Detailed information for compound 130731

Basic information

Technical information
  • TDR Targets ID: 130731
  • Name: 1-(4-chlorophenyl)-3-(4-propylphenyl)sulfonyl urea
  • MW: 352.836 | Formula: C16H17ClN2O3S
  • H donors: 2 H acceptors: 3 LogP: 4.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1ccc(cc1)S(=O)(=O)NC(=O)Nc1ccc(cc1)Cl
  • InChi: 1S/C16H17ClN2O3S/c1-2-3-12-4-10-15(11-5-12)23(21,22)19-16(20)18-14-8-6-13(17)7-9-14/h4-11H,2-3H2,1H3,(H2,18,19,20)
  • InChiKey: DKAGPAWGOVXQMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-chlorophenyl)-3-(4-propylphenyl)sulfonyl-urea
  • 3-(4-chlorophenyl)-1-(4-propylphenyl)sulfonylurea
  • 3-(4-chlorophenyl)-1-(4-propylphenyl)sulfonyl-urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0035 0.0531 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0185 0.0185
Schistosoma mansoni survival motor neuron protein 0.0049 0.0863 0.0933
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0089 0.0053
Onchocerca volvulus 0.0027 0.0363 0.0097
Echinococcus multilocularis cathepsin L 0.0018 0.0146 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0185
Brugia malayi hypothetical protein 0.0241 0.5255 0.5255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Brugia malayi cathepsin L-like precursor 0.0023 0.0269 0.0269
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0185 0.0185
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0406 0.0406
Echinococcus granulosus lamin 0.0027 0.0363 0.0351
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0146 0.053
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0531 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0531 0.0269
Loa Loa (eye worm) cysteine protease 0.0035 0.0531 0.0531
Onchocerca volvulus 0.0049 0.0863 0.0611
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0531 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.2759 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0269 0.0249
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0269 0.0249
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.0089 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0185
Loa Loa (eye worm) glutamate receptor 2 0.0015 0.0089 0.0089
Leishmania major cathepsin L-like protease 0.0132 0.2759 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1155 0.121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0185 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0185 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Onchocerca volvulus 0.0035 0.0531 0.0269
Entamoeba histolytica hypothetical protein 0.002 0.0185 0.101
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0089 0.0053
Trypanosoma cruzi cruzipain precursor, putative 0.0132 0.2759 1
Echinococcus granulosus cathepsin l1 0.0023 0.0269 0.0249
Schistosoma mansoni glutamate receptor NMDA 0.0103 0.2096 0.2264
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0185 0.0158
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0185 0.0158
Schistosoma mansoni regulator of G protein signaling 0.002 0.0185 0.02
Echinococcus granulosus glutamate receptor 2 0.0023 0.0269 0.0249
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0146 0.0146
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0057 0.1041 0.1087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0363 0.0363
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0039
Echinococcus granulosus glutamate receptor NMDA 0.008 0.1565 0.1655
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0185 0.0158
Echinococcus multilocularis cpg binding protein 0.0031 0.0444 0.0439
Loa Loa (eye worm) hypothetical protein 0.0027 0.0351 0.0351
Echinococcus multilocularis neutral amino acid transporter A 0.0128 0.2679 0.2864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0269 0.3182
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.0531 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0185 0.0158
Echinococcus granulosus sodium:dicarboxylate symporter 0.0128 0.2679 0.2864
Plasmodium vivax unspecified product 0.0018 0.0146 0.2757
Brugia malayi PXA domain containing protein 0.002 0.0185 0.0185
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.9256 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0128 0.2679 0.2864
Echinococcus granulosus nmda type glutamate receptor 0.0134 0.2815 0.3011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0146 0.0158
Schistosoma mansoni lozenge 0.0056 0.1025 0.1108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1155 0.2535
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.5255 0.5659
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0185 0.02
Plasmodium vivax vivapain-3 0.0018 0.0146 0.2757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0363 0.0363
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0531 0.0533
Echinococcus multilocularis glutamate receptor NMDA 0.008 0.1565 0.1655
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0128 0.2679 0.2864
Onchocerca volvulus 0.0035 0.0531 0.0269
Loa Loa (eye worm) ctsf protein 0.0035 0.0531 0.0531
Leishmania major cathepsin L-like protease 0.0132 0.2759 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.5255 0.5255
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0185 0.0185
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0089 0.0053
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.2759 1
Schistosoma mansoni lamin 0.0027 0.0363 0.0392
Onchocerca volvulus 0.0035 0.0531 0.0269
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0269 0.0269
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0128 0.2679 0.5
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0128 0.2679 0.2864
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0146 0.053
Echinococcus multilocularis musashi 0.0027 0.0363 0.0351
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0185 0.0158
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0057 0.1041 0.1125
Plasmodium vivax vivapain-2 0.0035 0.0531 1
Loa Loa (eye worm) RGS-3 protein 0.002 0.0185 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0146 0.0146
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0269 0.0249
Echinococcus granulosus excitatory amino acid transporter 2 0.0128 0.2679 0.2864
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0185 0.101
Echinococcus multilocularis Protein lozenge 0.0056 0.1025 0.107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0185 0.0158
Schistosoma mansoni regulator of G protein signaling 0.002 0.0185 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1155 0.1247
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0269 0.0249
Loa Loa (eye worm) excitatory amino acid transporter 0.0128 0.2679 0.2679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Echinococcus granulosus Excitatory amino acid transporter 0.0128 0.2679 0.2864
Loa Loa (eye worm) hypothetical protein 0.0023 0.0269 0.0269
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0531 0.0573
Trypanosoma cruzi major cysteine proteinase, putative 0.0104 0.2112 0.7656
Echinococcus granulosus expressed protein 0.038 0.8447 0.9122
Loa Loa (eye worm) hypothetical protein 0.0023 0.0269 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0531 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0269 0.0269
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0185 0.101
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0185 0.0185
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0269 0.0249
Brugia malayi follicle stimulating hormone receptor 0.0235 0.5128 0.5128
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Onchocerca volvulus 0.0035 0.0531 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0055 0.0988 0.1029
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0185 0.0158
Schistosoma mansoni cpg binding protein 0.0031 0.0444 0.048
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0531 0.0269
Echinococcus granulosus nmda type glutamate receptor 0.0088 0.1745 0.185
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0185 0.0158
Echinococcus multilocularis expressed protein 0.038 0.8447 0.9122
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0531 1
Schistosoma mansoni hypothetical protein 0.0049 0.0863 0.0933
Loa Loa (eye worm) runx1 0.0056 0.1025 0.1025
Onchocerca volvulus 0.0448 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1155 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1155 0.1248
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0185 0.0185
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.0089 0.0089
Brugia malayi Cathepsin L-like precursor 0.0035 0.0531 0.0531
Brugia malayi CXXC zinc finger family protein 0.0029 0.0406 0.0406
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0146 0.0116
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0531 1
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0185 0.0185
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0185 0.0158
Echinococcus granulosus cysteine protease 0.0018 0.0146 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0269 0.3182
Brugia malayi Cathepsin L-like precursor 0.0035 0.0531 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Schistosoma mansoni hypothetical protein 0.0415 0.9256 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0057 0.1041 0.1125
Brugia malayi Cathepsin L-like precursor 0.0035 0.0531 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0185 0.0158
Leishmania major cathepsin L-like protease 0.0132 0.2759 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0128 0.2679 0.2864
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.5128 0.5128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1155 1
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0096
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0073 0.0073
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0185 0.02
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0089 0.0053
Echinococcus multilocularis neutral amino acid transporter A 0.0128 0.2679 0.2864
Echinococcus granulosus excitatory amino acid transporter 2 0.0128 0.2679 0.2864
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0269 0.0249
Brugia malayi Cathepsin L-like precursor 0.0023 0.0269 0.0269
Loa Loa (eye worm) fibroinase 0.0035 0.0531 0.0531
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0531 0.0573
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0057 0.1041 0.1087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Echinococcus multilocularis NMDA receptor 0.0015 0.0089 0.0053
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0128 0.2679 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0185 0.0158
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0531 0.0533
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0185 0.101
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0185 0.101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0185 0.02
Echinococcus granulosus glutamate NMDA receptor subunit 0.0015 0.0089 0.0053
Echinococcus granulosus axis inhibition protein axin 0.002 0.0185 0.0158
Chlamydia trachomatis neutral amino acid transporter 0.0057 0.1041 0.1981
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0089 0.0053
Loa Loa (eye worm) hypothetical protein 0.0023 0.0269 0.0269
Schistosoma mansoni lamin 0.0027 0.0363 0.0392
Echinococcus multilocularis cysteine protease 0.0035 0.0531 0.0533
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1004 0.7586
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0531 0.0269
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0531 0.0531
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0863 0.0863
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0185 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0146 0.0158
Chlamydia trachomatis glutamate symporter 0.0128 0.2679 1
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0089 0.0096
Echinococcus granulosus excitatory amino acid transporter 3 0.0128 0.2679 0.2864
Echinococcus multilocularis neutral amino acid transporter A 0.0128 0.2679 0.2864
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1155 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0185 0.0158
Brugia malayi hypothetical protein 0.002 0.0185 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0185 0.101
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0185 0.02
Echinococcus multilocularis nmda type glutamate receptor 0.0134 0.2815 0.3011
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0015 0.0089 0.0053
Brugia malayi intermediate filament protein 0.0027 0.0363 0.0363
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0531 0.1924
Echinococcus granulosus neutral amino acid transporter A 0.0128 0.2679 0.2864
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0531 0.0533
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0089 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Plasmodium vivax vivapain-1 0.0018 0.0146 0.2757
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0269 0.029
Echinococcus multilocularis excitatory amino acid transporter 3 0.0128 0.2679 0.2864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.012 0.2497 0.905
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0185 0.0158
Plasmodium vivax vivapain-2 0.0035 0.0531 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0185 0.101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.2759 1
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0146 0.053
Echinococcus multilocularis nmda type glutamate receptor 0.0088 0.1745 0.185
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0531 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.2759 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0531 0.0531
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0023 0.0269 0.0249
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0185 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0185
Echinococcus multilocularis cysteine protease 0.0035 0.0531 0.0533
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0185
Onchocerca volvulus 0.0027 0.0363 0.0097
Echinococcus granulosus intermediate filament protein 0.0027 0.0363 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0023 0.0269 0.0249
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0185 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0185
Echinococcus multilocularis excitatory amino acid transporter 2 0.0128 0.2679 0.2864
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1155 1
Echinococcus multilocularis lamin dm0 0.0027 0.0363 0.0351
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0531 0.0531
Schistosoma mansoni regulator of G protein signaling 0.002 0.0185 0.02
Brugia malayi hypothetical protein 0.002 0.0185 0.0185
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.0531 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0185 0.101
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0089 0.0053
Schistosoma mansoni regulator of G protein signaling 0.002 0.0185 0.02
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0096
Echinococcus granulosus lamin dm0 0.0027 0.0363 0.0351
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0531 1
Echinococcus granulosus cathepsin L 0.0018 0.0146 0.0116
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0146 0.0158
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.5255 0.5659
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0531 0.0531
Brugia malayi Cathepsin L-like precursor 0.0035 0.0531 0.0531
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0096
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.0531 1
Onchocerca volvulus 0.0035 0.0531 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Treponema pallidum glutamate transporter 0.0057 0.1041 1
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0089 0.0053
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0185 0.0185
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1155 0.28
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0089 0.0096
Loa Loa (eye worm) hypothetical protein 0.0448 1 1
Treponema pallidum glutamate/aspartate transporter 0.0057 0.1041 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0185 0.0185
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0089 0.0053
Echinococcus multilocularis lamin 0.0027 0.0363 0.0351
Echinococcus multilocularis excitatory amino acid transporter 2 0.0128 0.2679 0.2864
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0185 0.0158
Schistosoma mansoni regulator of G protein signaling 0.002 0.0185 0.02
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0128 0.2679 0.2894
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0146 0.053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Brugia malayi Cathepsin L-like precursor 0.0035 0.0531 0.0531
Schistosoma mansoni axis inhibition protein axin 0.002 0.0185 0.02
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1155 0.1247
Echinococcus granulosus cathepsin l1 0.0035 0.0531 0.0533
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0185 0.0158
Echinococcus granulosus dnaJ subfamily B 0.0415 0.9256 1
Entamoeba histolytica hypothetical protein 0.002 0.0185 0.101
Onchocerca volvulus 0.0035 0.0531 0.0269
Brugia malayi PXA domain containing protein 0.002 0.0185 0.0185
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0128 0.2679 0.2477
Echinococcus granulosus cpg binding protein 0.0031 0.0444 0.0439
Loa Loa (eye worm) hypothetical protein 0.0448 1 1
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0185 0.0185
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1155 0.121
Echinococcus granulosus neutral amino acid transporter 0.0128 0.2679 0.2864
Brugia malayi Excitatory amino acid transporter 0.0128 0.2679 0.2679
Onchocerca volvulus 0.0035 0.0531 0.0269
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0363 0.0363
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0269 0.3182
Schistosoma mansoni cpg binding protein 0.0029 0.0406 0.0439
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0096
Brugia malayi Cathepsin L-like precursor 0.0035 0.0531 0.0531
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0363 0.0392
Loa Loa (eye worm) glutamate receptor 1 0.0015 0.0089 0.0089
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0146 0.053
Onchocerca volvulus 0.0029 0.0406 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0531 1
Schistosoma mansoni axis inhibition protein axin 0.002 0.0185 0.02
Loa Loa (eye worm) hypothetical protein 0.0027 0.0363 0.0363
Echinococcus multilocularis glutamate receptor 2 0.0023 0.0269 0.0249
Schistosoma mansoni cpg binding protein 0.0031 0.0444 0.048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0531 1
Entamoeba histolytica hypothetical protein 0.002 0.0185 0.101
Echinococcus granulosus neutral amino acid transporter A 0.0128 0.2679 0.2864
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0185 0.0158
Echinococcus granulosus Excitatory amino acid transporter 0.0128 0.2679 0.2864
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0185 0.0158

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 13.8 ug ml-1 Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 h to 50% of control growth ChEMBL. 2391684
IC50 (functional) = 13.8 ug ml-1 Concentration required to inhibit growth of CCRF-CEM cells in culture for 72 h to 50% of control growth ChEMBL. 2391684
Inhibition (functional) = 79 % Antitumor activity in vivo against the 6C3HED lymphosarcoma, dosed for 10 days at 300 mg/kg ChEMBL. 2391684

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 2391684

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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