Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4722 | 0.4688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0711 | 0.0651 |
Trypanosoma brucei | ISWI complex protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0191 | 0.0127 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4439 | 0.5381 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8876 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4439 | 0.5396 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.1014 | 0.0453 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4439 | 0.4403 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4722 | 0.6015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0082 | 0.1363 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0.0064 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7379 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7379 | 0.7362 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4722 | 0.6015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4722 | 0.4688 |
Onchocerca volvulus | 0.0035 | 0.4439 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7379 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7379 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.7379 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.7379 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7379 | 0.7362 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7379 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.1014 | 0.0453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0603 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0.0064 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7379 | 0.7362 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.