Detailed information for compound 1302194

Basic information

Technical information
  • TDR Targets ID: 1302194
  • Name: 4-[(4-fluorophenyl)methyl]-N-(1-phenylethyl)t hieno[2,3-d]pyrrole-5-carboxamide
  • MW: 378.462 | Formula: C22H19FN2OS
  • H donors: 1 H acceptors: 1 LogP: 4.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cn1c(cc2c1ccs2)C(=O)NC(c1ccccc1)C
  • InChi: 1S/C22H19FN2OS/c1-15(17-5-3-2-4-6-17)24-22(26)20-13-21-19(11-12-27-21)25(20)14-16-7-9-18(23)10-8-16/h2-13,15H,14H2,1H3,(H,24,26)
  • InChiKey: DFUFUHPFEWEEQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-fluorophenyl)methyl]-N-(1-phenylethyl)-5-thieno[2,3-d]pyrrolecarboxamide
  • 4-(4-fluorobenzyl)-N-(1-phenylethyl)thieno[2,3-d]pyrrole-5-carboxamide
  • C703-0635
  • NCGC00112138-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0025 0.0111 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Brugia malayi Matrixin family protein 0.0044 0.0342 0.055
Onchocerca volvulus 0.0206 0.2401 1
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0104 0.016
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0104 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0206 0.2401 0.6486
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.3871 0.6802
Echinococcus multilocularis prolyl endopeptidase 0.013 0.1441 0.1441
Entamoeba histolytica cysteine proteinase, putative 0.0094 0.0983 0.2604
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Plasmodium vivax hypothetical protein, conserved 0.0114 0.1235 0.5145
Loa Loa (eye worm) hypothetical protein 0.013 0.1441 0.2503
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0751 0.1968
Mycobacterium leprae PROBABLE HYDROLASE 0.0053 0.0463 0.2247
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0111 0.015
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.02 0.0462
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0094 0.0983 0.1515
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0111 0.0171
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.0635 0.1069
Brugia malayi neuropeptide F receptor 0.0025 0.0111 0.014
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.043 0.1168
Loa Loa (eye worm) hypothetical protein 0.0076 0.0751 0.1283
Loa Loa (eye worm) matrix metalloproteinase 0.0044 0.0342 0.0559
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Schistosoma mansoni amine GPCR 0.0025 0.0111 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1848 0.4973
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Onchocerca volvulus 0.0025 0.0111 0.0019
Schistosoma mansoni cathepsin B (C01 family) 0.0051 0.043 0.0663
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0107 0.0483
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0111 0.0171
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.02 0.0208
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0104 0.0138
Schistosoma mansoni cathepsin S (C01 family) 0.0051 0.043 0.0663
Echinococcus granulosus cathepsin l cysteine peptidase 0.0206 0.2401 0.3699
Chlamydia trachomatis pyruvate kinase 0.0033 0.02 0.2404
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.043 0.0715
Brugia malayi Serotonin receptor 0.0025 0.0111 0.014
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0051 0.043 0.1792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3684 1
Onchocerca volvulus Cathepsin F homolog 0.0206 0.2401 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0131 0.145 0.3883
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Toxoplasma gondii cathepsin CPL 0.0206 0.2401 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0051 0.043 0.1091
Onchocerca volvulus 0.0025 0.0111 0.0019
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0111 0.0111
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Giardia lamblia Cathepsin B precursor 0.0051 0.043 0.1168
Leishmania major cathepsin L-like protease 0.0206 0.2401 1
Schistosoma mansoni opsin-like receptor 0.0025 0.0111 0.0171
Leishmania major importin beta-1 subunit, putative 0.0024 0.0099 0.0283
Schistosoma mansoni amine GPCR 0.0025 0.0111 0.0171
Schistosoma mansoni biogenic amine receptor 0.0025 0.0111 0.0171
Echinococcus granulosus peptidase Clp S14 family 0.005 0.042 0.0646
Onchocerca volvulus 0.0025 0.0111 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0111 0.0111
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.024 0.037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Plasmodium falciparum serine repeat antigen 5 0.0051 0.043 0.1792
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.024 0.024
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0111 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Brugia malayi mbt repeat family protein 0.0046 0.0377 0.0612
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0044 0.0342 0.0527
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0111 0.0171
Entamoeba histolytica cysteine protease, putative 0.0206 0.2401 0.6486
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0782 0.2032
Brugia malayi cathepsin Z-like cysteine proteinase 0.0051 0.043 0.0706
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.1749 0.3048
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0751 0.4353
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0164 0.0253
Mycobacterium ulcerans hypothetical protein 0.0025 0.0107 0.0483
Brugia malayi Cathepsin L-like precursor 0.0163 0.1848 0.3216
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0107 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0142
Loa Loa (eye worm) matrixin family protein 0.0106 0.1127 0.1947
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0164 0.0164
Echinococcus multilocularis GPCR, family 2 0.0049 0.0409 0.0409
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0111 0.015
Giardia lamblia Cathepsin B precursor 0.0051 0.043 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Echinococcus multilocularis glutamate receptor 2 0.0062 0.0578 0.0578
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.043 0.1091
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.1235 0.5081
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0111 0.0171
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0111 0.015
Trichomonas vaginalis esterase, putative 0.0114 0.1235 0.3295
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.0032
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Brugia malayi RNA, U transporter 1 0.0086 0.0876 0.1495
Echinococcus granulosus cathepsin L cysteine protease 0.0094 0.0983 0.1515
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0111 0.0171
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1235 0.1903
Loa Loa (eye worm) beta-lactamase 0.0114 0.1235 0.2139
Loa Loa (eye worm) hypothetical protein 0.0068 0.0653 0.1108
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.005
Onchocerca volvulus 0.0025 0.0111 0.0019
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0051 0.043 0.1792
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0051 0.043 0.0663
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.007 0.0108
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0076 0.0121
Echinococcus multilocularis sex peptide receptor 0.0025 0.0111 0.0111
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0111 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.102 0.1571
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0051 0.043 0.1792
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0051 0.043 0.1091
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0111 0.0111
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0409 0.0668
Leishmania major cathepsin L-like protease 0.0206 0.2401 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0111 0.0111
Schistosoma mansoni neuropeptide receptor 0.0025 0.0111 0.0171
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0111 0.014
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0111 0.0111
Trypanosoma cruzi oligopeptidase b 0.0052 0.0446 0.1121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1235 0.3295
Echinococcus granulosus g protein coupled receptor 0.0025 0.0111 0.0171
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0104 0.016
Brugia malayi Tachykinin-like peptides receptor 99D 0.0465 0.5679 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0458 0.0706
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0111 0.0171
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.012 0.0501
Schistosoma mansoni cathepsin C 0.0051 0.043 0.0663
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.1532 0.2665
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.1235 0.1355
Brugia malayi Cathepsin L-like precursor 0.0044 0.0341 0.0548
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0131 0.145 0.3838
Giardia lamblia Cathepsin L-like protease 0.0051 0.043 0.1168
Loa Loa (eye worm) pyruvate kinase 0.0033 0.02 0.0308
Plasmodium falciparum serine repeat antigen 2 0.0051 0.043 0.1792
Loa Loa (eye worm) cathepsin B 0.0131 0.145 0.2519
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0111 0.0171
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.02 0.0462
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.02 0.0593
Brugia malayi neuropeptide F receptor 0.0025 0.0111 0.014
Brugia malayi cathepsin B-like cysteine proteinase 0.0311 0.3728 0.6545
Leishmania major cathepsin L-like protease 0.0206 0.2401 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0341 0.0558
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0377 0.0581
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0111 0.0171
Echinococcus granulosus serotonin receptor 0.0025 0.0111 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0111 0.0171
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0111 0.014
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0111 0.0171
Onchocerca volvulus 0.0114 0.1235 0.492
Brugia malayi Matrixin family protein 0.0044 0.0342 0.055
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0094 0.0983 0.1515
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0131 0.145 0.5987
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.043 0.1168
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0782 0.317
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0107 0.0483
Brugia malayi Cathepsin L-like precursor 0.0163 0.1848 0.3216
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0635 0.0635
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0458 0.0458
Mycobacterium ulcerans lipase LipD 0.0114 0.1235 0.726
Plasmodium vivax importin-beta 2, putative 0.003 0.0171 0.0712
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0072 0.0695 0.0695
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0111 0.0111
Echinococcus granulosus cathepsin l1 0.0206 0.2401 0.3699
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3684 1
Onchocerca volvulus Matrilysin homolog 0.0097 0.1016 0.3965
Plasmodium falciparum cysteine proteinase falcipain 3 0.0206 0.2401 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.043 0.0663
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0111 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Brugia malayi SWIRM domain containing protein 0.0074 0.0726 0.1229
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0104 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0111 0.0171
Brugia malayi cathepsin L-like precursor 0.0163 0.1848 0.3216
Brugia malayi mbt repeat family protein 0.0046 0.0377 0.0612
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.102 0.1758
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0111 0.0171
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1235 0.3256
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0032 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0107 0.0104
Schistosoma mansoni hypothetical protein 0.0025 0.0111 0.0171
Echinococcus multilocularis geminin 0.0529 0.649 0.649
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1235 0.3295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Brugia malayi Matrixin family protein 0.0044 0.0342 0.055
Leishmania major pyruvate kinase 0.0033 0.02 0.0713
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0032 0.0021
Giardia lamblia Cathepsin L precursor 0.0051 0.043 0.1168
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0104 0.016
Entamoeba histolytica hypothetical protein 0.0051 0.043 0.1091
Echinococcus multilocularis neuropeptide FF receptor 2 0.0465 0.5679 0.5679
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.02 0.0299
Echinococcus granulosus neuropeptide FF receptor 2 0.0465 0.5679 0.875
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0051 0.043 0.0706
Schistosoma mansoni cathepsin s 0.0044 0.0341 0.0526
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0094 0.0983 0.1515
Loa Loa (eye worm) hypothetical protein 0.0074 0.0726 0.1237
Echinococcus multilocularis cathepsin L cysteine protease 0.0206 0.2401 0.2401
Leishmania major cathepsin L-like protease 0.0206 0.2401 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0099 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.0983 0.2574
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0206 0.2401 0.2401
Onchocerca volvulus 0.0206 0.2401 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0751 0.0751
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.043 0.1078
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.02 0.0713
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.102 0.175
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0111 0.0171
Giardia lamblia Cysteine protease 0.0051 0.043 0.1168
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0051 0.043 0.0663
Loa Loa (eye worm) hypothetical protein 0.0068 0.0653 0.1108
Onchocerca volvulus 0.0025 0.0111 0.0019
Onchocerca volvulus 0.0025 0.0111 0.0019
Brugia malayi Cathepsin L-like precursor 0.0206 0.2401 0.4195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.043 0.1091
Echinococcus multilocularis somatostatin receptor 0.0025 0.0111 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.102 0.1571
Brugia malayi Cathepsin L-like precursor 0.0206 0.2401 0.4195
Giardia lamblia Cathepsin L precursor 0.0051 0.043 0.1168
Echinococcus granulosus lysine specific histone demethylase 1A 0.0068 0.0653 0.1005
Plasmodium falciparum serine repeat antigen 7 0.0051 0.043 0.1792
Trichomonas vaginalis ran, putative 0.0022 0.007 0.0105
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.0446 0.1748
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.1235 0.1355
Giardia lamblia Encystation-specific protease 0.0051 0.043 0.1168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Echinococcus multilocularis cathepsin L cysteine protease 0.0206 0.2401 0.2401
Giardia lamblia Hypothetical protein 0.0051 0.043 0.1168
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Echinococcus multilocularis glutamate receptor 2 0.0072 0.0695 0.0695
Toxoplasma gondii ABC1 family protein 0.0114 0.1235 0.5145
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0044 0.0341 0.0548
Entamoeba histolytica cysteine proteinase, putative 0.0206 0.2401 0.6486
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0341 0.0838
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0341 0.0558
Loa Loa (eye worm) hypothetical protein 0.0053 0.0458 0.0765
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.007 0.0162
Loa Loa (eye worm) hypothetical protein 0.0049 0.0409 0.0677
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.0715
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0111 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Echinococcus granulosus g protein coupled receptor 0.0025 0.0111 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0111 0.0171
Trypanosoma cruzi cysteine peptidase, putative 0.0206 0.2401 0.641
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3684 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.1749 0.3042
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.0715
Schistosoma mansoni hypothetical protein 0.0062 0.0573 0.0883
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0107 0.0316
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.0341 0.0838
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0111 0.0019
Brugia malayi G-protein coupled receptor 0.0025 0.0111 0.014
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0164 0.0253
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0159 0.1801 0.1801
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0111 0.0171
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0111 0.0171
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.1848 0.4973
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Echinococcus multilocularis importin subunit beta 1 0.003 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Brugia malayi Importin beta-1 subunit 0.003 0.0171 0.0247
Brugia malayi Hemopexin family protein 0.0062 0.0573 0.0959
Schistosoma mansoni neuropeptide receptor 0.0025 0.0111 0.0171
Brugia malayi G-protein coupled receptor 0.0025 0.0111 0.014
Onchocerca volvulus 0.0114 0.1235 0.492
Onchocerca volvulus Cathepsin L homolog 0.0206 0.2401 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.0715
Echinococcus granulosus hypothetical protein 0.0025 0.0111 0.0171
Echinococcus multilocularis cathepsin b 0.0311 0.3728 0.3728
Brugia malayi Probable ClpP-like protease 0.0076 0.0751 0.1274
Leishmania major hypothetical protein, conserved 0.0114 0.1235 0.5081
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0107 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Leishmania major cathepsin L-like protease 0.0206 0.2401 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0409 0.063
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.02 0.0457
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0983 0.2604
Giardia lamblia Cathepsin L precursor 0.0051 0.043 0.1168
Trypanosoma cruzi oligopeptidase b 0.0052 0.0446 0.1121
Onchocerca volvulus 0.0206 0.2401 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1692 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0072 0.0695 0.1071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Giardia lamblia Cysteine protease 0.0051 0.043 0.1168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1235 0.2139
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0026 0.0109
Schistosoma mansoni cathepsin F (C01 family) 0.0206 0.2401 0.3699
Plasmodium falciparum cysteine proteinase falcipain 1 0.0094 0.0983 0.4094
Trypanosoma cruzi cysteine peptidase, putative 0.0206 0.2401 0.641
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0409 0.0409
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.012 0.0086
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0751 0.3129
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0032 0.0003
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.0446 0.214
Onchocerca volvulus 0.0206 0.2401 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.007 0.0104
Echinococcus granulosus neuropeptide receptor 0.0025 0.0111 0.0171
Loa Loa (eye worm) hypothetical protein 0.0033 0.02 0.0308
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Echinococcus granulosus cathepsin L 0.0094 0.0983 0.1515
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.02 0.0409
Plasmodium falciparum serine repeat antigen 6 0.0051 0.043 0.1792
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0053 0.0463 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.043 0.1091
Brugia malayi Matrixin family protein 0.0044 0.0342 0.055
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0111 0.0171
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3684 1
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0104 0.016
Entamoeba histolytica cysteine protease, putative 0.0051 0.043 0.1091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0311 0.3728 0.5744
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.2157 0.2157
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.1235 0.1235
Schistosoma mansoni hypothetical protein 0.0025 0.0111 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Echinococcus multilocularis snurportin 1 0.0322 0.3871 0.3871
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1235 0.1903
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0111 0.0171
Loa Loa (eye worm) hypothetical protein 0.0114 0.1235 0.2139
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.0446 0.1121
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0051 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Giardia lamblia Cathepsin B precursor 0.0131 0.145 0.3936
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0051 0.043 0.1792
Onchocerca volvulus 0.0114 0.1235 0.492
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.019
Mycobacterium leprae conserved hypothetical protein 0.0114 0.1235 0.7121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0099 0.0184
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.042 0.0451
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0111 0.015
Brugia malayi fibroinase precursor 0.0051 0.043 0.0706
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0111 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0111 0.0171
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0111 0.014
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0111 0.0111
Echinococcus granulosus cathepsin l1 0.0163 0.1848 0.2847
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0107 0.0483
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0104 0.016
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0111 0.0171
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0111 0.0111
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.1235 0.1355
Brugia malayi Dopamine receptor protein 2 0.0025 0.0111 0.014
Schistosoma mansoni neuropeptide receptor 0.0025 0.0111 0.0171
Loa Loa (eye worm) cysteine protease 0.0206 0.2401 0.4201
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0545 0.084
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0206 0.2401 0.4201
Onchocerca volvulus 0.0163 0.1848 0.7591
Giardia lamblia Cathepsin B precursor 0.0051 0.043 0.1168
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0782 0.326
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0111 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.043 0.1091
Brugia malayi amine oxidase, flavin-containing family protein 0.002 0.0037 0.001
Brugia malayi hypothetical protein 0.0078 0.0782 0.133
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.1129 0.1943
Onchocerca volvulus Prolyl endopeptidase homolog 0.013 0.1441 0.5818
Onchocerca volvulus 0.006 0.0545 0.1913
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Loa Loa (eye worm) pyruvate kinase 0.0033 0.02 0.0308
Loa Loa (eye worm) hypothetical protein 0.0106 0.1129 0.1951
Entamoeba histolytica cysteine proteinase, putative 0.0206 0.2401 0.6486
Entamoeba histolytica cysteine protease, putative 0.0051 0.043 0.1091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0409 0.0677
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0111 0.0171
Echinococcus multilocularis pyruvate kinase 0.0026 0.0114 0.0114
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0751 0.4353
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0311 0.3728 0.5744
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0782 0.326
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0111 0.0111
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0111 0.0111
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.043 0.0706
Brugia malayi Melatonin receptor type 1A 0.0025 0.0111 0.014
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0111 0.0111
Giardia lamblia Cathepsin B precursor 0.0051 0.043 0.1168
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0107 0.0316
Schistosoma mansoni hypothetical protein 0.0049 0.0409 0.063
Loa Loa (eye worm) hypothetical protein 0.0044 0.0342 0.0559
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0111 0.015
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0111 0.0171
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0032 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0983 0.4016
Echinococcus multilocularis tumor protein p63 0.0408 0.4959 0.4959
Toxoplasma gondii prolyl endopeptidase 0.013 0.1441 0.6003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.021 0.049
Onchocerca volvulus 0.0025 0.0111 0.0019
Giardia lamblia Cathepsin B precursor 0.0131 0.145 0.3936
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.3684 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Onchocerca volvulus 0.0044 0.0342 0.1027
Brugia malayi MH2 domain containing protein 0.0138 0.1532 0.2658
Echinococcus granulosus dna polymerase kappa 0.0019 0.0032 0.0049
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1692 1
Schistosoma mansoni cathepsin F (C01 family) 0.0163 0.1848 0.2847
Onchocerca volvulus Cathepsin L homolog 0.0206 0.2401 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0051 0.043 0.1792
Echinococcus granulosus pyruvate kinase 0.0033 0.02 0.0309
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0107 0.0483
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0111 0.0111
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0003
Toxoplasma gondii cathepsin CPC2 0.0051 0.043 0.1792
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0111 0.0171
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0164 0.0164
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0107 0.0483
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.02 0.0299
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0377 0.0581
Toxoplasma gondii hypothetical protein 0.0026 0.012 0.0501
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0111 0.0171
Schistosoma mansoni neuropeptide receptor 0.0025 0.0111 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.043 0.1091
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0051 0.043 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0051 0.043 0.1091
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0032 0.0032
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0111 0.0171
Loa Loa (eye worm) hypothetical protein 0.0163 0.1848 0.3223
Brugia malayi Cathepsin L-like precursor 0.0206 0.2401 0.4195
Plasmodium vivax unspecified product 0.0044 0.0341 0.1422
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0273
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Loa Loa (eye worm) hypothetical protein 0.0163 0.1848 0.3223
Loa Loa (eye worm) hypothetical protein 0.0078 0.0782 0.1338
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0104 0.016
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0458 0.0756
Entamoeba histolytica cysteine protease, putative 0.0051 0.043 0.1091
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0111 0.0111
Brugia malayi GnHR receptor homolog 0.0025 0.0111 0.014
Loa Loa (eye worm) hypothetical protein 0.0114 0.1235 0.2139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.043 0.1091
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0377 0.1179
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.021 0.049
Schistosoma mansoni myosin xvIII 0.0025 0.0111 0.0171
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0111 0.0171
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0032 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0099 0.0184
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0111 0.0111
Onchocerca volvulus 0.0206 0.2401 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Echinococcus granulosus GPCR family 2 0.0049 0.0409 0.063
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0782 0.2032
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0078
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0051 0.043 0.1792
Schistosoma mansoni amine GPCR 0.0025 0.0111 0.0171
Mycobacterium ulcerans hypothetical protein 0.0114 0.1235 0.726
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.043 0.1091
Plasmodium falciparum pyruvate kinase 0.0033 0.02 0.0835
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0111 0.0171
Mycobacterium ulcerans beta-lactamase 0.0114 0.1235 0.726
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0051 0.043 0.1792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.043 0.1091
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.2157 0.3323
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0111 0.0171
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.3684 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3684 1
Echinococcus granulosus g protein coupled receptor 0.0025 0.0111 0.0171
Plasmodium vivax serine-repeat antigen (SERA) 0.0051 0.043 0.1792
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0111 0.014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.043 0.0663
Schistosoma mansoni ran 0.0022 0.007 0.0108
Echinococcus multilocularis cathepsin L 0.0094 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0163 0.1848 0.3223
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.0446 0.1748
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0377 0.0621
Brugia malayi Matrixin family protein 0.0106 0.1127 0.1939
Echinococcus granulosus glutamate receptor 1 0.0042 0.032 0.0493
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0111 0.015
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0111 0.014
Schistosoma mansoni histamine h1 receptor 0.0025 0.0111 0.0171
Brugia malayi Cathepsin L-like precursor 0.0206 0.2401 0.4195
Loa Loa (eye worm) hypothetical protein 0.0042 0.032 0.052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0311 0.3728 0.5744
Plasmodium vivax unspecified product 0.0094 0.0983 0.4094
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0206 0.2401 0.2401
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0032 0.002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Leishmania major hypothetical protein, conserved 0.0078 0.0782 0.317
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0053 0.0463 0.0763
Mycobacterium leprae Probable lipase LipE 0.0114 0.1235 0.7121
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.1532 0.2665
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0751 0.4067
Echinococcus granulosus glutamate receptor 4 0.0042 0.032 0.0493
Echinococcus granulosus dna polymerase eta 0.0019 0.0032 0.0049
Echinococcus multilocularis pyruvate kinase 0.0033 0.02 0.02
Brugia malayi beta-lactamase family protein 0.0114 0.1235 0.2131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.102 0.1571
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0164 0.0253
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0751 1
Trypanosoma cruzi cruzipain precursor, putative 0.0206 0.2401 0.641
Echinococcus granulosus cysteine protease 0.0094 0.0983 0.1515
Loa Loa (eye worm) hypothetical protein 0.0044 0.0342 0.0559
Giardia lamblia Cathepsin B precursor 0.0131 0.145 0.3936
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.1235 0.1355
Schistosoma mansoni importin beta-1 0.003 0.0171 0.0264
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.0715
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.043 0.1078
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Brugia malayi prolyl oligopeptidase family protein 0.013 0.1441 0.2496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.1848 0.4973
Leishmania major pyruvate kinase 0.0033 0.02 0.0713
Schistosoma mansoni hypothetical protein 0.0025 0.0111 0.0171
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.3684 1
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0111 0.0111
Giardia lamblia Cathepsin L-like protease 0.0051 0.043 0.1168
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.0635 0.1069
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0076 0.0088
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0032 0.002
Trypanosoma brucei pyruvate kinase 1 0.0033 0.02 0.0713
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1235 0.3295
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0111 0.0111
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0111 0.0171
Plasmodium vivax vivapain-2 0.0206 0.2401 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0051 0.043 0.1091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.043 0.1091
Brugia malayi Cathepsin L-like precursor 0.0206 0.2401 0.4195
Giardia lamblia Cysteine protease 0.0051 0.043 0.1168
Echinococcus granulosus fmrfamide receptor 0.0025 0.0111 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0111 0.0111
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.02 0.0835
Echinococcus granulosus glutamate receptor 2 0.0062 0.0578 0.0891
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0282 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.043 0.1091
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0026 0.0014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0032 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0099 0.0184
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Giardia lamblia Cathepsin L precursor 0.0051 0.043 0.1168
Entamoeba histolytica cysteine protease, putative 0.0051 0.043 0.1091
Loa Loa (eye worm) hypothetical protein 0.0114 0.1235 0.2139
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0051 0.043 0.1792
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0111 0.0111
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0206 0.2401 1
Echinococcus granulosus cathepsin b 0.0311 0.3728 0.5744
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.013 0.1441 0.595
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0051 0.043 0.1792
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0111 0.0111
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0311 0.3728 0.5744
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Echinococcus granulosus neuropeptide receptor 0.0025 0.0111 0.0171
Onchocerca volvulus 0.0046 0.0377 0.1179
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0142
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.02 0.0409
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0729 0.903 1
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Brugia malayi Dopamine receptor 0.0025 0.0111 0.014
Trypanosoma cruzi cysteine proteinase, putative 0.0094 0.0983 0.2574
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.3684 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.1235 0.1355
Schistosoma mansoni biogenic amine receptor 0.0025 0.0111 0.0171
Mycobacterium tuberculosis Probable peptidase 0.0052 0.0446 0.048
Mycobacterium tuberculosis Conserved protein 0.0114 0.1235 0.1355
Plasmodium vivax serine-repeat antigen (SERA) 0.0051 0.043 0.1792
Giardia lamblia DINP protein human, muc B family 0.0019 0.0032 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.043 0.1091
Brugia malayi beta-lactamase 0.0114 0.1235 0.2131
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0032 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Brugia malayi Papain family cysteine protease containing protein 0.0206 0.2401 0.4195
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1235 0.3295
Schistosoma mansoni ran 0.0022 0.007 0.0108
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0051 0.043 0.1792
Onchocerca volvulus 0.0074 0.0726 0.2699
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0377 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.02 0.0457
Giardia lamblia Cathepsin B precursor 0.0051 0.043 0.1168
Brugia malayi beta-lactamase family protein 0.0114 0.1235 0.2131
Onchocerca volvulus 0.0025 0.0111 0.0019
Giardia lamblia Cathepsin L precursor 0.0051 0.043 0.1168
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.007 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.043 0.1091
Entamoeba histolytica cysteine proteinase 1, putative 0.0094 0.0983 0.2604
Schistosoma mansoni DNA polymerase eta 0.0019 0.0032 0.0049
Onchocerca volvulus 0.0025 0.0111 0.0019
Echinococcus multilocularis serotonin receptor 0.0025 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0042 0.032 0.052
Entamoeba histolytica cysteine proteinase, putative 0.0094 0.0983 0.2604
Loa Loa (eye worm) fibroinase 0.0206 0.2401 0.4201
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.043 0.0706
Toxoplasma gondii exonuclease III APE 0.0019 0.0032 0.0135
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0111 0.0171
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0458 0.0706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Echinococcus granulosus orexin receptor type 2 0.0025 0.0111 0.0171
Entamoeba histolytica cysteine proteinase 2 0.0094 0.0983 0.2604
Entamoeba histolytica cysteine proteinase, putative 0.0094 0.0983 0.2604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0111 0.0171
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.0446 0.048
Giardia lamblia Cysteine protease 0.0051 0.043 0.1168
Brugia malayi putative neuropeptide receptor 0.0025 0.0111 0.014
Schistosoma mansoni hypothetical protein 0.0106 0.1129 0.174
Echinococcus granulosus importin subunit beta 1 0.003 0.0171 0.0264
Brugia malayi Cathepsin L-like precursor 0.0206 0.2401 0.4195
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0111 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3684 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.013 0.1441 0.2221
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0032 0.0033
Onchocerca volvulus 0.0025 0.0111 0.0019
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0111 0.0171
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.007 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0032 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1235 0.3295
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.001
Plasmodium falciparum serine repeat antigen 9 0.0051 0.043 0.1792
Onchocerca volvulus 0.0025 0.0111 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.1235 0.2131
Echinococcus multilocularis pyruvate kinase 0.0033 0.02 0.02
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.102 0.102
Echinococcus multilocularis cathepsin b 0.0311 0.3728 0.3728
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0751 0.1157
Trypanosoma cruzi cysteine peptidase, putative 0.0206 0.2401 0.641
Trypanosoma cruzi cysteine proteinase, putative 0.0094 0.0983 0.2574
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0751 1
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.0635 0.1078
Brugia malayi Papain family cysteine protease containing protein 0.0094 0.0983 0.1684
Onchocerca volvulus Cathepsin L homolog 0.0051 0.043 0.1411
Brugia malayi RE15519p 0.0025 0.0111 0.014
Echinococcus multilocularis cysteine protease 0.0206 0.2401 0.2401
Echinococcus granulosus somatostatin receptor 0.0025 0.0111 0.0171
Plasmodium vivax vivapain-2 0.0206 0.2401 1
Schistosoma mansoni hypothetical protein 0.0322 0.3871 0.5965
Mycobacterium tuberculosis Conserved protein 0.0114 0.1235 0.1355
Mycobacterium ulcerans hydrolase 0.0053 0.0463 0.2621
Brugia malayi G protein-coupled receptor 0.0025 0.0111 0.014
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1692 0.1861
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0111 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0409 0.063
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0111 0.0171
Entamoeba histolytica hypothetical protein 0.0024 0.0099 0.0184
Loa Loa (eye worm) MBCTL1 0.0053 0.0458 0.0765
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.1749 0.3042
Onchocerca volvulus 0.0025 0.0111 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1235 0.3256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.102 0.1571
Trypanosoma cruzi prolyl endopeptidase 0.013 0.1441 0.3814
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0171 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0751 0.3129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0107 0.0133
Toxoplasma gondii cathepsin CPC1 0.0051 0.043 0.1792
Echinococcus multilocularis cysteine protease 0.0206 0.2401 0.2401
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0782 0.326
Leishmania major GTP-binding protein, putative 0.0022 0.007 0.0162
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.002
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0751 0.3129
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Brugia malayi cathepsin L-like cysteine proteinase 0.0051 0.043 0.0706
Echinococcus granulosus glutamate receptor subunit protein glur 0.0051 0.0437 0.0673
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0068 0.0653 0.1005
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.0446 0.1748
Schistosoma mansoni cathepsin F (C01 family) 0.0206 0.2401 0.3699
Echinococcus granulosus cathepsin b 0.0311 0.3728 0.5744
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0051 0.043 0.1091
Schistosoma mansoni hypothetical protein 0.0049 0.0409 0.063
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.042 0.042
Schistosoma mansoni adenoreceptor 0.0025 0.0111 0.0171
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0107 0.0483
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0111 0.0171
Onchocerca volvulus 0.0206 0.2401 1
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.005
Brugia malayi AKH receptor 0.0025 0.0111 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0051 0.043 0.1091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Entamoeba histolytica cysteine proteinase, putative 0.0094 0.0983 0.2604
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0051 0.043 0.1792
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0234 0.0234
Onchocerca volvulus 0.0206 0.2401 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Schistosoma mansoni hypothetical protein 0.0529 0.649 1
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0111 0.0111
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0026 0.0109
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0051 0.043 0.0715
Onchocerca volvulus 0.0025 0.0111 0.0019
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0068 0.0653 0.0653
Echinococcus multilocularis serotonin receptor 0.0025 0.0111 0.0111
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0107 0.0316
Echinococcus granulosus geminin 0.0529 0.649 1
Schistosoma mansoni amine GPCR 0.0025 0.0111 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0206 0.2401 1
Brugia malayi larval opioid receptor 0.0025 0.0111 0.014
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0292
Schistosoma mansoni biogenic amine receptor 0.0025 0.0111 0.0171
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0111 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0206 0.2401 0.6486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0094 0.0983 0.4016
Loa Loa (eye worm) pyruvate kinase 0.0033 0.02 0.0308
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0409 0.0668
Leishmania major cysteine peptidase A (CPA) 0.0206 0.2401 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.1235 0.1355
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0171 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0111 0.015
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0111 0.0111
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0032 0.001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0135
Echinococcus granulosus sex peptide receptor 0.0025 0.0111 0.0171
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0032 0.0033
Brugia malayi Papain family cysteine protease containing protein 0.0094 0.0983 0.1684
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.0715
Schistosoma mansoni opsin-like receptor 0.0025 0.0111 0.0171
Plasmodium falciparum serine repeat antigen 3 0.0051 0.043 0.1792
Onchocerca volvulus Matrilysin homolog 0.0044 0.0342 0.1027
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0117 0.1268 0.1391
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0111 0.0111
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0135
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0111 0.0111
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0051 0.043 0.1792
Echinococcus granulosus cathepsin L cysteine proteinase 0.0206 0.2401 0.3699
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0142
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.1235 0.726
Schistosoma mansoni amine GPCR 0.0025 0.0111 0.0171
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0164 0.0253
Schistosoma mansoni hypothetical protein 0.0049 0.0409 0.063
Echinococcus granulosus allatostatin A receptor 0.0025 0.0111 0.0171
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.1235 0.1903
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0111 0.0171
Leishmania major oligopeptidase b 0.0052 0.0446 0.1748
Loa Loa (eye worm) ctsf protein 0.0206 0.2401 0.4201
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0111 0.0171
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0377 0.0581
Mycobacterium ulcerans pyruvate kinase 0.0033 0.02 0.1047
Brugia malayi Serotonin receptor 0.0025 0.0111 0.014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0409 0.0409
Onchocerca volvulus 0.0025 0.0111 0.0019
Entamoeba histolytica Ran family GTPase 0.0022 0.007 0.0105
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0458 0.0706
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.012 0.0241
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0111 0.0111
Plasmodium falciparum serine repeat antigen 1 0.0051 0.043 0.1792
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0111 0.0171
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.0446 0.1121
Echinococcus granulosus glutamate receptor 2 0.0072 0.0695 0.1071
Plasmodium vivax pyruvate kinase, putative 0.0033 0.02 0.0835
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3684 1
Schistosoma mansoni pyruvate kinase 0.0033 0.02 0.0309
Loa Loa (eye worm) hypothetical protein 0.006 0.0545 0.0919
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0377 0.0581
Entamoeba histolytica cysteine protease, putative 0.0051 0.043 0.1091
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0164 0.0164
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0111 0.0171
Schistosoma mansoni hypothetical protein 0.0286 0.3415 0.5262
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0111 0.0171
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0111 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0032 0.0037
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0751 0.3129
Trypanosoma brucei prolyl endopeptidase 0.013 0.1441 0.595
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0206 0.2401 0.6486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0206 0.2401 0.6486
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.02 0.0409
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0282 0.0434
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0751 0.1157
Trypanosoma brucei oligopeptidase b 0.0052 0.0446 0.1748
Onchocerca volvulus Matrix metalloproteinase homolog 0.0097 0.1016 0.3965
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0107 0.0104
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Toxoplasma gondii cathepsin B 0.0131 0.145 0.604
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.024 0.0369
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.043 0.0715
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0111 0.0171
Giardia lamblia Cathepsin L precursor 0.0051 0.043 0.1168
Onchocerca volvulus 0.0062 0.0573 0.2035
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0111 0.0171
Brugia malayi Cathepsin L-like cysteine proteinase 0.0163 0.1848 0.3216
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0111 0.0171
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.0715
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.007 0.0292
Echinococcus granulosus snurportin 1 0.0322 0.3871 0.5965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.043 0.1091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0111 0.0111
Echinococcus granulosus pyruvate kinase 0.0033 0.02 0.0309
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0107 0.0205
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0159 0.1801 0.2775
Loa Loa (eye worm) hypothetical protein 0.0311 0.3728 0.6548
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0111 0.0111
Giardia lamblia Pyruvate kinase 0.0033 0.02 0.0544
Echinococcus multilocularis glutamate receptor 4 0.0042 0.032 0.032
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0107 0.0483
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0111 0.014
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0111 0.015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0111 0.0171
Brugia malayi Dopamine receptor protein 1 0.0025 0.0111 0.014
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0111 0.015
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0458 0.0458
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0032 0.0002
Plasmodium vivax unspecified product 0.0051 0.043 0.1792
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0111 0.0111
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0111 0.0171
Mycobacterium tuberculosis Conserved protein 0.0114 0.1235 0.1355
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0111 0.0111
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0051 0.043 0.1792
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0111 0.014
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0171 0.0712
Schistosoma mansoni opsin-like receptor 0.0025 0.0111 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.0983 0.2604
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0111 0.0171
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.043 0.0706
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0234 0.0361
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0032 0.0049
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.0049
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0111 0.0111
Loa Loa (eye worm) matrixin family protein 0.0097 0.1016 0.1751
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.012 0.0501
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3684 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.043 0.0663
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0751 1
Echinococcus multilocularis cathepsin L 0.0051 0.043 0.043
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0111 0.014
Brugia malayi cathepsin F-like cysteine proteinase 0.0044 0.0341 0.0548
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0094 0.0983 0.2574
Plasmodium vivax vivapain-1 0.0094 0.0983 0.4094
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0111 0.015
Plasmodium falciparum serine repeat antigen 4 0.0051 0.043 0.1792
Brugia malayi cathepsin Z-like cysteine proteinase 0.0051 0.043 0.0706
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.013 0.1441 0.2221
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.043 0.0663
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Leishmania major cathepsin L-like protease 0.0206 0.2401 1
Onchocerca volvulus 0.0025 0.0111 0.0019
Loa Loa (eye worm) hypothetical protein 0.0042 0.032 0.052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.043 0.0663
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.043 0.1091
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0111 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Loa Loa (eye worm) hypothetical protein 0.0044 0.0341 0.0558
Schistosoma mansoni hypothetical protein 0.0049 0.0409 0.063
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0032 0.0002
Onchocerca volvulus 0.0051 0.043 0.1411
Echinococcus granulosus cathepsin L 0.0051 0.043 0.0663
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.024 0.0379
Onchocerca volvulus 0.0025 0.0111 0.0019
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0111 0.015
Brugia malayi hypothetical protein 0.0025 0.0111 0.014
Brugia malayi ORL1-like opioid receptor 0.0025 0.0111 0.014
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.042 0.1975
Loa Loa (eye worm) hypothetical protein 0.0053 0.0463 0.0772
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0111 0.0111
Schistosoma mansoni pyruvate kinase 0.0033 0.02 0.0309
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0206 0.2401 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Loa Loa (eye worm) hypothetical protein 0.0114 0.1235 0.2139
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.042 0.0451
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0051 0.043 0.1792
Giardia lamblia Hypothetical protein 0.0051 0.043 0.1168
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Schistosoma mansoni hypothetical protein 0.0529 0.649 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Trypanosoma cruzi cysteine protease, putative 0.0094 0.0983 0.2574
Entamoeba histolytica cysteine protease, putative 0.0094 0.0983 0.2604
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0032 0.005
Brugia malayi sulfakinin receptor protein 0.0025 0.0111 0.014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0163 0.1848 0.4914
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0032 0.0002
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Entamoeba histolytica cysteine protease, putative 0.0051 0.043 0.1091
Schistosoma mansoni hypothetical protein 0.0025 0.0111 0.0171
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.1235 0.726
Loa Loa (eye worm) hypothetical protein 0.0044 0.0341 0.0558
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.043 0.1091
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0782 0.326
Loa Loa (eye worm) hypothetical protein 0.0044 0.0342 0.0559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.102 0.1571
Loa Loa (eye worm) hypothetical protein 0.0206 0.2401 0.4201
Echinococcus granulosus prolyl endopeptidase 0.013 0.1441 0.2221
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.007 0.007
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.1235 0.1355
Plasmodium falciparum importin beta, putative 0.003 0.0171 0.0712
Brugia malayi cathepsin L precursor 0.0051 0.043 0.0706
Echinococcus multilocularis dna polymerase eta 0.0019 0.0032 0.0032
Echinococcus granulosus tumor protein p63 0.0408 0.4959 0.7642
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0111 0.0111
Plasmodium vivax vivapain-3 0.0094 0.0983 0.4094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.102 0.102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0107 0.0205
Plasmodium falciparum serine repeat antigen 8 0.0051 0.043 0.1792
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0111 0.0171
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.043 0.0706
Leishmania major cathepsin L-like protease 0.0206 0.2401 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.1235 0.2139
Trypanosoma brucei cysteine peptidase C (CPC) 0.0131 0.145 0.5987
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0131 0.145 0.2234
Loa Loa (eye worm) hypothetical protein 0.003 0.0171 0.0256
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0377 0.0581
Schistosoma mansoni hypothetical protein 0.0035 0.0234 0.0361
Trypanosoma cruzi cysteine peptidase, putative 0.0206 0.2401 0.641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0111 0.0171
Loa Loa (eye worm) hypothetical protein 0.0114 0.1235 0.2139
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.0446 0.252
Loa Loa (eye worm) hypothetical protein 0.0046 0.0377 0.0621
Loa Loa (eye worm) hypothetical protein 0.0465 0.5679 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0155 0.1749 0.3048
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0051 0.043 0.1168
Brugia malayi hypothetical protein 0.0051 0.043 0.0706
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.043 0.1168
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0206 0.2401 0.4201
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0002
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0311 0.3728 1
Leishmania major cathepsin L-like protease 0.0206 0.2401 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0107 0.0205
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0051 0.043 0.0663

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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