Detailed information for compound 1301924

Basic information

Technical information
  • TDR Targets ID: 1301924
  • Name: 1-(4-methylspiro[3,4-dihydrobenzo[h]quinoline -2,1'-cyclohexane]-1-yl)ethanone
  • MW: 307.429 | Formula: C21H25NO
  • H donors: 0 H acceptors: 1 LogP: 4.88 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N1c2c(ccc3c2cccc3)C(CC21CCCCC2)C
  • InChi: 1S/C21H25NO/c1-15-14-21(12-6-3-7-13-21)22(16(2)23)20-18(15)11-10-17-8-4-5-9-19(17)20/h4-5,8-11,15H,3,6-7,12-14H2,1-2H3
  • InChiKey: DRHYUOHYWWHCIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-methyl-1-spiro[3,4-dihydrobenzo[h]quinoline-2,1'-cyclohexane]yl)ethanone
  • Oprea1_294051
  • 1-acetyl-4-methyl-3,4-dihydro-1H-spiro[benzo[h]quinoline-2,1'-cyclohexane]
  • MLS000533315
  • SMR000140753

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0062 0.0039
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.3213 0.3207
Loa Loa (eye worm) hypothetical protein 0.0056 0.0384 0.0351
Echinococcus multilocularis peptidase Clp (S14 family) 0.0171 0.1442 0.1408
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0039 0.023 0.0226
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.015 0.1247 0.3261
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0381 0.0342
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0061 0.0063
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0974 0.0966
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0308 0.0486
Echinococcus granulosus axis inhibition protein axin 0.002 0.0061 0.0021
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0038
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0369 0.0327
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0073 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0248 0.021
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0248 0.0552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0381 0.0358
Echinococcus granulosus lysine specific demethylase 6a 0.0047 0.0308 0.0268
Echinococcus granulosus dna polymerase kappa 0.002 0.0062 0.0022
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0045 0.0047
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0062 0.0039
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.015 0.1247 0.2017
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.015 0.1247 0.3261
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0039 0.023 0.0207
Echinococcus multilocularis lysine specific demethylase 6a 0.0047 0.0308 0.0268
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0337 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0015
Echinococcus granulosus lysine specific demethylase 5A 0.0181 0.1531 0.1497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0381 0.0342
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0273 0.0233
Trypanosoma brucei ISWI complex protein 0.0016 0.0023 0.0019
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0061 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0369 0.0336
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0061 0.0063
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0061 0.0021
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0073 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0369 0.1331
Giardia lamblia Fructose-bisphosphate aldolase 0.0309 0.2707 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0248 0.021
Loa Loa (eye worm) RGS-3 protein 0.002 0.0061 0.0015
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0337 0.0298
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0102 0.0058
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.1106 1 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0974 0.0966
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0421 0.3732 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0557 0.0893
Loa Loa (eye worm) hypothetical protein 0.0041 0.0247 0.0209
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0423 0.0381
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0308 0.0272
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0062 0.0047
Toxoplasma gondii thioredoxin reductase 0.0054 0.0365 0.0323
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2707 1
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.015 0.1247 0.3261
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0062 0.0085
Brugia malayi Bloom's syndrome protein homolog 0.0028 0.0127 0.0132
Schistosoma mansoni hypothetical protein 0.0043 0.0273 0.025
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0365 0.058
Echinococcus multilocularis GPCR, family 2 0.0038 0.0223 0.0183
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0095 0.0747 0.0725
Brugia malayi Bromodomain containing protein 0.0081 0.0618 0.0641
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0557 0.0716
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0062 0.0085
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0421 0.3732 1
Brugia malayi PXA domain containing protein 0.002 0.0061 0.0063
Leishmania major hypothetical protein, conserved 0.0075 0.0557 0.0548
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0421 0.3732 0.3729
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0039 0.023 0.0238
Mycobacterium tuberculosis Conserved protein 0.0041 0.0248 0.0552
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0062 0.0058
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0177 0.1497 0.1462
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0061 0.019
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.0993 0.2572
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0073 0.0063
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0423 0.0414
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0061 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0045 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2707 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0248 0.0258
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0039 0.023 0.0501
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.004 0.0017
Schistosoma mansoni hypothetical protein 0.0022 0.0075 0.0052
Onchocerca volvulus 0.0036 0.0202 0.0213
Schistosoma mansoni zinc finger protein 0.0022 0.0081 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2707 1
Echinococcus multilocularis Biotin lipoyl attachment 0.0039 0.023 0.019
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0061 0.0021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0248 0.0209
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0308 0.0272
Schistosoma mansoni jumonji/arid domain-containing protein 0.0181 0.1531 0.1511
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0062 0.0016
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.015 0.1247 0.1212
Plasmodium falciparum glutathione reductase 0.0054 0.0365 0.0448
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0039 0.023 0.0501
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0248 0.0244
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0038
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.0993 0.2572
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0993 0.2572
Echinococcus multilocularis jumonji domain containing 1A 0.0047 0.0308 0.0268
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1633 0.4308
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0061 0.019
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0248 0.0884
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1067 0.9645 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0073 0.0233
Echinococcus multilocularis phd:f box containing protein 0.0047 0.0308 0.0268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0223 0.0184
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0097 0.0072
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0681 0.0659
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0308 0.0272
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0039 0.023 0.019
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.1128 0.1127
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0401 0.0416
Echinococcus granulosus expressed protein 0.0395 0.3492 0.3466
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0248 0.0389
Loa Loa (eye worm) jmjC domain-containing protein 0.0181 0.1531 0.1547
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0261 0.226 0.6007
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0384 0.0361
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.0334
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0365 0.0326
Trypanosoma brucei trypanothione reductase 0.0054 0.0365 0.0361
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0045 0.0131
Chlamydia trachomatis biotin carboxylase 0.0383 0.3377 1
Brugia malayi jmjC domain containing protein 0.0177 0.1497 0.1552
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0039 0.023 0.022
Echinococcus granulosus cpg binding protein 0.0034 0.0188 0.0148
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0345 0.0546
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0061 0.0063
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0061 0.0021
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0045 0.0041
Echinococcus multilocularis microtubule associated protein 2 0.0731 0.6562 0.6548
Leishmania major propionyl-coa carboxylase beta chain, putative 0.015 0.1247 0.1239
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0039 0.023 0.0359
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0019 0.0046 0.0001
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0308 0.0486
Schistosoma mansoni pyruvate carboxylase 0.0421 0.3732 0.3717
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0045 0.0057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0223 0.0183
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0062 0.0022
Brugia malayi mbt repeat family protein 0.0051 0.0337 0.035
Brugia malayi hypothetical protein 0.0043 0.0273 0.0283
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0248 0.0552
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0421 0.3732 1
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0102 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0381 0.0342
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0369 0.033
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0369 0.0585
Mycobacterium tuberculosis Probable reductase 0.0122 0.0993 0.2572
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0047 0.0308 0.0285
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0423 0.1026
Trypanosoma cruzi ISWI complex protein 0.0016 0.0023 0.0022
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0062 0.0047
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0681 0.0706
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0477 0.0455
Brugia malayi MH2 domain containing protein 0.0137 0.1128 0.117
Loa Loa (eye worm) RecQ helicase 0.0028 0.0127 0.0084
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0039 0.023 0.0501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0381 0.0358
Schistosoma mansoni phd/f-box containing protein 0.0047 0.0308 0.0285
Loa Loa (eye worm) hypothetical protein 0.0041 0.0248 0.021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0223 0.0183
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.2707 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0401 0.0362
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0061 0.0021
Schistosoma mansoni hypothetical protein 0.0038 0.0223 0.02
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.015 0.1247 0.1239
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1455 0.2356
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0039 0.023 0.0359
Brugia malayi CXXC zinc finger family protein 0.003 0.0154 0.0159
Loa Loa (eye worm) hypothetical protein 0.0041 0.0248 0.021
Echinococcus multilocularis dna polymerase eta 0.002 0.0062 0.0022
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0369 0.033
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0015
Brugia malayi hypothetical protein 0.0499 0.4441 0.4604
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0062 0.0058
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.015 0.1247 0.1244
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0065 0.0068
Echinococcus multilocularis bloom syndrome protein 0.0028 0.0127 0.0087
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0015
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0557 0.0716
Echinococcus granulosus dnaJ subfamily B 0.0433 0.3839 0.3814
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0039 0.023 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0202 0.0179
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0039 0.023 0.0501
Trichomonas vaginalis esterase, putative 0.0041 0.0248 0.0884
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0062 0.0085
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0423 0.0401
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0345 0.0546
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0039 0.023 0.022
Plasmodium falciparum thioredoxin reductase 0.0054 0.0365 0.0448
Leishmania major carbamoyl-phosphate synthase, putative 0.0095 0.0747 0.0738
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0073 0.0103
Schistosoma mansoni jumonji domain containing protein 0.0047 0.0308 0.0285
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0039 0.023 0.019
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0213
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0073 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0045 0.0057
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0051 0.0342 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2707 1
Brugia malayi jmjC domain containing protein 0.0047 0.0308 0.0319
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0102 0.0079
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0681 0.0643
Echinococcus granulosus GPCR family 2 0.0038 0.0223 0.0183
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0626 0.0649
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0699 0.2456
Toxoplasma gondii carbamoylphosphate synthetase 0.0095 0.0747 0.0706
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0039 0.023 0.022
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0223 0.0231
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.015 0.1247 0.3608
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.009 0.0699 0.1645
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0261 0.2266 0.3103
Mycobacterium tuberculosis Conserved protein 0.0041 0.0248 0.0552
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1455 0.1447
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0381 0.0395
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0421 0.3732 0.6068
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.015 0.1247 0.3155
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0421 0.3732 0.3706
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0369 0.1217
Mycobacterium leprae Probable lipase LipE 0.0041 0.0248 0.0404
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0261 0.2266 0.2232
Entamoeba histolytica hypothetical protein 0.0043 0.0273 0.0975
Plasmodium vivax glutathione reductase, putative 0.0054 0.0365 0.0448
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.015 0.1247 0.3261
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0062 0.0058
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0041
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.015 0.1247 0.3261
Entamoeba histolytica hypothetical protein 0.0043 0.0273 0.0975
Brugia malayi hypothetical protein 0.0048 0.0316 0.0327
Mycobacterium ulcerans pyruvate carboxylase 0.0421 0.3732 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0304 0.0269
Schistosoma mansoni hypothetical protein 0.0202 0.1727 0.1708
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0171 0.1442 0.379
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0337 0.0315
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0039 0.023 0.0226
Schistosoma mansoni DNA polymerase eta 0.002 0.0062 0.0039
Schistosoma mansoni hypothetical protein 0.0038 0.0223 0.02
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0993 0.2572
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0369 0.0346
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0039 0.023 0.0359
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0401 0.0379
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0039 0.023 0.0187
Toxoplasma gondii pyruvate carboxylase 0.0421 0.3732 0.3704
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0062 0.0194
Brugia malayi hypothetical protein 0.002 0.0061 0.0063
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0557 0.0516
Brugia malayi beta-lactamase family protein 0.0041 0.0248 0.0258
Loa Loa (eye worm) hypothetical protein 0.0047 0.0308 0.0272
Entamoeba histolytica hypothetical protein 0.002 0.0061 0.019
Echinococcus granulosus phd:f box containing protein 0.0047 0.0308 0.0268
Loa Loa (eye worm) hypothetical protein 0.0075 0.0561 0.0536
Loa Loa (eye worm) MBCTL1 0.0057 0.0401 0.037
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.015 0.1247 0.3155
Onchocerca volvulus 0.0041 0.0248 0.0418
Loa Loa (eye worm) hypothetical protein 0.0139 0.1144 0.1143
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0369 0.0585
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0421 0.3732 0.6068
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0421 0.3732 0.3729
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0047 0.0308 0.0265
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0154
Echinococcus multilocularis lysine specific demethylase 5A 0.0177 0.1497 0.1462
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0045 0.0035
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0039 0.023 0.0258
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0154 0.0112
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0039 0.023 0.022
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0365 0.0869
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0095 0.0747 0.1202
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0102 0.0154
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0038
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.1128 0.1127
Brugia malayi glutathione reductase 0.0054 0.0365 0.0379
Schistosoma mansoni hypothetical protein 0.0102 0.0806 0.0785
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0045 0.0035
Brugia malayi beta-lactamase 0.0041 0.0248 0.0258
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0202 0.0159
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0005
Plasmodium vivax SET domain protein, putative 0.0036 0.0202 0.0219
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0223 0.0183
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0095 0.0747 0.1202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0248 0.0225
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0421 0.3732 0.3706
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0223 0.0184
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.3213 0.321
Loa Loa (eye worm) hypothetical protein 0.0051 0.0337 0.0303
Trypanosoma brucei unspecified product 0.002 0.0062 0.0058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0045 0.0057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0073 0.0032
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0061 0.0063
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0102 0.0058
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0061 0.0038
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0073 0.0075
Brugia malayi beta-lactamase family protein 0.0041 0.0248 0.0258
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.1106 1 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0369 0.0359
Trichomonas vaginalis DNA helicase recq1, putative 0.0028 0.0127 0.0435
Loa Loa (eye worm) hypothetical protein 0.0039 0.023 0.0191
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0039 0.023 0.0555
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2707 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0911 0.8211 0.8204
Schistosoma mansoni ap endonuclease 0.0022 0.0073 0.0049
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0073 0.0075
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0095 0.0747 0.1904
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0365 0.0448
Onchocerca volvulus 0.0041 0.0248 0.0418
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0248 0.0552
Entamoeba histolytica hypothetical protein 0.002 0.0061 0.019
Schistosoma mansoni hypothetical protein 0.0311 0.2725 0.2708
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0273 0.025
Echinococcus granulosus dna polymerase eta 0.002 0.0062 0.0022
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0369 0.033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0248 0.0552
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.1118 0.291
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0045 0.0041
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0045 0.0057
Brugia malayi hypothetical protein 0.002 0.0061 0.0063
Onchocerca volvulus 0.0088 0.0681 0.2321
Schistosoma mansoni axis inhibition protein axin 0.002 0.0061 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0248 0.021
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0095 0.0747 0.0743
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0061 0.0015
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0073 0.0069
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0073 0.0075
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0061 0.0021
Schistosoma mansoni cpg binding protein 0.003 0.0154 0.013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0309 0.2707 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0202 0.0209
Entamoeba histolytica hypothetical protein 0.0025 0.0102 0.0341
Mycobacterium ulcerans beta-lactamase 0.0041 0.0248 0.0552
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0073 0.0075
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.3839 0.3814
Schistosoma mansoni cpg binding protein 0.0034 0.0188 0.0165
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0047 0.0308 0.0265
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.015 0.1247 0.2017
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0061 0.0021
Onchocerca volvulus 0.0041 0.0248 0.0418
Brugia malayi jmjC domain containing protein 0.0047 0.0308 0.0319
Leishmania major hypothetical protein, conserved 0.0047 0.0308 0.0298
Leishmania major carboxylase, putative 0.0421 0.3732 0.3726
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.011 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0248 0.0884
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0248 0.0389
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0421 0.3732 0.3717
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0699 0.0914
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0401 0.0362
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0061 0.0021
Echinococcus granulosus jumonji domain containing 1A 0.0047 0.0308 0.0268
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.011 0.0069
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0202 0.0162
Brugia malayi PXA domain containing protein 0.002 0.0061 0.0063
Echinococcus granulosus zinc finger protein 0.0022 0.0081 0.004
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.1259 0.3292
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.1118 0.291
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0557 0.0553
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0223 0.0183
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0365 0.0326
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0248 0.0552
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2707 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0065 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0423 0.1026
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0062 0.0047
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0045 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0073 0.0032
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0261 0.2266 0.8343
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1736 0.1703
Entamoeba histolytica hypothetical protein 0.0043 0.0273 0.0975
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0102 0.017
Mycobacterium ulcerans hypothetical protein 0.0041 0.0248 0.0552
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0223 0.0184
Onchocerca volvulus 0.0051 0.0337 0.0809
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0421 0.3732 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0061 0.0021
Treponema pallidum pyruvate carboxylase subunit B 0.0039 0.023 0.0694
Echinococcus granulosus survival motor neuron protein 1 0.0499 0.4441 0.4418
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0095 0.0747 0.0981
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Schistosoma mansoni jumonji domain containing protein 0.0177 0.1497 0.1477
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0038
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0039 0.023 0.0258
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0102 0.0154
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0045 0.0131
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0261 0.2266 0.2235
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0974 0.101
Trypanosoma brucei protein kinase, putative 0.0054 0.0369 0.0365
Schistosoma mansoni axis inhibition protein axin 0.002 0.0061 0.0038
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.047 0.0431
Loa Loa (eye worm) hypothetical protein 0.0499 0.4441 0.4578
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0065 0.002
Schistosoma mansoni microtubule-associated protein tau 0.0731 0.6562 0.6554
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0039 0.023 0.0207
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0248 0.0552
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0062 0.0052
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.1118 0.291
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0039 0.023 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0367 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0367 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0075 0.003
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0061 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0248 0.0884
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0045 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0381 0.0358
Plasmodium falciparum JmjC domain-containing protein, putative 0.0047 0.0308 0.0367
Loa Loa (eye worm) hypothetical protein 0.0047 0.0308 0.0272
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0248 0.0884
Loa Loa (eye worm) glutathione reductase 0.0054 0.0365 0.0332
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0062 0.0194
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0039 0.023 0.0353
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0245 0.2117 0.2157
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0015
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0261 0.2266 0.2235
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0102 0.0154
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0337 0.0298
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0039 0.023 0.0207
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.015 0.1247 0.1227
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0074 0.0051
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0095 0.0747 0.1904
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0062 0.0194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2707 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0423 0.0384
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0061 0.0021
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0177 0.1497 0.1462
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.015 0.1247 0.2017
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0061 0.0038
Toxoplasma gondii hypothetical protein 0.0059 0.0414 0.0372
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0061 0.0021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0171 0.1442 0.379
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1736 0.1703
Brugia malayi Thioredoxin reductase 0.0054 0.0365 0.0379
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0045 0.0035
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0039 0.023 0.0501
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0061 0.0015
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0039 0.023 0.019
Schistosoma mansoni bromodomain containing protein 0.0069 0.0504 0.0482
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0337 0.0809
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0045 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.023 0.0191
Schistosoma mansoni hypothetical protein 0.0082 0.0626 0.0604
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0345 0.0341
Trypanosoma brucei unspecified product 0.0277 0.2411 0.2407
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0248 0.0552
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0062 0.0047
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0248 0.0404
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0039 0.023 0.0359
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0065 0.0042
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0801 0.7202 1
Echinococcus multilocularis zinc finger protein 0.0022 0.0081 0.004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0045 0.0022
Schistosoma mansoni hypothetical protein 0.0433 0.3839 0.3824
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.015 0.1247 0.3261
Trypanosoma cruzi ISWI complex protein 0.0016 0.0023 0.0022
Brugia malayi hypothetical protein 0.0075 0.0557 0.0578
Loa Loa (eye worm) hypothetical protein 0.0261 0.2266 0.2313
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0337 0.0298
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0039 0.023 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0062 0.0022
Loa Loa (eye worm) beta-lactamase 0.0041 0.0248 0.021
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0073 0.0039
Loa Loa (eye worm) hypothetical protein 0.0041 0.0248 0.021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0073 0.0103
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0039 0.023 0.0555
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0045 0.0057
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0039 0.023 0.0187
Onchocerca volvulus 0.0056 0.0384 0.1013
Loa Loa (eye worm) hypothetical protein 0.0047 0.0308 0.0272
Entamoeba histolytica hypothetical protein 0.002 0.0061 0.019
Echinococcus multilocularis tumor protein p63 0.038 0.3349 0.3322
Brugia malayi Bromodomain containing protein 0.0041 0.0246 0.0255
Onchocerca volvulus 0.0279 0.2426 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0061 0.019
Mycobacterium tuberculosis Conserved protein 0.0041 0.0248 0.0552
Echinococcus multilocularis survival motor neuron protein 1 0.0499 0.4441 0.4418
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0061 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0248 0.0884
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0261 0.2266 0.6025
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0062 0.0065
Toxoplasma gondii exonuclease III APE 0.0022 0.0073 0.0029
Mycobacterium ulcerans hypothetical protein 0.0039 0.023 0.0501
Toxoplasma gondii ABC1 family protein 0.0041 0.0248 0.0206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0223 0.0231
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0073 0.0233
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0039 0.023 0.019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0039 0.023 0.0501
Leishmania major acetyl-CoA carboxylase, putative 0.1106 1 1
Schistosoma mansoni hypothetical protein 0.0202 0.1727 0.1708
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.047 0.0431
Schistosoma mansoni cpg binding protein 0.0034 0.0188 0.0165
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0337 0.0315
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0047 0.0308 0.0304
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0681 0.0643
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0345 0.0546
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0365 0.0332
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.015 0.1247 0.1209
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0039 0.023 0.0555
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0369 0.0585
Schistosoma mansoni protein phosphatase 2C 0.0047 0.0308 0.0285
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0557 0.0893
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.1106 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.1259 0.3292
Echinococcus multilocularis JmjC domain containing protein 4 0.0047 0.0308 0.0268
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0369 0.0585
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0061 0.0021
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0421 0.3732 0.3717
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0202 0.0179
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0039 0.023 0.0238
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.015 0.1247 0.1212
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1455 0.1451
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0016
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0337 0.0315
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0381 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Entamoeba histolytica hypothetical protein 0.0043 0.0273 0.0975
Giardia lamblia DINP protein human, muc B family 0.002 0.0062 0.0064
Echinococcus granulosus peptidase Clp S14 family 0.0171 0.1442 0.1408
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0039 0.023 0.0501
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.015 0.1247 0.3261
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0061 0.019
Leishmania major hypothetical protein, conserved 0.0041 0.0248 0.0239
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0261 0.2266 0.6025
Mycobacterium ulcerans lipase LipD 0.0041 0.0248 0.0552
Loa Loa (eye worm) hypothetical protein 0.0057 0.0401 0.037
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0369 0.1331
Echinococcus multilocularis cpg binding protein 0.0034 0.0188 0.0148
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0181 0.0141
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0248 0.0209
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0421 0.3732 1
Leishmania major trypanothione reductase 0.0054 0.0365 0.0356
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0699 0.0914
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0045 0.0057
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0065 0.0025
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0171 0.1442 0.3693
Schistosoma mansoni hypothetical protein 0.0038 0.0223 0.02
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0421 0.3732 1
Schistosoma mansoni aspartate carbamoyltransferase 0.0095 0.0747 0.0725
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0039 0.023 0.0353
Toxoplasma gondii hypothetical protein 0.009 0.0699 0.0658
Brugia malayi mbt repeat family protein 0.0051 0.0337 0.035
Schistosoma mansoni ap endonuclease 0.0022 0.0073 0.0049
Mycobacterium ulcerans hypothetical protein 0.0192 0.1633 0.4308
Schistosoma mansoni regulator of G protein signaling 0.002 0.0061 0.0038
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0039 0.023 0.0226
Brugia malayi PHD-finger family protein 0.0028 0.0132 0.0137
Schistosoma mansoni phosphatidylserine receptor 0.0047 0.0308 0.0285
Plasmodium falciparum carbamoyl phosphate synthetase 0.0095 0.0747 0.0981
Schistosoma mansoni acetyl-CoA carboxylase 0.1106 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0181 0.0158
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0127 0.0435
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0095 0.0747 0.0725
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0401 0.0362
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0039 0.023 0.0555
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0065 0.002
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0061 0.0038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0367 0.0328
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0261 0.2266 0.3103
Treponema pallidum fructose-bisphosphate aldolase 0.0309 0.2707 1
Brugia malayi Probable ClpP-like protease 0.0261 0.2266 0.2349
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.015 0.1247 0.3261
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Brugia malayi jmjC domain containing protein 0.0181 0.1531 0.1588
Echinococcus granulosus Biotin lipoyl attachment 0.0039 0.023 0.019
Leishmania major DNA polymerase eta, putative 0.002 0.0062 0.0052
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0039 0.023 0.0359
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0806 0.0836
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0184 0.0144
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0421 0.3732 0.3726
Echinococcus granulosus bloom syndrome protein 0.0028 0.0127 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0974 0.101
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.004 0.0017
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0039 0.023 0.0258
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0801 0.7202 1
Schistosoma mansoni survival motor neuron protein 0.0102 0.0806 0.0785
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0261 0.2266 0.5962
Loa Loa (eye worm) hypothetical protein 0.0082 0.0626 0.0604
Echinococcus granulosus microtubule associated protein 2 0.0731 0.6562 0.6548
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3213 0.5223
Trypanosoma brucei acetyl-CoA carboxylase 0.1106 1 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0261 0.2266 0.2248
Loa Loa (eye worm) hypothetical protein 0.0075 0.0557 0.0532
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0061 0.0063
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0102 0.0079
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0039 0.023 0.0359
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0401 0.0362
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.011 0.0069
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0189 0.1602 0.5848
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0051 0.0342 0.0303
Brugia malayi Pre-SET motif family protein 0.0245 0.2117 0.2195
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.0993 0.2456
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0557 0.0716
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0261 0.2266 0.6025
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0065 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0248 0.0284
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0045 0.0057
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0369 0.0365
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0102 0.0092
Brugia malayi jmjC domain containing protein 0.0047 0.0308 0.0319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0309 0.2707 1
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.015 0.1247 0.3155
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0061 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0061 0.019
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0248 0.0552
Brugia malayi jmjC domain containing protein 0.0047 0.0308 0.0319
Echinococcus granulosus JmjC domain containing protein 4 0.0047 0.0308 0.0268
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0039 0.023 0.0258
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0039 0.023 0.0207
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0061 0.0021
Brugia malayi MAP kinase sur-1 0.0054 0.0369 0.0383
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0073 0.0104
Leishmania major hypothetical protein, conserved 0.0016 0.0023 0.0014
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0369 0.033
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0261 0.2266 0.6666
Echinococcus multilocularis expressed protein 0.0395 0.3492 0.3466
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0248 0.0552
Trichomonas vaginalis set domain proteins, putative 0.0279 0.2426 0.8957
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0189 0.1602 0.5902
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0369 0.0359
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0039 0.023 0.0187
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0039 0.023 0.0238
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0062 0.0065
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0381 0.0348
Echinococcus granulosus geminin 0.0202 0.1727 0.1694
Plasmodium vivax JmjC domain containing protein 0.0047 0.0308 0.0367
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0423 0.0401
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0273 0.0233
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0062 0.0085
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0261 0.2266 0.6666
Echinococcus multilocularis dna polymerase kappa 0.002 0.0062 0.0022
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.0993 0.2572
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0423 0.1026
Echinococcus granulosus axis inhibition protein axin 0.002 0.0061 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0248 0.0225
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0261 0.2266 0.2232
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0073 0.0233
Loa Loa (eye worm) hypothetical protein 0.0088 0.0681 0.0661
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0065 0.0025
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0233
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0045 0.0057
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0421 0.3732 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0423 0.1026
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0061 0.019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0437 0.0395
Schistosoma mansoni hypothetical protein 0.0038 0.0223 0.02
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0367 0.0328
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.1259 0.3187
Echinococcus granulosus tumor protein p63 0.038 0.3349 0.3322
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0181 0.0141
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0248 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0062 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0062 0.0085
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.015 0.1247 0.3261
Trypanosoma cruzi acetyl-CoA carboxylase 0.0685 0.6143 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0181 0.1531 0.1511
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0223 0.0184
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0423 0.0384
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0039 0.023 0.0226
Echinococcus multilocularis geminin 0.0202 0.1727 0.1694
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0369 0.1331
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0039 0.023 0.0258
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0015
Leishmania major DNA polymerase kappa, putative 0.002 0.0062 0.0052
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0369 0.1331
Brugia malayi Carboxyl transferase domain containing protein 0.1067 0.9645 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.023 0.0191
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0447 0.0713
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0015
Onchocerca volvulus 0.0102 0.0806 0.2873
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0337 0.0298
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3213 0.5223
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.1118 0.2799

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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