Detailed information for compound 1305231

Basic information

Technical information
  • TDR Targets ID: 1305231
  • Name: 3-(1,3-benzodioxol-5-ylmethyl)-1-tert-butylth iourea
  • MW: 266.359 | Formula: C13H18N2O2S
  • H donors: 1 H acceptors: 0 LogP: 2.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: SC(=NC(C)(C)C)NCc1ccc2c(c1)OCO2
  • InChi: 1S/C13H18N2O2S/c1-13(2,3)15-12(18)14-7-9-4-5-10-11(6-9)17-8-16-10/h4-6H,7-8H2,1-3H3,(H2,14,15,18)
  • InChiKey: CQNPXCUJWMTUQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1,3-benzodioxol-5-ylmethyl)-1-tert-butyl-thiourea
  • MLS000417180
  • SMR000264331
  • T5341894
  • ZINC03437863

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0006 0.0043 0.0098
Loa Loa (eye worm) hypothetical protein 0.0006 0.0043 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0406 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0406 0.0911
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0406 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0406 0.0911
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0406 0.0406
Brugia malayi ecdysteroid receptor 0.0012 0.0406 0.0911
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0406 0.0406
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0406 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.1145 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0043 0.0098
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0406 0.0406
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.1145 0.1145
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0406 0.0911
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0406 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0377 0.0377
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0406 0.0406
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.1145 0.1145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0406 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0406 0.0911
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0406 0.0911
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0406 0.0406
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.1145 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4456 0.4456
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.1145 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4456 0.4456
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0406 0.0911
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.1145 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4456 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0406 0.0911
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.1145 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0406 0.0406
Brugia malayi nuclear receptor RXR 0.0006 0.0043 0.0098
Loa Loa (eye worm) RecQ helicase 0.0024 0.1145 0.2569
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.2435 0.2435
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.1145 0.2569
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Loa Loa (eye worm) hypothetical protein 0.0006 0.0043 0.0098
Brugia malayi RNA binding protein 0.0076 0.4456 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0406 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2435 0.2435
Brugia malayi nuclear receptor NHR-88 0.0012 0.0406 0.0911
Loa Loa (eye worm) RNA binding protein 0.0076 0.4456 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.1145 0.5
Onchocerca volvulus 0.0012 0.0406 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4456 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2435 0.2435
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0406 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0406 0.0911
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.1145 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0406 0.0911
Schistosoma mansoni hypothetical protein 0.0165 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4456 0.4456
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0406 0.0911
Loa Loa (eye worm) hypothetical protein 0.0006 0.0043 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0406 0.0406
Echinococcus multilocularis bloom syndrome protein 0.0024 0.1145 0.1145
Brugia malayi hypothetical protein 0.0006 0.0043 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0406 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0406 0.0911
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.2435 0.2435
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.2435 0.5464
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0406 0.0911
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0406 0.0406
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.1145 0.5
Schistosoma mansoni DNA helicase recq5 0.0024 0.1145 0.1145
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0043 0.0098
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0043 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0406 0.0406
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.1145 0.2569
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0406 0.0911
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0043 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0406 0.0911
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.2435 0.2435
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.1145 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0406 0.0406
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0406 0.0406
Echinococcus multilocularis geminin 0.0165 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0406 0.0911
Schistosoma mansoni DNA helicase recq1 0.0024 0.1145 0.1145
Brugia malayi steroid hormone receptor 0.0012 0.0406 0.0911
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0406 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.1145 0.1145
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0406 0.0406
Schistosoma mansoni coup transcription factor 0.0012 0.0406 0.0406
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0406 0.0406
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0406 0.0406
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0406 0.0406
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0406 0.0911
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0043 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0043 0.0043
Brugia malayi hypothetical protein 0.0006 0.0043 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0406 0.0406
Echinococcus granulosus bloom syndrome protein 0.0024 0.1145 0.1145
Loa Loa (eye worm) hypothetical protein 0.0024 0.1145 0.2569
Echinococcus granulosus tar DNA binding protein 0.0076 0.4456 0.4456
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4456 0.4456
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.1145 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.2435 0.5464
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0406 0.0911
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.1145 0.2569
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0406 0.0406
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0006 0.0043 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0406 0.0406
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0406 0.0911
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0406 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0406 0.0406
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4456 0.4456
Entamoeba histolytica recQ family helicase, putative 0.0024 0.1145 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0406 0.0406
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0406 0.0406
Schistosoma mansoni hypothetical protein 0.0165 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0406 0.0406
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0406 0.0406
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0406 0.0381
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0406 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0406 0.0911
Brugia malayi nuclear hormone receptor 0.0012 0.0406 0.0911
Brugia malayi TAR-binding protein 0.0076 0.4456 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.1145 0.2569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.2435 0.2435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.2435 0.2435
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0043 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0406 0.0406
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4456 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0406 0.0911
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.0406 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.1145 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4456 0.4456
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0406 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0406 0.0911
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0406 0.0406
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.1145 0.1145

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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