Detailed information for compound 1306265

Basic information

Technical information
  • TDR Targets ID: 1306265
  • Name: (4E)-2-[(E)-2-(4-chlorophenyl)ethenyl]-4-[(E) -3-(2-methoxyphenyl)prop-2-enylidene]-1,3-oxa zol-5-one
  • MW: 365.81 | Formula: C21H16ClNO3
  • H donors: 0 H acceptors: 1 LogP: 5.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1/C=C/C=C\1/N=C(OC1=O)/C=C/c1ccc(cc1)Cl
  • InChi: 1S/C21H16ClNO3/c1-25-19-8-3-2-5-16(19)6-4-7-18-21(24)26-20(23-18)14-11-15-9-12-17(22)13-10-15/h2-14H,1H3/b6-4+,14-11+,18-7+
  • InChiKey: WWOXPBKTIHRVCV-ISNHSJIUSA-N  


Substructure search Similarity search

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Synonyms

  • (4E)-2-[(E)-2-(4-chlorophenyl)vinyl]-4-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]oxazol-5-one
  • (4E)-2-[(E)-2-(4-chlorophenyl)vinyl]-4-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]-5-oxazolone
  • SMR000206648
  • (4E)-2-[(E)-2-(4-chlorophenyl)vinyl]-4-[(2E)-3-(2-methoxyphenyl)prop-2-enylidene]-1,3-oxazol-5(4H)-one
  • MLS000583462

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0045 0.0156 0.0156
Brugia malayi PHD-finger family protein 0.0194 0.1118 0.1105
Leishmania major cathepsin L-like protease 0.0077 0.0361 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0335 0.0345
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.1579 0.1779
Loa Loa (eye worm) dihydrofolate reductase 0.1566 1 1
Echinococcus granulosus peregrin 0.0197 0.1137 0.1124
Loa Loa (eye worm) thioredoxin reductase 0.0077 0.0362 0.0362
Brugia malayi glutathione reductase 0.0077 0.0362 0.0348
Schistosoma mansoni jumonji domain containing protein 0.0559 0.3478 0.3469
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0086 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.1579 0.1779
Brugia malayi F/Y-rich N-terminus family protein 0.0072 0.0329 0.0314
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0361 0.0493
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.013 0.0701 0.0668
Schistosoma mansoni jumonji/arid domain-containing protein 0.0291 0.1745 0.1732
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0117 0.0288
Loa Loa (eye worm) hypothetical protein 0.0049 0.018 0.018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0078 0.0365 0.0351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0084 0.0407 0.0393
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0193 0.1111 0.1098
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1047 0.6639 1
Plasmodium falciparum thioredoxin reductase 0.0077 0.0362 0.0495
Schistosoma mansoni bromodomain containing protein 0.0076 0.0357 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Echinococcus multilocularis transcription factor btf3 0.0035 0.0086 0.0071
Toxoplasma gondii PHD-finger domain-containing protein 0.0194 0.1118 0.164
Treponema pallidum fructose-bisphosphate aldolase 0.0265 0.1579 1
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0086 0.0077
Brugia malayi Dihydrofolate reductase 0.1566 1 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5256 0.5249
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0361 0.0493
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0073 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Echinococcus multilocularis lysine specific demethylase 5A 0.0289 0.173 0.1717
Schistosoma mansoni hypothetical protein 0.0308 0.1858 0.1846
Trichomonas vaginalis chromobox protein, putative 0.0079 0.037 0.0386
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0156 0.0141
Loa Loa (eye worm) hypothetical protein 0.0066 0.0288 0.0288
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0327 0.1976 0.1948
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0193 0.1111 0.1098
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0073 0.0044
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0176 0.1002 0.0971
Onchocerca volvulus Alhambra homolog 0.0194 0.1118 0.1111
Brugia malayi Thioredoxin reductase 0.0077 0.0362 0.0348
Echinococcus multilocularis expressed protein 0.004 0.0123 0.0108
Echinococcus granulosus lysine specific demethylase 6a 0.0077 0.036 0.0346
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0361 0.0493
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0196 0.113 0.1098
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0079 0.0375 0.0361
Echinococcus granulosus expressed protein 0.004 0.0123 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Schistosoma mansoni transcription factor btf3 0.0035 0.0086 0.0071
Leishmania major trypanothione reductase 0.0077 0.0362 0.0495
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.1579 0.1779
Onchocerca volvulus 0.0327 0.1976 0.2114
Echinococcus granulosus chromobox protein 1 0.013 0.0705 0.0691
Echinococcus multilocularis jumonji domain containing protein 0.027 0.1611 0.1598
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0073 0.0058
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0117 0.0124
Plasmodium falciparum phd finger protein, putative 0.0194 0.1118 0.164
Trichomonas vaginalis rotamase, putative 0.0039 0.0117 0.0094
Schistosoma mansoni glutaminase 0.0248 0.1468 0.1455
Schistosoma mansoni hypothetical protein 0.0308 0.1858 0.1846
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0117 0.0124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0193 0.1111 0.1098
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0038 0.0023
Loa Loa (eye worm) hypothetical protein 0.0194 0.1118 0.1118
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0197 0.0186
Schistosoma mansoni dihydrofolate reductase 0.1566 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0335 0.0335
Schistosoma mansoni protein phosphatase 2C 0.0077 0.036 0.0346
Brugia malayi jmjC domain containing protein 0.0077 0.036 0.0346
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0073 0.0044
Plasmodium falciparum JmjC domain-containing protein, putative 0.0077 0.036 0.0492
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0077 0.036 0.0492
Plasmodium vivax hypothetical protein, conserved 0.0194 0.1118 0.164
Brugia malayi Bromodomain containing protein 0.0091 0.0448 0.0434
Chlamydia trachomatis dihydrofolate reductase 0.1566 1 1
Brugia malayi jmjC domain containing protein 0.0077 0.036 0.0346
Leishmania major cathepsin L-like protease 0.0077 0.0361 0.0493
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0077 0.036 0.0492
Loa Loa (eye worm) glutaminase 2 0.0248 0.1468 0.1468
Schistosoma mansoni lipoxygenase 0.005 0.0187 0.0173
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0314 0.0299
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0172 0.0978 0.0964
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0327 0.1976 0.1934
Echinococcus granulosus chromobox protein 1 0.013 0.0705 0.0691
Loa Loa (eye worm) thymidylate synthase 0.0327 0.1976 0.1976
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0086 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0194 0.1116 0.1102
Onchocerca volvulus 0.0194 0.1116 0.1107
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0086 0.0084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.1579 0.1779
Echinococcus granulosus PHD finger protein rhinoceros 0.0194 0.1118 0.1105
Loa Loa (eye worm) heterochromatin protein 1 0.013 0.0705 0.0705
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0086 0.0077
Schistosoma mansoni chromobox protein 0.013 0.0705 0.0691
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.013 0.0701 0.0668
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0327 0.1976 0.1964
Schistosoma mansoni hypothetical protein 0.0031 0.0063 0.0048
Brugia malayi Pre-SET motif family protein 0.0172 0.0978 0.0964
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0194 0.1118 0.1105
Echinococcus granulosus histone lysine methyltransferase setb 0.0193 0.1111 0.1098
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0073 0.0058
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0117 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Brugia malayi AF-10 protein 0.0063 0.0273 0.0258
Brugia malayi jmjC domain containing protein 0.0689 0.4324 0.4316
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0361 0.0493
Trichomonas vaginalis set domain proteins, putative 0.1368 0.8715 1
Loa Loa (eye worm) hypothetical protein 0.0347 0.2109 0.2109
Brugia malayi Bromodomain containing protein 0.0197 0.1137 0.1124
Loa Loa (eye worm) glutathione reductase 0.0077 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.036
Schistosoma mansoni hypothetical protein 0.0025 0.0023 0.0008
Schistosoma mansoni jumonji domain containing protein 0.0077 0.036 0.0346
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1047 0.6639 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0015 0.0015
Plasmodium vivax thioredoxin reductase, putative 0.0077 0.0362 0.0495
Echinococcus granulosus jumonji domain containing protein 0.027 0.1611 0.1598
Plasmodium falciparum glutathione reductase 0.0077 0.0362 0.0495
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0407 0.0393
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1566 1 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0063 0.0273 0.036
Echinococcus multilocularis peregrin 0.0197 0.1137 0.1124
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0084 0.0407 0.0393
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0073 0.0044
Schistosoma mansoni phosphatidylserine receptor 0.0077 0.036 0.0346
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0023 0.0023
Plasmodium vivax SET domain protein, putative 0.0172 0.0978 0.1427
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0156 0.0156
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0073 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0084 0.0407 0.0393
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1566 1 1
Brugia malayi hypothetical protein 0.0155 0.0868 0.0854
Echinococcus granulosus JmjC domain containing protein 4 0.0077 0.036 0.0346
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0047 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1047 0.6639 1
Echinococcus granulosus thymidylate synthase 0.0327 0.1976 0.1964
Loa Loa (eye worm) hypothetical protein 0.0085 0.0415 0.0415
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0172 0.0978 0.0964
Echinococcus multilocularis chromobox protein 1 0.013 0.0705 0.0691
Trypanosoma brucei trypanothione reductase 0.0077 0.0362 0.0495
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5256 0.5249
Loa Loa (eye worm) inositol-1 0.0033 0.0073 0.0073
Brugia malayi chromobox protein homolog 3 0.0073 0.0335 0.032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.005 0.0187 0.0173
Schistosoma mansoni inositol monophosphatase 0.0033 0.0073 0.0059
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0123 0.0108
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0172 0.0978 0.1427
Brugia malayi PHD-finger family protein 0.003 0.0057 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0407 0.0393
Brugia malayi MH2 domain containing protein 0.0217 0.1268 0.1255
Loa Loa (eye worm) glutaminase 0.0248 0.1468 0.1468
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0073 0.0058
Echinococcus granulosus transcription factor btf3 0.0035 0.0086 0.0071
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0063 0.0273 0.036
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0035 0.002
Trypanosoma cruzi trypanothione reductase, putative 0.0077 0.0362 0.0495
Loa Loa (eye worm) jmjC domain-containing protein 0.0401 0.2456 0.2456
Schistosoma mansoni rotamase 0.004 0.0123 0.0108
Echinococcus granulosus phd:f box containing protein 0.0077 0.036 0.0346
Mycobacterium tuberculosis Hypothetical protein 0.0155 0.0868 0.0835
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.036
Echinococcus multilocularis thymidylate synthase 0.0327 0.1976 0.1964
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0176 0.1002 0.0971
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0073 0.0059
Echinococcus multilocularis chromobox protein 1 0.013 0.0705 0.0691
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5256 0.5249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0084 0.0407 0.0393
Plasmodium vivax glutathione reductase, putative 0.0077 0.0362 0.0495
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1202 0.764 0.764
Loa Loa (eye worm) transcription factor SMAD2 0.0217 0.1268 0.1268
Echinococcus multilocularis tumor protein p63 0.0324 0.1962 0.195
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.0063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0073 0.0058
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0689 0.4324 0.4316
Onchocerca volvulus 0.0057 0.0232 0.0074
Schistosoma mansoni hypothetical protein 0.0063 0.0273 0.0258
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0086 0.0077
Trichomonas vaginalis rotamase, putative 0.004 0.0123 0.0101
Echinococcus multilocularis lysine specific demethylase 6a 0.0077 0.036 0.0346
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0035 0.002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0073 0.0335 0.0193
Leishmania major hypothetical protein, conserved 0.0077 0.036 0.0492
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0079 0.0375 0.0361
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0077 0.036 0.0492
Mycobacterium ulcerans glutaminase 0.0248 0.1468 0.1438
Loa Loa (eye worm) jmjC domain-containing protein 0.0291 0.1745 0.1745
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1047 0.6639 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.005 0.0187 0.0173
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0196 0.113 0.1084
Brugia malayi SET domain containing protein 0.0028 0.0041 0.0026
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0265 0.1579 1
Echinococcus granulosus dihydrofolate reductase 0.1566 1 1
Brugia malayi PHD-finger family protein 0.0066 0.0288 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Toxoplasma gondii PHD-finger domain-containing protein 0.0194 0.1118 0.164
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.113 0.1098
Schistosoma mansoni inositol monophosphatase 0.0033 0.0073 0.0059
Trichomonas vaginalis chromobox protein, putative 0.013 0.0705 0.0772
Brugia malayi jmjC domain containing protein 0.0077 0.036 0.0346
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0265 0.1579 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.1579 0.1779
Mycobacterium tuberculosis Probable reductase 0.0176 0.1002 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0335 0.0345
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.013 0.0701 0.0653
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0317 0.0427
Mycobacterium tuberculosis Probable dehydrogenase 0.0176 0.1002 0.0971
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0084 0.0407 0.0393
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0143 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0868 0.0959
Giardia lamblia PHD finger protein 15 0.0194 0.1118 0.7018
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0086 0.0086
Echinococcus multilocularis jumonji domain containing 1A 0.0077 0.036 0.0346
Brugia malayi jmjC domain containing protein 0.0077 0.036 0.0346
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1566 1 1
Schistosoma mansoni hypothetical protein 0.0194 0.1118 0.1105
Echinococcus granulosus zinc finger protein 0.0024 0.0015 0.0000085623
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.036 0.036
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0073 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.036 0.036
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0035 0.002
Brugia malayi beta-NAC-like protein 0.0035 0.0086 0.0071
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0077 0.036 0.0492
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.037 0.0235
Brugia malayi jmjC domain containing protein 0.0291 0.1745 0.1732
Trichomonas vaginalis glutaminase, putative 0.0248 0.1468 0.1651
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0063 0.0273 0.036
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0196 0.113 0.1098
Loa Loa (eye worm) hypothetical protein 0.0193 0.1111 0.1111
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0273 0.036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0156 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0086 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0086 0.0059
Echinococcus granulosus lysine specific demethylase 5A 0.0291 0.1745 0.1732
Onchocerca volvulus 0.1368 0.8715 1
Echinococcus granulosus geminin 0.0308 0.1858 0.1846
Entamoeba histolytica hypothetical protein 0.0035 0.0086 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1047 0.6639 1
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0086 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.1579 0.1779
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0176 0.1002 0.0971
Brugia malayi glutaminase DH11.1 0.0248 0.1468 0.1455
Brugia malayi Bromodomain containing protein 0.0046 0.0161 0.0147
Brugia malayi Inositol-1 0.0033 0.0073 0.0059
Leishmania major cathepsin L-like protease 0.0077 0.0361 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0361 0.0493
Echinococcus multilocularis geminin 0.0308 0.1858 0.1846
Echinococcus multilocularis JmjC domain containing protein 4 0.0077 0.036 0.0346
Brugia malayi Pre-SET motif family protein 0.1202 0.764 0.7637
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1047 0.6639 1
Echinococcus multilocularis dihydrofolate reductase 0.1566 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0329 0.0314
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0029 0.0051 0.0016
Giardia lamblia Fructose-bisphosphate aldolase 0.0265 0.1579 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0117 0.0124
Brugia malayi Heterochromatin protein 1 0.013 0.0705 0.0691
Trichomonas vaginalis chromobox protein, putative 0.0079 0.037 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0123 0.0101
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0117 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0086 0.0059
Echinococcus multilocularis phd:f box containing protein 0.0077 0.036 0.0346
Schistosoma mansoni phd/f-box containing protein 0.0077 0.036 0.0346
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.036 0.036
Brugia malayi thymidylate synthase 0.0327 0.1976 0.1964
Echinococcus granulosus jumonji domain containing 1A 0.0077 0.036 0.0346
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0689 0.4324 0.4316
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0176 0.1002 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0197 0.0186
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0038 0.0023
Plasmodium vivax JmjC domain containing protein 0.0077 0.036 0.0492
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.1579 0.1779
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0329 0.0314
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0143 0.0128
Echinococcus multilocularis PHD finger protein rhinoceros 0.0194 0.1118 0.1105
Schistosoma mansoni chromobox protein 0.013 0.0705 0.0691
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0273 0.036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0291 0.1745 0.1732
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0166 0.0937 0.0923
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0038 0.0023
Trichomonas vaginalis chromobox protein, putative 0.013 0.0705 0.0772
Mycobacterium ulcerans thymidylate synthase 0.0327 0.1976 0.1948
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0254 0.0331
Echinococcus granulosus tumor protein p63 0.0324 0.1962 0.195
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0077 0.0362 0.0328
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0077 0.036 0.0492
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0063 0.0273 0.036
Schistosoma mansoni zinc finger protein 0.0024 0.0015 0.0000085623
Leishmania major basic transcription factor 3a, putative 0.0035 0.0086 0.0077
Loa Loa (eye worm) hypothetical protein 0.0057 0.0232 0.0232
Echinococcus multilocularis zinc finger protein 0.0024 0.0015 0.0000085623
Echinococcus granulosus thioredoxin glutathione reductase 0.0078 0.0365 0.0351
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0155 0.0868 0.126
Toxoplasma gondii thioredoxin reductase 0.0077 0.0362 0.0495
Schistosoma mansoni cellular tumor antigen P53 0.0047 0.0169 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0084 0.0407 0.0393
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0084 0.0407 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.1579 0.1779
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0077 0.036 0.0346
Loa Loa (eye worm) PHD-finger family protein 0.0194 0.1118 0.1118
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0035 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0217 0.1268 0.1268
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0073 0.0038
Loa Loa (eye worm) hypothetical protein 0.0052 0.0195 0.0195
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0176 0.1002 0.0971
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0063 0.0048

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 4.7755 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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