TDR Targets

Basic information

Technical information

TDR Targets ID: 1302646
Name: N-[2,5-dimethoxy-4-(thiophene-2-carbonylamino )phenyl]furan-2-carboxamide
MW: 372.395 | Formula: C18H16N2O5S
H donors: 2 H acceptors: 2 LogP: 2.95 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(NC(=O)c2cccs2)c(cc1NC(=O)c1ccco1)OC
InChi: 1S/C18H16N2O5S/c1-23-14-10-12(20-18(22)16-6-4-8-26-16)15(24-2)9-11(14)19-17(21)13-5-3-7-25-13/h3-10H,1-2H3,(H,19,21)(H,20,22)
InChiKey: OJIWQOKZZYAZAV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[2,5-dimethoxy-4-[[oxo-(2-thienyl)methyl]amino]phenyl]-2-furancarboxamide
N-[2,5-dimethoxy-4-(thiophene-2-carbonylamino)phenyl]-2-furamide
N-[2,5-dimethoxy-4-(thiophen-2-ylcarbonylamino)phenyl]furan-2-carboxamide
ZINC00933350
ASN 03066284
Furan-2-carboxylic acid {2,5-dimethoxy-4-[(thiophene-2-carbonyl)-amino]-phenyl}-amide
MLS000029217
SMR000001974

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Werner syndrome, RecQ helicase-like	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Equus caballus	Ferritin light chain	Starlite/ChEMBL	No references
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium yoelii	ATP-dependent DNA helicase recQ-related	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	blooms syndrome DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	bloom syndrome protein	Get druggable targets OG5_126644	All targets in OG5_126644
Theileria parva	DNA helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Entamoeba histolytica	recQ family DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania donovani	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium yoelii	ATP-dependent DNA helicase-related	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium knowlesi	ATP-dependent DNA helicase Q1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	DNA helicase recq5	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	ATP dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	bloom syndrome protein	Get druggable targets OG5_126644	All targets in OG5_126644
Cryptosporidium parvum	RecQ bloom helicase (RNA helicase+hrdc)	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium falciparum	ATP-dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania mexicana	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma brucei gambiense	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium berghei	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Candida albicans	DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Giardia lamblia	Sgs1 DNA helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	Bloom's syndrome protein homolog	Get druggable targets OG5_126644	All targets in OG5_126644
Babesia bovis	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Cryptosporidium hominis	DEAD/DEAH box helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania infantum	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium berghei	ATP-dependent DNA helicase Q1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	ATP-dependent DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	ATP dependent DNA helicase Q5	Get druggable targets OG5_126644	All targets in OG5_126644
Babesia bovis	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	RecQ helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Neospora caninum	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Treponema pallidum	ATP-dependent DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium knowlesi	ADP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Candida albicans	DNA helicase	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma japonicum	ko:K03654 ATP-dependent DNA helicase RecQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus multilocularis	ATP dependent DNA helicase Q1	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma mansoni	DNA helicase recq1	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Echinococcus granulosus	ATP dependent DNA helicase Q5	Get druggable targets OG5_126644	All targets in OG5_126644
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	Get druggable targets OG5_126644	All targets in OG5_126644
Neospora caninum	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Trichomonas vaginalis	DNA helicase recq1, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Entamoeba histolytica	recQ family helicase, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Theileria parva	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Leishmania braziliensis	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	Get druggable targets OG5_126644	All targets in OG5_126644
Schistosoma japonicum	Bloom syndrome protein homolog, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	Get druggable targets OG5_126644	All targets in OG5_126644
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126644	All targets in OG5_126644

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	44.4 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	142 aa	29.6 %
Schistosoma mansoni	apoferritin-2	Ferritin light chain	175 aa	146 aa	28.8 %
Echinococcus granulosus	expressed protein	Ferritin light chain	175 aa	146 aa	28.8 %
Echinococcus multilocularis	expressed protein	Ferritin light chain	175 aa	146 aa	30.1 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Schistosoma mansoni	ferritin	Ferritin light chain	175 aa	171 aa	43.9 %
Schistosoma japonicum	Ferritin, putative	Ferritin light chain	175 aa	144 aa	24.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	bloom syndrome protein	0.0029	0.0448	0.0444
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0053	0.005
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.001	0.0081	0.5
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0004	0.0011
Brugia malayi	hypothetical protein	0.0009	0.0053	0.0146
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0053	0.005
Trichomonas vaginalis	DNA helicase recq1, putative	0.0029	0.0448	1
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0053	0.0137
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0626	0.184
Schistosoma mansoni	ferritin	0.001	0.0081	0.0208
Echinococcus granulosus	geminin	0.0205	0.3883	0.3881
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Schistosoma mansoni	ferritin	0.001	0.0081	0.0208
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.0004	0.001
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0972	0.2859
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0115	0.0328
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0053	0.0137
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0882	0.227
Schistosoma mansoni	hypothetical protein	0.0038	0.0626	0.1613
Schistosoma mansoni	dishevelled	0.0009	0.0053	0.0137
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.001	0.0081	0.5
Schistosoma mansoni	hypothetical protein	0.0205	0.3883	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0226	0.0222
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0972	0.2867
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0053	0.005
Schistosoma mansoni	hypothetical protein	0.0018	0.0226	0.0582
Schistosoma mansoni	apoferritin-2	0.001	0.0081	0.0208
Brugia malayi	RNA binding protein	0.0068	0.1206	0.3551
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0012	0.0115	0.0111
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0226	0.0667
Trypanosoma cruzi	hypothetical protein	0.0006	0.0004	0.0205
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0012	0.0115	0.0111
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0882	0.0878
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.1206	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0053	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2735	0.8072
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0882	0.227
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0053	0.005
Schistosoma mansoni	ferritin	0.001	0.0081	0.0208
Trichomonas vaginalis	DNA helicase recq, putative	0.0015	0.0184	0.4051
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0226	0.0656
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.002	0.0264	0.5
Echinococcus multilocularis	bloom syndrome protein	0.0029	0.0448	0.0444
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0184	0.5
Entamoeba histolytica	hypothetical protein	0.0006	0.0004	0.0205
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0115	0.4422
Giardia lamblia	Sgs1 DNA helicase, putative	0.0012	0.0115	0.5
Schistosoma mansoni	hypothetical protein	0.0205	0.3883	1
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0004	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0011
Brugia malayi	N-terminal motif family protein	0.0179	0.3389	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0012	0.0115	0.0111
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0882	0.0878
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0053	0.0137
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.1206	0.1202
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0882	0.227
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0115	0.4422
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.026	1
Schistosoma mansoni	dep domain containing protein	0.0009	0.0053	0.0137
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0004	0.001
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.1206	0.3558
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.0004	0.001
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0053	0.005
Brugia malayi	Bloom's syndrome protein homolog	0.0029	0.0448	0.1312
Schistosoma mansoni	blooms syndrome DNA helicase	0.0023	0.0328	0.0846
Mycobacterium ulcerans	bacterioferritin BfrB	0.001	0.0081	0.5
Entamoeba histolytica	recQ family helicase, putative	0.0015	0.0184	1
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0004	0.001
Schistosoma mansoni	DNA helicase recq5	0.0012	0.0115	0.0296
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0972	0.2859
Schistosoma mansoni	dishevelled	0.0009	0.0053	0.0137
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0053	0.0146
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.001	0.0081	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1206	0.3105
Schistosoma mansoni	ferritin light chain	0.001	0.0081	0.0208
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0226	0.0656
Schistosoma mansoni	apoferritin-2	0.001	0.0081	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0226	0.0667
Trichomonas vaginalis	ferritin, putative	0.001	0.0081	0.1739
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0626	0.1849
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.1206	0.3558
Loa Loa (eye worm)	hypothetical protein	0.0179	0.3389	1
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0053	0.0146
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.001	0.0081	0.5
Schistosoma mansoni	hypothetical protein	0.0018	0.0226	0.0582
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0053	0.005
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0226	0.0222
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0053	0.0146
Echinococcus granulosus	tar DNA binding protein	0.0068	0.1206	0.1202
Schistosoma mansoni	ferritin	0.001	0.0081	0.0208
Toxoplasma gondii	hypothetical protein	0.0009	0.0053	0.2055
Echinococcus granulosus	neuropeptide receptor A26	0.0517	1	1
Onchocerca volvulus		0.0009	0.0053	0.0146
Trypanosoma cruzi	guanine nucleotide releasing protein, putative	0.0006	0.0004	0.0205
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0226	0.0222
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0053	0.0157
Echinococcus multilocularis	neuropeptide s receptor	0.0517	1	1
Schistosoma mansoni	ferritin light chain	0.001	0.0081	0.0208
Mycobacterium ulcerans	bacterioferritin BfrA	0.001	0.0081	0.5
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0053	0.0157
Schistosoma mansoni	hypothetical protein	0.0018	0.0226	0.0582
Echinococcus multilocularis	neuropeptide receptor A26	0.0517	1	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Echinococcus multilocularis	ferritin	0.001	0.0081	0.0077
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1206	0.3105
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1206	0.3105
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0053	0.005
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Treponema pallidum	bacterioferrin (TpF1)	0.001	0.0081	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Echinococcus granulosus	GPCR family 2	0.0018	0.0226	0.0222
Loa Loa (eye worm)	RecQ helicase	0.0029	0.0448	0.1321
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1206	0.3105
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0053	0.005
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0882	0.2594
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0972	0.2867
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0184	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0053	0.0157
Echinococcus granulosus	ferritin	0.001	0.0081	0.0077
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0882	0.2602
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0053	0.005
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0025	0.0379	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0015	0.0184	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0179	0.3389	1
Loa Loa (eye worm)	RNA binding protein	0.0068	0.1206	0.3558
Schistosoma mansoni	DNA helicase recq1	0.0012	0.0115	0.0296
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0011
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1206	0.3105
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0226	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0115	0.0339
Brugia malayi	hypothetical protein	0.0009	0.0053	0.0146
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.0115	0.0328
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0053	0.0146
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0012	0.0115	0.0111
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0004	0.0205
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0012	0.0115	0.0339
Trypanosoma cruzi	hypothetical protein	0.0006	0.0004	0.0205
Schistosoma mansoni	hypothetical protein	0.0018	0.0226	0.0582
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0882	0.0878
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0004	0.0011
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0882	0.0878
Echinococcus granulosus	expressed protein	0.001	0.0081	0.0077
Echinococcus multilocularis	geminin	0.0205	0.3883	0.3881
Brugia malayi	DIX domain containing protein	0.0009	0.0053	0.0146
Echinococcus multilocularis	expressed protein	0.001	0.0081	0.0077
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0226	0.0222
Brugia malayi	TAR-binding protein	0.0068	0.1206	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0053	0.0157
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0053	0.005
Trichomonas vaginalis	DNA helicase recq, putative	0.0029	0.0448	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.13 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.3981 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1419951

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1302646