Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.2678 | 0.1367 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.2678 | 0.1367 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.8482 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1518 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0062 | 0.2529 | 0.4744 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.5946 | 0.5946 |
Trypanosoma brucei | glucosidase, putative | 0.0044 | 0.1518 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0062 | 0.2529 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.1518 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.1518 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.2678 | 0.2678 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2678 | 0.1665 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.5946 | 0.5946 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0044 | 0.1518 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0062 | 0.2529 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0044 | 0.1518 | 0.1518 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 0.4331 | 1 |
Onchocerca volvulus | 0.0114 | 0.5404 | 0.6094 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0044 | 0.1518 | 0.1518 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2678 | 0.1665 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.1518 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0176 | 0.8868 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.2678 | 0.2678 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.2678 | 0.2678 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0044 | 0.1518 | 0.1797 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0044 | 0.1518 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1518 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.8868 | 0.8868 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1518 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.2678 | 0.2678 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0062 | 0.2529 | 0.1192 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.1518 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 0.3317 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.8482 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2678 | 0.1665 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0062 | 0.2529 | 0.1192 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 0.3317 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.2678 | 0.2678 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.4331 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0.4331 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.5946 | 0.5946 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2678 | 0.1665 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1518 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.4331 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.1518 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0044 | 0.1518 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0.4331 | 0.404 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.4331 | 0.4331 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.4331 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.1518 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0176 | 0.8868 | 0.8868 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2678 | 0.1665 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.2678 | 0.2678 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1518 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0094 | 0.4331 | 0.4331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.