Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | PHD-finger family protein | 0.0033 | 0.1688 | 0.1688 |
Schistosoma mansoni | lamin | 0.0031 | 0.15 | 0.2629 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0423 | 0.0423 |
Schistosoma mansoni | lamin | 0.0031 | 0.15 | 0.2629 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4423 | 0.7754 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0069 | 0.4358 | 0.4358 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.1688 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4423 | 0.7754 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.4423 | 0.5814 |
Schistosoma mansoni | jumonji domain containing protein | 0.0087 | 0.5705 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4423 | 0.7754 |
Brugia malayi | jmjC domain containing protein | 0.0109 | 0.7393 | 0.7393 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.15 | 0.15 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.004 | 0.2215 | 0.2701 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0033 | 0.1688 | 0.1688 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.4423 | 0.5814 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.267 | 0.3341 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0257 | 0.0257 |
Brugia malayi | RNA binding protein | 0.007 | 0.4423 | 0.4423 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.03 | 0.03 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0033 | 0.1688 | 0.1957 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.3479 | 0.3479 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.15 | 0.1692 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.1688 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.4423 | 0.4423 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.2215 | 0.3883 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.4423 | 0.4423 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.4423 | 0.4423 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.004 | 0.2215 | 0.2701 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0109 | 0.7393 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4423 | 0.7754 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.1688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1457 | 0.1457 |
Brugia malayi | Bromodomain containing protein | 0.0033 | 0.1688 | 0.1688 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1688 | 0.2959 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0109 | 0.7393 | 1 |
Plasmodium falciparum | phd finger protein, putative | 0.0033 | 0.1688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.15 | 0.15 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.15 | 0.1692 |
Giardia lamblia | PHD finger protein 15 | 0.0033 | 0.1688 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.15 | 0.15 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0033 | 0.1688 | 0.1957 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0423 | 0.0423 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.15 | 0.2629 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0033 | 0.1688 | 0.2959 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.4423 | 0.4423 |
Onchocerca volvulus | Alhambra homolog | 0.0033 | 0.1688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1688 | 0.1688 |
Echinococcus multilocularis | musashi | 0.0031 | 0.15 | 0.1692 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.267 | 0.3341 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.15 | 0.15 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4423 | 0.7754 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.15 | 0.1692 |
Echinococcus multilocularis | peregrin | 0.0033 | 0.1688 | 0.1957 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.15 | 0.15 |
Brugia malayi | jmjC domain containing protein | 0.004 | 0.2215 | 0.2215 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.004 | 0.2215 | 0.2215 |
Echinococcus multilocularis | lamin | 0.0031 | 0.15 | 0.1692 |
Brugia malayi | TAR-binding protein | 0.007 | 0.4423 | 0.4423 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0257 | 0.0257 |
Echinococcus granulosus | lamin | 0.0031 | 0.15 | 0.1692 |
Echinococcus granulosus | peregrin | 0.0033 | 0.1688 | 0.1957 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.2215 | 0.3883 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.