Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0849 | 0.0849 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.073 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.073 | 0.073 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0849 | 0.0849 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.073 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.3316 | 0.3316 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.073 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.073 | 0.5 |
Brugia malayi | RNA binding protein | 0.0071 | 0.3316 | 0.3316 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.073 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.073 | 0.5 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0849 | 0.0849 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3316 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3316 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.3316 | 0.3316 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.3316 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3316 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.3316 | 0.3316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3316 | 1 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.3316 | 0.3316 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.073 | 0.5 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0849 | 0.0849 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.3316 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.3316 | 0.3316 |
Brugia malayi | hypothetical protein | 0.0028 | 0.073 | 0.073 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.3316 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.