Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase | 0.0562 | 0.4461 | 0.4461 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1011 | 0.2083 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0134 | 0.0329 | 0.0329 |
Schistosoma mansoni | hypothetical protein | 0.0419 | 0.308 | 0.6344 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1011 | 0.2083 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0327 | 0.2188 | 0.2188 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0329 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.05 | 0.3861 | 0.3861 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0603 | 0.4854 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0327 | 0.2188 | 0.2188 |
Schistosoma mansoni | tar DNA-binding protein | 0.0327 | 0.2188 | 0.4508 |
Onchocerca volvulus | 0.051 | 0.3956 | 0.095 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0327 | 0.2188 | 0.2188 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0452 | 0.3396 | 0.6995 |
Schistosoma mansoni | glutaminase | 0.0562 | 0.4461 | 0.9189 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.01 | 0 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0603 | 0.4854 | 1 |
Schistosoma mansoni | kinase | 0.0306 | 0.1993 | 0.4106 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0603 | 0.4854 | 1 |
Brugia malayi | Pip kinase protein 2 | 0.05 | 0.3861 | 0.3861 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.05 | 0.3861 | 0.7954 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0419 | 0.308 | 0.6344 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0423 | 0.3122 | 0.3122 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0134 | 0.0329 | 0.0678 |
Brugia malayi | hypothetical protein | 0.0419 | 0.308 | 0.308 |
Brugia malayi | glutaminase DH11.1 | 0.0562 | 0.4461 | 0.4461 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0452 | 0.3396 | 0.6995 |
Brugia malayi | RNA binding protein | 0.0327 | 0.2188 | 0.2188 |
Schistosoma mansoni | hypothetical protein | 0.0289 | 0.1829 | 0.3768 |
Echinococcus granulosus | GPCR family 2 | 0.0134 | 0.0329 | 0.0678 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0603 | 0.4854 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0327 | 0.2188 | 0.4508 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0423 | 0.3122 | 0.3122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0327 | 0.2188 | 0.4508 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1136 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0327 | 0.2188 | 0.4508 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0452 | 0.3396 | 0.6995 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0134 | 0.0329 | 0.0329 |
Mycobacterium ulcerans | glutaminase | 0.0562 | 0.4461 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0603 | 0.4854 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0603 | 0.4854 | 0.4854 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0603 | 0.4854 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0289 | 0.1829 | 0.1829 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0134 | 0.0329 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.3122 | 0.3122 |
Brugia malayi | TAR-binding protein | 0.0327 | 0.2188 | 0.2188 |
Echinococcus multilocularis | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.05 | 0.3861 | 0.7954 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0134 | 0.0329 | 0.0329 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0423 | 0.3122 | 0.3122 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.01 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.3956 | 0.3956 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0603 | 0.4854 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0603 | 0.4854 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0603 | 0.4854 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0327 | 0.2188 | 0.4508 |
Echinococcus granulosus | geminin | 0.0205 | 0.1011 | 0.2083 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0603 | 0.4854 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0562 | 0.4461 | 0.866 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1829 | 0.1829 |
Loa Loa (eye worm) | pip kinase 2 | 0.05 | 0.3861 | 0.3861 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0419 | 0.308 | 0.6344 |
Leishmania major | hypothetical protein, conserved | 0.0452 | 0.3396 | 0.6995 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0603 | 0.4854 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1136 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0134 | 0.0329 | 0.0678 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0329 | 0.0678 |
Loa Loa (eye worm) | glutaminase 2 | 0.0562 | 0.4461 | 0.4461 |
Brugia malayi | hypothetical protein | 0.051 | 0.3956 | 0.3956 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1011 | 0.2083 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.01 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0329 | 0.0678 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0603 | 0.4854 | 1 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.05 | 0.3861 | 0.7954 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0134 | 0.0329 | 0.0678 |
Schistosoma mansoni | tar DNA-binding protein | 0.0327 | 0.2188 | 0.4508 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0603 | 0.4854 | 1 |
Giardia lamblia | Kinase, PLK | 0.0603 | 0.4854 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0603 | 0.4854 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0603 | 0.4854 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0603 | 0.4854 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0134 | 0.0329 | 0.0678 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.01 | 0 | 0.5 |
Echinococcus granulosus | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.05 | 0.3861 | 0.7954 |
Loa Loa (eye worm) | TAR-binding protein | 0.0327 | 0.2188 | 0.2188 |
Echinococcus multilocularis | tar DNA binding protein | 0.0327 | 0.2188 | 0.4508 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0603 | 0.4854 | 0.4854 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0419 | 0.308 | 0.6344 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.0329 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0329 | 0.0329 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.01 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0461 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.