TDR Targets

Basic information

Technical information

TDR Targets ID: 1303530
Name: N-(4-methylpyridin-2-yl)-5-[(2,3,5,6-tetraflu orophenoxy)methyl]furan-2-carboxamide
MW: 380.293 | Formula: C18H12F4N2O3
H donors: 1 H acceptors: 2 LogP: 3.69 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccnc(c1)NC(=O)c1ccc(o1)COc1c(F)c(F)cc(c1F)F
InChi: 1S/C18H12F4N2O3/c1-9-4-5-23-14(6-9)24-18(25)13-3-2-10(27-13)8-26-17-15(21)11(19)7-12(20)16(17)22/h2-7H,8H2,1H3,(H,23,24,25)
InChiKey: AKHZZRJVKLPFHS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-methyl-2-pyridyl)-5-[(2,3,5,6-tetrafluorophenoxy)methyl]furan-2-carboxamide
N-(4-methyl-2-pyridyl)-5-[(2,3,5,6-tetrafluorophenoxy)methyl]-2-furancarboxamide
N-(4-methyl-2-pyridyl)-5-[(2,3,5,6-tetrafluorophenoxy)methyl]-2-furamide
Oprea1_372195
ST025904
ZINC01083419
MLS001164520
N-(4-methyl-2-pyridinyl)-5-[(2,3,5,6-tetrafluorophenoxy)methyl]-2-furamide
SMR000497663

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0324	1
Brugia malayi	jmjC domain containing protein	0.0061	0.2213	0.2213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1591	0.1591
Loa Loa (eye worm)	RNA binding protein	0.0076	0.2938	0.2938
Loa Loa (eye worm)	hypothetical protein	0.012	0.4909	0.4909
Toxoplasma gondii	exonuclease III APE	0.0019	0.0324	0.2648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.1045	0.1045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0227	0.0227
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0436	0.1559
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2938	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.1045	0.1045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0324	0.1323
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.1803	0.7367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.2213	0.7531
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1045	0.1045
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0324	0.1089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.1596	0.1596
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0324	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0436	0.1781
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.1135	0.1135
Brugia malayi	hypothetical protein	0.012	0.4909	0.4909
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.1045	0.0768
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0227	0.3395
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0324	0.0324
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.9712	1
Echinococcus multilocularis	cysteine protease	0.0017	0.0227	0.0227
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0177	0.0177
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1045	0.3555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0227	0.2169
Mycobacterium ulcerans	lipase LipD	0.0035	0.1045	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1045	0.0768
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0227	0.0227
Brugia malayi	jmjC domain containing protein	0.0061	0.2213	0.2213
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1596	0.543
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	0.0809	0.2755
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0064	0.0617
Echinococcus multilocularis	lysine specific demethylase 5A	0.0061	0.2213	0.2213
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0436	0.0436
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.1596	0.1596
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0436	0.0436
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.0438	0.1151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.1045	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.1045	0.1045
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1045	0.0768
Loa Loa (eye worm)	CYP4Cod1	0.002	0.0351	0.0351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0227	0.2169
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0227	0.1997
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1045	0.0768
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0177	0.0177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0324	0.1103
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.2938	0.2938
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0177	0.0177
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0436	0.1781
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0177	0.0601
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.012	0.4909	0.4909
Entamoeba histolytica	hypothetical protein	0.0037	0.1135	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0436	0.1559
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.2186	0.8932
Brugia malayi	Cytochrome P450 family protein	0.002	0.0351	0.0351
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0227	0.0227
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Leishmania major	cathepsin L-like protease	0.0066	0.2448	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Onchocerca volvulus		0.0035	0.1045	0.1747
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.002	0.0351	0.0374
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.2938	0.2938
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0436	0.0436
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.1045	0.4112
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.1045	0.0768
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1045	0.4267
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0064	0.0617
Toxoplasma gondii	cathepsin CPL	0.0017	0.0227	0.1655
Echinococcus granulosus	serine protein kinase ATM	0.003	0.0809	0.0809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1596	0.543
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.1045	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1045	0.3555
Leishmania major	cathepsin L-like protease	0.0066	0.2448	1
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0177	0.0177
Echinococcus multilocularis	serine protein kinase ATM	0.003	0.0809	0.0809
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.1045	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.2448	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	0.0809	0.3126
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0324	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1045	0.1045
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0227	0.022
Mycobacterium ulcerans	beta-lactamase	0.0035	0.1045	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0227	0.0227
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.1045	0.0768
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.1135	0.3861
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0436	0.1142
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0436	0.1781
Echinococcus granulosus	survival motor neuron protein 1	0.0231	1	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0436	0.1142
Toxoplasma gondii	FATC domain-containing protein	0.003	0.0809	0.7601
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0436	0.1781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0436	0.1484
Loa Loa (eye worm)	beta-lactamase	0.0035	0.1045	0.1045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0436	0.0436
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0177	0.0177
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0227	0.0926
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0227	0.1997
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0436	0.1484
Plasmodium vivax	vivapain-2	0.0017	0.0227	0.0577
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.2448	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0436	0.3842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0016	0.0177	0.047
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1596	0.1596
Schistosoma mansoni	hypothetical protein	0.0037	0.1135	0.3861
Trichomonas vaginalis	esterase, putative	0.0035	0.1045	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0436	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0177	0.0177
Echinococcus multilocularis	cysteine protease	0.0017	0.0227	0.0227
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0324	0.5
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0227	0.0227
Mycobacterium leprae	Probable lipase LipE	0.0035	0.1045	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1045	0.4267
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.003	0.0809	0.0809
Leishmania major	cathepsin L-like protease	0.0066	0.2448	1
Brugia malayi	jmjC domain containing protein	0.0016	0.0177	0.0177
Echinococcus granulosus	tar DNA binding protein	0.0076	0.2938	0.2938
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0436	0.0436
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0227	0.0227
Brugia malayi	beta-lactamase family protein	0.0035	0.1045	0.1045
Trypanosoma brucei	cytochrome P450, putative	0.002	0.0351	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0231	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.2938	0.2938
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0227	0.3395
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0064	0.0064
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.1045	0.1045
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0177	0.0721
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0436	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0617	0.0617
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0177	0.0177
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0177	0.0177
Loa Loa (eye worm)	fibroinase	0.0017	0.0227	0.0227
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0324	0.3101
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1596	0.543
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	1	1
Leishmania major	hypothetical protein, conserved	0.0035	0.1045	0.3822
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0324	0.0324
Leishmania major	cathepsin L-like protease	0.0017	0.0227	0.022
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2938	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0177	0.0177
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1045	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0061	0.2213	0.2213
Entamoeba histolytica	hypothetical protein	0.0037	0.1135	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0436	0.379
Leishmania major	cytochrome p450-like protein	0.002	0.0351	0.0768
Giardia lamblia	GTOR	0.0022	0.0436	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0227	0.0771
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0227	0.0227
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0324	0.2855
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0177	0.0721
Leishmania major	cathepsin L-like protease	0.0017	0.0227	0.022
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.2448	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.1135	0.1135
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0016	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0177	0.0177
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.2938	0.2938
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1045	0.1045
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0177	0.0601
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1045	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0351	0.0351
Brugia malayi	RNA binding protein	0.0076	0.2938	0.2938
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0227	0.1997
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2938	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0061	0.2213	0.7531
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.1045	0.0768
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1045	1
Entamoeba histolytica	hypothetical protein	0.0037	0.1135	1
Schistosoma mansoni	jumonji domain containing protein	0.0061	0.2213	0.7531
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0227	0.0227
Loa Loa (eye worm)	ctsf protein	0.0017	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0227	0.0227
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0177	0.0601
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0438	0.1789
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0177	0.0177
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0436	0.1559
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0227	0.0227
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.1045	0.0768
Onchocerca volvulus	Huntingtin homolog	0.012	0.4909	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0436	0.0436
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0351	0.0351
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0177	0.0601
Brugia malayi	beta-lactamase	0.0035	0.1045	0.1045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0227	0.0227
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1045	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1045	0.1045
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0324	0.1323
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.1045	0.0768
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Onchocerca volvulus		0.0035	0.1045	0.1747
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0324	0.0324
Schistosoma mansoni	hypothetical protein	0.0047	0.1591	0.5414
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1596	0.1596
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0436	0.1142
Entamoeba histolytica	hypothetical protein	0.003	0.0809	0.7134
Mycobacterium ulcerans	hypothetical protein	0.0035	0.1045	1
Plasmodium vivax	vivapain-2	0.0017	0.0227	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0016	0.0177	0.1144
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1045	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0324	0.0324
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1596	0.1596
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.2448	1
Brugia malayi	Cytochrome P450 family protein	0.002	0.0351	0.0351
Leishmania major	cathepsin L-like protease	0.0017	0.0227	0.022
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1045	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0436	0.1559
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0436	0.1559
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0227	0.0771
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1596	0.1596
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0227	0.0227
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0436	0.3842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0809	0.7749
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2938	1
Onchocerca volvulus	Huntingtin homolog	0.012	0.4909	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Brugia malayi	TAR-binding protein	0.0076	0.2938	0.2938
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0351	0.1434
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0061	0.2213	0.2213
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0324	0.3101
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0016	0.0177	0.0177
Schistosoma mansoni	ap endonuclease	0.0019	0.0324	0.1103
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.1045	0.0768
Onchocerca volvulus		0.0047	0.1591	0.2913
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0436	0.0436
Leishmania major	cathepsin L-like protease	0.0017	0.0227	0.022
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0177	0.0177
Brugia malayi	hypothetical protein	0.0037	0.1135	0.1135
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.2213	0.2213
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0227	0.2169
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2938	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0436	0.0436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Brugia malayi	jmjC domain containing protein	0.0016	0.0177	0.0177
Entamoeba histolytica	hypothetical protein	0.0037	0.1135	1
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0177	0.0177
Toxoplasma gondii	ABC1 family protein	0.0035	0.1045	1
Onchocerca volvulus		0.0035	0.1045	0.1747
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0227	0.0227
Brugia malayi	jmjC domain containing protein	0.0016	0.0177	0.0177
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Leishmania major	cathepsin L-like protease	0.0017	0.0227	0.022
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.0617	0.2521
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0324	0.1698
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1591	0.5414
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0177	0.0601
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0227	0.0227
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0351	0.1434
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1045	0.1045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Echinococcus granulosus	cathepsin l1	0.0017	0.0227	0.0227
Brugia malayi	jmjC domain containing protein	0.0016	0.0177	0.0177
Loa Loa (eye worm)	cysteine protease	0.0017	0.0227	0.0227
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0016	0.0177	0.1144
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0436	0.4173
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0436	0.1781
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	0.0809	0.3307
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0177	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0227	0.2169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.2448	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0061	0.2213	0.2213
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0227	0.3395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1045	0.1045
Brugia malayi	beta-lactamase family protein	0.0035	0.1045	0.1045

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.8184 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1422447

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1303530