Detailed information for compound 1303045

Basic information

Technical information
  • TDR Targets ID: 1303045
  • Name: N-(1,3-dimethyl-2-oxo-6-piperidin-1-ylbenzimi dazol-5-yl)-4-methylbenzamide
  • MW: 378.467 | Formula: C22H26N4O2
  • H donors: 1 H acceptors: 2 LogP: 3.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C(=O)Nc1cc2c(cc1N1CCCCC1)n(c(=O)n2C)C
  • InChi: 1S/C22H26N4O2/c1-15-7-9-16(10-8-15)21(27)23-17-13-19-20(25(3)22(28)24(19)2)14-18(17)26-11-5-4-6-12-26/h7-10,13-14H,4-6,11-12H2,1-3H3,(H,23,27)
  • InChiKey: FUWJOBZXVSQSSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1,3-dimethyl-2-oxo-6-(1-piperidyl)benzimidazol-5-yl]-4-methyl-benzamide
  • N-[1,3-dimethyl-2-oxo-6-(1-piperidyl)-5-benzimidazolyl]-4-methylbenzamide
  • N-(2-keto-1,3-dimethyl-6-piperidino-benzimidazol-5-yl)-4-methyl-benzamide
  • N-(1,3-dimethyl-2-oxo-6-piperidin-1-yl-benzimidazol-5-yl)-4-methyl-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.0147 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0942 1 1
Plasmodium vivax thioredoxin reductase, putative 0.008 0.0708 0.8702
Leishmania major cathepsin L-like protease 0.0053 0.0422 0.1628
Trypanosoma cruzi major cysteine proteinase, putative 0.0042 0.0299 0.1156
Mycobacterium leprae Probable lipase LipE 0.0036 0.0236 0.1033
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0041 0.0296 0.1473
Brugia malayi beta-lactamase 0.0036 0.0236 0.0236
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0236 0.09
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0444 0.0444
Mycobacterium ulcerans lipase LipD 0.0036 0.0236 0.1631
Echinococcus granulosus SAM and MBT domain containing protein 0.0041 0.0296 0.0418
Onchocerca volvulus 0.0036 0.0236 0.1178
Schistosoma mansoni smad1 5 8 and 0.0064 0.0541 0.1277
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0299 0.0299
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0185 0.0262
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0128 0.1574
Schistosoma mansoni ferritin light chain 0.0017 0.003 0.0071
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0202 0.2026 0.8718
Loa Loa (eye worm) thioredoxin reductase 0.008 0.0708 0.0708
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0708 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0236 0.0236
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0635 0.0898
Loa Loa (eye worm) hypothetical protein 0.0102 0.0948 0.0948
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.0147 0.0925
Schistosoma mansoni Smad4 0.0029 0.0159 0.0375
Plasmodium falciparum glutathione reductase 0.008 0.0708 0.9996
Onchocerca volvulus 0.0026 0.0128 0.0638
Plasmodium vivax glutathione reductase, putative 0.008 0.0708 0.8702
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0474 0.0671
Schistosoma mansoni ferritin light chain 0.0017 0.003 0.0071
Brugia malayi follicle stimulating hormone receptor 0.0193 0.1927 0.1927
Brugia malayi jmjC domain containing protein 0.0041 0.0297 0.0297
Loa Loa (eye worm) MBCTL1 0.0047 0.0357 0.0357
Echinococcus multilocularis peregrin 0.0041 0.0291 0.0411
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2319 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.0147 0.0208
Loa Loa (eye worm) calpain 5 0.0016 0.0027 0.0027
Plasmodium vivax calpain, putative 0.0016 0.0027 0.0327
Brugia malayi calpain family protein 1 0.0055 0.0444 0.0444
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0757 0.3774
Plasmodium falciparum thioredoxin reductase 0.0028 0.0147 0.2079
Echinococcus multilocularis tumor protein p63 0.067 0.7067 1
Brugia malayi TAR-binding protein 0.0062 0.0521 0.0521
Echinococcus granulosus cpg binding protein 0.0035 0.0222 0.0314
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0027 0.0103
Leishmania major kinesin, putative 0.0016 0.0027 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0521 0.1229
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0027 0.0103
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0147 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0236 0.0912
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0474 0.1118
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.0813 0.1151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0947 0.2233
Loa Loa (eye worm) hypothetical protein 0.0039 0.0267 0.0267
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.0813 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0674 0.9515
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0147 0.0568
Loa Loa (eye worm) hypothetical protein 0.0047 0.0357 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0521 0.1229
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0088 0.0088
Giardia lamblia Kinase, PLK 0.0084 0.0757 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0139 0.0139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Echinococcus granulosus histone acetyltransferase KAT2B 0.0287 0.2944 0.4166
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.1294 0.552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Loa Loa (eye worm) hypothetical protein 0.0098 0.0906 0.0906
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.424 0.6
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0027 0.0001
Leishmania major mitochondrial DNA polymerase beta 0.0254 0.2591 1
Schistosoma mansoni smad1 5 8 and 0.0064 0.0541 0.1277
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0027 0.0103
Loa Loa (eye worm) acetyltransferase 0.0298 0.3061 0.3061
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.008 0.019
Onchocerca volvulus 0.0098 0.0906 0.4515
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0521 0.0521
Onchocerca volvulus Serine\/threonine kinase homolog 0.0084 0.0757 0.3774
Loa Loa (eye worm) Smad1 0.0064 0.0541 0.0541
Leishmania major cathepsin L-like protease 0.0053 0.0422 0.1628
Echinococcus multilocularis histone acetyltransferase MYST2 0.0047 0.0357 0.0506
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0147 0.0568
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0027 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0757 0.3774
Loa Loa (eye worm) hypothetical protein 0.0036 0.0236 0.0236
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0027 0.0001
Onchocerca volvulus 0.0036 0.0236 0.1178
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0027 0.0103
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0947 0.0947
Brugia malayi PHD-finger family protein 0.0036 0.0234 0.0234
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.0813 0.4053
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.0147 0.0511
Brugia malayi Bromodomain containing protein 0.0041 0.0291 0.0291
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0128 0.0302
Echinococcus multilocularis calpain 0.0016 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0076 0.0665 0.0665
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0029 0.0159 0.0792
Toxoplasma gondii ABC1 family protein 0.0036 0.0236 0.2905
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0236 0.0557
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0147 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0147 0.0568
Echinococcus granulosus lamin 0.0027 0.0139 0.0197
Mycobacterium ulcerans beta-lactamase 0.0036 0.0236 0.1631
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0084 0.0757 0.1072
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0317 0.0448
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0048 0.0364 0.0364
Trypanosoma cruzi polo-like protein kinase, putative 0.0084 0.0757 0.2923
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0297 0.07
Loa Loa (eye worm) hypothetical protein 0.0102 0.0948 0.0948
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.0147 0.2079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0176 0.1746 0.1746
Schistosoma mansoni sex comb on midleg homolog 0.0041 0.0296 0.0697
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0757 0.3774
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0048 0.0364 0.0515
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.0147 0.181
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0906 0.2137
Brugia malayi calpain family protein 1 0.0055 0.0444 0.0444
Brugia malayi MH1 domain containing protein 0.0035 0.0232 0.0232
Brugia malayi serine/threonine-protein kinase plk-2 0.0084 0.0757 0.0757
Schistosoma mansoni smad1 5 8 and 0.0064 0.0541 0.1277
Schistosoma mansoni myelin transcription factor 1 myt1 0.0047 0.0357 0.0843
Echinococcus granulosus expressed protein 0.0017 0.003 0.0043
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0048 0.0364 0.0858
Echinococcus multilocularis geminin 0.0169 0.1669 0.2361
Echinococcus granulosus thioredoxin glutathione reductase 0.008 0.0713 0.1008
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0041 0.0296 0.0697
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0185 0.0262
Schistosoma mansoni hypothetical protein 0.0251 0.2559 0.6036
Brugia malayi Bromodomain containing protein 0.0048 0.0369 0.0369
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0036 0.0235 0.0908
Loa Loa (eye worm) hypothetical protein 0.0026 0.0134 0.0134
Treponema pallidum NADH oxidase 0.0028 0.0147 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0084 0.0757 0.0757
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0027 0.0103
Schistosoma mansoni Smad4 0.0029 0.0159 0.0375
Schistosoma mansoni Smad4 0.0064 0.0541 0.1277
Schistosoma mansoni transcription factor LCR-F1 0.0287 0.2941 0.6935
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0757 0.3774
Entamoeba histolytica protein kinase, putative 0.0017 0.003 0.01
Brugia malayi hypothetical protein 0.0049 0.0382 0.0382
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0236 0.1178
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0521 0.0738
Loa Loa (eye worm) MH2 domain-containing protein 0.0064 0.0541 0.0541
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0163 0.1606 0.2273
Onchocerca volvulus 0.0039 0.0267 0.1331
Echinococcus granulosus dnaJ subfamily B 0.0407 0.424 0.6
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0129 0.0182
Mycobacterium ulcerans hypothetical protein 0.0036 0.0236 0.1631
Mycobacterium tuberculosis Probable dehydrogenase 0.0182 0.1807 0.7764
Echinococcus multilocularis mothers against decapentaplegic 6 0.0029 0.0159 0.0225
Schistosoma mansoni Mername-AA248 (C02 family) 0.0016 0.0027 0.0063
Onchocerca volvulus Alhambra homolog 0.0031 0.0185 0.0924
Loa Loa (eye worm) glutathione reductase 0.008 0.0708 0.0708
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.0147 0.181
Echinococcus multilocularis cpg binding protein 0.0035 0.0222 0.0314
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0236 0.2905
Schistosoma mansoni calpain (C02 family) 0.0016 0.0027 0.0063
Brugia malayi calpain 5 0.0016 0.0027 0.0027
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0182 0.1807 0.7764
Loa Loa (eye worm) hypothetical protein 0.0055 0.0444 0.0444
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0325 0.0766
Echinococcus multilocularis expressed protein 0.0017 0.003 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0299 0.149
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.0147 0.0472
Brugia malayi hypothetical protein 0.0102 0.0948 0.0948
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0048 0.0364 0.264
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0027 0.0103
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0543 0.0543
Echinococcus multilocularis thioredoxin glutathione reductase 0.008 0.0713 0.1008
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.0422 0.1628
Schistosoma mansoni ferritin 0.0017 0.003 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0185 0.228
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0236 0.09
Trypanosoma brucei polo-like protein kinase 0.0084 0.0757 0.2851
Onchocerca volvulus Huntingtin homolog 0.0102 0.0948 0.4725
Brugia malayi calpain 7 0.0016 0.0027 0.0027
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0219 0.031
Loa Loa (eye worm) calpain 0.0016 0.0027 0.0027
Schistosoma mansoni lamin 0.0027 0.0139 0.0329
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.0708 0.2732
Echinococcus granulosus calpain 7 C02 family 0.0016 0.0027 0.0038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0947 0.0947
Echinococcus granulosus polycomb protein SCMH1 0.0041 0.0296 0.0418
Echinococcus multilocularis smad 0.0064 0.0541 0.0766
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0182 0.1807 0.7764
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0147 0.0733
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0521 0.1229
Entamoeba histolytica hypothetical protein 0.0287 0.2941 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0064 0.0541 0.0766
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0111 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Schistosoma mansoni hypothetical protein 0.0287 0.2941 0.6935
Entamoeba histolytica hypothetical protein 0.0287 0.2941 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0128 0.0181
Schistosoma mansoni cpg binding protein 0.0031 0.0181 0.0427
Plasmodium falciparum phd finger protein, putative 0.0031 0.0185 0.2619
Brugia malayi mbt repeat family protein 0.0041 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0041 0.0292 0.0292
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0036 0.0235 0.0908
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0185 0.228
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0297 0.0297
Entamoeba histolytica serine/threonine protein kinase, putative 0.0084 0.0757 0.2576
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0147 0.0568
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0236 0.1033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0299 0.0299
Echinococcus multilocularis calpain A 0.0058 0.0474 0.0671
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.012 0.1147 0.4427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0128 0.0302
Leishmania major hypothetical protein, conserved 0.0036 0.0236 0.0912
Brugia malayi Bromodomain containing protein 0.0089 0.0811 0.0811
Echinococcus granulosus calpain 5 0.0016 0.0027 0.0038
Brugia malayi hypothetical protein 0.0076 0.0674 0.0674
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0062
Trypanosoma brucei trypanothione reductase 0.008 0.0708 0.2658
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0757 0.1786
Onchocerca volvulus 0.0027 0.0139 0.0694
Onchocerca volvulus 0.0036 0.0236 0.1178
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.008 0.0708 0.2961
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0048 0.0364 0.0515
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0674 0.2601
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0047 0.0357 0.0506
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0036 0.0235 0.0815
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0132 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Loa Loa (eye worm) hypothetical protein 0.0036 0.0236 0.0236
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0068 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0422 0.1628
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0147 0.0568
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0298 0.3061 0.4331
Loa Loa (eye worm) MH2 domain-containing protein 0.0029 0.0159 0.0159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0947 0.134
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0147 0.0472
Onchocerca volvulus Huntingtin homolog 0.0102 0.0948 0.4725
Mycobacterium tuberculosis Conserved protein 0.0036 0.0236 0.09
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.0147 1
Brugia malayi Thioredoxin reductase 0.008 0.0708 0.0708
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0254 0.2591 1
Leishmania major cathepsin L-like protease 0.0053 0.0422 0.1628
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0147 0.0733
Echinococcus granulosus histone lysine methyltransferase setb 0.0044 0.0325 0.0459
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0147 0.0568
Trichomonas vaginalis esterase, putative 0.0036 0.0236 0.1178
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0147 0.0568
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0185 0.228
Brugia malayi hypothetical protein 0.0287 0.2941 0.2941
Brugia malayi mothers against decapentaplegic homolog 3 0.0029 0.0159 0.0159
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.0813 0.4053
Brugia malayi PHD-finger family protein 0.0031 0.0185 0.0185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0947 0.134
Loa Loa (eye worm) hypothetical protein 0.0028 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0169 0.1669 0.3935
Loa Loa (eye worm) MH2 domain-containing protein 0.0942 1 1
Echinococcus granulosus calpain A 0.0016 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0397 0.0397
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0084 0.0757 0.1072
Plasmodium falciparum glutathione reductase 0.0028 0.0147 0.2079
Brugia malayi MH2 domain containing protein 0.0029 0.0159 0.0159
Schistosoma mansoni ferritin 0.0017 0.003 0.0071
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0139 0.0139
Schistosoma mansoni lamin 0.0027 0.0139 0.0329
Echinococcus granulosus mothers against decapentaplegic 6 0.0029 0.0159 0.0225
Loa Loa (eye worm) hypothetical protein 0.0041 0.0296 0.0296
Entamoeba histolytica hypothetical protein 0.0287 0.2941 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0046 0.0066
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0674 0.2601
Brugia malayi glutathione reductase 0.008 0.0708 0.0708
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0068 0.0068
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0027 0.0103
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0048 0.0364 0.1404
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0236 0.0819
Loa Loa (eye worm) hypothetical protein 0.0076 0.0674 0.0674
Trypanosoma brucei kinesin, putative 0.0016 0.0027 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0287 0.2941 0.4161
Echinococcus granulosus ferritin 0.0017 0.003 0.0043
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.0147 0.0208
Schistosoma mansoni hypothetical protein 0.0022 0.0088 0.0207
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.0147 0.2079
Trypanosoma cruzi ISWI complex protein 0.0016 0.0026 0.0101
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0949 0.1343
Mycobacterium tuberculosis Conserved protein 0.0036 0.0236 0.09
Echinococcus multilocularis SAM and MBT domain containing protein 0.0041 0.0296 0.0418
Plasmodium vivax SET domain protein, putative 0.0026 0.0128 0.1574
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0236 0.0236
Brugia malayi RNA binding protein 0.0062 0.0521 0.0521
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0027 0.0001
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0093 0.0093
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0236 0.1631
Trypanosoma cruzi kinesin, putative 0.0016 0.0027 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0438 0.0438
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0046 0.0066
Brugia malayi Pre-SET motif family protein 0.0026 0.0128 0.0128
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0046 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0674 0.9515
Loa Loa (eye worm) hypothetical protein 0.0029 0.0159 0.0159
Echinococcus granulosus calpain A 0.0058 0.0474 0.0671
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0949 0.1343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0474 0.0671
Echinococcus granulosus tar DNA binding protein 0.0062 0.0521 0.0738
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0236 0.1178
Schistosoma mansoni bromodomain containing protein 0.0077 0.0676 0.1595
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0674 0.8283
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0202 0.2026 0.8718
Loa Loa (eye worm) hypothetical protein 0.0036 0.0236 0.0236
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0185 0.0185
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0299 0.0299
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0708 0.9193
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0674 0.8283
Trichomonas vaginalis set domain proteins, putative 0.02 0.2007 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0182 0.1807 0.8905
Loa Loa (eye worm) hypothetical protein 0.0031 0.0185 0.0185
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0236 0.1178
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.0813 1
Schistosoma mansoni cpg binding protein 0.0035 0.0222 0.0523
Loa Loa (eye worm) mbt repeat family protein 0.0041 0.0296 0.0296
Loa Loa (eye worm) MH1 domain-containing protein 0.0064 0.0541 0.0541
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0236 0.0334
Toxoplasma gondii thioredoxin reductase 0.008 0.0708 0.8702
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0757 0.3774
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0129 0.0303
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0236 0.1178
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0046 0.011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0236 0.09
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.0147 0.0347
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0053 0.0425 0.0425
Schistosoma mansoni smad 0.0064 0.0541 0.1277
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0047 0.0357 0.0357
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0147 0.0568
Echinococcus multilocularis musashi 0.0027 0.0139 0.0197
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0044 0.0329 0.0329
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0202 0.2026 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0016 0.0027 0.0103
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0723 0.1705
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.0232
Schistosoma mansoni intermediate filament proteins 0.0027 0.0139 0.0329
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0027 0.0103
Brugia malayi mbt repeat family protein 0.0041 0.0296 0.0296
Echinococcus multilocularis lamin 0.0027 0.0139 0.0197
Echinococcus granulosus mothers against decapentaplegic 2 0.0029 0.0159 0.0225
Brugia malayi MH1 domain containing protein 0.0064 0.0541 0.0541
Echinococcus granulosus peregrin 0.0041 0.0291 0.0411
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0182 0.1807 0.7764
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0193 0.1927 0.1927
Schistosoma mansoni sex comb on midleg homolog 0.0041 0.0296 0.0697
Entamoeba histolytica calpain large subunit domain III containing protein 0.0016 0.0027 0.009
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0521 0.0521
Schistosoma mansoni hypothetical protein 0.0028 0.0157 0.0369
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0521 0.0521
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0052 0.0122
Schistosoma mansoni apoferritin-2 0.0017 0.003 0.0071
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0474 0.1118
Echinococcus multilocularis hypothetical protein 0.0016 0.0027 0.0038
Brugia malayi MH2 domain containing protein 0.0064 0.0541 0.0541
Mycobacterium tuberculosis Probable oxidoreductase 0.0202 0.2026 0.8718
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.0147 0.0925
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0163 0.1606 0.2273
Schistosoma mansoni ferritin 0.0017 0.003 0.0071
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0236 0.1178
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0147 0.0568
Echinococcus granulosus tumor protein p63 0.067 0.7067 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0016 0.0027 0.0001
Echinococcus multilocularis lamin dm0 0.0027 0.0139 0.0197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0947 0.2233
Brugia malayi acetyltransferase, GNAT family protein 0.0298 0.3061 0.3061
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0297 0.042
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0027 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0147 0.0568
Echinococcus granulosus zinc finger protein 0.003 0.0172 0.0244
Mycobacterium ulcerans hypothetical protein 0.0134 0.1294 1
Schistosoma mansoni hypothetical protein 0.0031 0.0185 0.0437
Loa Loa (eye worm) RNA binding protein 0.0062 0.0521 0.0521
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Giardia lamblia PHD finger protein 15 0.0031 0.0185 0.0627
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0264 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0521 0.1229
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.0147 0.0147
Echinococcus granulosus calpain 0.0016 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0299 0.0299
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0147 0.0568
Echinococcus granulosus smad 0.0064 0.0541 0.0766
Loa Loa (eye worm) hypothetical protein 0.0055 0.0444 0.0444
Loa Loa (eye worm) nuclear factor I 0.0035 0.0232 0.0232
Trypanosoma cruzi kinesin, putative 0.0016 0.0027 0.0103
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0016 0.0027 0.0103
Leishmania major hypothetical protein, conserved 0.0016 0.0026 0.0101
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.012 0.1147 0.4427
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.0147 0.0925
Schistosoma mansoni zinc finger protein 0.0016 0.0026 0.0062
Entamoeba histolytica hypothetical protein 0.0287 0.2941 1
Leishmania major hypothetical protein, conserved 0.0076 0.0674 0.2601
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0325 0.0766
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0044 0.0325 0.0459
Schistosoma mansoni hypothetical protein 0.0169 0.1669 0.3935
Leishmania major trypanothione reductase 0.008 0.0708 0.2732
Brugia malayi latrophilin 2 splice variant baaae 0.0028 0.0157 0.0157
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0267 0.0378
Echinococcus multilocularis Smad4 0.0064 0.0541 0.0766
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0236 0.1631
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0129 0.0182
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0635 0.0898
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0562 0.1326
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.0147 0.181
Schistosoma mansoni kinase 0.0043 0.0311 0.0734
Echinococcus multilocularis zinc finger protein 0.003 0.0172 0.0244
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0036 0.0235 0.0908
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0219 0.031
Loa Loa (eye worm) beta-lactamase 0.0036 0.0236 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0236 0.0912
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0317 0.0448
Trypanosoma cruzi polo-like protein kinase, putative 0.0084 0.0757 0.2923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0947 0.2233
Loa Loa (eye worm) MH1 domain-containing protein 0.0029 0.0159 0.0159
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0236 0.09
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0236 0.09
Mycobacterium tuberculosis Conserved protein 0.0036 0.0236 0.09
Brugia malayi jmjC domain containing protein 0.0102 0.0949 0.0949
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0297 0.07
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0674 0.2525
Trypanosoma cruzi ISWI complex protein 0.0016 0.0026 0.0101
Trypanosoma brucei antigen, putative 0.0016 0.0027 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0422 0.1628
Mycobacterium tuberculosis Probable reductase 0.0182 0.1807 0.7764
Brugia malayi Smad1 0.0064 0.0541 0.0541
Schistosoma mansoni hypothetical protein 0.0407 0.424 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0048 0.0364 0.264
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0147 0.0472
Loa Loa (eye worm) hypothetical protein 0.0036 0.0236 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Onchocerca volvulus 0.02 0.2007 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0181 0.0181
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0267 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0521 0.1229
Echinococcus multilocularis ferritin 0.0017 0.003 0.0043
Brugia malayi MH1 domain containing protein 0.0064 0.0541 0.0541
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.012 0.1147 0.437
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0048 0.0364 0.1457
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0185 0.0437
Onchocerca volvulus 0.0027 0.0139 0.0694
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0254 0.2591 1
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0422 0.1628
Brugia malayi CXXC zinc finger family protein 0.0031 0.0181 0.0181
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0708 0.2408
Schistosoma mansoni calpain C (C02 family) 0.0016 0.0027 0.0063
Trypanosoma brucei calpain-like protein, putative 0.0016 0.0027 0.0001
Brugia malayi intermediate filament protein 0.0027 0.0139 0.0139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0947 0.134
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0139 0.0139
Echinococcus granulosus intermediate filament protein 0.0027 0.0139 0.0197
Onchocerca volvulus 0.0041 0.0296 0.1473
Schistosoma mansoni zinc finger protein 0.003 0.0172 0.0407
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.0147 0.181
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0084 0.0757 0.2923
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0236 0.0557
Brugia malayi MH2 domain containing protein 0.0064 0.0541 0.0541
Echinococcus granulosus lamin dm0 0.0027 0.0139 0.0197
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0444 0.1047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0236 0.0236
Echinococcus granulosus Smad4 0.0064 0.0541 0.0766
Schistosoma mansoni cpg binding protein 0.0035 0.0222 0.0523
Echinococcus multilocularis mothers against decapentaplegic 5 0.0064 0.0541 0.0766
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0064 0.0541 0.0766
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0298 0.3061 0.7219
Onchocerca volvulus 0.0031 0.0181 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0757 0.3774
Schistosoma mansoni ferritin 0.0017 0.003 0.0071
Brugia malayi beta-lactamase family protein 0.0036 0.0236 0.0236
Echinococcus multilocularis calpain 7 (C02 family) 0.0016 0.0027 0.0038
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0256 0.0362
Loa Loa (eye worm) hypothetical protein 0.0039 0.0267 0.0267
Echinococcus granulosus geminin 0.0169 0.1669 0.2361
Echinococcus multilocularis mothers against decapentaplegic 2 0.0029 0.0159 0.0225
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0047 0.0357 0.0506
Brugia malayi Pre-SET motif family protein 0.0176 0.1746 0.1746
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.0813 1
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.0757 0.3774
Loa Loa (eye worm) hypothetical protein 0.0044 0.0325 0.0325
Toxoplasma gondii hypothetical protein 0.0041 0.0292 0.3589
Brugia malayi beta-lactamase family protein 0.0036 0.0236 0.0236
Trichomonas vaginalis ferritin, putative 0.0017 0.003 0.0151
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0182 0.1807 0.7764
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0236 0.09
Plasmodium falciparum thioredoxin reductase 0.008 0.0708 0.9996
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0236 0.09
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0027 0.0103
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.008 0.019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0592 0.7282
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0139
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0287 0.2941 0.4161
Brugia malayi MH1 domain containing protein 0.0035 0.0232 0.0232
Echinococcus multilocularis polycomb protein SCMH1 0.0041 0.0296 0.0418
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0064 0.0541 0.1277
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0264 0.0374
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0048 0.0372 0.1437
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.0147 0.0472
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0517
Echinococcus multilocularis calpain 5 0.0016 0.0027 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0254 0.2591 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.032 0.1234
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0299 0.149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0236 0.0334
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0016 0.0027 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Echinococcus granulosus TGF beta signal transducer SmadC 0.0064 0.0541 0.0766
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0422 0.1543
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0147 0.0568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0947 0.134
Echinococcus granulosus histone acetyltransferase MYST2 0.0047 0.0357 0.0506
Schistosoma mansoni smad 0.0029 0.0159 0.0375
Schistosoma mansoni apoferritin-2 0.0017 0.003 0.0071

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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