Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0294 | 0.0294 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0086 | 0.1396 | 0.1124 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0086 | 0.1396 | 0.1396 |
Echinococcus multilocularis | acetylcholinesterase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0511 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0086 | 0.1396 | 0.1124 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0306 | 0.0306 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0086 | 0.1396 | 0.1124 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0086 | 0.1396 | 0.1124 |
Onchocerca volvulus | 0.0086 | 0.1396 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0086 | 0.1396 | 0.1124 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0306 | 0.0306 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0086 | 0.1396 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0511 | 1 | 1 |
Onchocerca volvulus | 0.0086 | 0.1396 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0086 | 0.1396 | 0.1124 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0086 | 0.1396 | 0.1124 |
Schistosoma mansoni | acetylcholinesterase | 0.0086 | 0.1396 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1396 | 0.1396 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0086 | 0.1396 | 0.1124 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1396 | 0.1396 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1396 | 0.1396 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1396 | 0.1396 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0086 | 0.1396 | 0.1124 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0086 | 0.1396 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0086 | 0.1396 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0086 | 0.1396 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0086 | 0.1396 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0086 | 0.1396 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1396 | 0.1396 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0511 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0086 | 0.1396 | 0.1396 |
Brugia malayi | Carboxylesterase family protein | 0.0086 | 0.1396 | 0.1396 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1396 | 0.1396 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0086 | 0.1396 | 0.1124 |
Onchocerca volvulus | 0.0086 | 0.1396 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0086 | 0.1396 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0511 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0086 | 0.1396 | 0.1396 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0306 | 0.0306 |
Onchocerca volvulus | 0.0086 | 0.1396 | 1 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0306 | 0.0306 |
Echinococcus granulosus | acetylcholinesterase | 0.0511 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0306 | 0.0306 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0086 | 0.1396 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0086 | 0.1396 | 0.1124 |
Onchocerca volvulus | 0.0086 | 0.1396 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0086 | 0.1396 | 0.1396 |
Brugia malayi | Carboxylesterase family protein | 0.0086 | 0.1396 | 0.1396 |
Loa Loa (eye worm) | carboxylesterase | 0.0086 | 0.1396 | 0.1396 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1396 | 0.1396 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0086 | 0.1396 | 0.1124 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.