Detailed information for compound 1306594

Basic information

Technical information
  • TDR Targets ID: 1306594
  • Name: ZINC01033982
  • MW: 369.441 | Formula: C18H19N5O2S
  • H donors: 2 H acceptors: 5 LogP: 2.87 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C(C)C)CSc1nnc(n1c1cccnc1)O
  • InChi: 1S/C18H19N5O2S/c1-12(2)13-5-7-14(8-6-13)20-16(24)11-26-18-22-21-17(25)23(18)15-4-3-9-19-10-15/h3-10,12H,11H2,1-2H3,(H,20,24)(H,21,25)
  • InChiKey: AKQJQBHXWZDFFV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0028 0.0128 0.0335
Echinococcus multilocularis diphosphomevalonate decarboxylase 0.0083 0.102 0.1018
Schistosoma mansoni cyclin B3 0.0213 0.3105 0.4138
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0293 0.0258
Echinococcus granulosus protein kinase shaggy 0.0054 0.0553 0.0551
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0696 0.0926
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0901 0.1199
Schistosoma mansoni cell adhesion molecule 0.0021 0.0012 0.0013
Echinococcus granulosus contactin 0.0021 0.0012 0.001
Plasmodium falciparum protein kinase 5 0.0049 0.0469 0.3723
Leishmania major fucose kinase, putative 0.0083 0.102 0.0987
Loa Loa (eye worm) TK protein kinase 0.0131 0.1798 0.2494
Echinococcus multilocularis protein kinase c iota type 0.0035 0.0241 0.0239
Schistosoma mansoni g1/s-specific cyclin C 0.0023 0.0047 0.006
Schistosoma mansoni hypothetical protein 0.003 0.0163 0.0214
Entamoeba histolytica cyclin, putative 0.0094 0.12 0.1169
Echinococcus granulosus diphosphomevalonate decarboxylase 0.0083 0.102 0.1018
Trypanosoma brucei protein kinase, putative 0.0057 0.0603 0.0923
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.069 0.0689
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1351 0.2938
Brugia malayi serine/threonine-protein kinase 6 0.0063 0.0696 0.096
Schistosoma mansoni protein kinase 0.0082 0.1002 0.1333
Echinococcus multilocularis neuroglian 0.0035 0.0238 0.0236
Trichomonas vaginalis galactokinase, putative 0.0298 0.4485 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0469 0.0951
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0603 0.1253
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0063 0.069 0.0689
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0021 0.0012 0.001
Echinococcus multilocularis tyrosine kinase 0.0028 0.0128 0.0126
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0023 0.0047 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0292 0.0553
Echinococcus multilocularis tyrosine protein kinase 0.0272 0.4061 0.406
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0603 0.0923
Echinococcus granulosus Cyclin L1 0.0023 0.0047 0.0045
Trichomonas vaginalis cyclin B, putative 0.0147 0.205 0.4515
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.045 0.0416
Schistosoma mansoni serine/threonine protein kinase 0.0485 0.7502 1
Trypanosoma cruzi mitotic cyclin, putative 0.0023 0.0047 0.0011
Entamoeba histolytica protein kinase , putative 0.0063 0.0696 0.0663
Brugia malayi SH2 domain containing protein 0.0028 0.0128 0.0175
Brugia malayi Plexin repeat family protein 0.0028 0.0131 0.0178
Brugia malayi Protein kinase domain containing protein 0.0047 0.0445 0.0612
Brugia malayi plexin A 0.0036 0.0253 0.0346
Entamoeba histolytica hypothetical protein 0.0162 0.2284 0.2256
Echinococcus granulosus c-Jun N-terminal kinases 0.0248 0.3678 0.3676
Echinococcus multilocularis cyclin y 0.0023 0.0047 0.0045
Giardia lamblia Aurora kinase 0.0063 0.0696 0.2326
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0696 0.1463
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0901 0.0935
Giardia lamblia Kinase, STE STE20 0.0082 0.1002 0.3419
Mycobacterium ulcerans phosphomevalonate kinase 0.0196 0.2839 0.213
Schistosoma mansoni tyrosine kinase 0.0165 0.2338 0.3114
Entamoeba histolytica protein kinase, putative 0.0054 0.0553 0.0519
Loa Loa (eye worm) hypothetical protein 0.0253 0.3764 0.5223
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0082 0.1002 0.1382
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0123 0.1666 0.1665
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.045 0.0619
Echinococcus multilocularis cyclin B3 1 0.0094 0.12 0.1198
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.065 0.0896
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0021 0.0012 0.001
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0033 0.0206 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0292 0.0553
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0628 0.0626
Trypanosoma cruzi galactokinase, putative 0.0557 0.8661 0.8656
Echinococcus granulosus c src tyrosine kinase 0.0032 0.0191 0.0189
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.057 0.0789
Leishmania major homoserine kinase, putative 0.0196 0.2839 0.2814
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0077 0.0105
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0603 0.0601
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.1351 0.132
Trypanosoma brucei polo-like protein kinase 0.0104 0.1351 0.2067
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0054 0.0553 0.0519
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.045 0.0416
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0866 0.1151
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0026 0.0094 0.0093
Schistosoma mansoni tyrosine kinase 0.0146 0.204 0.2718
Echinococcus granulosus epidermal growth factor receptor 0.0165 0.2338 0.2336
Brugia malayi MAP kinase sur-1 0.0057 0.0603 0.0831
Echinococcus multilocularis tyrosine protein kinase HCK 0.0049 0.0477 0.0475
Echinococcus multilocularis nervana 2 0.0029 0.0148 0.0146
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.045 0.0416
Loa Loa (eye worm) cyclin domain-containing protein 0.0213 0.3105 0.4309
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0032 0.0191 0.0252
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0033 0.0206 0.1863
Echinococcus multilocularis cpg binding protein 0.0037 0.0271 0.0269
Plasmodium falciparum cyclin 1 0.0023 0.0047 0.0097
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.045 0.0416
Echinococcus multilocularis protein kinase shaggy 0.0054 0.0553 0.0551
Loa Loa (eye worm) TK/EGFR protein kinase 0.0238 0.352 0.4884
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0023 0.0047 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.014 0.021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0187 0.0257
Leishmania major mevalonate-diphosphate decarboxylase, putative 0.0083 0.102 0.0987
Trypanosoma cruzi fucose kinase, putative 0.0113 0.15 0.147
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0024 0.0069 0.0094
Schistosoma mansoni transcription factor LCR-F1 0.0162 0.2284 0.3043
Echinococcus granulosus MAM 0.003 0.0163 0.0161
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0054 0.0553 0.0551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.045 0.0908
Trichomonas vaginalis galactokinase, putative 0.0298 0.4485 1
Trichomonas vaginalis cyclin D, putative 0.0094 0.12 0.2598
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0282 0.4228 0.5867
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0143
Trichomonas vaginalis cyclins, putative 0.0094 0.12 0.2598
Trichomonas vaginalis cyclin D, putative 0.0094 0.12 0.2598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0292 0.0553
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.1351 0.1349
Trypanosoma brucei aurora B kinase 0.0063 0.0696 0.1066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.057 0.0758
Onchocerca volvulus 0.0028 0.0128 0.0335
Brugia malayi CXXC zinc finger family protein 0.0035 0.0239 0.0328
Brugia malayi Cyclin, N-terminal domain containing protein 0.0147 0.205 0.2831
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0696 0.0964
Brugia malayi Cyclin, N-terminal domain containing protein 0.0213 0.3105 0.4289
Loa Loa (eye worm) CYL-1 protein 0.0023 0.0047 0.0063
Schistosoma mansoni hypothetical protein 0.003 0.0163 0.0214
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0063 0.0696 0.7601
Mycobacterium ulcerans diphosphomevalonate decarboxylase 0.0083 0.102 0.013
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0469 0.0435
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1351 0.2938
Echinococcus granulosus tyrosine protein kinase shark 0.0254 0.3765 0.3763
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0026 0.0094 0.0123
Schistosoma mansoni cyclins 0.0094 0.12 0.1597
Leishmania major galactokinase-like protein 0.0641 1 1
Echinococcus granulosus protein kinase c iota type 0.0035 0.0241 0.0239
Entamoeba histolytica protein kinase, putative 0.0063 0.0696 0.0663
Schistosoma mansoni cell adhesion molecule 0.0021 0.0012 0.0013
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0101 0.0561
Echinococcus multilocularis cyclin G2 0.0023 0.0047 0.0045
Schistosoma mansoni Cyclin fold protein 0.0023 0.0047 0.006
Loa Loa (eye worm) hypothetical protein 0.022 0.3226 0.4476
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0553 0.0765
Entamoeba histolytica protein kinase, putative 0.0063 0.0696 0.0663
Brugia malayi Tyrosine-protein kinase abl-1 0.0032 0.0191 0.0261
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0028 0.0128 0.0126
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0028 0.0128 0.0126
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0063 0.0696 0.0663
Loa Loa (eye worm) hypothetical protein 0.003 0.0163 0.0223
Brugia malayi SH2 domain containing protein 0.0028 0.0128 0.0175
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0047 0.0063
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0603 0.0834
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0082 0.1002 0.0969
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0165 0.2338 0.2336
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0026 0.0105 0.0138
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0063 0.0696 0.0663
Echinococcus multilocularis cyclin G2 0.0023 0.0047 0.0045
Echinococcus multilocularis tyrosine protein kinase Blk 0.0059 0.0628 0.0626
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0445 0.0897
Loa Loa (eye worm) hypothetical protein 0.0147 0.205 0.2844
Brugia malayi Cyclin, N-terminal domain containing protein 0.0147 0.205 0.2831
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0026 0.0094 0.0128
Toxoplasma gondii cyclin 4, putative 0.0023 0.0047 0.0025
Brugia malayi Protein kinase domain containing protein 0.0028 0.0128 0.0175
Echinococcus granulosus tyrosine kinase 0.0059 0.0628 0.0626
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0469 0.0435
Echinococcus granulosus dual specificity mitogen activated protein 0.0082 0.1002 0.1
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0553 0.0519
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0063 0.069 0.0689
Loa Loa (eye worm) hypothetical protein 0.0031 0.0187 0.0257
Loa Loa (eye worm) TK/ABL protein kinase 0.0028 0.0128 0.0175
Leishmania major mitotic cyclin, putative 0.0023 0.0047 0.0011
Onchocerca volvulus 0.0028 0.0131 0.0345
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0603 0.0601
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0023 0.0047 0.006
Echinococcus multilocularis cyclin A3 4 0.0023 0.0047 0.0045
Echinococcus granulosus tyrosine kinase 0.0028 0.0128 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1351 0.2938
Echinococcus multilocularis dual specificity mitogen activated protein 0.0082 0.1002 0.1
Trichomonas vaginalis cyclins, putative 0.0147 0.205 0.4515
Entamoeba histolytica protein kinase, putative 0.0049 0.0477 0.0443
Trichomonas vaginalis cyclins, putative 0.0147 0.205 0.4515
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0082 0.1002 0.0969
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0248 0.3678 0.5103
Echinococcus granulosus tyrosine protein kinase ABL1 0.0028 0.0128 0.0126
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0603 0.1275
Loa Loa (eye worm) plexin A 0.0036 0.0253 0.0348
Trichomonas vaginalis galactokinase, putative 0.0298 0.4485 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0469 0.0467
Schistosoma mansoni tyrosine kinase 0.0032 0.0191 0.0252
Echinococcus granulosus cpg binding protein 0.0037 0.0271 0.0269
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0239 0.0329
Schistosoma mansoni tyrosine kinase 0.0238 0.352 0.469
Echinococcus multilocularis plexin a4 0.0036 0.0253 0.0251
Echinococcus granulosus nervana 2 0.0029 0.0148 0.0146
Entamoeba histolytica protein kinase 2, putative 0.0033 0.0206 0.0171
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0032 0.0191 0.0189
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.1351 0.1349
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0469 0.0951
Entamoeba histolytica cyclin family protein 0.0094 0.12 0.1169
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0028 0.0128 0.0093
Echinococcus granulosus roundabout 2 0.0021 0.0012 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0096 0.011
Toxoplasma gondii hypothetical protein 0.0023 0.0047 0.0025
Echinococcus granulosus cyclin 0.0023 0.0047 0.0045
Schistosoma mansoni tyrosine kinase 0.0123 0.1666 0.2219
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0901 0.1946
Loa Loa (eye worm) hypothetical protein 0.0053 0.0531 0.0734
Brugia malayi Protein kinase domain containing protein 0.0028 0.0128 0.0175
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.057 0.0568
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0047 0.0062
Brugia malayi Furin-like cysteine rich region family protein 0.0238 0.352 0.4861
Brugia malayi hypothetical protein 0.0023 0.0047 0.0062
Schistosoma mansoni kinase 0.0054 0.0555 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0136 0.02
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0553 0.1141
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0696 0.0964
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0023 0.0047 0.0025
Giardia lamblia Kinase, PLK 0.0104 0.1351 0.4669
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0033 0.0206 0.0204
Giardia lamblia Kinase, AGC PKA 0.0033 0.0206 0.057
Echinococcus granulosus cyclin G2 0.0023 0.0047 0.0045
Treponema pallidum galactokinase 0.0557 0.8661 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0213 0.3105 0.3104
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.045 0.0448
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0469 0.0623
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0241 0.0318
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0063
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1249
Schistosoma mansoni protein kinase 0.0022 0.0036 0.0045
Mycobacterium ulcerans galactokinase 0.0641 1 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0481 0.1387
Echinococcus multilocularis c src tyrosine kinase 0.0032 0.0191 0.0189
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0047 0.0062
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0026 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0034 0.0222 0.0306
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Entamoeba histolytica PH domain containing protein kinase, putative 0.0033 0.0206 0.0171
Trypanosoma cruzi cyclin 9, putative 0.0023 0.0047 0.0011
Echinococcus granulosus defective proboscis extension response 0.0026 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0063
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0063 0.0696 0.0695
Schistosoma mansoni tyrosine kinase 0.0244 0.3614 0.4816
Schistosoma mansoni nephrin 0.004 0.032 0.0424
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0023 0.0047 0.0072
Echinococcus multilocularis protein tyrosine kinase 0.0286 0.4288 0.4287
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0469 0.0951
Trypanosoma brucei protein kinase, putative 0.0022 0.0036 0.0055
Echinococcus granulosus cyclins 0.0094 0.12 0.1198
Loa Loa (eye worm) hypothetical protein 0.0042 0.0354 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0292 0.0553
Brugia malayi Cyclin C 0.0023 0.0047 0.0062
Echinococcus granulosus cyclin t1 0.0023 0.0047 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0047 0.0011
Schistosoma mansoni cpg binding protein 0.0037 0.0271 0.0359
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0469 0.0649
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.1351 0.5372
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.069 0.0689
Echinococcus granulosus fibroblast growth factor receptor 4 0.0123 0.1666 0.1665
Schistosoma mansoni cpg binding protein 0.0035 0.0239 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0095 0.0109
Schistosoma mansoni cyclin k 0.0023 0.0047 0.006
Echinococcus multilocularis cyclins 0.0094 0.12 0.1198
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0021 0.0012 0.0013
Echinococcus multilocularis 0.0067 0.0764 0.0762
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.045 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0253 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.045 0.0908
Schistosoma mansoni cyclin G 0.0023 0.0047 0.006
Entamoeba histolytica hypothetical protein 0.0162 0.2284 0.2256
Echinococcus granulosus Protein kinase C brain isozyme 0.0035 0.0241 0.0239
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0603 0.0569
Brugia malayi Protein kinase domain containing protein 0.0272 0.4061 0.561
Brugia malayi Immunoglobulin I-set domain containing protein 0.0131 0.1798 0.2483
Brugia malayi Probable ClpP-like protease 0.0076 0.0901 0.1243
Loa Loa (eye worm) TK/ALK protein kinase 0.0268 0.4006 0.5559
Brugia malayi intracellular kinase 0.0054 0.0553 0.0762
Schistosoma mansoni tyrosine kinase 0.0146 0.204 0.2718
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0083 0.102 0.0987
Chlamydia trachomatis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0083 0.102 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0021 0.0012 0.001
Brugia malayi protein-tyrosine kinase 0.0059 0.0628 0.0865
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Echinococcus granulosus tyrosine protein kinase Blk 0.0059 0.0628 0.0626
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0469 0.0467
Echinococcus granulosus cyclins 0.0094 0.12 0.1198
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0026 0.0094 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0136 0.02
Loa Loa (eye worm) TK/FAK protein kinase 0.0289 0.4339 0.6022
Echinococcus multilocularis roundabout 2 0.0021 0.0012 0.001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.045 0.0597
Trichomonas vaginalis STE family protein kinase 0.0082 0.1002 0.2151
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0469 0.0623
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0023 0.0047 0.0045
Plasmodium falciparum serine/threonine protein kinase, putative 0.0063 0.0696 0.5675
Trypanosoma cruzi fucose kinase, putative 0.0113 0.15 0.147
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0022 0.0036 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Schistosoma mansoni hypothetical protein 0.0041 0.0343 0.0455
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0063 0.069 0.0689
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.045 0.0448
Trypanosoma brucei mevalonate kinase, putative 0.0196 0.2839 0.4345
Onchocerca volvulus 0.0147 0.2044 0.8229
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0603 0.0601
Schistosoma mansoni nephrin 0.0021 0.0012 0.0013
Schistosoma mansoni tyrosine kinase 0.0063 0.069 0.0918
Echinococcus granulosus neuroglian 0.0021 0.0012 0.001
Schistosoma mansoni tyrosine kinase 0.0286 0.4288 0.5714
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.057 0.0568
Echinococcus granulosus cyclin y 0.0023 0.0047 0.0045
Trichomonas vaginalis cyclins, putative 0.0147 0.205 0.4515
Onchocerca volvulus 0.0028 0.0128 0.0335
Echinococcus granulosus cyclin B 0.0147 0.205 0.2049
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0063 0.069 0.0689
Brugia malayi mevalonate kinase family protein 0.0196 0.2839 0.3921
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0603 0.1253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.057 0.0568
Brugia malayi SRC-1 0.0063 0.069 0.0951
Brugia malayi Cyclin, N-terminal domain containing protein 0.0274 0.409 0.5649
Trichomonas vaginalis cyclin B, putative 0.0147 0.205 0.4515
Echinococcus granulosus tyrosine protein kinase 0.0272 0.4061 0.406
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0901 1
Entamoeba histolytica hypothetical protein 0.0162 0.2284 0.2256
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0553 0.1813
Echinococcus multilocularis cyclins 0.0094 0.12 0.1198
Schistosoma mansoni tyrosine kinase 0.0206 0.3004 0.4003
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0023 0.0047 0.0045
Entamoeba histolytica cyclin, putative 0.0147 0.205 0.2022
Entamoeba histolytica cyclin C, putative 0.0023 0.0047 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0343 0.0474
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0445 0.0897
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1351 0.132
Entamoeba histolytica cyclin family protein 0.0094 0.12 0.1169
Trichomonas vaginalis cyclin B, putative 0.0094 0.12 0.2598
Echinococcus multilocularis neuroglian 0.0021 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0354 0.0489
Echinococcus multilocularis cyclins 0.0094 0.12 0.1198
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0059 0.0628 0.0626
Echinococcus granulosus neuroglian 0.0035 0.0238 0.0236
Echinococcus granulosus insulin receptor 0.0206 0.3004 0.3003
Schistosoma mansoni protein kinase 0.0063 0.0696 0.0926
Schistosoma mansoni hypothetical protein 0.0023 0.0047 0.006
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0021 0.0012 0.001
Entamoeba histolytica cyclin, domain containing protein 0.0023 0.0047 0.0011
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0032 0.0191 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0241 0.0318
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0445 0.0897
Schistosoma mansoni tyrosine kinase 0.0063 0.069 0.0918
Giardia lamblia Cyclin A 0.0094 0.12 0.4129
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0033 0.0206 0.1465
Schistosoma mansoni protein kinase 0.0022 0.0036 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0445 0.0897
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0739 0.1581
Brugia malayi serine/threonine protein kinase 6 0.0063 0.0696 0.096
Trypanosoma brucei mevalonate-diphosphate decarboxylase 0.0083 0.102 0.156
Echinococcus granulosus cyclin k 0.0023 0.0047 0.0045
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0469 0.0435
Trypanosoma brucei rac serine-threonine kinase, putative 0.0047 0.0445 0.0681
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0469 0.0649
Schistosoma mansoni plexin 0.0028 0.0131 0.0172
Echinococcus granulosus twitchin 0.0038 0.0295 0.0294
Trichomonas vaginalis cyclin B3, putative 0.0094 0.12 0.2598
Echinococcus multilocularis N acetylgalactosamine kinase 0.0298 0.4485 0.4484
Schistosoma mansoni vav2 0.0026 0.0094 0.0123
Echinococcus granulosus cyclin y 0.0023 0.0047 0.0045
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0035 0.0241 0.0239
Echinococcus multilocularis cyclin 0.0023 0.0047 0.0045
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0187 0.0256
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0047 0.0062
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0029 0.0148 0.0146
Trypanosoma cruzi cyclin 6, putative 0.0147 0.205 0.2022
Loa Loa (eye worm) galactokinase 0.0298 0.4485 0.6224
Trypanosoma brucei cyclin 9 0.0023 0.0047 0.0072
Brugia malayi RhoGAP domain containing protein 0.0026 0.0094 0.0128
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.014 0.021
Toxoplasma gondii hypothetical protein 0.0072 0.0833 0.1793
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0054 0.0553 0.1163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0253 0.0463
Loa Loa (eye worm) hypothetical protein 0.0045 0.0411 0.0568
Schistosoma mansoni hypothetical protein 0.0162 0.2284 0.3043
Onchocerca volvulus 0.0147 0.205 0.8256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0337 0.0654
Echinococcus granulosus plexin a4 0.0036 0.0253 0.0251
Onchocerca volvulus 0.0083 0.102 0.4007
Mycobacterium leprae Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0196 0.2839 1
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.0641 1 1
Giardia lamblia GTOR 0.0048 0.045 0.1443
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0047 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.045 0.0908
Echinococcus granulosus serine threonine protein kinase nrc 0.0033 0.0206 0.0204
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0343 0.0472
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0553 0.1813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0197 0.0337
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0469 0.0467
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Mycobacterium tuberculosis Possible D-alpha-D-heptose-7-phosphate kinase HddA 0.0196 0.2839 0.2478
Schistosoma mansoni ephrin receptor 0.0024 0.006 0.0077
Onchocerca volvulus 0.0054 0.0553 0.2086
Schistosoma mansoni galactokinase 0.0298 0.4485 0.5977
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0553 0.1141
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0023 0.0047 0.0025
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Schistosoma mansoni tyrosine kinase 0.0206 0.3004 0.4003
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0481 0.0479
Brugia malayi Stress-activated protein kinase jnk-1 0.0248 0.3678 0.5079
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0175
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.065 0.09
Trichomonas vaginalis STE family protein kinase 0.0082 0.1002 0.2151
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0469 0.0435
Trypanosoma brucei cdc2-related kinase 3 0.0049 0.0469 0.0718
Trypanosoma cruzi mitotic cyclin, putative 0.0023 0.0047 0.0011
Echinococcus multilocularis Cyclin L1 0.0023 0.0047 0.0045
Entamoeba histolytica PH domain containing protein kinase, putative 0.0033 0.0206 0.0171
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0553 0.0519
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0047 0.0062
Echinococcus multilocularis rac serine:threonine kinase 0.0033 0.0206 0.0204
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0049 0.0469 0.0974
Echinococcus multilocularis nervana 2 0.0029 0.0148 0.0146
Echinococcus multilocularis activin receptor type 0.0022 0.0036 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0021 0.0012 0.0013
Brugia malayi hypothetical protein 0.003 0.0163 0.0222
Plasmodium vivax protein kinase Crk2 0.0049 0.0469 0.4941
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0696 0.0964
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0199 0.2883 0.4
Echinococcus multilocularis cyclins 0.0094 0.12 0.1198
Echinococcus multilocularis cyclin B 0.0147 0.205 0.2049
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0047 0.0097
Entamoeba histolytica hypothetical protein 0.0023 0.0047 0.0011
Echinococcus granulosus N acetylgalactosamine kinase 0.0298 0.4485 0.4484
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0033 0.0206 0.0171
Trypanosoma cruzi galactokinase-like protein, putative 0.0557 0.8661 0.8656
Loa Loa (eye worm) hypothetical protein 0.003 0.0163 0.0223
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0469 0.0435
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0021 0.0012 0.0013
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0469 0.1512
Echinococcus granulosus nervana 2 0.0029 0.0148 0.0146
Trypanosoma brucei protein kinase, putative 0.0054 0.0553 0.0847
Loa Loa (eye worm) TK/INSR protein kinase 0.0206 0.3004 0.4168
Echinococcus multilocularis cyclins 0.0094 0.12 0.1198
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0063 0.0696 0.0663
Echinococcus multilocularis G1:S specific cyclin D1 0.0023 0.0047 0.0045
Loa Loa (eye worm) AGC/AKT protein kinase 0.0047 0.0445 0.0615
Echinococcus multilocularis cyclin t1 0.0023 0.0047 0.0045
Echinococcus multilocularis cyclin y 0.0023 0.0047 0.0045
Leishmania major protein kinase, putative 0.0063 0.0696 0.0663
Mycobacterium leprae PROBABLE HOMOSERINE KINASE THRB 0.0083 0.102 0.3354
Entamoeba histolytica protein kinase, putative 0.0047 0.0445 0.0411
Echinococcus multilocularis Immunoglobulin 0.0026 0.0105 0.0103
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.045 0.0622
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.069 0.0689
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0023 0.0047 0.0063
Echinococcus granulosus activin receptor type 0.0022 0.0036 0.0034
Trypanosoma cruzi mevalonate kinase, putative 0.0196 0.2839 0.2814
Trypanosoma cruzi CYC2-like cyclin, putative 0.0147 0.205 0.2022
Entamoeba histolytica cyclin, domain containing protein 0.0023 0.0047 0.0011
Brugia malayi hypothetical protein 0.0028 0.0128 0.0175
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0083 0.102 0.0987
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0027 0.011 0.0108
Trichomonas vaginalis cyclin A, putative 0.0147 0.205 0.4515
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Brugia malayi hypothetical protein 0.0162 0.2284 0.3154
Mycobacterium tuberculosis Probable homoserine kinase ThrB 0.0083 0.102 0.0566
Echinococcus multilocularis epidermal growth factor receptor 0.0238 0.352 0.3518
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0077 0.0104
Brugia malayi Protein kinase domain containing protein 0.0094 0.12 0.1656
Trypanosoma brucei mitotic cyclin 6 0.0147 0.205 0.3138
Schistosoma mansoni serine/threonine-protein kinase 0.0033 0.0206 0.0272
Brugia malayi p70 ribosomal S6 kinase beta 0.0047 0.0445 0.0612
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0034 0.0222 0.022
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.069 0.0689
Treponema pallidum hypothetical protein 0.0196 0.2839 0.3199
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0146
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0901 0.09
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0196 0.2839 0.4345
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0049 0.0469 0.0435
Echinococcus granulosus N chimaerin 0.0026 0.0094 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0041 0.0052
Trypanosoma brucei mitotic cyclin 0.0023 0.0047 0.0072
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0553 0.0765
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0022 0.0036 0.0034
Loa Loa (eye worm) SRC-1 0.0063 0.069 0.0956
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0603 0.0569
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0082 0.1002 0.1533
Echinococcus granulosus cyclin A3 4 0.0023 0.0047 0.0045
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0054 0.0553 0.0735
Echinococcus granulosus Glutaredoxin protein 5 0.0029 0.0148 0.0146
Trypanosoma cruzi Protein kinase B 0.0033 0.0206 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.014 0.021
Echinococcus granulosus tyrosine protein kinase Src64B 0.0063 0.069 0.0689
Echinococcus granulosus tyrosine protein kinase Lyn 0.0066 0.0748 0.0747
Schistosoma mansoni cyclin G2 0.0023 0.0047 0.006
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0445 0.0897
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0123 0.1666 0.1665
Toxoplasma gondii hypothetical protein 0.0026 0.0101 0.0147
Brugia malayi Cyclin, N-terminal domain containing protein 0.0023 0.0047 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.057 0.0758
Echinococcus multilocularis roundabout 2 0.0047 0.0436 0.0435
Echinococcus granulosus raf serine:threonine protein kinase 0.0485 0.7502 0.7502
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0187 0.0256
Trichomonas vaginalis galactokinase, putative 0.0298 0.4485 1
Trichomonas vaginalis mevalonate kinase, putative 0.0083 0.102 0.2191
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0901 0.2923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0095 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1351 0.2938
Brugia malayi Protein kinase domain containing protein 0.0206 0.3004 0.4149
Leishmania major mitotic cyclin, putative 0.0023 0.0047 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0241 0.0318
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.045 0.0416
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0128 0.0175
Entamoeba histolytica hypothetical protein 0.0162 0.2284 0.2256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0096 0.011
Brugia malayi cyclin fold protein 1 variant b 0.0023 0.0047 0.0062
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.1351 0.1864
Trypanosoma brucei galactokinase-like protein, putative 0.0425 0.6535 1
Brugia malayi Protein kinase domain containing protein 0.0028 0.0128 0.0175
Brugia malayi Protein kinase domain containing protein 0.0049 0.0469 0.0646
Echinococcus multilocularis tyrosine protein kinase shark 0.0254 0.3765 0.3763
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0063 0.069 0.0689
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0293 0.0258
Plasmodium vivax glycogen synthase kinase 3, putative 0.0054 0.0553 0.5925
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0047 0.0063
Schistosoma mansoni tyrosine kinase 0.0034 0.0227 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0603 0.0801
Leishmania major mevalonate kinase, putative 0.0196 0.2839 0.2814
Brugia malayi Immunoglobulin I-set domain containing protein 0.0199 0.2883 0.3982
Echinococcus granulosus serine/threonine protein kinase 0.0033 0.0206 0.0204
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0023 0.0047 0.0045
Trichomonas vaginalis diphosphomevalonate decarboxylase, putative 0.0083 0.102 0.2191
Brugia malayi Protein kinase domain containing protein 0.0028 0.0128 0.0175
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0213 0.3105 0.3104
Loa Loa (eye worm) hypothetical protein 0.0031 0.0187 0.0257
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0481 0.0479
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0901 0.7435
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.033 0.0328
Echinococcus granulosus cyclin B3 1 0.0094 0.12 0.1198
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0123 0.1666 0.1665
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0036 0.0055
Trichomonas vaginalis cyclins, putative 0.0147 0.205 0.4515
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0033 0.0206 0.0171
Loa Loa (eye worm) TK/ROR protein kinase 0.0027 0.011 0.015
Schistosoma mansoni cpg binding protein 0.0037 0.0271 0.0359
Echinococcus multilocularis protein kinase c epsilon type 0.0035 0.0241 0.0239
Echinococcus multilocularis tyrosine protein kinase Srms 0.0059 0.0628 0.0626
Brugia malayi Protein kinase domain containing protein 0.0028 0.0128 0.0175
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0082 0.1002 0.1388
Echinococcus granulosus cyclins 0.0094 0.12 0.1198
Brugia malayi Protein kinase domain containing protein 0.0269 0.4007 0.5535
Onchocerca volvulus 0.0035 0.0245 0.0815
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.057 0.0785
Plasmodium falciparum glycogen synthase kinase 3 0.0054 0.0553 0.4445
Loa Loa (eye worm) TK protein kinase 0.0272 0.4061 0.5636
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.065 0.0896
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0603 0.1253
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0469 0.0467
Schistosoma mansoni cyclin l 0.0023 0.0047 0.006
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0029 0.0148 0.0146
Trichomonas vaginalis cyclin B, putative 0.0147 0.205 0.4515
Trichomonas vaginalis galactokinase, putative 0.0113 0.15 0.3274
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.3678 0.4901
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0696 0.0663
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.1351 0.132
Echinococcus multilocularis N chimaerin 0.0026 0.0094 0.0093
Giardia lamblia Diphosphomevalonate decarboxylase 0.0083 0.102 0.3483
Trypanosoma cruzi galactokinase, putative 0.0641 1 1
Toxoplasma gondii AGC kinase 0.0047 0.0445 0.092
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0696 0.1463
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0026 0.0105 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0095 0.0109
Echinococcus granulosus roundabout 2 0.0047 0.0436 0.0435
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.069 0.0689
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0469 0.0467
Loa Loa (eye worm) hypothetical protein 0.0196 0.2839 0.3939
Schistosoma mansoni diphosphomevalonate decarboxylase 0.0083 0.102 0.1357
Loa Loa (eye worm) raf kinase 0.0467 0.7205 1
Schistosoma mansoni tyrosine kinase 0.0165 0.2338 0.3114
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.033 0.0328
Schistosoma mansoni cyclin B 0.0147 0.205 0.2731
Schistosoma mansoni vesicular amine transporter 0.0026 0.0105 0.0138
Entamoeba histolytica tyrosin kinase, putative 0.0026 0.01 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0253 0.0463
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0534 0.1097
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0248 0.3678 0.3676
Trichomonas vaginalis cyclin B, putative 0.0147 0.205 0.4515
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.069 0.0689
Schistosoma mansoni cell adhesion molecule 0.0039 0.0304 0.0403
Leishmania major fucose kinase, putative 0.0083 0.102 0.0987
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0083 0.102 0.0987
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0028 0.0128 0.0126
Brugia malayi galactokinase family protein 0.0298 0.4485 0.6195
Toxoplasma gondii cyclin dependent kinase binding protein 0.0023 0.0047 0.0025
Trypanosoma brucei cyclin 3 0.0023 0.0047 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.057 0.0758
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0047 0.0063
Echinococcus multilocularis MAM 0.003 0.0163 0.0161
Plasmodium falciparum cyclin 0.0094 0.12 1
Trypanosoma cruzi homoserine kinase 0.0196 0.2839 0.2814
Schistosoma mansoni tyrosine kinase 0.0032 0.0191 0.0252
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0469 0.0467
Loa Loa (eye worm) hypothetical protein 0.0028 0.0131 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.102 0.2191
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.1351 0.1798
Echinococcus multilocularis Glutaredoxin protein 5 0.0029 0.0148 0.0146
Leishmania major phosphomevalonate kinase protein, putative 0.0196 0.2839 0.2814
Echinococcus granulosus Immunoglobulin 0.0026 0.0105 0.0103
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0603 0.0601
Trypanosoma brucei mevalonate diphosphate decarboxylase 0.0083 0.102 0.156
Toxoplasma gondii GHMP kinase, putative 0.0196 0.2839 0.6302
Loa Loa (eye worm) hypothetical protein 0.006 0.065 0.09
Echinococcus multilocularis Immunoglobulin 0.0026 0.0105 0.0103
Trichomonas vaginalis STE family protein kinase 0.0082 0.1002 0.2151
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.045 0.0689
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0469 0.0467
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0696 0.1463
Onchocerca volvulus Tyrosine kinase homolog 0.0173 0.2474 1
Echinococcus multilocularis insulin receptor 0.0206 0.3004 0.3003
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0534 0.1097
Schistosoma mansoni tyrosine kinase 0.0254 0.3765 0.5017
Echinococcus granulosus roundabout 2 0.0021 0.0012 0.001
Echinococcus multilocularis Mevalonate galactokinase 0.0196 0.2839 0.2838
Echinococcus granulosus tyrosine protein kinase Src42A 0.0063 0.069 0.0689
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0047 0.0063
Schistosoma mansoni serine/threonine-protein kinase 0.0033 0.0206 0.0272
Onchocerca volvulus 0.0028 0.0128 0.0335
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0063 0.069 0.0689
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0047 0.0445 0.0615
Brugia malayi cell division control protein 2 homolog 0.0049 0.0469 0.0646
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0603 0.0569
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0603 0.0569
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0054 0.0553 0.0551
Schistosoma mansoni tyrosine kinase 0.0028 0.0128 0.0168
Trypanosoma cruzi cyclin, putative 0.0147 0.205 0.2022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0096 0.011
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0211 0.3086 0.3085
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0603 0.1991
Echinococcus granulosus protein kinase c epsilon type 0.0035 0.0241 0.0239
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0063 0.069 0.0689
Echinococcus granulosus G1:S specific cyclin D1 0.0023 0.0047 0.0045
Loa Loa (eye worm) TK protein kinase 0.0049 0.0477 0.066
Brugia malayi hypothetical protein 0.0031 0.0187 0.0256
Mycobacterium ulcerans homoserine kinase 0.0196 0.2839 0.213
Echinococcus multilocularis cyclins 0.0094 0.12 0.1198
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1351 0.2938
Schistosoma mansoni mevalonate kinase 0.0196 0.2839 0.3783
Trypanosoma brucei homoserine kinase 0.0196 0.2839 0.4345
Onchocerca volvulus 0.0035 0.0239 0.0791
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0063 0.069 0.0689
Schistosoma mansoni neuroglian 0.0021 0.0012 0.0013
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0469 0.0467
Brugia malayi diphosphomevalonate decarboxylase family protein 0.0083 0.102 0.1406
Brugia malayi protein kinase C II. 0.0035 0.0241 0.033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.0143
Echinococcus granulosus cyclins 0.0094 0.12 0.1198
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0021 0.0012 0.001
Wolbachia endosymbiont of Brugia malayi 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0196 0.2839 1
Entamoeba histolytica galactokinase, putative 0.0641 1 1
Echinococcus granulosus epidermal growth factor receptor 0.0238 0.352 0.3518
Brugia malayi Raf kinase 0.0469 0.7239 1
Schistosoma mansoni cyclin d 0.0023 0.0047 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.12 0.2598
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0196 0.2839 0.213
Schistosoma mansoni hypothetical protein 0.0023 0.0047 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1351 0.2938
Echinococcus multilocularis raf serine:threonine protein kinase 0.0485 0.7502 0.7502
Entamoeba histolytica protein kinase, putative 0.0047 0.0445 0.0411
Loa Loa (eye worm) cyclin C 0.0023 0.0047 0.0063
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0035 0.0241 0.0331
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.1351 0.1873
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0298 0.4485 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0253 0.0488
Echinococcus granulosus cyclins 0.0023 0.0047 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0445 0.0897
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1351 0.2938
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0094 0.0128
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.045 0.0689
Loa Loa (eye worm) cyclin domain-containing protein 0.0023 0.0047 0.0063
Echinococcus multilocularis epidermal growth factor receptor 0.0165 0.2338 0.2336
Echinococcus multilocularis roundabout 2 0.0021 0.0012 0.001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0101 0.0632
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0147 0.205 0.2022
Brugia malayi hypothetical protein 0.0023 0.0047 0.0062
Trypanosoma cruzi homoserine kinase 0.0196 0.2839 0.2814
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0196 0.2839 0.213
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0211 0.3086 0.3085
Echinococcus granulosus aurora kinase A 0.0063 0.0696 0.0695
Echinococcus granulosus tyrosine protein kinase Srms 0.0028 0.0128 0.0126
Loa Loa (eye worm) hypothetical protein 0.003 0.0163 0.0223
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0469 0.0435
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0083 0.102 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0253 0.0463
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1351 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0253 0.0463
Echinococcus multilocularis galactokinase 0.0641 1 1
Echinococcus multilocularis cyclins 0.0094 0.12 0.1198
Schistosoma mansoni atypical protein kinase C 0.0035 0.0241 0.0318
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0603 0.1253
Echinococcus granulosus tyrosine protein kinase HCK 0.0049 0.0477 0.0475
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0027 0.011 0.0108
Echinococcus granulosus Mevalonate galactokinase 0.0196 0.2839 0.2838
Echinococcus multilocularis tyrosine protein kinase Abl 0.0032 0.0191 0.0189
Echinococcus multilocularis cyclin b3 0.0094 0.12 0.1198
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0063 0.0696 0.0695
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0049 0.0469 0.0435
Giardia lamblia Hypothetical protein 0.0094 0.12 0.4129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0292 0.0553
Loa Loa (eye worm) cyclin domain-containing protein 0.0274 0.409 0.5676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.018 0.0299
Giardia lamblia G2/mitotic-specific cyclin B 0.0147 0.205 0.7175
Echinococcus granulosus cyclin G2 0.0023 0.0047 0.0045
Schistosoma mansoni protein kinase 0.0022 0.0036 0.0045
Echinococcus granulosus cyclin b3 0.0094 0.12 0.1198
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0469 0.0649
Brugia malayi serine/threonine kinase 12 0.0063 0.0696 0.096
Brugia malayi Protein kinase domain containing protein 0.0289 0.4339 0.5994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0253 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0253 0.0463
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0696 0.1463
Trichomonas vaginalis galactokinase, putative 0.0083 0.102 0.2191
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0054 0.0553 0.0519
Giardia lamblia Mevalonate kinase 0.0196 0.2839 1
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0469 0.1512
Loa Loa (eye worm) hypothetical protein 0.0147 0.205 0.2844
Leishmania major cyclin 9, putative 0.0023 0.0047 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0445 0.0897
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0162 0.2284 0.2283
Onchocerca volvulus 0.0028 0.0128 0.0335
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.057 0.0568
Entamoeba histolytica protein kinase domain containing protein 0.0026 0.01 0.0064
Loa Loa (eye worm) hypothetical protein 0.0076 0.0903 0.1251
Toxoplasma gondii aurora kinase 0.0063 0.0696 0.1485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0096 0.011
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0026 0.0105 0.0138
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0162 0.2284 0.2283
Trypanosoma cruzi cyclin, putative 0.0147 0.205 0.2022
Entamoeba histolytica protein kinase, putative 0.0047 0.0445 0.0411
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0293 0.0449
Echinococcus granulosus protein tyrosine kinase 0.0286 0.4288 0.4287
Onchocerca volvulus 0.0028 0.0128 0.0335
Trichomonas vaginalis cyclins, putative 0.0076 0.0897 0.1916
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0603 0.0569
Brugia malayi Immunoglobulin I-set domain containing protein 0.0021 0.0012 0.0013
Trypanosoma cruzi galactokinase, putative 0.0641 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.102 0.1413
Leishmania major cyclin 0.0147 0.205 0.2022
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0603 0.0569
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0901 0.1946
Onchocerca volvulus 0.003 0.0163 0.0477
Trypanosoma brucei cdc2-related kinase 1 0.0049 0.0469 0.0718
Schistosoma mansoni tyrosine kinase 0.0146 0.204 0.2718
Echinococcus multilocularis cyclin k 0.0023 0.0047 0.0045
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0901 0.09
Trypanosoma cruzi aurora B kinase, putative 0.0063 0.0696 0.0663
Echinococcus granulosus cyclins 0.0094 0.12 0.1198
Brugia malayi Immunoglobulin I-set domain containing protein 0.0021 0.0012 0.0013
Loa Loa (eye worm) TK protein kinase 0.0059 0.0628 0.0869
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0044 0.0068
Echinococcus multilocularis aurora kinase A 0.0063 0.0696 0.0695

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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