Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0299 | 0.0613 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0299 | 0.0613 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.2526 | 0.2526 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0253 | 0.4847 | 0.993 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0299 | 0.0613 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0299 | 0.0613 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0487 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0255 | 0.4881 | 0.4881 |
Brugia malayi | hypothetical protein | 0.0253 | 0.4847 | 0.4847 |
Brugia malayi | TAR-binding protein | 0.0255 | 0.4881 | 0.4881 |
Entamoeba histolytica | hypothetical protein | 0.0253 | 0.4847 | 0.6273 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 0.4847 | 0.993 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0253 | 0.4847 | 0.993 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0299 | 0.0613 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.2526 | 0.2526 |
Entamoeba histolytica | hypothetical protein | 0.0253 | 0.4847 | 0.6273 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0299 | 0.0299 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0253 | 0.4847 | 0.993 |
Brugia malayi | RNA binding protein | 0.0255 | 0.4881 | 0.4881 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.2526 | 0.2526 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1495 | 0.1495 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0299 | 0.0299 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0299 | 0.0613 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0487 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0255 | 0.4881 | 1 |
Giardia lamblia | DNA repair protein RAD52 | 0.0345 | 0.6875 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0299 | 0.0299 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.4881 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.4881 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0255 | 0.4881 | 0.4881 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0299 | 0.0613 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0299 | 0.0613 |
Entamoeba histolytica | hypothetical protein | 0.0253 | 0.4847 | 0.6273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.4881 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.1495 | 0.1495 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0299 | 0.0613 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0299 | 0.0299 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0299 | 0.0613 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0255 | 0.4881 | 0.4881 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0345 | 0.6875 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.2526 | 0.2526 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.4881 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0253 | 0.4847 | 0.6273 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0255 | 0.4881 | 0.4881 |
Echinococcus multilocularis | tar DNA binding protein | 0.0255 | 0.4881 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.4881 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1495 | 0.3064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.