0808 | 0.0724 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0808 | 0.0724 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.3564 | 0.753 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1368 | 0.2891 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1625 | 0.3432 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.2865 | 0.6054 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.009 | 0.0191 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0305 | 0.0217 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0808 | 0.0724 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2865 | 0.28 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0419 | 0.0332 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0808 | 0.0724 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.2865 | 0.28 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.1222 | 0.1142 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0305 | 0.0644 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.2647 | 0.258 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.2865 | 0.6054 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0808 | 0.1707 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0242 | 0.0153 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0561 | 0.1186 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0106 | 0.4733 | 0.4685 |
Schistosoma mansoni | lamin | 0.0033 | 0.0808 | 0.0724 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.151 | 0.319 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0106 | 0.4733 | 0.4685 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0106 | 0.4733 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.4733 | 0.4685 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.4733 | 0.4685 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.4733 | 0.4685 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0419 | 0.0332 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.2865 | 0.6054 |
Onchocerca volvulus | 0.0033 | 0.0808 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0071 | 0.2865 | 0.6054 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.2647 | 0.258 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.1222 | 0.1142 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0808 | 0.0724 |
Onchocerca volvulus | 0.0033 | 0.0808 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2865 | 0.28 |
Brugia malayi | RNA binding protein | 0.0071 | 0.2865 | 0.6054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2865 | 0.28 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2865 | 0.28 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0127 | 0.0268 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.9093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.