Detailed information for compound 1300999

Basic information

Technical information
  • TDR Targets ID: 1300999
  • Name: N-cyclopentyl-2-[furan-2-ylmethyl-[2-(5-thiop hen-2-yltetrazol-2-yl)acetyl]amino]-2-thiophe n-2-ylacetamide
  • MW: 496.605 | Formula: C23H24N6O3S2
  • H donors: 1 H acceptors: 5 LogP: 3.75 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C(c1cccs1)C(=O)NC1CCCC1)Cc1ccco1)Cn1nnc(n1)c1cccs1
  • InChi: 1S/C23H24N6O3S2/c30-20(15-29-26-22(25-27-29)19-10-5-13-34-19)28(14-17-8-3-11-32-17)21(18-9-4-12-33-18)23(31)24-16-6-1-2-7-16/h3-5,8-13,16,21H,1-2,6-7,14-15H2,(H,24,31)
  • InChiKey: OPWSZHPZQNYNFX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclopentyl-2-[2-furylmethyl-[2-[5-(2-thienyl)tetrazol-2-yl]acetyl]amino]-2-(2-thienyl)acetamide
  • N-cyclopentyl-2-[2-furylmethyl-[1-oxo-2-[5-(2-thienyl)-2-tetrazolyl]ethyl]amino]-2-(2-thienyl)acetamide
  • N-cyclopentyl-2-[furan-2-ylmethyl-[2-(5-thiophen-2-yl-1,2,3,4-tetrazol-2-yl)ethanoyl]amino]-2-thiophen-2-yl-ethanamide
  • ASN 04495274
  • N-Cyclopentyl-2-{furan-2-ylmethyl-[2-(5-thiophen-2-yl-tetrazol-2-yl)-acetyl]-amino}-2-thiophen-2-yl-acetamide
  • SMR000003625
  • MLS000074662

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0009 0.003 0.0045
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0036 0.0392 0.2429
Schistosoma mansoni chromatin regulatory protein sir2 0.0126 0.1614 0.1614
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Loa Loa (eye worm) runx1 0.0064 0.0772 0.1141
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.092 0.5693
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.044 0.0607
Schistosoma mansoni ap endonuclease 0.0021 0.0192 0.0192
Echinococcus granulosus protein kinase C gamma type 0.0034 0.0369 0.0369
Entamoeba histolytica protein kinase, putative 0.0034 0.0369 0.2284
Brugia malayi RNA binding protein 0.0205 0.2679 0.3958
Entamoeba histolytica PH domain containing protein kinase, putative 0.0007 0.0009 0.0059
Brugia malayi transcriptional regulator, Sir2 family protein 0.0019 0.0163 0.0241
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0063 0.0063
Schistosoma mansoni transcription factor btf3 0.0039 0.044 0.044
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.007 0.0851 0.0851
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0369 0.0369
Schistosoma mansoni chromatin regulatory protein sir2 0.0019 0.0163 0.0163
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3763 0.3763
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0063 0.0063
Mycobacterium ulcerans beta-lactamase 0.0075 0.092 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0041 0.0057
Brugia malayi RasGEF domain containing protein 0.0007 0.0004 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0192 0.0284
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.092 0.1223
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0192 0.1138
Loa Loa (eye worm) hypothetical protein 0.018 0.2344 0.3464
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.003 0.003
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0034 0.0369 0.0369
Brugia malayi hypothetical protein 0.0036 0.0392 0.0579
Leishmania major hypothetical protein, conserved 0.0075 0.092 0.5679
Trypanosoma brucei rac serine-threonine kinase, putative 0.0105 0.1332 0.8243
Schistosoma mansoni hypothetical protein 0.0036 0.0392 0.0392
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.1961 0.1961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0063 0.0092
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0152 0.1961 0.2897
Echinococcus granulosus protein kinase c epsilon type 0.0034 0.0369 0.0369
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0033 0.0359 0.0495
Entamoeba histolytica protein kinase, putative 0.0007 0.0009 0.0059
Toxoplasma gondii histone deacetylase SIR2-like 0.0019 0.0163 0.1244
Schistosoma mansoni smad 0.0009 0.003 0.003
Toxoplasma gondii AGC kinase 0.0099 0.1244 1
Loa Loa (eye worm) hypothetical protein 0.0508 0.6768 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0019 0.0163 0.0957
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.007 0.0851 0.1258
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0851 0.1258
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0241
Loa Loa (eye worm) hypothetical protein 0.0075 0.092 0.136
Echinococcus multilocularis Glutaredoxin protein 5 0.0065 0.0788 0.0788
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0192 0.2317
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0063 0.0063
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.092 0.1223
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0019 0.0163 0.0163
Brugia malayi beta-lactamase family protein 0.0075 0.092 0.136
Brugia malayi N-terminal motif family protein 0.0007 0.0004 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0063 0.0092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0369 0.0544
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0041 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0063 0.0092
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.165 0.2438
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0041 0.0061
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0004 0.0004
Schistosoma mansoni Smad4 0.0009 0.003 0.003
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.092 0.1223
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0063 0.0063
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0004 0.0004
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0709 0.5668
Schistosoma mansoni tar DNA-binding protein 0.0205 0.2679 0.2679
Toxoplasma gondii hypothetical protein 0.001 0.0041 0.0258
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0039 0.044 0.2724
Loa Loa (eye worm) hypothetical protein 0.0141 0.1808 0.2672
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0072 0.0885 0.5474
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0066 0.0798 0.865
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0369 0.0369
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0019 0.0163 0.0957
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.254 0.3506
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0709 0.7212
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0709 0.7212
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0192 0.2004
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0063 0.0086
Loa Loa (eye worm) ICD-1 protein 0.0039 0.044 0.065
Trichomonas vaginalis set domain proteins, putative 0.0544 0.7245 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.1961 0.1961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0836 0.0836
Onchocerca volvulus 0.0058 0.0697 0.0963
Entamoeba histolytica PH domain containing protein kinase, putative 0.0007 0.0009 0.0059
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Brugia malayi beta-lactamase 0.0075 0.092 0.136
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0126 0.1614 0.1614
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0369 0.0369
Echinococcus granulosus GPCR family 2 0.0032 0.0347 0.0347
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0032 0.0347 0.0347
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0192 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.165 0.2438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0063 0.0092
Loa Loa (eye worm) hypothetical protein 0.0075 0.092 0.136
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0369 0.0509
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0192 0.0265
Loa Loa (eye worm) transcriptional regulator 0.0019 0.0163 0.0241
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0019 0.0163 0.0957
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0163 0.1686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0063 0.0092
Brugia malayi ecdysteroid receptor 0.0011 0.0063 0.0092
Echinococcus granulosus protein kinase c iota type 0.0034 0.0369 0.0369
Mycobacterium ulcerans hypothetical protein 0.0075 0.092 1
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0041 0.0061
Mycobacterium ulcerans lipase LipD 0.0075 0.092 1
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0019 0.0163 0.1949
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0836 0.0836
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0369 0.0369
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0063 0.0063
Toxoplasma gondii ABC1 family protein 0.0075 0.092 0.7378
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.1961 0.1961
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0369 0.0544
Echinococcus granulosus NDR protein kinase 0.0034 0.0369 0.0369
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.092 0.127
Schistosoma mansoni tar DNA-binding protein 0.0205 0.2679 0.2679
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0004 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0004 0.0004
Brugia malayi MH2 domain containing protein 0.0129 0.165 0.2438
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0004 0.0004
Entamoeba histolytica protein kinase, putative 0.0007 0.0009 0.0059
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.003 0.003
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0019 0.0163 0.0163
Echinococcus granulosus Glutaredoxin protein 5 0.0065 0.0788 0.0788
Entamoeba histolytica PH domain containing protein kinase, putative 0.0072 0.0885 0.5485
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0063 0.0092
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0369 0.0369
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0004 0.0006
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0007 0.0009 0.0033
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0063 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0836 0.0836
Brugia malayi Protein kinase domain containing protein 0.0034 0.0369 0.0544
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0836 0.0836
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0163 0.101
Loa Loa (eye worm) hypothetical protein 0.0141 0.1808 0.2672
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0063 0.0092
Onchocerca volvulus 0.0011 0.0063 0.0086
Entamoeba histolytica PH domain containing protein kinase, putative 0.0007 0.0009 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0508 0.6768 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0126 0.1614 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0063 0.0063
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Onchocerca volvulus 0.0544 0.7245 1
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0063 0.0092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0347 0.0347
Echinococcus multilocularis Smad4 0.0009 0.003 0.003
Onchocerca volvulus Huntingtin homolog 0.0141 0.1808 0.2496
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0092
Loa Loa (eye worm) RNA binding protein 0.0205 0.2679 0.3958
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0004 0.0004
Schistosoma mansoni serine/threonine-protein kinase 0.0072 0.0885 0.0885
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0007 0.0009 0.0033
Entamoeba histolytica protein kinase 2, putative 0.0066 0.0798 0.4942
Schistosoma mansoni smad1 5 8 and 0.0009 0.003 0.003
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0041 0.0041
Echinococcus granulosus serine threonine protein kinase nrc 0.0066 0.0798 0.0798
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0063 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0836 0.0836
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.003 0.0045
Brugia malayi protein kinase C II. 0.0034 0.0369 0.0544
Brugia malayi Muscleblind-like protein 0.018 0.2344 0.3464
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0369 0.0369
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.092 0.1223
Echinococcus multilocularis muscleblind protein 0.018 0.2344 0.2344
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0061
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0369 0.0544
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0063 0.0063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Onchocerca volvulus 0.0075 0.092 0.127
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0709 0.0709
Schistosoma mansoni tar DNA-binding protein 0.0205 0.2679 0.2679
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0392 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0063 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0063 0.0092
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0392 0.0392
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.092 0.1223
Schistosoma mansoni hypothetical protein 0.0058 0.0697 0.0697
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0019 0.0163 0.0163
Brugia malayi NAD-dependent deacetylase SIRT1 0.0019 0.0163 0.0241
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0092
Brugia malayi MH2 domain containing protein 0.0009 0.003 0.0045
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0041 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0347 0.0347
Entamoeba histolytica protein kinase, putative 0.0099 0.1244 0.771
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.092 0.092
Plasmodium vivax NAD-dependent deacetylase, putative 0.0019 0.0163 0.1686
Echinococcus multilocularis rac serine:threonine kinase 0.0072 0.0885 0.0885
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0369 0.0369
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0019 0.0163 0.0987
Trichomonas vaginalis AGC family protein kinase 0.0105 0.1332 0.1838
Schistosoma mansoni hypothetical protein 0.0032 0.0347 0.0347
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0019 0.0163 0.1949
Loa Loa (eye worm) hypothetical protein 0.018 0.2344 0.3464
Brugia malayi N-terminal motif family protein 0.0195 0.254 0.3753
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.0075 0.092 0.136
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0369 0.0369
Schistosoma mansoni chromatin regulatory protein sir2 0.0019 0.0163 0.0163
Brugia malayi RNA recognition motif domain containing protein 0.0205 0.2679 0.3958
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0192 0.0284
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.092 0.127
Loa Loa (eye worm) beta-lactamase 0.0075 0.092 0.136
Schistosoma mansoni hypothetical protein 0.0032 0.0347 0.0347
Plasmodium vivax SET domain protein, putative 0.0069 0.0836 0.9074
Echinococcus granulosus nervana 2 0.0065 0.0788 0.0788
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0709 0.4363
Echinococcus granulosus chromatin regulatory protein sir2 0.0126 0.1614 0.1614
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0065 0.0788 0.0788
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0092
Brugia malayi beta-lactamase family protein 0.0075 0.092 0.136
Echinococcus multilocularis smad 0.0009 0.003 0.003
Schistosoma mansoni regulator of G protein signaling 0.001 0.0041 0.0041
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0041 0.0041
Echinococcus multilocularis Protein lozenge 0.0064 0.0772 0.0772
Trypanosoma cruzi NIMA-related kinase, putative 0.0007 0.0009 0.0033
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0041 0.0041
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0007 0.0009 0.0033
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0066 0.0798 1
Schistosoma mansoni ap endonuclease 0.0021 0.0192 0.0192
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0369 0.0544
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0061
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0192 0.0383
Schistosoma mansoni chromatin regulatory protein sir2 0.0126 0.1614 0.1614
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0007 0.0009 0.0033
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0004 0.0004
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0041 0.0041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0063 0.0092
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.003 0.0045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0709 0.7212
Loa Loa (eye worm) TAR-binding protein 0.0205 0.2679 0.3958
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0006
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0007 0.0009 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.092 0.092
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0007 0.0009 0.0013
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0347 0.0512
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.044 0.4722
Entamoeba histolytica protein kinase, putative 0.0007 0.0009 0.0059
Onchocerca volvulus 0.001 0.0041 0.0057
Mycobacterium tuberculosis Conserved protein 0.0075 0.092 0.1223
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.092 0.127
Brugia malayi MH1 domain containing protein 0.0009 0.003 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0205 0.2679 0.2679
Brugia malayi N-terminal motif family protein 0.0007 0.0004 0.0006
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0369 0.0369
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0063 0.0063
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0041 0.0041
Schistosoma mansoni dishevelled 0.001 0.0041 0.0041
Echinococcus granulosus smad 0.0009 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0092
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0006
Brugia malayi steroid hormone receptor 0.0011 0.0063 0.0092
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0102 0.1286 0.19
Echinococcus granulosus transcription factor btf3 0.0039 0.044 0.044
Onchocerca volvulus 0.0007 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0748 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.1961 0.1961
Brugia malayi transcriptional regulator, Sir2 family protein 0.0126 0.1614 0.2384
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0063 0.0092
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0019 0.0163 0.0163
Brugia malayi Protein kinase domain containing protein 0.0105 0.1332 0.1968
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3683 0.5442
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0019 0.0163 0.0163
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0063 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Brugia malayi RasGEF domain containing protein 0.0007 0.0004 0.0006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0192 0.1138
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0063 0.0086
Entamoeba histolytica hypothetical protein 0.0036 0.0392 0.2429
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0063 0.0063
Schistosoma mansoni survival motor neuron protein 0.0058 0.0697 0.0697
Schistosoma mansoni tar DNA-binding protein 0.0205 0.2679 0.2679
Loa Loa (eye worm) hypothetical protein 0.0075 0.092 0.136
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0192 0.5
Schistosoma mansoni coup transcription factor 0.0011 0.0063 0.0063
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0126 0.1614 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0063 0.0063
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0004 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0126 0.1614 0.2227
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0063 0.0092
Brugia malayi Pre-SET motif family protein 0.0478 0.6355 0.9389
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.004 0.0456 0.063
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0041 0.0041
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0709 0.0709
Echinococcus multilocularis GPCR, family 2 0.0032 0.0347 0.0347
Brugia malayi hypothetical protein 0.001 0.0041 0.0061
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0192 0.0265
Leishmania major basic transcription factor 3a, putative 0.0039 0.044 0.2681
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.092 0.5693
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.044 0.2681
Echinococcus granulosus son of sevenless 1 0.0007 0.0004 0.0004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.092 0.136
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0347 0.0512
Schistosoma mansoni dishevelled 0.001 0.0041 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0105 0.1332 0.1838
Onchocerca volvulus 0.0075 0.092 0.127
Trichomonas vaginalis esterase, putative 0.0075 0.092 0.127
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0004 0.0006
Entamoeba histolytica p21-activated kinase 0.0007 0.0009 0.0059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0347 0.0347
Trichomonas vaginalis AGC family protein kinase 0.0105 0.1332 0.1838
Brugia malayi DIX domain containing protein 0.001 0.0041 0.0061
Brugia malayi hypothetical protein 0.0141 0.1808 0.2672
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0066 0.0798 0.4929
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0369 0.0369
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Trichomonas vaginalis AGC family protein kinase 0.0105 0.1332 0.1838
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0063 0.0092
Schistosoma mansoni atypical protein kinase C 0.0034 0.0369 0.0369
Loa Loa (eye worm) transcriptional regulator 0.0019 0.0163 0.0241
Toxoplasma gondii exonuclease III APE 0.0021 0.0192 0.1479
Echinococcus granulosus Protein kinase C brain isozyme 0.0034 0.0369 0.0369
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0369 0.0544
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0004 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0063 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0019 0.0163 0.0987
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0041 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Brugia malayi follicle stimulating hormone receptor 0.028 0.3683 0.5442
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0478 0.6355 1
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.044 0.2705
Loa Loa (eye worm) hypothetical protein 0.001 0.0041 0.0061
Echinococcus granulosus serine/threonine protein kinase 0.0072 0.0885 0.0885
Brugia malayi hypothetical protein 0.0286 0.3763 0.5559
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0066 0.0798 0.0798
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0063 0.0092
Echinococcus granulosus Protein son of sevenless 0.0007 0.0004 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.1961 0.1961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0836 0.0836
Echinococcus multilocularis serine threonine protein kinase 0.0034 0.0369 0.0369
Giardia lamblia Hypothetical protein 0.0126 0.1614 1
Entamoeba histolytica hypothetical protein 0.0007 0.0004 0.0026
Loa Loa (eye worm) hypothetical protein 0.0075 0.092 0.136
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0092
Entamoeba histolytica protein kinase, putative 0.0007 0.0009 0.0059
Leishmania major sir2-family protein-like protein 0.0019 0.0163 0.0957
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0126 0.1614 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1286 0.19
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0192 0.119
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0063 0.0063
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.003 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0709 0.0709
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.092 0.5679
Entamoeba histolytica PH domain containing protein kinase, putative 0.0072 0.0885 0.5485
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.044 0.0607
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0004 0.0006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0126 0.1614 0.2227
Brugia malayi Hr1 repeat family protein 0.0034 0.0369 0.0544
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0063 0.0063
Brugia malayi MH1 domain containing protein 0.0009 0.003 0.0045
Entamoeba histolytica hypothetical protein 0.0036 0.0392 0.2429
Echinococcus granulosus nervana 2 0.0065 0.0788 0.0788
Echinococcus multilocularis muscleblind protein 1 0.018 0.2344 0.2344
Schistosoma mansoni smad1 5 8 and 0.0009 0.003 0.003
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0019 0.0163 0.0163
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.092 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0063 0.0063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Trypanosoma cruzi NIMA-related kinase, putative 0.0007 0.0009 0.0033
Echinococcus granulosus muscleblind protein 0.018 0.2344 0.2344
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0192 0.0192
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0041 0.0041
Brugia malayi hypothetical protein 0.0508 0.6768 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0034 0.0369 0.0544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.1961 0.1961
Schistosoma mansoni serine/threonine-protein kinase 0.0072 0.0885 0.0885
Brugia malayi Pre-SET motif family protein 0.0069 0.0836 0.1235
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0347 0.0347
Toxoplasma gondii NAC domain-containing protein 0.0039 0.044 0.3484
Loa Loa (eye worm) hypothetical protein 0.0286 0.3763 0.5559
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.092 0.136
Brugia malayi Smad1 0.0009 0.003 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.092 0.092
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Brugia malayi nuclear hormone receptor 0.0011 0.0063 0.0092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1286 0.19
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0032 0.0347 0.0512
Schistosoma mansoni dep domain containing protein 0.001 0.0041 0.0041
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.044 0.2705
Echinococcus granulosus tar DNA binding protein 0.0205 0.2679 0.2679
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0019 0.0163 0.101
Brugia malayi Protein kinase domain containing protein 0.0034 0.0369 0.0544
Loa Loa (eye worm) hypothetical protein 0.0075 0.092 0.136
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0152 0.1961 0.2897
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.044 0.0607
Echinococcus granulosus Smad4 0.0009 0.003 0.003
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.044 0.5459
Brugia malayi RasGEF domain containing protein 0.0007 0.0004 0.0006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0069 0.0836 0.6695
Entamoeba histolytica protein kinase, putative 0.0105 0.1332 0.8253
Loa Loa (eye worm) sirtuin 4 0.0019 0.0163 0.0241
Echinococcus multilocularis nervana 2 0.0065 0.0788 0.0788
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0006
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0126 0.1614 0.1614
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0004 0.0006
Brugia malayi nuclear receptor NHR-88 0.0011 0.0063 0.0092
Brugia malayi beta-NAC-like protein 0.0039 0.044 0.065
Mycobacterium leprae conserved hypothetical protein 0.0075 0.092 0.5
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0369 0.0509
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.1961 0.1961
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0063 0.0092
Loa Loa (eye worm) transcriptional regulator 0.0126 0.1614 0.2384
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0369 0.0369
Trichomonas vaginalis AGC family protein kinase 0.0105 0.1332 0.1838
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.044 0.2724
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0369 0.0369
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1286 0.19
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0192 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0063 0.0092
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0063 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.092 0.127
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0041 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0369 0.0509
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0007 0.0009 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0063 0.0063
Loa Loa (eye worm) AGC/AKT protein kinase 0.0105 0.1332 0.1968
Toxoplasma gondii histone deacetylase SIR2 0.0019 0.0163 0.1244
Schistosoma mansoni chromatin regulatory protein sir2 0.0126 0.1614 0.1614
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0007 0.0009 0.0033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0347 0.0512
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0007 0.0009 0.0033
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0099 0.1244 0.1838
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0192 0.1167
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0007 0.0009 0.0033
Entamoeba histolytica hypothetical protein 0.0036 0.0392 0.2429
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0063 0.0063
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0697 0.103
Trypanosoma cruzi Protein kinase B 0.0072 0.0885 0.5474
Trichomonas vaginalis AGC family protein kinase 0.0105 0.1332 0.1838
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0069 0.0836 0.0836
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0126 0.1614 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0478 0.6355 0.9389
Brugia malayi hypothetical protein 0.001 0.0041 0.0061
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0205 0.2679 0.3958
Onchocerca volvulus 0.0069 0.0836 0.1154
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0007 0.0004 0.0006
Entamoeba histolytica hypothetical protein 0.0007 0.0009 0.0059
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0126 0.1614 1
Onchocerca volvulus 0.0508 0.6768 0.9342
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0709 0.0882
Onchocerca volvulus Huntingtin homolog 0.0141 0.1808 0.2496
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3763 0.3763
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0709 0.0709
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0041 0.0041
Mycobacterium leprae Probable lipase LipE 0.0075 0.092 0.5
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0069 0.0836 0.1235
Echinococcus multilocularis son of sevenless 1 0.0007 0.0004 0.0004
Echinococcus multilocularis transcription factor btf3 0.0039 0.044 0.044
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0063 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0075 0.092 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0369 0.0369
Entamoeba histolytica protein kinase, putative 0.0105 0.1332 0.8253
Echinococcus multilocularis chromatin regulatory protein sir2 0.0126 0.1614 0.1614
Trichomonas vaginalis AGC family protein kinase 0.0105 0.1332 0.1838
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0065 0.0788 0.0788
Schistosoma mansoni hypothetical protein 0.0032 0.0347 0.0347
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0063 0.0092
Entamoeba histolytica PH domain containing protein kinase, putative 0.0007 0.0009 0.0059
Entamoeba histolytica protein kinase, putative 0.0007 0.0009 0.0059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.0802 0.0802
Brugia malayi transcriptional regulator, Sir2 family protein 0.0019 0.0163 0.0241
Entamoeba histolytica hypothetical protein 0.0007 0.0009 0.0059
Echinococcus multilocularis geminin 0.0748 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0066 0.0798 0.0798
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0063 0.0092
Brugia malayi p70 ribosomal S6 kinase beta 0.0099 0.1244 0.1838
Echinococcus multilocularis nervana 2 0.0065 0.0788 0.0788
Schistosoma mansoni smad1 5 8 and 0.0009 0.003 0.003
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0004 0.0026
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0369 0.0369
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0063 0.0086
Brugia malayi TAR-binding protein 0.0205 0.2679 0.3958
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0392 0.0392
Schistosoma mansoni serine/threonine kinase 0.0034 0.0369 0.0369
Loa Loa (eye worm) Smad1 0.0009 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0195 0.254 0.3753
Giardia lamblia Kinase, AGC PKA 0.0066 0.0798 0.4374
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.092 0.1223
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0041 0.0061
Mycobacterium tuberculosis Conserved protein 0.0075 0.092 0.1223
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0063 0.0092
Leishmania major silent information regulator 2, putative 0.0126 0.1614 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.092 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0192 0.1167
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.092 0.127
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.092 0.1223
Echinococcus multilocularis tar DNA binding protein 0.0205 0.2679 0.2679
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0041 0.0041
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.003 0.003
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0019 0.0163 0.101
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0369 0.0369
Mycobacterium tuberculosis Conserved protein 0.0075 0.092 0.1223
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0192 0.0192
Echinococcus multilocularis protein kinase c epsilon type 0.0034 0.0369 0.0369
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0019 0.0163 0.0225
Schistosoma mansoni lozenge 0.0064 0.0772 0.0772
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0192 0.02
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0369 0.0544
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0019 0.0163 0.0163
Schistosoma mansoni chromatin regulatory protein sir2 0.0019 0.0163 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0009 0.0013
Echinococcus multilocularis protein kinase c iota type 0.0034 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.005 0.0591 0.0591
Onchocerca volvulus 0.0075 0.092 0.127
Schistosoma mansoni hypothetical protein 0.0748 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0063 0.0092

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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