Detailed information for compound 1306225

Basic information

Technical information
  • TDR Targets ID: 1306225
  • Name: 2-[(2,3-dimethylphenyl)-methylsulfonylamino]- N-[2-(phenylmethylsulfanyl)ethyl]acetamide
  • MW: 406.562 | Formula: C20H26N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 3.29 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)C)c1cccc(c1C)C)NCCSCc1ccccc1
  • InChi: 1S/C20H26N2O3S2/c1-16-8-7-11-19(17(16)2)22(27(3,24)25)14-20(23)21-12-13-26-15-18-9-5-4-6-10-18/h4-11H,12-15H2,1-3H3,(H,21,23)
  • InChiKey: NOKREMPLNFGAKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2,3-dimethylphenyl)-methylsulfonyl-amino]-N-[2-(phenylmethylsulfanyl)ethyl]acetamide
  • 2-[(2,3-dimethylphenyl)-methylsulfonylamino]-N-[2-(phenylmethylthio)ethyl]acetamide
  • N-[2-(benzylthio)ethyl]-2-[(2,3-dimethylphenyl)-mesyl-amino]acetamide
  • 2-[(2,3-dimethylphenyl)-methylsulfonyl-amino]-N-[2-(phenylmethylsulfanyl)ethyl]ethanamide
  • MLS000682900
  • N~1~-[2-(benzylthio)ethyl]-N~2~-(2,3-dimethylphenyl)-N~2~-(methylsulfonyl)glycinamide
  • SMR000312983

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.038 0.7114 1
Loa Loa (eye worm) TAR-binding protein 0.0075 0.099 0.099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0355 0.0355
Echinococcus multilocularis lysine specific demethylase 5A 0.0097 0.1429 0.1429
Echinococcus granulosus cathepsin l1 0.0259 0.4682 0.4682
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.038 0.7114 1
Giardia lamblia Cathepsin L-like protease 0.0081 0.1113 0.2613
Leishmania major DNA polymerase eta, putative 0.0093 0.1348 0.1895
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Plasmodium falciparum serine repeat antigen 3 0.0081 0.1113 0.1565
Echinococcus multilocularis cathepsin L cysteine protease 0.038 0.7114 0.7114
Echinococcus multilocularis cysteine protease 0.038 0.7114 0.7114
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0142 0.2338 0.4607
Echinococcus granulosus lysine specific demethylase 5A 0.0097 0.1429 0.1429
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0771 0.0771
Echinococcus granulosus cathepsin b 0.0523 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0355 0.4543
Giardia lamblia Cathepsin L precursor 0.0081 0.1113 0.2613
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0081 0.1113 0.1565
Trypanosoma cruzi cysteine proteinase, putative 0.0202 0.3546 0.3546
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0202 0.3546 0.3546
Brugia malayi Papain family cysteine protease containing protein 0.038 0.7114 0.7114
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1606 0.1606
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Brugia malayi Cathepsin L-like precursor 0.038 0.7114 0.7114
Onchocerca volvulus Cathepsin F homolog 0.038 0.7114 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0355 0.4543
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Onchocerca volvulus 0.0043 0.0355 0.0488
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0081 0.1113 0.1113
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0608 0.0608
Loa Loa (eye worm) fibroinase 0.038 0.7114 0.7114
Schistosoma mansoni jumonji/arid domain-containing protein 0.0097 0.1429 0.1429
Echinococcus multilocularis cathepsin l cysteine peptidase 0.038 0.7114 0.7114
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0141 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Plasmodium falciparum serine repeat antigen 2 0.0081 0.1113 0.1565
Giardia lamblia Cysteine protease 0.0081 0.1113 0.2613
Giardia lamblia Hypothetical protein 0.0081 0.1113 0.2613
Leishmania major DNA polymerase eta, putative 0.0049 0.0458 0.0644
Brugia malayi Bromodomain containing protein 0.0033 0.0141 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.038 0.7114 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0153 0.0153
Schistosoma mansoni cathepsin C 0.0081 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0121 0.1913 0.1913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0081 0.1113 0.2613
Onchocerca volvulus 0.038 0.7114 1
Onchocerca volvulus 0.038 0.7114 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.1113 0.1113
Leishmania major cathepsin L-like protease 0.038 0.7114 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0081 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0081 0.1113 0.1113
Trypanosoma brucei DNA polymerase eta, putative 0.0093 0.1348 0.1895
Echinococcus granulosus jumonji domain containing protein 0.0046 0.04 0.04
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0369 0.0369
Plasmodium falciparum serine repeat antigen 7 0.0081 0.1113 0.1565
Brugia malayi glutathione reductase 0.0056 0.0608 0.0608
Loa Loa (eye worm) cathepsin B 0.0218 0.3862 0.3862
Plasmodium falciparum serine repeat antigen 4 0.0081 0.1113 0.1565
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0771 0.0771
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1113 0.1122
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0338 0.0338
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0008 0.0011
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.04 0.04
Schistosoma mansoni DNA polymerase eta 0.0093 0.1348 0.1348
Echinococcus granulosus cathepsin L cysteine proteinase 0.038 0.7114 0.7114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Giardia lamblia Hypothetical protein 0.0081 0.1113 0.2613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Toxoplasma gondii cathepsin B 0.0218 0.3862 0.5428
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0608 0.1185
Mycobacterium tuberculosis Probable oxidoreductase 0.0142 0.2338 0.4607
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0081 0.1113 0.1565
Trypanosoma cruzi cysteine proteinase, putative 0.0202 0.3546 0.3546
Echinococcus multilocularis cathepsin b 0.0523 1 1
Plasmodium falciparum phd finger protein, putative 0.0033 0.0141 0.0198
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0081 0.1113 0.1565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0202 0.3546 0.4721
Schistosoma mansoni hypothetical protein 0.0033 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0153
Plasmodium falciparum cysteine proteinase falcipain 2b 0.038 0.7114 1
Loa Loa (eye worm) glutathione reductase 0.0056 0.0608 0.0608
Mycobacterium tuberculosis Conserved protein 0.0043 0.0355 0.0685
Brugia malayi Cathepsin L-like precursor 0.038 0.7114 0.7114
Entamoeba histolytica cysteine proteinase, putative 0.038 0.7114 1
Echinococcus granulosus cathepsin L cysteine protease 0.0202 0.3546 0.3546
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0355 0.0355
Echinococcus granulosus peregrin 0.0033 0.0141 0.0141
Leishmania major cathepsin L-like protease 0.038 0.7114 1
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0121 0.1913 0.1913
Echinococcus multilocularis cathepsin b 0.0523 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.038 0.7114 0.7114
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0128 0.2052 0.404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0355 0.0499
Onchocerca volvulus 0.038 0.7114 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0355 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0202 0.3546 0.4721
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0081 0.1113 0.1113
Mycobacterium ulcerans lipase LipD 0.0043 0.0355 0.4543
Entamoeba histolytica hypothetical protein 0.0043 0.0338 0.0464
Schistosoma mansoni cathepsin F (C01 family) 0.038 0.7114 0.7114
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5066 1
Loa Loa (eye worm) hypothetical protein 0.0259 0.4682 0.4682
Schistosoma mansoni cathepsin S (C01 family) 0.0081 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.1113 0.1122
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0081 0.1113 0.1122
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.1113 0.1113
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0081 0.1113 0.1565
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0128 0.2052 0.404
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1113 0.1122
Plasmodium falciparum serine repeat antigen 1 0.0081 0.1113 0.1565
Brugia malayi Thioredoxin reductase 0.0056 0.0608 0.0608
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0259 0.4682 0.4682
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0523 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0121 0.1913 0.1913
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0081 0.1113 0.1122
Entamoeba histolytica cysteine protease, putative 0.0081 0.1113 0.1555
Trichomonas vaginalis DNA polymerase eta, putative 0.0064 0.0771 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.1113 0.1122
Leishmania major cathepsin L-like protease 0.038 0.7114 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0355
Brugia malayi MH2 domain containing protein 0.0142 0.2326 0.2326
Giardia lamblia Cathepsin B precursor 0.0081 0.1113 0.2613
Giardia lamblia Cathepsin B precursor 0.0081 0.1113 0.2613
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0165 0.2793 0.2793
Plasmodium vivax vivapain-2 0.038 0.7114 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0355 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.4682 0.6401
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0355 0.0685
Brugia malayi Cathepsin L-like precursor 0.0259 0.4682 0.4682
Onchocerca volvulus 0.038 0.7114 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0771 0.1508
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0771 1
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0008 0.0008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.0771 0.1508
Schistosoma mansoni tar DNA-binding protein 0.0075 0.099 0.099
Brugia malayi cathepsin F-like cysteine proteinase 0.0081 0.1113 0.1113
Leishmania major trypanothione reductase 0.0056 0.0608 0.0854
Entamoeba histolytica cysteine protease, putative 0.0081 0.1113 0.1555
Trypanosoma brucei trypanothione reductase 0.0056 0.0608 0.0854
Loa Loa (eye worm) hypothetical protein 0.0121 0.1913 0.1913
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.4682 0.6576
Leishmania major cathepsin L-like protease 0.038 0.7114 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.1113 0.1113
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0458 0.0644
Entamoeba histolytica cysteine protease, putative 0.038 0.7114 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0369 0.0369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0369 0.0369
Plasmodium falciparum glutathione reductase 0.0056 0.0608 0.0854
Loa Loa (eye worm) beta-lactamase 0.0043 0.0355 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0355 0.0355
Leishmania major cathepsin L-like protease 0.038 0.7114 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.1606 0.1606
Loa Loa (eye worm) hypothetical protein 0.0523 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Echinococcus multilocularis dna polymerase kappa 0.0064 0.0771 0.0771
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Schistosoma mansoni tar DNA-binding protein 0.0075 0.099 0.099
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Trypanosoma cruzi cysteine peptidase, putative 0.038 0.7114 0.7114
Echinococcus granulosus dna polymerase eta 0.0093 0.1348 0.1348
Onchocerca volvulus Cathepsin L homolog 0.038 0.7114 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0097 0.1429 0.1429
Brugia malayi cathepsin L-like precursor 0.0259 0.4682 0.4682
Plasmodium falciparum cysteine proteinase falcipain 2a 0.038 0.7114 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0369 0.0369
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0081 0.1113 0.2613
Brugia malayi Cathepsin L-like cysteine proteinase 0.0259 0.4682 0.4682
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0355 0.0355
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0081 0.1113 0.1565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Echinococcus multilocularis peregrin 0.0033 0.0141 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0008 0.0008
Giardia lamblia Cathepsin B precursor 0.0218 0.3862 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0202 0.3546 0.4985
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0771 0.1084
Echinococcus multilocularis cathepsin L cysteine protease 0.038 0.7114 0.7114
Echinococcus granulosus cathepsin b 0.0523 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0608 0.0608
Onchocerca volvulus 0.0043 0.0355 0.0488
Brugia malayi Cathepsin L-like precursor 0.0121 0.1913 0.1913
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0081 0.1113 0.2613
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0128 0.2052 0.404
Plasmodium vivax serine-repeat antigen (SERA) 0.0081 0.1113 0.1565
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0355 0.0685
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0355 0.0685
Brugia malayi RNA recognition motif domain containing protein 0.0075 0.099 0.099
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1606 0.1606
Trypanosoma cruzi cruzipain precursor, putative 0.038 0.7114 0.7114
Trypanosoma cruzi cysteine peptidase, putative 0.038 0.7114 0.7114
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0202 0.3546 0.3546
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0355 0.0685
Brugia malayi Papain family cysteine protease containing protein 0.0202 0.3546 0.3546
Brugia malayi Cathepsin L-like precursor 0.038 0.7114 0.7114
Toxoplasma gondii cathepsin CPL 0.038 0.7114 1
Toxoplasma gondii thioredoxin reductase 0.0056 0.0608 0.0854
Echinococcus granulosus cathepsin l cysteine peptidase 0.038 0.7114 0.7114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0081 0.1113 0.1122
Entamoeba histolytica cysteine proteinase 2 0.0202 0.3546 0.4979
Trypanosoma brucei unspecified product 0.0044 0.037 0.0521
Echinococcus multilocularis geminin 0.0355 0.6611 0.6611
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0141 0.0141
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.1113 0.1113
Entamoeba histolytica cysteine protease, putative 0.0081 0.1113 0.1555
Onchocerca volvulus 0.038 0.7114 1
Plasmodium falciparum thioredoxin reductase 0.0056 0.0608 0.0854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1113 0.1122
Brugia malayi fibroinase precursor 0.0081 0.1113 0.1113
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0075 0.099 0.099
Giardia lamblia Cathepsin L precursor 0.0081 0.1113 0.2613
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.1113 0.1122
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0934 0.0934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0142 0.2338 0.4607
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0081 0.1113 0.1122
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0141 0.0141
Entamoeba histolytica hypothetical protein 0.0043 0.0338 0.0464
Toxoplasma gondii cathepsin CPC2 0.0081 0.1113 0.1565
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0771 0.0771
Plasmodium falciparum serine repeat antigen 6 0.0081 0.1113 0.1565
Loa Loa (eye worm) hypothetical protein 0.0259 0.4682 0.4682
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.038 0.7114 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0771 0.0771
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0141 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0075 0.099 0.099
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.1113 0.1113
Brugia malayi PHD-finger family protein 0.0033 0.0141 0.0141
Loa Loa (eye worm) ctsf protein 0.038 0.7114 0.7114
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Onchocerca volvulus 0.038 0.7114 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0081 0.1113 0.1113
Schistosoma mansoni tar DNA-binding protein 0.0075 0.099 0.099
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0355 0.1487
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.1113 0.1113
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0202 0.3546 0.3546
Schistosoma mansoni cathepsin F (C01 family) 0.0259 0.4682 0.4682
Schistosoma mansoni cathepsin s 0.0121 0.1913 0.1913
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0008 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0097 0.1429 0.1429
Brugia malayi beta-lactamase family protein 0.0043 0.0355 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0081 0.1113 0.1122
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Loa Loa (eye worm) RNA binding protein 0.0075 0.099 0.099
Giardia lamblia Cathepsin L precursor 0.0081 0.1113 0.2613
Brugia malayi Papain family cysteine protease containing protein 0.0202 0.3546 0.3546
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0075 0.099 0.099
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0844 0.0844
Brugia malayi Cathepsin L-like precursor 0.038 0.7114 0.7114
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0153 0.0153
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0608 0.0854
Plasmodium falciparum serine repeat antigen 8 0.0081 0.1113 0.1565
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0523 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.037 0.0521
Brugia malayi Cathepsin L-like precursor 0.038 0.7114 0.7114
Giardia lamblia DINP protein human, muc B family 0.0064 0.0771 0.1693
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0355 0.0355
Leishmania major cysteine peptidase A (CPA) 0.038 0.7114 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0141 0.0198
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0355 0.0355
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Entamoeba histolytica hypothetical protein 0.0081 0.1113 0.1555
Loa Loa (eye worm) transcription factor SMAD2 0.0142 0.2326 0.2326
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0771 0.0771
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.1113 0.1122
Entamoeba histolytica cysteine proteinase, putative 0.0202 0.3546 0.4979
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0008 0.0011
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0202 0.3546 0.3546
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0771 0.0771
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0153 0.0153
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0165 0.2793 0.2793
Echinococcus multilocularis cathepsin L 0.0202 0.3546 0.3546
Brugia malayi hypothetical protein 0.0043 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1113 0.1122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0202 0.3546 0.4985
Entamoeba histolytica hypothetical protein 0.0043 0.0338 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0081 0.1113 0.1565
Echinococcus granulosus cathepsin L 0.0202 0.3546 0.3546
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0141 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1113 0.1122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0369 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0153 0.0153
Plasmodium falciparum serine repeat antigen 5 0.0081 0.1113 0.1565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0369 0.0369
Echinococcus multilocularis GPCR, family 2 0.0033 0.0153 0.0153
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0771 0.0771
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0523 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Schistosoma mansoni hypothetical protein 0.0043 0.0338 0.0338
Giardia lamblia Cysteine protease 0.0081 0.1113 0.2613
Loa Loa (eye worm) cysteine protease 0.038 0.7114 0.7114
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0771 0.0771
Echinococcus granulosus tar DNA binding protein 0.0075 0.099 0.099
Giardia lamblia Cathepsin L-like protease 0.0081 0.1113 0.2613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0081 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0081 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0259 0.4682 0.4682
Giardia lamblia Cathepsin B precursor 0.0218 0.3862 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Brugia malayi Cathepsin L-like precursor 0.0259 0.4682 0.4682
Giardia lamblia Cathepsin B precursor 0.0218 0.3862 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0081 0.1113 0.1565
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.038 0.7114 0.7114
Brugia malayi RNA binding protein 0.0075 0.099 0.099
Giardia lamblia Cysteine protease 0.0081 0.1113 0.2613
Schistosoma mansoni jumonji domain containing protein 0.0143 0.2348 0.2348
Trypanosoma cruzi cysteine peptidase, putative 0.0202 0.3546 0.3546
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0128 0.2052 0.404
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0218 0.3862 0.5428
Trypanosoma cruzi DNA polymerase kappa, putative 0.0064 0.0771 0.0771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Brugia malayi jmjC domain containing protein 0.0165 0.2793 0.2793
Mycobacterium tuberculosis Conserved protein 0.0043 0.0355 0.0685
Brugia malayi beta-lactamase 0.0043 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.038 0.7114 0.7114
Loa Loa (eye worm) hypothetical protein 0.0121 0.1913 0.1913
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0608 0.0608
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0369 0.0369
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0081 0.1113 0.1555
Brugia malayi cathepsin F-like cysteine proteinase 0.0121 0.1913 0.1913
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0081 0.1113 0.2613
Echinococcus granulosus dna polymerase kappa 0.0064 0.0771 0.0771
Brugia malayi cathepsin Z-like cysteine proteinase 0.0081 0.1113 0.1113
Toxoplasma gondii cathepsin CPC1 0.0081 0.1113 0.1565
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0355 0.0685
Trypanosoma cruzi major cysteine proteinase, putative 0.0081 0.1113 0.1113
Entamoeba histolytica hypothetical protein 0.0043 0.0338 0.0464
Plasmodium vivax unspecified product 0.0081 0.1113 0.1565
Schistosoma mansoni cathepsin F (C01 family) 0.038 0.7114 0.7114
Onchocerca volvulus 0.0259 0.4682 0.6576
Loa Loa (eye worm) hypothetical protein 0.0081 0.1113 0.1113
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Plasmodium vivax unspecified product 0.0121 0.1913 0.2689
Loa Loa (eye worm) papain family cysteine protease containing protein 0.038 0.7114 0.7114
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0064 0.0771 0.0616
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0355
Plasmodium vivax glutathione reductase, putative 0.0056 0.0608 0.0854
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0355 0.0685
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0218 0.3862 0.3862
Echinococcus granulosus GPCR family 2 0.0033 0.0153 0.0153
Giardia lamblia Cathepsin L precursor 0.0081 0.1113 0.2613
Trypanosoma cruzi DNA polymerase eta, putative 0.0093 0.1348 0.1348
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0355 0.0499
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0153
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0338 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0218 0.3862 0.5188
Echinococcus granulosus geminin 0.0355 0.6611 0.6611
Trypanosoma cruzi cysteine peptidase, putative 0.038 0.7114 0.7114
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0771 0.0771
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0081 0.1113 0.1122
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0142 0.2338 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0355
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0141 0.0141
Brugia malayi cathepsin Z-like cysteine proteinase 0.0081 0.1113 0.1113
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0081 0.1113 0.1565
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0008 0.0008
Trypanosoma cruzi cysteine protease, putative 0.0202 0.3546 0.3546
Mycobacterium tuberculosis Conserved protein 0.0043 0.0355 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1113 0.1122
Mycobacterium ulcerans hypothetical protein 0.0043 0.0355 0.4543
Echinococcus multilocularis cysteine protease 0.038 0.7114 0.7114
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0081 0.1113 0.1113
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0153 0.0153
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0153 0.0153
Leishmania major cathepsin L-like protease 0.038 0.7114 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0081 0.1113 0.1113
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.0771 0.1084
Schistosoma mansoni cathepsin B (C01 family) 0.0081 0.1113 0.1113
Brugia malayi jmjC domain containing protein 0.0097 0.1429 0.1429
Entamoeba histolytica cysteine protease, putative 0.0081 0.1113 0.1555
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Giardia lamblia Cathepsin B precursor 0.0081 0.1113 0.2613
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.1113 0.1122
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.037 0.0521
Plasmodium vivax unspecified product 0.0202 0.3546 0.4985
Trypanosoma cruzi cysteine peptidase, putative 0.038 0.7114 0.7114
Schistosoma mansoni hypothetical protein 0.0355 0.6611 0.6611
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0081 0.1113 0.1565
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0355 0.4543
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0355 0.0355
Plasmodium falciparum serine repeat antigen 9 0.0081 0.1113 0.1565
Echinococcus granulosus cathepsin L 0.0081 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Brugia malayi beta-lactamase family protein 0.0043 0.0355 0.0355
Leishmania major DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Mycobacterium leprae Probable lipase LipE 0.0043 0.0355 0.1487
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Brugia malayi ImpB/MucB/SamB family protein 0.0093 0.1348 0.1348
Onchocerca volvulus Alhambra homolog 0.0033 0.0141 0.0187
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1606 0.1606
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0128 0.2052 0.8769
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0608 0.0608
Brugia malayi Papain family cysteine protease containing protein 0.0081 0.1113 0.1113
Giardia lamblia Cathepsin L precursor 0.0081 0.1113 0.2613
Onchocerca volvulus 0.038 0.7114 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0081 0.1113 0.1565
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Mycobacterium ulcerans DNA polymerase IV 0.0064 0.0771 1
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0771 0.1084
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1113 0.1122
Trypanosoma brucei unspecified product 0.0044 0.037 0.0521
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.037 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0081 0.1113 0.1555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.1113 0.1122
Trypanosoma brucei unspecified product 0.0064 0.0771 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Onchocerca volvulus 0.0081 0.1113 0.1555
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Onchocerca volvulus Cathepsin L homolog 0.038 0.7114 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Giardia lamblia Cysteine protease 0.0081 0.1113 0.2613
Giardia lamblia Cathepsin L precursor 0.0081 0.1113 0.2613
Toxoplasma gondii ABC1 family protein 0.0043 0.0355 0.0499
Trypanosoma cruzi major cysteine proteinase, putative 0.0081 0.1113 0.1113
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0153 0.0153
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0081 0.1113 0.1113
Entamoeba histolytica cysteine proteinase, putative 0.0202 0.3546 0.4979
Plasmodium vivax vivapain-1 0.0202 0.3546 0.4985
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0523 1 1
Brugia malayi TAR-binding protein 0.0075 0.099 0.099
Plasmodium falciparum cysteine proteinase falcipain 3 0.038 0.7114 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0202 0.3546 0.4979
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0369 0.0369
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.2326 0.2326
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0081 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0093 0.1348 0.1348
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0771 0.1074
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0081 0.1113 0.1565
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0141 0.0198
Brugia malayi Cathepsin L-like precursor 0.038 0.7114 0.7114
Entamoeba histolytica cysteine protease, putative 0.0202 0.3546 0.4979
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.1913 0.1913
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0523 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0218 0.3862 0.3862
Schistosoma mansoni hypothetical protein 0.0033 0.0153 0.0153
Giardia lamblia Cathepsin B precursor 0.0081 0.1113 0.2613
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.038 0.7114 1
Giardia lamblia Encystation-specific protease 0.0081 0.1113 0.2613
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0081 0.1113 0.1113
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0081 0.1113 0.1565
Trypanosoma brucei DNA polymerase IV, putative 0.0064 0.0771 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Schistosoma mansoni hypothetical protein 0.0072 0.0934 0.0934
Schistosoma mansoni hypothetical protein 0.0355 0.6611 0.6611
Leishmania major hypothetical protein, conserved 0.0043 0.0355 0.0499
Trypanosoma cruzi cruzipain precursor, putative 0.0121 0.1913 0.1913
Echinococcus granulosus cathepsin l1 0.038 0.7114 0.7114
Plasmodium vivax vivapain-2 0.038 0.7114 1
Echinococcus multilocularis dna polymerase eta 0.0093 0.1348 0.1348
Loa Loa (eye worm) hypothetical protein 0.0072 0.0934 0.0934
Plasmodium vivax vivapain-3 0.0202 0.3546 0.4985
Giardia lamblia Cathepsin B precursor 0.0081 0.1113 0.2613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0202 0.3546 0.4985
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0338 0.0338
Echinococcus multilocularis tar DNA binding protein 0.0075 0.099 0.099
Leishmania major cathepsin L-like protease 0.038 0.7114 1
Mycobacterium tuberculosis Probable reductase 0.0128 0.2052 0.404
Mycobacterium tuberculosis Probable dehydrogenase 0.0128 0.2052 0.404
Entamoeba histolytica cysteine proteinase, putative 0.0202 0.3546 0.4979
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0081 0.1113 0.1565
Loa Loa (eye worm) hypothetical protein 0.0081 0.1113 0.1113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.4682 0.6401
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0458 0.0458
Onchocerca volvulus Cathepsin L homolog 0.0081 0.1113 0.1555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.7114 1
Entamoeba histolytica cysteine protease, putative 0.0081 0.1113 0.1555
Trypanosoma brucei cysteine peptidase C (CPC) 0.0218 0.3862 0.5428
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0081 0.1113 0.1565
Loa Loa (eye worm) hypothetical protein 0.0081 0.1113 0.1113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.7114 1
Brugia malayi cathepsin L precursor 0.0081 0.1113 0.1113
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0081 0.1113 0.1555
Echinococcus multilocularis cathepsin L 0.0081 0.1113 0.1113
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0771 0.1084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0919 0.0919
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0081 0.1113 0.1565
Onchocerca volvulus 0.0043 0.0355 0.0488
Entamoeba histolytica cysteine proteinase, putative 0.0202 0.3546 0.4979
Echinococcus granulosus cysteine protease 0.0202 0.3546 0.3546

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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