Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | G protein-coupled receptor 55 | Starlite/ChEMBL | No references |
Homo sapiens | galactosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0033 | 0.0971 | 0.0968 |
Brugia malayi | Melibiase family protein | 0.0082 | 0.4177 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0082 | 0.4177 | 0.4175 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0082 | 0.4177 | 0.4175 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3037 | 0.3034 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0124 | 0.6824 | 0.6482 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3037 | 0.3034 |
Echinococcus multilocularis | geminin | 0.0173 | 1 | 1 |
Toxoplasma gondii | melibiase subfamily protein | 0.0124 | 0.6824 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0971 | 0.2325 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0124 | 0.6824 | 0.6822 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3037 | 0.727 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0971 | 0.2325 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0124 | 0.6824 | 0.6822 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0124 | 0.6824 | 0.6822 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0124 | 0.6824 | 0.6822 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0971 | 0.0968 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0124 | 0.6824 | 0.6482 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0124 | 0.6824 | 0.6482 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0971 | 0.2325 |
Onchocerca volvulus | 0.0033 | 0.0971 | 0.5 | |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0082 | 0.4177 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3037 | 0.727 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0971 | 0.2325 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3037 | 0.727 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3037 | 0.3034 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3037 | 0.727 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0971 | 0.2325 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.3037 | 0.2288 |
Brugia malayi | RNA binding protein | 0.0065 | 0.3037 | 0.727 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.3037 | 0.2288 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3037 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4177 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.0971 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3037 | 0.727 |
Schistosoma mansoni | lamin | 0.0033 | 0.0971 | 0.0968 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3037 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0933 | 0.2233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.583621 uM | PUBCHEM_BIOASSAY: Image-Based HTS for Selective Antagonists for GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2026, AID2809, AID2814, AID2815, AID2820, AID2822, AID2835, AID2836, AID485277, AID485278, AID485282, AID485283, AID485285, AID485286, AID485287, AID488947] | ChEMBL. | No reference |
Potency (functional) | = 0.0032 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.