Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0044 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.2452 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.8705 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.2452 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.5173 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.2452 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.2452 | 0.2452 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.003 | 0.5028 | 0.5028 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.2452 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.003 | 0.5173 | 0.4352 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.5173 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3136 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2452 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.3136 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2452 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.8705 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3136 | 1 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.5173 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.8705 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.2452 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.003 | 0.5173 | 0.4352 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.003 | 0.5173 | 0.4352 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3136 | 1 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.5173 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.3136 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.3136 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.8705 | 1 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.5173 | 0.4352 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0044 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.5028 | 0.4121 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3136 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.004 | 0.8705 | 0.8284 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.8705 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.004 | 0.8705 | 0.8705 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3136 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.5028 | 0.3413 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.8705 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.3136 | 0.3136 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.3136 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.8705 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.5173 | 0.5173 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.