Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2386 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2386 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2386 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2386 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2386 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0932 | 0.1976 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2386 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0932 | 0.1976 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2386 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0932 | 0.1976 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.2386 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2386 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2386 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2386 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2386 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0932 | 0.1976 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0932 | 0.1976 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2386 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2386 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
No. of mice (functional) | = 8 | On set and incidence of arthitis in the Mouse Type II collagen model following 0.5 mg/kg on day 30. | ChEMBL. | 9240355 |
No. of mice (functional) | = 11 | On set and incidence of arthitis in the Mouse Type II collagen model at 0.5 dose mg/kg on day 37, expressed as ratio of number treated to that of control | ChEMBL. | 9240355 |
No. of mice (functional) | = 11 | On set and incidence of arthitis in the Mouse Type II collagen model at 0.5 dose mg/kg on day 40, expressed as ratio of number treated to that of control | ChEMBL. | 9240355 |
No. of mice (functional) | = 12 | On set and incidence of arthitis in the Mouse Type II collagen model at 0.5 dose mg/kg on day 44, expressed as ratio of number treated to that of control | ChEMBL. | 9240355 |
Paw swelling (functional) | = 100 % | Extent of paw swelling after treatment with thymopentin-5 (TP-5) compound in the Mouse Type II collagen arthritis at a dosage of 1.0 mg/kg on day 44 | ChEMBL. | 9240355 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.