Detailed information for compound 1307285

Basic information

Technical information
  • TDR Targets ID: 1307285
  • Name: N-(1,1-dioxothiolan-3-yl)-2-methoxy-N-(thioph en-2-ylmethyl)benzamide
  • MW: 365.467 | Formula: C17H19NO4S2
  • H donors: 0 H acceptors: 3 LogP: 2.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C(=O)N(C1CCS(=O)(=O)C1)Cc1cccs1
  • InChi: 1S/C17H19NO4S2/c1-22-16-7-3-2-6-15(16)17(19)18(11-14-5-4-9-23-14)13-8-10-24(20,21)12-13/h2-7,9,13H,8,10-12H2,1H3
  • InChiKey: CYOANWHNXWSEMQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(1,1-dioxothiolan-3-yl)-2-methoxy-N-(2-thienylmethyl)benzamide
  • N-(1,1-dioxo-3-thiolanyl)-2-methoxy-N-(2-thienylmethyl)benzamide
  • N-(1,1-diketothiolan-3-yl)-2-methoxy-N-(2-thienylmethyl)benzamide
  • IFLab1_006435
  • MLS000039398
  • SMR000034973
  • STOCK4S-01554

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Macaaca fascicularis T-complex protein 1 subunit beta Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) Get druggable targets OG5_127730 All targets in OG5_127730
Trichomonas vaginalis chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium knowlesi T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum TCP-1/cpn60 family chaperonin, putative Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei gambiense T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum GroEL-like chaperone (ATpase); T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium berghei T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium yoelii putative T-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii t-complex protein beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica T-complex protein 1 beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K09494 T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium vivax T-complex protein 1 subunit beta, putative Get druggable targets OG5_127730 All targets in OG5_127730
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans similar to S. cerevisiae CCT2 (YIL142W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania mexicana T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb Get druggable targets OG5_127730 All targets in OG5_127730
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis chaperonin-60kD, ch60, putative Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta Get druggable targets OG5_127730 All targets in OG5_127730
Giardia lamblia TCP-1 chaperonin subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi T-complex protein 1, beta subunit Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani T-complex protein 1, beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Babesia bovis T-complex protein beta subunit, putative Get druggable targets OG5_127730 All targets in OG5_127730
Plasmodium falciparum T-complex protein 1 subunit beta Get druggable targets OG5_127730 All targets in OG5_127730
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) T-complex protein 1 Get druggable targets OG5_127730 All targets in OG5_127730
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis TCP-1/cpn60 chaperonin-related protein Get druggable targets OG5_127730 All targets in OG5_127730
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 547 aa 32.7 %
Plasmodium knowlesi T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 544 aa 23.5 %
Theileria parva T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 580 aa 33.3 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Leishmania donovani T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Echinococcus multilocularis T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.7 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Trypanosoma brucei gambiense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Brugia malayi T-complex protein 1, zeta subunit T-complex protein 1 subunit beta   535 aa 517 aa 27.7 %
Leishmania braziliensis T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Plasmodium yoelii T-complex protein 1 T-complex protein 1 subunit beta   535 aa 534 aa 26.2 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 533 aa 33.8 %
Brugia malayi T-complex protein 1, eta subunit T-complex protein 1 subunit beta   535 aa 534 aa 33.1 %
Leishmania mexicana chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.6 %
Cryptosporidium hominis CCTepsilon subunit T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Cryptosporidium parvum t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Giardia lamblia TCP-1 chaperonin subunit epsilon T-complex protein 1 subunit beta   535 aa 535 aa 31.6 %
Trypanosoma cruzi chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 528 aa 33.0 %
Neospora caninum Thermosome subunit, related T-complex protein 1 subunit beta   535 aa 527 aa 31.3 %
Leishmania infantum chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Babesia bovis t-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Cryptosporidium hominis T-complex protein 1 T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Candida albicans similar to S. cerevisiae CCT7 (YJL111W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 523 aa 35.4 %
Plasmodium vivax heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 540 aa 21.9 %
Trypanosoma brucei gambiense T-complex protein 1, eta subunit, putative,t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.4 %
Theileria parva T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 522 aa 32.4 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Leishmania major T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 28.8 %
Schistosoma mansoni T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-complex protein 1 subunit beta   535 aa 552 aa 33.5 %
Leishmania infantum T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.4 %
Plasmodium knowlesi T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.1 %
Entamoeba histolytica chaperonin containing TCP-1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 508 aa 32.7 %
Schistosoma mansoni chaperonin containing t-complex protein 1 delta subunit tcpd T-complex protein 1 subunit beta   535 aa 530 aa 32.8 %
Toxoplasma gondii T complex chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.0 %
Plasmodium knowlesi T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 526 aa 31.0 %
Trypanosoma brucei T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 524 aa 34.4 %
Trypanosoma brucei gambiense T-complex protein 1, theta subunit, putative,CCT-theta, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Toxoplasma gondii T-complex protein 1, epsilon subunit (TCP-1-epsilon), putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Drosophila melanogaster T-complex Chaperonin 5 T-complex protein 1 subunit beta   535 aa 506 aa 34.6 %
Schistosoma mansoni chaperonin containing t-complex protein 1 gamma subunit tcpg T-complex protein 1 subunit beta   535 aa 552 aa 29.7 %
Giardia lamblia TCP-1 chaperonin subunit gamma T-complex protein 1 subunit beta   535 aa 561 aa 29.8 %
Giardia lamblia TCP-1 chaperonin subunit eta T-complex protein 1 subunit beta   535 aa 543 aa 32.0 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 575 aa 23.1 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 29.8 %
Leishmania infantum chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.7 %
Echinococcus multilocularis chaperonin containing TCP1, subunit 5 (epsilon) T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Theileria parva T-complex protein 1, alpha subunit , putative T-complex protein 1 subunit beta   535 aa 527 aa 34.9 %
Brugia malayi T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 502 aa 26.3 %
Trypanosoma brucei gambiense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Trypanosoma brucei gambiense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Leishmania major chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Echinococcus granulosus T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Cryptosporidium parvum putative t-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 545 aa 28.3 %
Plasmodium vivax T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 539 aa 22.4 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 533 aa 28.3 %
Theileria parva T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 27.1 %
Trypanosoma cruzi chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 33.5 %
Dictyostelium discoideum chaperonin containing TCP1 epsilon subunit T-complex protein 1 subunit beta   535 aa 520 aa 34.4 %
Entamoeba histolytica T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 31.6 %
Babesia bovis T-complex protein 1 epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 32.6 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Plasmodium knowlesi T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 33.7 %
Mycobacterium tuberculosis 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (a T-complex protein 1 subunit beta   535 aa 565 aa 23.5 %
Dictyostelium discoideum chaperonin containing TCP1 eta subunit T-complex protein 1 subunit beta   535 aa 528 aa 33.5 %
Plasmodium berghei T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Trypanosoma congolense T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 28.6 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 545 aa 29.7 %
Entamoeba histolytica hypothetical protein T-complex protein 1 subunit beta   535 aa 516 aa 22.5 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Trypanosoma congolense T-complex protein 1, alpha subunit, putative T-complex protein 1 subunit beta   535 aa 525 aa 34.1 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 604 aa 22.9 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 550 aa 32.9 %
Plasmodium falciparum T-complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 546 aa 34.4 %
Brugia malayi T-complex protein 1, gamma subunit T-complex protein 1 subunit beta   535 aa 529 aa 28.4 %
Trypanosoma brucei T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 543 aa 29.8 %
Echinococcus multilocularis T complex protein 1 subunit alpha T-complex protein 1 subunit beta   535 aa 539 aa 37.1 %
Entamoeba histolytica chaperonin-containing TCP-1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 550 aa 23.5 %
Entamoeba histolytica T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 536 aa 29.9 %
Brugia malayi T-complex protein 1, epsilon subunit T-complex protein 1 subunit beta   535 aa 513 aa 31.4 %
Leishmania braziliensis chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Plasmodium yoelii chaperonin, 60 kDa T-complex protein 1 subunit beta   535 aa 530 aa 34.9 %
Leishmania major T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.5 %
Trypanosoma congolense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 32.2 %
Trypanosoma brucei T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 528 aa 20.8 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Giardia lamblia TCP-1 chaperonin subunit alpha T-complex protein 1 subunit beta   535 aa 528 aa 32.6 %
Plasmodium vivax T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.5 %
Toxoplasma gondii T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.8 %
Plasmodium falciparum T-complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 542 aa 34.9 %
Candida albicans similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 541 aa 27.4 %
Plasmodium yoelii putative chaperonin T-complex protein 1 subunit beta   535 aa 497 aa 22.7 %
Echinococcus multilocularis t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Cryptosporidium parvum T complex chaperonin T-complex protein 1 subunit beta   535 aa 525 aa 33.1 %
Trichomonas vaginalis rubisco subunit binding-protein alpha subunit, ruba, putative T-complex protein 1 subunit beta   535 aa 580 aa 23.3 %
Toxoplasma gondii T-complex protein 1 delta subunit T-complex protein 1 subunit beta   535 aa 521 aa 31.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni chaperonin containing t-complex protein 1 zeta subunit tcpz T-complex protein 1 subunit beta   535 aa 544 aa 26.3 %
Trypanosoma cruzi T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 509 aa 29.5 %
Schistosoma japonicum ko:K09498 T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 552 aa 25.7 %
Loa Loa (eye worm) CCT-5 protein T-complex protein 1 subunit beta   535 aa 521 aa 31.3 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 516 aa 26.2 %
Plasmodium yoelii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 523 aa 30.0 %
Schistosoma japonicum ko:K09496 T-complex protein 1 subunit delta, putative T-complex protein 1 subunit beta   535 aa 533 aa 32.1 %
Leishmania mexicana chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.3 %
Loa Loa (eye worm) T-complex protein 1 T-complex protein 1 subunit beta   535 aa 550 aa 32.0 %
Dictyostelium discoideum hypothetical protein T-complex protein 1 subunit beta   535 aa 549 aa 20.6 %
Leishmania major T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.3 %
Leishmania mexicana T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.6 %
Leishmania major T-complex protein 1, theta subunit, putative,chaperonin, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.8 %
Echinococcus multilocularis T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Trypanosoma brucei gambiense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 548 aa 26.3 %
Plasmodium vivax T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 538 aa 27.3 %
Schistosoma japonicum ko:K09493 T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 585 aa 31.5 %
Leishmania donovani chaperonin containing t-complex protein, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.8 %
Candida albicans similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 548 aa 32.8 %
Neospora caninum GL18351, related T-complex protein 1 subunit beta   535 aa 530 aa 26.2 %
Trypanosoma cruzi T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Plasmodium berghei T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 523 aa 30.2 %
Trypanosoma cruzi T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 29.7 %
Neospora caninum hypothetical protein T-complex protein 1 subunit beta   535 aa 531 aa 29.0 %
Leishmania infantum T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Plasmodium falciparum T-complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 522 aa 29.9 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 542 aa 27.7 %
Babesia bovis TCP-1/cpn60 chaperonin family protein T-complex protein 1 subunit beta   535 aa 538 aa 30.5 %
Candida albicans similar to S. cerevisiae CCT5 (YJR064W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 524 aa 34.2 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 546 aa 33.7 %
Plasmodium berghei T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 539 aa 34.1 %
Leishmania infantum T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.0 %
Echinococcus granulosus t complex protein 1 subunit gamma T-complex protein 1 subunit beta   535 aa 556 aa 30.6 %
Cryptosporidium parvum putative T complex chaperonin T-complex protein 1 subunit beta   535 aa 546 aa 25.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Leishmania braziliensis T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Entamoeba histolytica T-complex protein 1 theta subunit, putative T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Candida albicans similar to S. cerevisiae CCT8 (YJL008C) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 497 aa 27.2 %
Onchocerca volvulus Integrator complex subunit 3 homolog T-complex protein 1 subunit beta   535 aa 534 aa 35.8 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 561 aa 27.1 %
Plasmodium knowlesi T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 530 aa 34.7 %
Toxoplasma gondii CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 531 aa 29.2 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Trypanosoma congolense T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 521 aa 29.6 %
Trichomonas vaginalis chaperonin, putative T-complex protein 1 subunit beta   535 aa 561 aa 23.0 %
Toxoplasma gondii TCP-1 chaperonin, putative T-complex protein 1 subunit beta   535 aa 531 aa 26.9 %
Trypanosoma brucei T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 535 aa 29.7 %
Schistosoma japonicum ko:K09497 T-complex protein 1 subunit epsilon, putative T-complex protein 1 subunit beta   535 aa 505 aa 33.5 %
Entamoeba histolytica chaperonin containing TCP-1 delta subunit, putative T-complex protein 1 subunit beta   535 aa 531 aa 30.7 %
Schistosoma japonicum ko:K09499 T-complex protein 1 subunit eta, putative T-complex protein 1 subunit beta   535 aa 536 aa 34.0 %
Giardia lamblia TCP-1 chaperonin subunit theta T-complex protein 1 subunit beta   535 aa 563 aa 25.2 %
Echinococcus multilocularis T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 27.1 %
Trypanosoma brucei T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 510 aa 29.4 %
Loa Loa (eye worm) T-complex protein 1 theta subunit T-complex protein 1 subunit beta   535 aa 514 aa 26.5 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, eta subunit, tcph, putative T-complex protein 1 subunit beta   535 aa 549 aa 35.7 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, gamma subunit, tcpg, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Candida albicans similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol T-complex protein 1 subunit beta   535 aa 546 aa 31.0 %
Echinococcus granulosus T complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 517 aa 27.1 %
Cryptosporidium hominis chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.9 %
Theileria parva chaperonin 60 kDa, putative T-complex protein 1 subunit beta   535 aa 544 aa 26.1 %
Neospora caninum TCP-1/cpn60 family chaperonin, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.4 %
Plasmodium falciparum T-complex protein 1 subunit theta T-complex protein 1 subunit beta   535 aa 516 aa 23.1 %
Babesia bovis T-complex protein 1 zeta subunit T-complex protein 1 subunit beta   535 aa 532 aa 26.7 %
Trypanosoma congolense t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.9 %
Plasmodium falciparum T-complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 539 aa 23.4 %
Leishmania infantum chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 579 aa 23.1 %
Drosophila melanogaster CG8351 gene product from transcript CG8351-RA T-complex protein 1 subunit beta   535 aa 527 aa 32.3 %
Cryptosporidium hominis CCT chaperonin gamma subunit T-complex protein 1 subunit beta   535 aa 536 aa 28.4 %
Schistosoma mansoni chaperonin containing t-complex protein 1 theta subunit tcpq T-complex protein 1 subunit beta   535 aa 515 aa 27.2 %
Plasmodium yoelii T-complex protein 1 epsilon subunit T-complex protein 1 subunit beta   535 aa 508 aa 32.9 %
Leishmania mexicana T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 35.1 %
Echinococcus granulosus chaperonin containing TCP1 subunit 5 epsilon T-complex protein 1 subunit beta   535 aa 513 aa 33.1 %
Plasmodium berghei T-complex protein 1 subunit theta, putative T-complex protein 1 subunit beta   535 aa 526 aa 25.7 %
Dictyostelium discoideum chaperonin containing TCP1 theta subunit T-complex protein 1 subunit beta   535 aa 501 aa 27.1 %
Leishmania donovani T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Babesia bovis HSP60 fold T-complex protein 1, putative T-complex protein 1 subunit beta   535 aa 497 aa 28.0 %
Leishmania donovani chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.5 %
Echinococcus granulosus T complex protein 1 subunit eta T-complex protein 1 subunit beta   535 aa 535 aa 34.0 %
Onchocerca volvulus T-complex protein 1 subunit beta   535 aa 511 aa 26.2 %
Trypanosoma congolense T-complex protein 1, zeta subunit, putative T-complex protein 1 subunit beta   535 aa 549 aa 26.0 %
Brugia malayi T-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 534 aa 35.6 %
Trypanosoma cruzi chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 547 aa 26.0 %
Leishmania mexicana chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 538 aa 26.8 %
Leishmania donovani T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.8 %
Cryptosporidium parvum TCP-1/cpn60 chaperonin family, T-complex protein subunit 7 (eta) T-complex protein 1 subunit beta   535 aa 527 aa 36.2 %
Leishmania major chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.1 %
Leishmania braziliensis chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 542 aa 26.2 %
Cryptosporidium hominis t-complex protein 1, alpha subunit T-complex protein 1 subunit beta   535 aa 544 aa 33.1 %
Leishmania major chaperonin TCP20, putative T-complex protein 1 subunit beta   535 aa 543 aa 26.3 %
Echinococcus granulosus T complex protein 1 subunit zeta T-complex protein 1 subunit beta   535 aa 544 aa 26.5 %
Leishmania donovani chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Cryptosporidium parvum conserved probable chaperonin containing TCP-1 delta subunit T-complex protein 1 subunit beta   535 aa 534 aa 30.7 %
Plasmodium vivax T-complex protein 1 subunit gamma, putative T-complex protein 1 subunit beta   535 aa 529 aa 31.2 %
Babesia bovis heat shock protein 60, putative T-complex protein 1 subunit beta   535 aa 530 aa 22.3 %
Schistosoma mansoni chaperonin containing t-complex protein 1 epsilon subunit tcpe T-complex protein 1 subunit beta   535 aa 505 aa 33.9 %
Plasmodium berghei T-complex protein 1 subunit zeta, putative T-complex protein 1 subunit beta   535 aa 537 aa 23.5 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative T-complex protein 1 subunit beta   535 aa 517 aa 30.4 %
Toxoplasma gondii T-complex protein 1 eta subunit T-complex protein 1 subunit beta   535 aa 546 aa 33.9 %
Leishmania infantum T-complex protein 1, eta subunit, putative T-complex protein 1 subunit beta   535 aa 519 aa 34.7 %
Giardia lamblia TCP-1 chaperonin subunit zeta T-complex protein 1 subunit beta   535 aa 516 aa 24.8 %
Leishmania braziliensis T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 29.1 %
Schistosoma mansoni chaperonin containing t-complex protein 1 eta subunit tcph T-complex protein 1 subunit beta   535 aa 536 aa 32.8 %
Dictyostelium discoideum chaperonin containing TCP1 zeta subunit T-complex protein 1 subunit beta   535 aa 523 aa 26.6 %
Trichomonas vaginalis chaperonin-60kD, ch60, putative T-complex protein 1 subunit beta   535 aa 538 aa 33.6 %
Trichomonas vaginalis chaperonin containing t-complex protein 1, beta subunit, tcpb, putative T-complex protein 1 subunit beta   535 aa 541 aa 35.5 %
Plasmodium vivax T-complex protein 1 subunit alpha, putative T-complex protein 1 subunit beta   535 aa 540 aa 34.1 %
Leishmania donovani T-complex protein 1, theta subunit, putative T-complex protein 1 subunit beta   535 aa 507 aa 28.2 %
Leishmania mexicana T-complex protein 1, delta subunit, putative T-complex protein 1 subunit beta   535 aa 528 aa 29.2 %
Leishmania braziliensis T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 526 aa 30.0 %
Trypanosoma congolense T-complex protein 1, gamma subunit, putative T-complex protein 1 subunit beta   535 aa 540 aa 29.4 %
Trypanosoma brucei t- complex protein 1 (eta subunit), putative T-complex protein 1 subunit beta   535 aa 518 aa 34.6 %
Trypanosoma brucei T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Trypanosoma brucei gambiense T-complex protein 1, epsilon subunit, putative T-complex protein 1 subunit beta   535 aa 534 aa 31.8 %
Dictyostelium discoideum chaperonin containing TCP1 alpha subunit T-complex protein 1 subunit beta   535 aa 535 aa 33.3 %
Leishmania braziliensis chaperonin alpha subunit, putative T-complex protein 1 subunit beta   535 aa 529 aa 33.5 %
Trypanosoma cruzi chaperonin/T-complex protein 1 gamma subunit, putative T-complex protein 1 subunit beta   535 aa 530 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.182 0.6361
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.182 0.6361
Trypanosoma brucei glucosidase, putative 0.0044 0.182 0.6361
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0356 0.1231
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.1049 0.1049
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.2775 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0029 0.1049 0.1049
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.182 0.6361
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 1 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0356 0.0783
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.2775 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0356 0.0783
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.182 0.6361
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.182 0.6361
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0029 0.1049 0.5383
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0356 0.0783
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.182 0.6361
Onchocerca volvulus 0.0114 0.5568 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.00000000023342 0.00000000084108
Schistosoma mansoni alpha glucosidase 0.0044 0.182 0.2132
Plasmodium falciparum T-complex protein 1 subunit beta 0.0029 0.1049 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0729 0.2203
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.1049 0.1229
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0029 0.1049 0.3424
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.2775 0.2775
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.182 0.182
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0356 0.0783
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0468 0.0548
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0356 0.0783
Giardia lamblia TCP-1 chaperonin subunit beta 0.0029 0.1049 0.3781
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.182 0.6361
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0729 0.0729
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.182 0.6361
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.2775 0.3251
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0356 0.0783
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.182 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2775 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.2775 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0356 0.0783
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.2775 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.182 0.6361
Trichomonas vaginalis chaperonin, putative 0.0029 0.1049 0.3424
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2775 1
Echinococcus granulosus bloom syndrome protein 0.0023 0.0729 0.0729
Loa Loa (eye worm) RecQ helicase 0.0023 0.0729 0.0729
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.1049 0.1229
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.182 0.6361
Loa Loa (eye worm) T-complex protein 1 0.0029 0.1049 0.1049
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0729 0.0729
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0317 0.1142
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.2775 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.2775 0.2775
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.182 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.182 0.6361
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2775 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.2775 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.182 0.6361
Schistosoma mansoni alpha-glucosidase 0.0169 0.8536 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.182 0.182
Brugia malayi MAP kinase sur-1 0.0062 0.2775 0.2775
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0029 0.1049 0.3424
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0029 0.1049 0.1049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0356 0.0356
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0356 0.0783
Brugia malayi T-complex protein 1, beta subunit 0.0029 0.1049 0.1049
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.2775 0.2775
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0356 0.0356
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0029 0.1049 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.182 0.182
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0356 0.0783
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0356 0.0783
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.182 0.182
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.2775 0.2775
Loa Loa (eye worm) hypothetical protein 0.0117 0.5737 0.5737
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0578 0.5511
Trypanosoma brucei protein kinase, putative 0.0062 0.2775 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2775 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.2775 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.2775 0.2775
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0029 0.1049 0.3424
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.2775 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.8536 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0729 0.2203
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.182 0.6559
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0356 0.0783
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0356 0.0783
Leishmania major T-complex protein 1, beta subunit, putative 0.0029 0.1049 0.3424
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0029 0.1049 0.1229
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 1 1
Toxoplasma gondii t-complex protein beta subunit 0.0029 0.1049 0.3781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.2775 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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