Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0187 | 0.7017 | 0.6884 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.2501 | 0.3564 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.7017 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.1193 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0187 | 0.7017 | 0.6613 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.1193 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.2501 | 0.3564 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3983 | 0.3167 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.6529 | 0.6059 |
Brugia malayi | hypothetical protein | 0.0051 | 0.1193 | 0.0801 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.7017 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.1193 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1193 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.7017 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0258 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0187 | 0.7017 | 0.6884 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.6529 | 0.9305 |
Echinococcus granulosus | tar DNA binding protein | 0.0187 | 0.7017 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.2501 | 0.3564 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2501 | 0.1485 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0258 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.1193 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.1193 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.7017 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3983 | 0.3715 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.2501 | 0.3564 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.2501 | 0.3564 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.2501 | 0.1485 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0187 | 0.7017 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.2501 | 0.3564 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.2501 | 0.2167 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3983 | 0.3167 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.2501 | 0.3564 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1193 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0176 | 0.6529 | 0.6374 |
Schistosoma mansoni | tar DNA-binding protein | 0.0187 | 0.7017 | 1 |
Brugia malayi | RNA binding protein | 0.0187 | 0.7017 | 0.6884 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.2501 | 0.3564 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.2501 | 0.3564 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.2501 | 0.2167 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0187 | 0.7017 | 0.6613 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.2501 | 0.3564 |
Loa Loa (eye worm) | RNA binding protein | 0.0187 | 0.7017 | 0.6613 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.1193 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.