Detailed information for compound 1302434

Basic information

Technical information
  • TDR Targets ID: 1302434
  • Name: 2-(2-phenyl-1,3-benzothiazol-5-yl)acetamide
  • MW: 268.334 | Formula: C15H12N2OS
  • H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)Cc1ccc2c(c1)nc(s2)c1ccccc1
  • InChi: 1S/C15H12N2OS/c16-14(18)9-10-6-7-13-12(8-10)17-15(19-13)11-4-2-1-3-5-11/h1-8H,9H2,(H2,16,18)
  • InChiKey: GLVKZSDQOYHCRS-UHFFFAOYSA-N  


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Synonyms

  • 2-(2-phenyl-1,3-benzothiazol-5-yl)ethanamide
  • CBMicro_032585
  • BIM-0032507.P001
  • Oprea1_259662
  • MLS000391716
  • SMR000260751
  • ZINC00134537

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens signal transducer and activator of transcription 1, 91kDa Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0439
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0323 0.0836
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0071 0.0182
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0445 0.1149
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0139 0.1912
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0204 0.0204
Brugia malayi hypothetical protein 0.0043 0.0323 0.0834
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0071 0.0182
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0666 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0139 0.0359
Loa Loa (eye worm) hypothetical protein 0.0051 0.0401 0.1037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0166 0.3917
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0604
Brugia malayi hypothetical protein 0.0049 0.0385 0.0996
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0014 0.0014 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1365 0.3525
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0204 0.1909
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0439
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1103 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0445 0.0445
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.0893 0.2306
Schistosoma mansoni dep domain containing protein 0.0019 0.0071 0.0183
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0139 0.0359
Brugia malayi Latrophilin receptor protein 2 0.0099 0.0893 0.2306
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.017 0.5
Schistosoma mansoni patched 1 0.0051 0.0401 0.1039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0323 0.0323
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0014 0.0014 0.0036
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.2837
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0666 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0119 0.1103 0.285
Brugia malayi CHE-14 protein 0.0051 0.0401 0.1037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0445 0.1152
Schistosoma mansoni hypothetical protein 0.0043 0.0323 0.0836
Echinococcus multilocularis expressed conserved protein 0.0112 0.1029 0.1029
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0666 1
Echinococcus multilocularis ras GTP exchange factor 0.0014 0.0014 0.0014
Echinococcus granulosus tar DNA binding protein 0.0386 0.3863 1
Echinococcus granulosus expressed conserved protein 0.0112 0.1029 0.2663
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0182
Brugia malayi TAR-binding protein 0.0386 0.3863 0.9979
Echinococcus multilocularis protein patched 0.0051 0.0401 0.0401
Echinococcus multilocularis son of sevenless 1 0.0014 0.0014 0.0014
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0071 0.0183
Schistosoma mansoni hypothetical protein 0.0099 0.0893 0.2311
Loa Loa (eye worm) RNA binding protein 0.0386 0.3863 0.9979
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.099
Brugia malayi STAT protein, DNA binding domain containing protein 0.0159 0.1516 0.3916
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.017 0.7175
Onchocerca volvulus 0.0029 0.017 0.0439
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0204 0.2913
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0245
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0439
Schistosoma mansoni ran 0.0026 0.0139 0.0359
Onchocerca volvulus 0.0014 0.0014 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.2076 0.5361
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0311 0.3095 0.7994
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0166 0.2326
Echinococcus granulosus GPCR family 2 0.0099 0.0893 0.2311
Schistosoma mansoni hypothetical protein 0.0034 0.0229 0.0593
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0182
Schistosoma mansoni dishevelled 0.0019 0.0071 0.0183
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0014 0.0014 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.0893 0.2311
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0071 0.0182
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.017 0.7175
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0204 0.0527
Schistosoma mansoni tar DNA-binding protein 0.0386 0.3863 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0183
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.017 0.143
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0401 0.1039
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0204 0.0527
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0311 0.3095 0.7994
Echinococcus granulosus importin subunit beta 1 0.0035 0.0234 0.0605
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0013 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0386 0.3863 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0445 0.1152
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.0893 0.0893
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1122 0.2905
Brugia malayi hypothetical protein 0.0019 0.0071 0.0182
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0666 1
Brugia malayi RNA recognition motif domain containing protein 0.0386 0.3863 0.9979
Brugia malayi Calcitonin receptor-like protein seb-1 0.0311 0.3095 0.7994
Schistosoma mansoni hypothetical protein 0.0099 0.0893 0.2311
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.017 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0071 0.0183
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.0893 0.2311
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0401 0.1039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.017 0.143
Loa Loa (eye worm) hypothetical protein 0.0099 0.0893 0.2306
Schistosoma mansoni ras GTP exchange factor 0.0014 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0387 0.3872 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0071 0.0182
Entamoeba histolytica Ran family GTPase 0.0026 0.0139 0.1145
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.2837
Schistosoma mansoni tar DNA-binding protein 0.0386 0.3863 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0439
Loa Loa (eye worm) hypothetical protein 0.0077 0.0666 0.1721
Echinococcus multilocularis GPCR, family 2 0.0099 0.0893 0.0893
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0071 0.0071
Echinococcus granulosus ras GTP exchange factor 0.0014 0.0014 0.0036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.017 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0095 0.0997
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0445 0.1149
Brugia malayi N-terminal motif family protein 0.0014 0.0014 0.0036
Brugia malayi DIX domain containing protein 0.0019 0.0071 0.0182
Leishmania major importin beta-1 subunit, putative 0.0028 0.0166 0.0511
Echinococcus granulosus snurportin 1 0.0372 0.3718 0.9623
Echinococcus multilocularis snurportin 1 0.0372 0.3718 0.3718
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0071 0.0183
Brugia malayi Importin beta-1 subunit 0.0035 0.0234 0.0604
Brugia malayi RasGEF domain containing protein 0.0014 0.0014 0.0036
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0204 0.1238
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1103 0.285
Schistosoma mansoni ran 0.0026 0.0139 0.0359
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0589
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0204 0.1909
Loa Loa (eye worm) STAT protein 0.0159 0.1516 0.3916
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0182
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0014 0.0036
Mycobacterium ulcerans hypothetical protein 0.0029 0.017 1
Brugia malayi RasGEF domain containing protein 0.0014 0.0014 0.0036
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0234 0.2741
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0014 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0245
Schistosoma mansoni hypothetical protein 0.0099 0.0893 0.2311
Plasmodium vivax importin-beta 2, putative 0.0035 0.0234 0.243
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0204 0.0204
Brugia malayi isocitrate dehydrogenase 0.0032 0.0204 0.0527
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3718 0.9603
Echinococcus granulosus Protein son of sevenless 0.0014 0.0014 0.0036
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0014 0.0036
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1365 0.3525
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0229 0.0593
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0071 0.0071
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0204 0.0204
Brugia malayi N-terminal motif family protein 0.0387 0.3872 1
Echinococcus granulosus son of sevenless 1 0.0014 0.0014 0.0036
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0139 0.1146
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0014 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0323 0.0836
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0245
Loa Loa (eye worm) hypothetical protein 0.0213 0.2076 0.5361
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0062 0.052 0.1343
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0014 0.0014 0.0036
Trichomonas vaginalis ran, putative 0.0026 0.0139 0.3221
Onchocerca volvulus 0.0157 0.1499 0.3872
Schistosoma mansoni importin beta-1 0.0035 0.0234 0.0605
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0071 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0029 0.017 0.0439
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0139 0.0359
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0229 0.0229
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0234 0.1802
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0014 0.0036
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0666 1
Brugia malayi hypothetical protein 0.0019 0.0071 0.0182
Echinococcus multilocularis protein dispatched 1 0.0058 0.0476 0.0476
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0666 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0204 0.0204
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0014 0.0014 0.0014
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0204 0.0528
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0204 0.2241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0445 0.0445
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0071 0.0182
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0204 0.2241
Loa Loa (eye worm) hypothetical protein 0.0157 0.1499 0.3872
Schistosoma mansoni tar DNA-binding protein 0.0386 0.3863 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.017 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0071 0.0183
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1103 0.1103
Brugia malayi MH2 domain containing protein 0.0144 0.1365 0.3525
Brugia malayi RNA binding protein 0.0386 0.3863 0.9979
Schistosoma mansoni hypothetical protein 0.0372 0.3718 0.9623
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0036
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0071 0.0183
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0014 0.0036
Plasmodium falciparum importin beta, putative 0.0035 0.0234 0.243
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1631 0.4221
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.017 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0204 0.1238
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0204 0.0528
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0204 0.1238
Brugia malayi RNA, U transporter 1 0.0099 0.0898 0.2319
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0204 0.2913
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0401 0.1037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0445 0.1152
Leishmania major hypothetical protein, conserved 0.0077 0.0666 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0166 0.3917
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0139 0.5
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0139 0.0766
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0166 0.3917
Echinococcus multilocularis tar DNA binding protein 0.0386 0.3863 0.3863
Loa Loa (eye worm) hypothetical protein 0.0021 0.0095 0.0245
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1103 0.2856
Brugia malayi RasGEF domain containing protein 0.0014 0.0014 0.0036
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0139 0.0766
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0139 0.1912
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0589
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0666 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0204 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0139 0.0139
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0387 0.3872 1
Brugia malayi hypothetical protein 0.0077 0.0666 0.1721
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.0893 0.0893
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.099
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.2837
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0071 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0445 0.1152
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0234 0.1802
Echinococcus multilocularis Protein son of sevenless 0.0014 0.0014 0.0014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0386 0.3863 0.9979
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1631 0.1631
Loa Loa (eye worm) hypothetical protein 0.0311 0.3095 0.7994
Brugia malayi N-terminal motif family protein 0.0014 0.0014 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.017 0.0589
Onchocerca volvulus 0.0019 0.0071 0.0182
Schistosoma mansoni hypothetical protein 0.0213 0.2076 0.5373
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0439
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0014 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0445 0.1152
Schistosoma mansoni tar DNA-binding protein 0.0386 0.3863 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0401 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.0893 0.2306
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0071 0.0183
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0071 0.0182
Schistosoma mansoni hypothetical protein 0.0099 0.0893 0.2311
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.017 1
Loa Loa (eye worm) TAR-binding protein 0.0386 0.3863 0.9979
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0095 0.5
Entamoeba histolytica hypothetical protein 0.0028 0.0166 0.1393
Schistosoma mansoni hypothetical protein 0.0049 0.0382 0.099
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0234 0.0234
Entamoeba histolytica hypothetical protein 0.0043 0.0323 0.2837
Brugia malayi hypothetical protein 0.0157 0.1499 0.3872
Schistosoma mansoni dishevelled 0.0019 0.0071 0.0183
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.017 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.017 0.143
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0071 0.0071

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.463 um PUBCHEM_BIOASSAY: Dose response cell-based assay to measure STAT1 activation. (Class of assay: confirmatory) [Related pubchem assays: 871, 1262, 862, 932, 1316, 1306 ] ChEMBL. No reference
EC50 (functional) = 36.477 um PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response. (Class of assay: confirmatory) [Related pubchem assays: 1239 ] ChEMBL. No reference
EC50 (functional) > 55.7 um PUBCHEM_BIOASSAY: Dose response counterscreen for STAT1 activators: cell-based high throughput assay to measure STAT3 activation. (Class of assay: confirmatory) [Related pubchem assays: 871, 1262, 932, 1316, 1306 ] ChEMBL. No reference
Potency (functional) 0.4109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1.0047 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a cell-based translational read-through assay (72 hour incubation). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.157 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM ATP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2648 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a cell-based assay to assess the activity of miR-21. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6343 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate and 500microM CoASH. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0046 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a cell-based translational read-through assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1682 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.3582 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 6.1857 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with an in-house formulation of detection reagent. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3391 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with a commercial detection reagent - BriteliteTM Plus (PerkinElmer). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.982 uM PUBCHEM_BIOASSAY: FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM D-luciferin. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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