Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei gambiense | ATP-dependent phosphofructokinase,6-phospho-1-fructokinase | No references | |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | 6-phosphofructokinase | 0.0131 | 0.661 | 0.6472 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 0.661 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2831 | 0.2538 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0131 | 0.661 | 0.6472 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0131 | 0.661 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0131 | 0.661 | 0.5271 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0 | 0.5 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0035 | 0 | 0.5 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0131 | 0.661 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2831 | 0.3922 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0131 | 0.661 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2831 | 0.2538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2831 | 0.3922 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1707 | 0.1368 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0131 | 0.661 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 0.661 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2831 | 0.2538 |
Brugia malayi | phosphofructokinase | 0.0131 | 0.661 | 0.6472 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0131 | 0.661 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0131 | 0.661 | 0.6472 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0131 | 0.661 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2831 | 0.2538 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 0.661 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2831 | 0.2538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2831 | 0.3922 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | phosphofructokinase | 0.0131 | 0.661 | 0.6472 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1707 | 0.1368 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 0.661 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2831 | 0.3922 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7501 | 0.7399 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7501 | 0.7399 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7501 | 0.7399 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0131 | 0.661 | 0.6472 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 0.661 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0131 | 0.661 | 0.5271 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0131 | 0.661 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 0.661 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2831 | 0.2538 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1707 | 0.1368 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0131 | 0.661 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2831 | 0.3922 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1707 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0131 | 0.661 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 0.661 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 7.9433 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.9955 uM | PUBCHEM_BIOASSAY: Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: Inhibitors of T. brucei phosphofructokinase: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.