Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.126 | 0.3529 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0346 | 0.5563 | 0.5563 |
Echinococcus multilocularis | tar DNA binding protein | 0.0185 | 0.2644 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.006 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0109 | 0.126 | 0.4768 |
Echinococcus granulosus | tar DNA binding protein | 0.0185 | 0.2644 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.006 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0109 | 0.126 | 0.4768 |
Loa Loa (eye worm) | RNA binding protein | 0.0185 | 0.2644 | 0.2644 |
Schistosoma mansoni | tar DNA-binding protein | 0.0185 | 0.2644 | 0.7402 |
Echinococcus multilocularis | GPCR, family 2 | 0.0109 | 0.126 | 0.4768 |
Loa Loa (eye worm) | TAR-binding protein | 0.0185 | 0.2644 | 0.2644 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0236 | 0.3572 | 0.3572 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0346 | 0.5563 | 0.5563 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.3572 | 0.3572 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.3572 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.5563 | 0.5563 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.006 | 0.0228 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0589 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0346 | 0.5563 | 0.5563 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.006 | 0.0228 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0185 | 0.2644 | 0.2644 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.006 | 0.0169 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0109 | 0.126 | 0.126 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.006 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0185 | 0.2644 | 0.2644 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0109 | 0.126 | 0.4768 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0109 | 0.126 | 0.126 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.126 | 0.126 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.126 | 0.3529 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0589 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0185 | 0.2644 | 0.2644 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.006 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.126 | 0.3529 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0109 | 0.126 | 0.4768 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.006 | 0.0169 |
Schistosoma mansoni | tar DNA-binding protein | 0.0185 | 0.2644 | 0.7402 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0109 | 0.126 | 0.126 |
Schistosoma mansoni | tar DNA-binding protein | 0.0185 | 0.2644 | 0.7402 |
Schistosoma mansoni | tar DNA-binding protein | 0.0185 | 0.2644 | 0.7402 |
Schistosoma mansoni | tar DNA-binding protein | 0.0185 | 0.2644 | 0.7402 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.126 | 0.3529 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0109 | 0.126 | 0.4768 |
Brugia malayi | TAR-binding protein | 0.0185 | 0.2644 | 0.2644 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.