Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0093 | 0.2915 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0145 | 0.4906 | 0.4906 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.0021 | 0.0158 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2112 | 0.2913 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0041 | 0.0925 | 0.0803 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.2049 | 0.1942 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0061 | 0.1681 | 0.1548 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 0.2802 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.1509 | 0.2015 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0163 | 0.5615 | 0.5545 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0403 | 0.1972 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0072 | 0.2112 | 0.2005 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0145 | 0.4906 | 0.708 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0093 | 0.2915 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0021 | 0.0158 | 0.5 |
Brugia malayi | N-terminal motif family protein | 0.0191 | 0.6692 | 0.6692 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0158 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0093 | 0.2915 | 0.4112 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0158 | 0.0025 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0021 | 0.0158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0649 | 0.0523 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0158 | 0.0158 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0061 | 0.1681 | 0.1548 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0403 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0158 | 0.0025 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0089 | 0.2756 | 0.3873 |
Brugia malayi | jmjC domain containing protein | 0.0112 | 0.3641 | 0.3641 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0403 | 0.0972 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0093 | 0.2915 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0228 | 0.8113 | 0.8113 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0145 | 0.4906 | 0.4825 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0072 | 0.2112 | 0.1985 |
Brugia malayi | jmjC domain containing protein | 0.0041 | 0.0925 | 0.0925 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0925 | 0.1145 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0145 | 0.4906 | 0.4825 |
Echinococcus granulosus | geminin | 0.0196 | 0.6865 | 0.6814 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.6692 | 0.6648 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0403 | 0.0274 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0403 | 0.0972 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0191 | 0.6692 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0158 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0163 | 0.5615 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0072 | 0.2112 | 0.2112 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0403 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0403 | 0.089 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0403 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0163 | 0.5615 | 0.8137 |
Brugia malayi | Probable ClpP-like protease | 0.0093 | 0.2915 | 0.2915 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2112 | 0.2005 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0403 | 0.0972 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0366 | 0.0754 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0021 | 0.0158 | 0.0158 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0163 | 0.5615 | 0.5545 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0021 | 0.0158 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0032 | 0.0568 | 0.1487 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0048 | 0.1164 | 0.1022 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0156 | 0.5335 | 0.5335 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.0021 | 0.0158 | 0.0089 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0403 | 0.0403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0145 | 0.4906 | 0.708 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2112 | 0.2913 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0158 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.6865 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.8113 | 0.8088 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0228 | 0.8113 | 0.8088 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0228 | 0.8113 | 0.8113 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0403 | 0.045 |
Onchocerca volvulus | 0.0028 | 0.0403 | 0.0376 | |
Entamoeba histolytica | hypothetical protein | 0.0163 | 0.5615 | 1 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0032 | 0.0568 | 0.1487 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0032 | 0.0568 | 0.1563 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0061 | 0.1681 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.0034 | 0.0649 | 0.0751 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0072 | 0.2112 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0158 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.6865 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0057 | 0.1509 | 0.1509 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0061 | 0.1681 | 0.5525 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0649 | 0.1781 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0133 | 0.0274 |
Schistosoma mansoni | survival motor neuron protein | 0.0057 | 0.1509 | 0.2015 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0649 | 0.0499 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2112 | 0.2913 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0366 | 0.0837 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0403 | 0.045 |
Brugia malayi | topoisomerase | 0.0021 | 0.0158 | 0.0158 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0403 | 0.0972 |
Plasmodium falciparum | phd finger protein, putative | 0.0034 | 0.0649 | 0.1854 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0403 | 0.0403 |
Entamoeba histolytica | hypothetical protein | 0.0163 | 0.5615 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0403 | 0.0972 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.5335 | 0.772 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0649 | 0.0523 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0145 | 0.4906 | 0.4838 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0072 | 0.2112 | 0.1985 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.5615 | 0.8137 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0366 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0158 | 0.0025 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0403 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0145 | 0.4906 | 0.4825 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0366 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0145 | 0.4906 | 0.4825 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0366 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2915 | 0.282 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0021 | 0.0158 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0072 | 0.2112 | 0.1985 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 0.2802 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0403 | 0.0972 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0649 | 0.0732 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0034 | 0.0659 | 0.0533 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0277 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0649 | 0.1781 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.2112 | 0.2913 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0041 | 0.0925 | 0.1145 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.0649 | 0.1854 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0649 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5335 | 0.5272 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0403 | 0.089 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1588 | 0.1475 |
Onchocerca volvulus | 0.0057 | 0.1509 | 0.2068 | |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0112 | 0.3641 | 0.3539 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0021 | 0.0158 | 0.0158 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0403 | 0.045 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0277 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0048 | 0.1164 | 0.1022 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0403 | 0.0274 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0061 | 0.1681 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0163 | 0.5615 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0072 | 0.2112 | 0.1985 |
Chlamydia trachomatis | DNA ligase | 0.0021 | 0.0158 | 0.0089 |
Brugia malayi | hypothetical protein | 0.0163 | 0.5615 | 0.5615 |
Echinococcus granulosus | GPCR family 2 | 0.0072 | 0.2112 | 0.1985 |
Brugia malayi | Cytochrome P450 family protein | 0.0034 | 0.0659 | 0.0659 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0041 | 0.0925 | 0.078 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0032 | 0.0568 | 0.1487 |
Echinococcus multilocularis | peregrin | 0.0034 | 0.0649 | 0.0499 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0403 | 0.0972 |
Echinococcus granulosus | peregrin | 0.0034 | 0.0649 | 0.0499 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0649 | 0.0649 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0649 | 0.0732 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0158 | 0.0025 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0366 | 0.0366 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0072 | 0.2112 | 0.2112 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0403 | 0.0274 |
Echinococcus multilocularis | geminin | 0.0196 | 0.6865 | 0.6814 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0403 | 0.1972 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0.0158 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0021 | 0.0158 | 0.5 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.0021 | 0.0158 | 0.0089 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0112 | 0.3641 | 0.3539 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.2915 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0366 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0093 | 0.2915 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0034 | 0.0649 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0041 | 0.0925 | 0.078 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0145 | 0.4906 | 0.708 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0366 | 0.0837 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0403 | 0.0972 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.0649 | 0.0649 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0366 | 0.0837 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0032 | 0.0568 | 0.1563 |
Brugia malayi | DKFZp564C0469 protein | 0.0021 | 0.0158 | 0.0158 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.