Detailed information for compound 1301622

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.158 | Formula: C13H13IN2O3
  • H donors: 1 H acceptors: 3 LogP: 2.45 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccc(cc1)[N+](=O)[O-])C[n+]1ccccc1.[I-]
  • InChi: 1S/C13H13N2O3.HI/c16-13(10-14-8-2-1-3-9-14)11-4-6-12(7-5-11)15(17)18;/h1-9,13,16H,10H2;1H/q+1;/p-1
  • InChiKey: RWPOHQZDDQMASA-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0138 0.0836
Loa Loa (eye worm) hypothetical protein 0.0081 0.0152 0.0181
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0063 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Loa Loa (eye worm) hypothetical protein 0.0147 0.0381 0.0452
Leishmania major NADH dehydrogenase, putative 0.0057 0.0068 0.0115
Leishmania major cysteine peptidase A (CPA) 0.0055 0.0063 0.0085
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0142 0.0362 0.0426
Schistosoma mansoni ferritin 0.0053 0.0055 0.0065
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2479 0.843 1
Mycobacterium tuberculosis Conserved protein 0.0459 0.1458 0.1411
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0057 0.0068 0.0016
Mycobacterium tuberculosis Probable reductase 0.1404 0.4719 0.4689
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0057 0.0068 0.0115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0459 0.1458 0.173
Loa Loa (eye worm) hypothetical protein 0.0047 0.0035 0.0041
Plasmodium vivax thioredoxin reductase, putative 0.0616 0.1997 0.2327
Entamoeba histolytica hypothetical protein 0.0849 0.2803 1
Loa Loa (eye worm) Smad1 0.0085 0.0165 0.0196
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0057 0.0068 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0063 0.0381
Brugia malayi Bromodomain containing protein 0.008 0.0148 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Schistosoma mansoni ferritin 0.0053 0.0055 0.0065
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0057 0.0068 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0068 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0321 0.0982 0.1165
Loa Loa (eye worm) hypothetical protein 0.0084 0.0163 0.0194
Schistosoma mansoni ferritin light chain 0.0053 0.0055 0.0065
Brugia malayi MH2 domain containing protein 0.0085 0.0165 0.0196
Trichomonas vaginalis D-aminoacylase, putative 0.0459 0.1458 0.8856
Echinococcus granulosus cathepsin l1 0.0055 0.0063 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0035 0.0042
Mycobacterium ulcerans hypothetical protein 0.0459 0.1458 0.1676
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0213 0.0609 0.2886
Brugia malayi MH1 domain containing protein 0.0085 0.0165 0.0196
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.1625 0.5482 0.5457
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0213 0.0609 0.0662
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0213 0.0609 0.2886
Echinococcus granulosus intermediate filament protein 0.0174 0.0474 0.0563
Echinococcus multilocularis ferritin 0.0053 0.0055 0.0061
Loa Loa (eye worm) hypothetical protein 0.018 0.0496 0.0588
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0459 0.1458 0.1411
Brugia malayi Pre-SET motif family protein 0.0065 0.0097 0.0115
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0213 0.0609 0.2886
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0158 0.0958
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0057 0.0068 0.0016
Echinococcus granulosus smad 0.0085 0.0165 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0063 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0213 0.0609 0.0662
Loa Loa (eye worm) hypothetical protein 0.0459 0.1458 0.173
Mycobacterium ulcerans dehydrogenase 0.0057 0.0068 0.0016
Echinococcus multilocularis zinc finger protein 0.0041 0.0014 0.0012
Leishmania major cathepsin L-like protease 0.0209 0.0595 0.2816
Loa Loa (eye worm) hypothetical protein 0.0081 0.0152 0.0181
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0213 0.0609 0.0557
Schistosoma mansoni tar DNA-binding protein 0.0321 0.0982 0.1165
Onchocerca volvulus 0.006 0.008 0.0489
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.1625 0.5482 0.648
Leishmania major hypothetical protein, conserved 0.0057 0.0068 0.0115
Leishmania major hypothetical protein, conserved 0.0459 0.1458 0.7237
Onchocerca volvulus 0.0055 0.0063 0.0381
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2479 0.843 1
Loa Loa (eye worm) programmed cell death 8 0.0057 0.0068 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Echinococcus multilocularis thyroid hormone receptor alpha 0.0165 0.0444 0.0522
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0063 0.0085
Onchocerca volvulus 0.0055 0.0063 0.0381
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0057 0.0068 0.0027
Loa Loa (eye worm) hypothetical protein 0.005 0.0046 0.0055
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0057 0.0068 0.0115
Onchocerca volvulus 0.0055 0.0063 0.0381
Trypanosoma brucei hypothetical protein, conserved 0.0459 0.1458 0.7237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Entamoeba histolytica hypothetical protein 0.0849 0.2803 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0097 0.0115
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0038 0.0004 0.0022
Schistosoma mansoni smad1 5 8 and 0.0085 0.0165 0.0196
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0057 0.0068 0.0115
Schistosoma mansoni peptidase Clp (S14 family) 0.2479 0.843 1
Onchocerca volvulus Cathepsin F homolog 0.0055 0.0063 0.0381
Loa Loa (eye worm) TAR-binding protein 0.0321 0.0982 0.1165
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0055 0.0063 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0213 0.0609 0.0672
Schistosoma mansoni zinc finger protein 0.0041 0.0014 0.0016
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0057 0.0068 0.0244
Echinococcus multilocularis mothers against decapentaplegic 5 0.0085 0.0165 0.0192
Plasmodium falciparum thioredoxin reductase 0.0616 0.1997 0.2327
Trichomonas vaginalis esterase, putative 0.0459 0.1458 0.8856
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0057 0.0068 0.0416
Entamoeba histolytica cysteine protease, putative 0.0055 0.0063 0.0224
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0021 0.0025
Echinococcus granulosus mothers against decapentaplegic 6 0.0038 0.0004 0.0004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0131 0.0156
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0849 0.2803 0.3323
Brugia malayi Heterochromatin protein 1 0.0137 0.0345 0.0409
Trichomonas vaginalis D-aminoacylase, putative 0.0459 0.1458 0.8856
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0595 0.2816
Brugia malayi glutamate synthase 0.0057 0.0068 0.0081
Brugia malayi Probable ClpP-like protease 0.2479 0.843 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Onchocerca volvulus 0.0055 0.0063 0.0381
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0057 0.0068 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0213 0.0609 0.2886
Leishmania major hypothetical protein, conserved 0.0057 0.0068 0.0115
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0057 0.0068 0.0081
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1404 0.4719 0.4689
Schistosoma mansoni smad 0.0038 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Loa Loa (eye worm) MH2 domain-containing protein 0.0038 0.0004 0.0004
Echinococcus granulosus chromobox protein 1 0.0137 0.0345 0.0409
Brugia malayi Thioredoxin reductase 0.0616 0.1997 0.2369
Onchocerca volvulus 0.0459 0.1458 0.8856
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0142 0.0362 0.043
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0057 0.0068 0.0027
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0057 0.0068 0.0016
Echinococcus multilocularis smad 0.0085 0.0165 0.0192
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0213 0.0609 0.2886
Brugia malayi mothers against decapentaplegic homolog 3 0.0038 0.0004 0.0004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0302 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0138 0.0836
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2479 0.843 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1404 0.4719 0.4689
Toxoplasma gondii hypothetical protein 0.0854 0.2821 0.331
Schistosoma mansoni glutamate synthase 0.0057 0.0068 0.0081
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0452 0.1431 0.1698
Echinococcus multilocularis muscleblind protein 0.018 0.0496 0.0584
Loa Loa (eye worm) hypothetical protein 0.2479 0.843 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0213 0.0609 0.2886
Echinococcus granulosus lamin 0.0174 0.0474 0.0563
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0057 0.0068 0.0115
Brugia malayi Cathepsin L-like precursor 0.0055 0.0063 0.0074
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0057 0.0068 0.0081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0242 0.0288
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0084 0.0163 0.0189
Schistosoma mansoni chromobox protein 0.0137 0.0345 0.0409
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0213 0.0609 0.2886
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0097 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Entamoeba histolytica disulphide oxidoreductase, putative 0.0057 0.0068 0.0244
Schistosoma mansoni smad1 5 8 and 0.0085 0.0165 0.0196
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0057 0.0068 0.0416
Entamoeba histolytica thioredoxin reductase, putative 0.0057 0.0068 0.0244
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0213 0.0609 0.2886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Echinococcus granulosus Smad4 0.0085 0.0165 0.0196
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0057 0.0068 0.0077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0302 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Onchocerca volvulus 0.0459 0.1458 0.8856
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0157 0.0414 0.0491
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0057 0.0068 0.0081
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0057 0.0068 0.0115
Schistosoma mansoni smad1 5 8 and 0.0085 0.0165 0.0196
Echinococcus multilocularis cysteine protease 0.0055 0.0063 0.007
Plasmodium vivax vivapain-2 0.0055 0.0063 0.002
Loa Loa (eye worm) fibroinase 0.0055 0.0063 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Schistosoma mansoni tar DNA-binding protein 0.0321 0.0982 0.1165
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0213 0.0609 0.0662
Loa Loa (eye worm) hypothetical protein 0.006 0.008 0.0095
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0057 0.0068 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0219 0.026
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0057 0.0068 0.0081
Plasmodium vivax ferrodoxin reductase, putative 0.0057 0.0068 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0595 0.2816
Echinococcus granulosus lamin dm0 0.0174 0.0474 0.0563
Loa Loa (eye worm) glutathione reductase 0.0616 0.1997 0.2369
Leishmania major hypothetical protein, conserved 0.0057 0.0068 0.0115
Trypanosoma brucei trypanothione reductase 0.0616 0.1997 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0213 0.0609 0.0719
Plasmodium vivax SET domain protein, putative 0.0065 0.0097 0.006
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0213 0.0609 0.0647
Loa Loa (eye worm) MH1 domain-containing protein 0.0085 0.0165 0.0196
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0057 0.0068 0.0016
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0035 0.0042
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0345 0.2095
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0057 0.0068 0.0416
Plasmodium falciparum cysteine proteinase falcipain 3 0.0055 0.0063 0.002
Mycobacterium tuberculosis Probable lipase LipE 0.0459 0.1458 0.1411
Schistosoma mansoni Smad4 0.0038 0.0004 0.0004
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0057 0.0068 0.0416
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0057 0.0068 0.0014
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0057 0.0068 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.2479 0.843 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Echinococcus granulosus peptidase Clp S14 family 0.1625 0.5482 0.6503
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0213 0.0609 0.0723
Schistosoma mansoni ferritin 0.0053 0.0055 0.0065
Loa Loa (eye worm) ctsf protein 0.0055 0.0063 0.0074
Onchocerca volvulus 0.0174 0.0474 0.288
Loa Loa (eye worm) hypothetical protein 0.0171 0.0463 0.055
Schistosoma mansoni lamin 0.0174 0.0474 0.0563
Brugia malayi Cathepsin L-like precursor 0.0055 0.0063 0.0074
Loa Loa (eye worm) intermediate filament protein 0.0174 0.0474 0.0563
Echinococcus multilocularis muscleblind protein 1 0.018 0.0496 0.0584
Brugia malayi PHD-finger family protein 0.0052 0.0052 0.0062
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1561 0.5259 0.6215
Echinococcus granulosus glutamate synthase 0.0057 0.0068 0.0081
Loa Loa (eye worm) hypothetical protein 0.0057 0.0068 0.0081
Onchocerca volvulus 0.0087 0.0174 0.1056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0459 0.1458 0.173
Leishmania major cathepsin L-like protease 0.0055 0.0063 0.0085
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0057 0.0068 0.0027
Loa Loa (eye worm) hypothetical protein 0.0077 0.0138 0.0163
Treponema pallidum NADH oxidase 0.0213 0.0609 0.0662
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0057 0.0068 0.0416
Brugia malayi RNA recognition motif domain containing protein 0.0321 0.0982 0.1165
Schistosoma mansoni hypothetical protein 0.0205 0.0579 0.0687
Mycobacterium tuberculosis Conserved protein 0.0459 0.1458 0.1411
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.2479 0.843 1
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0158 0.0958
Schistosoma mansoni Smad4 0.0085 0.0165 0.0196
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0063 0.0074
Schistosoma mansoni hypothetical protein 0.0057 0.0068 0.0081
Loa Loa (eye worm) hypothetical protein 0.0089 0.0179 0.0213
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0057 0.0068 0.0115
Trypanosoma brucei NADH dehydrogenase 0.0057 0.0068 0.0115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Loa Loa (eye worm) heterochromatin protein 1 0.0137 0.0345 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0321 0.0982 0.1165
Trypanosoma cruzi NADH dehydrogenase, putative 0.0057 0.0068 0.0115
Schistosoma mansoni glutamate synthase 0.0057 0.0068 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1561 0.5259 0.5233
Echinococcus granulosus microtubule associated protein 2 0.0737 0.2416 0.2866
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0063 0.0074
Echinococcus granulosus tar DNA binding protein 0.0321 0.0982 0.1165
Loa Loa (eye worm) transcription factor SMAD2 0.1242 0.416 0.4935
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0213 0.0609 0.0672
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0057 0.0068 0.0016
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0057 0.0068 0.0416
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0088 0.0105
Toxoplasma gondii thioredoxin reductase 0.0616 0.1997 0.2327
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0057 0.0068 0.0077
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0057 0.0068 0.0115
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0035 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Echinococcus granulosus cathepsin l cysteine peptidase 0.0055 0.0063 0.0074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0213 0.0609 0.0662
Brugia malayi MH2 domain containing protein 0.1242 0.416 0.4935
Schistosoma mansoni disulfide oxidoreductase 0.0057 0.0068 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0057 0.0068 0.0027
Loa Loa (eye worm) RNA binding protein 0.0321 0.0982 0.1165
Trichomonas vaginalis set domain proteins, putative 0.0514 0.1647 1
Brugia malayi Pre-SET motif family protein 0.0452 0.1431 0.1698
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1561 0.5259 0.5233
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0242 0.0288
Brugia malayi Cathepsin L-like precursor 0.0055 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0107 0.0242 0.0288
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0459 0.1458 0.173
Loa Loa (eye worm) cysteine protease 0.0055 0.0063 0.0074
Trypanosoma cruzi cruzipain precursor, putative 0.0209 0.0595 0.2816
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0213 0.0609 0.2886
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0063 0.0074
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0321 0.0982 0.1165
Echinococcus multilocularis glutamate synthase 0.0057 0.0068 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Schistosoma mansoni ferritin 0.0053 0.0055 0.0065
Trichomonas vaginalis glutamate synthase, putative 0.0057 0.0068 0.0416
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0213 0.0609 0.2886
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.006 0.0367
Schistosoma mansoni intermediate filament proteins 0.0174 0.0474 0.0563
Toxoplasma gondii selenide, water dikinase 0.0057 0.0068 0.0027
Treponema pallidum oxidoreductase 0.0057 0.0068 0.0016
Brugia malayi Cathepsin L-like precursor 0.0055 0.0063 0.0074
Brugia malayi Intermediate filament tail domain containing protein 0.0174 0.0474 0.0563
Plasmodium vivax hypothetical protein, conserved 0.0459 0.1458 0.1684
Brugia malayi Cathepsin L-like precursor 0.0055 0.0063 0.0074
Loa Loa (eye worm) MH2 domain-containing protein 0.1242 0.416 0.4935
Brugia malayi glutathione reductase 0.0616 0.1997 0.2369
Loa Loa (eye worm) hypothetical protein 0.0246 0.0722 0.0857
Mycobacterium ulcerans monoxygenase 0.0057 0.0068 0.0016
Brugia malayi beta-lactamase family protein 0.0459 0.1458 0.173
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0213 0.0609 0.0672
Brugia malayi MH2 domain containing protein 0.0038 0.0004 0.0004
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0057 0.0068 0.0077
Schistosoma mansoni sulfide quinone reductase 0.0057 0.0068 0.0081
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0082 0.0158 0.0958
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0057 0.0068 0.0027
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0057 0.0068 0.0016
Echinococcus granulosus chromobox protein 1 0.0137 0.0345 0.0409
Brugia malayi chromobox protein homolog 3 0.0077 0.0138 0.0163
Echinococcus granulosus zinc finger protein 0.0041 0.0014 0.0016
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0057 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.01 0.0219 0.026
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0057 0.0068 0.0077
Schistosoma mansoni apoferritin-2 0.0053 0.0055 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Brugia malayi hypothetical protein 0.0849 0.2803 0.3326
Brugia malayi intermediate filament protein 0.0174 0.0474 0.0563
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0459 0.1458 0.1411
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0057 0.0068 0.0014
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0057 0.0068 0.0014
Leishmania major trypanothione reductase 0.0616 0.1997 1
Echinococcus multilocularis cysteine protease 0.0055 0.0063 0.007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0242 0.0288
Brugia malayi beta-lactamase family protein 0.0459 0.1458 0.173
Echinococcus granulosus tumor protein p63 0.1682 0.5676 0.6734
Onchocerca volvulus 0.0055 0.0063 0.0381
Leishmania major cathepsin L-like protease 0.0209 0.0595 0.2816
Brugia malayi beta-lactamase 0.0459 0.1458 0.173
Onchocerca volvulus 0.0057 0.0068 0.0416
Trichomonas vaginalis glutamate synthase, putative 0.0057 0.0068 0.0416
Schistosoma mansoni bromodomain containing protein 0.0132 0.0328 0.0389
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0057 0.0068 0.0416
Trypanosoma cruzi trypanothione reductase, putative 0.0616 0.1997 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0057 0.0068 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.006 0.0367
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0063 0.0381
Plasmodium falciparum ferrodoxin reductase-like protein 0.0057 0.0068 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Mycobacterium leprae Probable lipase LipE 0.0459 0.1458 0.1676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Echinococcus multilocularis chromobox protein 1 0.0137 0.0345 0.0405
Leishmania major cathepsin L-like protease 0.0055 0.0063 0.0085
Echinococcus multilocularis expressed protein 0.0053 0.0055 0.0061
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0063 0.0074
Giardia lamblia NADH oxidase lateral transfer candidate 0.0213 0.0609 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0617 0.2001 0.2371
Trypanosoma cruzi major cysteine proteinase, putative 0.0165 0.0441 0.2023
Trypanosoma cruzi NADH dehydrogenase, putative 0.0057 0.0068 0.0115
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0057 0.0068 0.0081
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0057 0.0068 0.0081
Leishmania major cathepsin L-like protease 0.0055 0.0063 0.0085
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0854 0.2821 0.331
Schistosoma mansoni glutamate synthase 0.0057 0.0068 0.0081
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1404 0.4719 0.4689
Trichomonas vaginalis ferritin, putative 0.0053 0.0055 0.0334
Echinococcus granulosus TGF beta signal transducer SmadC 0.0085 0.0165 0.0196
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3252 0.3856
Schistosoma mansoni thyroid hormone receptor 0.0165 0.0444 0.0526
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0055 0.0063 0.002
Echinococcus multilocularis chromobox protein 1 0.0137 0.0345 0.0405
Brugia malayi Muscleblind-like protein 0.018 0.0496 0.0588
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0057 0.0068 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0063 0.007
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0057 0.0068 0.0081
Echinococcus granulosus cathepsin L cysteine proteinase 0.0055 0.0063 0.0074
Schistosoma mansoni hypothetical protein 0.0142 0.0362 0.043
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0131 0.0151
Leishmania major cathepsin L-like protease 0.0055 0.0063 0.0085
Echinococcus granulosus histone lysine methyltransferase setb 0.01 0.0219 0.026
Loa Loa (eye worm) MH2 domain-containing protein 0.0085 0.0165 0.0196
Brugia malayi hypothetical protein 0.005 0.0046 0.0055
Schistosoma mansoni cellular tumor antigen P53 0.0246 0.0722 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0138 0.0836
Schistosoma mansoni hypothetical protein 0.0073 0.0126 0.0149
Schistosoma mansoni microtubule-associated protein tau 0.0737 0.2416 0.2866
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.0174 0.0206
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0213 0.0609 0.2886
Schistosoma mansoni lamin 0.0174 0.0474 0.0563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Echinococcus multilocularis musashi 0.0174 0.0474 0.0559
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0057 0.0068 0.0115
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0057 0.0068 0.0016
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0085 0.0165 0.0196
Mycobacterium leprae conserved hypothetical protein 0.0459 0.1458 0.1676
Mycobacterium tuberculosis Probable dehydrogenase 0.1404 0.4719 0.4689
Mycobacterium ulcerans lipase LipD 0.0459 0.1458 0.1676
Brugia malayi MH2 domain containing protein 0.0085 0.0165 0.0196
Plasmodium vivax glutathione reductase, putative 0.0616 0.1997 0.2327
Brugia malayi cytoplasmic intermediate filament protein 0.0093 0.0195 0.0232
Loa Loa (eye worm) hypothetical protein 0.0459 0.1458 0.173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.0595 0.2816
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0213 0.0609 0.0723
Brugia malayi Cathepsin L-like precursor 0.0055 0.0063 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0459 0.1458 0.8856
Schistosoma mansoni sulfide quinone reductase 0.0057 0.0068 0.0081
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0213 0.0609 0.0662
Brugia malayi Smad1 0.0085 0.0165 0.0196
Schistosoma mansoni apoferritin-2 0.0053 0.0055 0.0065
Trichomonas vaginalis apoptosis inducing factor, putative 0.0057 0.0068 0.0416
Schistosoma mansoni thyroid hormone receptor 0.0165 0.0444 0.0526
Echinococcus granulosus thioredoxin glutathione reductase 0.0617 0.2001 0.2374
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0057 0.0068 0.0016
Brugia malayi MH1 domain containing protein 0.0085 0.0165 0.0196
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0057 0.0068 0.0416
Schistosoma mansoni Smad4 0.0038 0.0004 0.0004
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0063 0.0381
Plasmodium vivax vivapain-2 0.0055 0.0063 0.002
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0057 0.0068 0.0027
Trichomonas vaginalis mercuric reductase, putative 0.0213 0.0609 0.37
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0057 0.0068 0.0081
Onchocerca volvulus 0.0514 0.1647 1
Toxoplasma gondii ABC1 family protein 0.0459 0.1458 0.1684
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1404 0.4719 0.5569
Echinococcus multilocularis peptidase Clp (S14 family) 0.1625 0.5482 0.6501
Mycobacterium ulcerans glutamate synthase subunit beta 0.0057 0.0068 0.0016
Loa Loa (eye worm) hypothetical protein 0.0174 0.0474 0.0563
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0057 0.0068 0.0244
Loa Loa (eye worm) hypothetical protein 0.0459 0.1458 0.173
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.2479 0.843 1
Leishmania major cathepsin L-like protease 0.0055 0.0063 0.0085
Echinococcus granulosus mothers against decapentaplegic 5 0.0085 0.0165 0.0196
Echinococcus granulosus beta LACTamase domain containing family member 0.0459 0.1458 0.173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0213 0.0609 0.2886
Echinococcus multilocularis microtubule associated protein 2 0.0737 0.2416 0.2863
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0057 0.0068 0.0014
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0063 0.007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0459 0.1458 0.173
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0213 0.0609 0.2886
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0084 0.0163 0.0194
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0854 0.2821 0.331
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0097 0.006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.01 0.0219 0.0256
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0093 0.0195 0.0232
Schistosoma mansoni smad 0.0085 0.0165 0.0196
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0068 0.0115
Schistosoma mansoni ferritin light chain 0.0053 0.0055 0.0065
Plasmodium falciparum thioredoxin reductase 0.0213 0.0609 0.0672
Schistosoma mansoni chromobox protein 0.0137 0.0345 0.0409
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0057 0.0068 0.0115
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1404 0.4719 0.4689
Loa Loa (eye worm) hypothetical protein 0.0459 0.1458 0.173
Schistosoma mansoni hypothetical protein 0.0205 0.0579 0.0687
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0057 0.0068 0.0416
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.2479 0.843 1
Plasmodium falciparum glutathione reductase 0.0213 0.0609 0.0672
Echinococcus granulosus expressed protein 0.0053 0.0055 0.0065
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0213 0.0609 0.0723
Echinococcus granulosus muscleblind protein 0.018 0.0496 0.0588
Mycobacterium ulcerans beta-lactamase 0.0459 0.1458 0.1676
Brugia malayi Bromodomain containing protein 0.0156 0.0412 0.0489
Loa Loa (eye worm) hypothetical protein 0.0073 0.0126 0.0149
Entamoeba histolytica hypothetical protein 0.0849 0.2803 1
Onchocerca volvulus 0.0055 0.0063 0.0381
Mycobacterium tuberculosis Probable esterase LipL 0.0459 0.1458 0.1411
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.2479 0.843 1
Echinococcus multilocularis lamin dm0 0.0174 0.0474 0.0559
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0174 0.0474 0.0563
Treponema pallidum thioredoxin reductase (trxB) 0.0057 0.0068 0.0016
Echinococcus multilocularis tumor protein p63 0.1682 0.5676 0.6732
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0057 0.0068 0.0244
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0057 0.0068 0.0027
Mycobacterium tuberculosis Conserved protein 0.0459 0.1458 0.1411
Loa Loa (eye worm) hypothetical protein 0.0055 0.0063 0.0074
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0055 0.0063 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0459 0.1458 0.7237
Loa Loa (eye worm) beta-lactamase 0.0459 0.1458 0.173
Echinococcus multilocularis Smad4 0.0085 0.0165 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Toxoplasma gondii NADPH-glutathione reductase 0.0213 0.0609 0.0672
Schistosoma mansoni tar DNA-binding protein 0.0321 0.0982 0.1165
Loa Loa (eye worm) hypothetical protein 0.0459 0.1458 0.173
Mycobacterium ulcerans hypothetical protein 0.0057 0.0068 0.0016
Trichomonas vaginalis glutathione reductase, putative 0.0213 0.0609 0.37
Loa Loa (eye worm) hypothetical protein 0.018 0.0496 0.0588
Mycobacterium ulcerans NADH dehydrogenase 0.0057 0.0068 0.0016
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0057 0.0068 0.0027
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2479 0.843 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0191 0.0533 0.2494
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.2479 0.843 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2479 0.843 1
Onchocerca volvulus 0.0055 0.0063 0.0381
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0057 0.0068 0.0016
Loa Loa (eye worm) thioredoxin reductase 0.0616 0.1997 0.2369
Brugia malayi RNA binding protein 0.0321 0.0982 0.1165
Plasmodium falciparum glutathione reductase 0.0616 0.1997 0.2327
Loa Loa (eye worm) nuclear factor I 0.0047 0.0035 0.0041
Onchocerca volvulus 0.0459 0.1458 0.8856
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0057 0.0068 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.0459 0.1458 0.8856
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0057 0.0068 0.0077
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0063 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.0459 0.1458 0.8856
Echinococcus granulosus ferritin 0.0053 0.0055 0.0065
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0057 0.0068 0.0115
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0057 0.0068 0.0014
Echinococcus granulosus geminin 0.0205 0.0579 0.0687
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0213 0.0609 0.0672
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0057 0.0068 0.0416
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0057 0.0068 0.0244
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0085 0.0165 0.0192
Entamoeba histolytica hypothetical protein 0.0849 0.2803 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0459 0.1458 0.1676
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0854 0.2821 0.3303
Brugia malayi TAR-binding protein 0.0321 0.0982 0.1165
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0459 0.1458 0.1411
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0057 0.0068 0.0016
Loa Loa (eye worm) MH1 domain-containing protein 0.0038 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.0209 0.0595 0.2816
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.2479 0.843 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0213 0.0609 0.2886
Schistosoma mansoni hypothetical protein 0.0043 0.0021 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0068 0.0115
Schistosoma mansoni transcription factor LCR-F1 0.0849 0.2803 0.3326
Echinococcus multilocularis geminin 0.0205 0.0579 0.0683
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0213 0.0609 0.0672
Loa Loa (eye worm) hypothetical protein 0.0085 0.0166 0.0197
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0616 0.1997 0.1953
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2479 0.843 1
Mycobacterium tuberculosis Probable hydrolase 0.0459 0.1458 0.1411
Trypanosoma cruzi trypanothione reductase, putative 0.0213 0.0609 0.2886
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0157 0.0414 0.0491
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0595 0.2816
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0126 0.0149
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0063 0.007
Loa Loa (eye worm) hypothetical protein 0.008 0.0149 0.0176
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0063 0.0224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0213 0.0609 0.2886
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0849 0.2803 0.3326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Echinococcus multilocularis tar DNA binding protein 0.0321 0.0982 0.1161
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0854 0.2821 0.3303
Mycobacterium tuberculosis Probable oxidoreductase 0.1561 0.5259 0.5233
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.1625 0.5482 0.5457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Toxoplasma gondii cathepsin CPL 0.0055 0.0063 0.002
Onchocerca volvulus 0.0246 0.0722 0.4388
Mycobacterium ulcerans esterase/lipase LipP 0.0459 0.1458 0.1676
Brugia malayi MH1 domain containing protein 0.0047 0.0035 0.0041
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0057 0.0068 0.0081
Echinococcus multilocularis beta LACTamase domain containing family member 0.0459 0.1458 0.1726
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0213 0.0609 0.2886
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0219 0.026
Mycobacterium ulcerans ferredoxin reductase 0.0057 0.0068 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0063 0.0381
Trypanosoma cruzi hypothetical protein, conserved 0.0459 0.1458 0.7237
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0057 0.0068 0.0081
Mycobacterium tuberculosis Probable lipase LipD 0.0459 0.1458 0.1411
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0345 0.2095
Schistosoma mansoni hypothetical protein 0.0849 0.2803 0.3326
Loa Loa (eye worm) hypothetical protein 0.0459 0.1458 0.173
Brugia malayi MH1 domain containing protein 0.0047 0.0035 0.0041
Echinococcus multilocularis lamin 0.0174 0.0474 0.0559
Onchocerca volvulus 0.0174 0.0474 0.288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0063 0.0381
Echinococcus granulosus mothers against decapentaplegic 2 0.0038 0.0004 0.0004

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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