Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0033 | 0.4001 | 0.2829 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.9022 | 0.9022 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.4707 | 0.4707 |
Brugia malayi | hypothetical protein | 0.0034 | 0.4381 | 0.4381 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4001 | 0.4001 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4001 | 0.2829 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4001 | 0.4001 |
Onchocerca volvulus | 0.0033 | 0.4001 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.932 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.4001 | 0.2829 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.932 | 0.932 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.932 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4001 | 0.2829 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.9022 | 0.9022 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4001 | 0.4001 |
Schistosoma mansoni | lamin | 0.0033 | 0.4001 | 0.2829 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.932 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.932 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.4001 | 0.2829 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4001 | 0.2829 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.9022 | 0.9022 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4001 | 0.4001 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.932 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.932 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.932 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4001 | 0.2829 |
Onchocerca volvulus | 0.0033 | 0.4001 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3843 | 0.3843 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.9022 | 0.9022 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.4707 | 0.4707 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.4707 | 0.3672 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4001 | 0.4001 |
Brugia malayi | hypothetical protein | 0.0053 | 0.932 | 0.932 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.932 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4001 | 0.2829 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.1216 uM | PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.