Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0617 | 0.0617 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0617 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2177 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0617 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0617 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2177 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2177 | 0.1662 |
Brugia malayi | TAR-binding protein | 0.0069 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0617 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0617 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.2177 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0617 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2177 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0617 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2177 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.2177 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.2177 | 0.2177 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.2177 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0617 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.2177 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.