Detailed information for compound 130754

Basic information

Technical information
  • TDR Targets ID: 130754
  • Name: 8-methyl-3-(2H-tetrazol-5-yl)quinazolin-4-one
  • MW: 228.21 | Formula: C10H8N6O
  • H donors: 1 H acceptors: 4 LogP: 0.7 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc2c1ncn(c2=O)c1n[nH]nn1
  • InChi: 1S/C10H8N6O/c1-6-3-2-4-7-8(6)11-5-16(9(7)17)10-12-14-15-13-10/h2-5H,1H3,(H,12,13,14,15)
  • InChiKey: WHANUZVJGJCMAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-methyl-3-(2H-tetrazol-5-yl)-4-quinazolinone
  • 8-methyl-3-(2H-1,2,3,4-tetrazol-5-yl)quinazolin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0047 0.004 0.0058
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0061 0.008 0.0107
Leishmania major hypothetical protein, conserved 0.0524 0.1478 0.7752
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0051 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.035 0.0514
Loa Loa (eye worm) hypothetical protein 0.0047 0.004 0.0058
Leishmania major cathepsin L-like protease 0.0195 0.0486 0.2364
Onchocerca volvulus 0.0259 0.068 0.4598
Brugia malayi beta-lactamase family protein 0.0524 0.1478 0.2173
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0061 0.008 0.0315
Mycobacterium leprae Probable lipase LipE 0.0524 0.1478 0.2131
Brugia malayi Thioredoxin reductase 0.0661 0.1892 0.2781
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.008 0.0156
Echinococcus multilocularis GPCR, family 2 0.0047 0.004 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0093 0.0137
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.006 0.0013
Mycobacterium ulcerans monoxygenase 0.0061 0.008 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.008 0.0156
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0061 0.008 0.0117
Schistosoma mansoni tar DNA-binding protein 0.046 0.1284 0.1888
Schistosoma mansoni apoferritin-2 0.0046 0.0036 0.0053
Brugia malayi MH2 domain containing protein 0.0112 0.0234 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Schistosoma mansoni hypothetical protein 0.0103 0.0206 0.0303
Mycobacterium tuberculosis Probable esterase LipL 0.0524 0.1478 0.1447
Echinococcus granulosus thioredoxin glutathione reductase 0.0661 0.1893 0.2783
Entamoeba histolytica hypothetical protein 0.0875 0.2539 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0061 0.008 0.0541
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0524 0.1478 0.2131
Brugia malayi MH1 domain containing protein 0.0112 0.0234 0.0345
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0168 0.0404 0.0594
Mycobacterium tuberculosis Conserved protein 0.0524 0.1478 0.1447
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0061 0.008 0.0065
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0125 0.0274 0.0403
Onchocerca volvulus 0.0051 0.0051 0.0346
Brugia malayi Cathepsin L-like precursor 0.0051 0.0051 0.0075
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0229 0.0588 0.2916
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0524 0.1478 0.2173
Trypanosoma cruzi NADH dehydrogenase, putative 0.0061 0.008 0.0156
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0229 0.0588 0.0816
Brugia malayi beta-lactamase 0.0524 0.1478 0.2173
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0061 0.008 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1508 0.4448 0.652
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0061 0.008 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0524 0.1478 0.1447
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0875 0.2539 0.3726
Schistosoma mansoni smad 0.0112 0.0234 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Trypanosoma cruzi major cysteine proteinase, putative 0.0154 0.036 0.1678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Brugia malayi Probable ClpP-like protease 0.2287 0.6802 1
Trypanosoma brucei hypothetical protein, conserved 0.0524 0.1478 0.7741
Onchocerca volvulus 0.0313 0.0841 0.5694
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0061 0.008 0.0315
Echinococcus multilocularis mothers against decapentaplegic 6 0.005 0.0047 0.006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0129 0.018
Entamoeba histolytica cysteine protease, putative 0.0051 0.0051 0.0202
Brugia malayi hypothetical protein 0.0054 0.006 0.0088
Loa Loa (eye worm) hypothetical protein 0.0524 0.1478 0.2173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.2287 0.6802 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0051 0.0075
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0102 0.0204 0.029
Echinococcus multilocularis musashi 0.0259 0.068 0.099
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0788 0.2276 0.331
Brugia malayi MH1 domain containing protein 0.0062 0.0083 0.0123
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0229 0.0588 0.2916
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Echinococcus granulosus lamin 0.0259 0.068 0.0999
Loa Loa (eye worm) MH2 domain-containing protein 0.0112 0.0234 0.0345
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0061 0.008 0.0541
Trichomonas vaginalis mercuric reductase, putative 0.0229 0.0588 0.3977
Mycobacterium ulcerans hypothetical protein 0.0061 0.008 0.0065
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0061 0.008 0.0065
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0061 0.008 0.0107
Echinococcus granulosus smad 0.0112 0.0234 0.0345
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2287 0.6802 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Echinococcus multilocularis beta LACTamase domain containing family member 0.0524 0.1478 0.2165
Echinococcus granulosus Smad4 0.0112 0.0234 0.0345
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0061 0.008 0.0156
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.006 0.0013
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0061 0.008 0.0541
Onchocerca volvulus 0.0524 0.1478 1
Onchocerca volvulus 0.0517 0.1458 0.9868
Loa Loa (eye worm) hypothetical protein 0.0051 0.0051 0.0075
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0051 0.0202
Mycobacterium tuberculosis Probable reductase 0.1508 0.4448 0.4428
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0061 0.008 0.0156
Loa Loa (eye worm) hypothetical protein 0.012 0.026 0.0382
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0051 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0524 0.1478 1
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0061 0.008 0.0044
Loa Loa (eye worm) hypothetical protein 0.0524 0.1478 0.2173
Leishmania major hypothetical protein, conserved 0.0061 0.008 0.0156
Brugia malayi Pre-SET motif family protein 0.0455 0.1269 0.1865
Giardia lamblia NADH oxidase lateral transfer candidate 0.0229 0.0588 1
Treponema pallidum oxidoreductase 0.0061 0.008 0.0065
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1508 0.4448 0.4428
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0112 0.0234 0.0345
Brugia malayi MH2 domain containing protein 0.005 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.0204 0.03
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.035 0.0514
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0229 0.0588 0.2916
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.1499 0.4423 0.4403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Echinococcus granulosus beta LACTamase domain containing family member 0.0524 0.1478 0.2173
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0229 0.0588 0.0855
Loa Loa (eye worm) nuclear factor I 0.0062 0.0083 0.0123
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0061 0.008 0.011
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0043 0.0052
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0229 0.0588 0.2916
Brugia malayi mothers against decapentaplegic homolog 3 0.005 0.0047 0.007
Trypanosoma cruzi trypanothione reductase, putative 0.0229 0.0588 0.2916
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.2287 0.6802 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0061 0.008 0.0065
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0043 0.0063
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0061 0.008 0.0315
Loa Loa (eye worm) hypothetical protein 0.0524 0.1478 0.2173
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0051 0.0346
Loa Loa (eye worm) hypothetical protein 0.015 0.035 0.0514
Loa Loa (eye worm) RNA binding protein 0.046 0.1284 0.1888
Brugia malayi beta-lactamase family protein 0.0524 0.1478 0.2173
Loa Loa (eye worm) hypothetical protein 0.0092 0.0173 0.0254
Plasmodium vivax glutathione reductase, putative 0.0661 0.1892 0.2726
Mycobacterium ulcerans beta-lactamase 0.0524 0.1478 0.2131
Brugia malayi Cathepsin L-like precursor 0.0051 0.0051 0.0075
Mycobacterium tuberculosis Probable lipase LipD 0.0524 0.1478 0.1447
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0229 0.0588 0.0795
Onchocerca volvulus 0.0051 0.0051 0.0346
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0524 0.1478 0.2173
Trichomonas vaginalis glutathione reductase, putative 0.0229 0.0588 0.3977
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.0051 0.0075
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0229 0.0588 0.2916
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.004 0.0048
Brugia malayi MH2 domain containing protein 0.1644 0.4859 0.7143
Echinococcus multilocularis mothers against decapentaplegic 2 0.005 0.0047 0.006
Toxoplasma gondii NADPH-glutathione reductase 0.0229 0.0588 0.0795
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Toxoplasma gondii ABC1 family protein 0.0524 0.1478 0.2113
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0788 0.2276 0.3295
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Plasmodium falciparum thioredoxin reductase 0.0229 0.0588 0.0795
Echinococcus multilocularis tar DNA binding protein 0.046 0.1284 0.1879
Echinococcus multilocularis expressed protein 0.0046 0.0036 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Echinococcus granulosus expressed protein 0.0046 0.0036 0.0053
Loa Loa (eye worm) hypothetical protein 0.0062 0.0083 0.0123
Mycobacterium ulcerans hypothetical protein 0.0524 0.1478 0.2131
Echinococcus granulosus microtubule associated protein 2 0.0751 0.2165 0.3183
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0229 0.0588 0.2916
Loa Loa (eye worm) hypothetical protein 0.0152 0.0355 0.0522
Brugia malayi RNA binding protein 0.046 0.1284 0.1888
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0524 0.1478 0.1447
Trypanosoma cruzi cruzipain precursor, putative 0.0195 0.0486 0.2364
Onchocerca volvulus 0.0065 0.0093 0.0631
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0051 0.0075
Loa Loa (eye worm) hypothetical protein 0.0524 0.1478 0.2173
Trichomonas vaginalis D-aminoacylase, putative 0.0524 0.1478 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.0051 0.0075
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0093 0.0127
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0229 0.0588 0.0864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Mycobacterium ulcerans dehydrogenase 0.0061 0.008 0.0065
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0061 0.008 0.0044
Schistosoma mansoni sulfide quinone reductase 0.0061 0.008 0.0117
Brugia malayi glutathione reductase 0.0661 0.1892 0.2781
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.006 0.0046
Leishmania major cathepsin L-like protease 0.0195 0.0486 0.2364
Brugia malayi TAR-binding protein 0.046 0.1284 0.1888
Mycobacterium tuberculosis Probable oxidoreductase 0.1676 0.4956 0.4937
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0011 0.0016
Onchocerca volvulus 0.0051 0.0051 0.0346
Onchocerca volvulus 0.0061 0.008 0.0541
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0524 0.1478 0.2173
Schistosoma mansoni hypothetical protein 0.0061 0.008 0.0117
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.003 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.008 0.011
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0061 0.008 0.0107
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.0307 0.0442
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0054 0.006 0.0088
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0007 0.001
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0061 0.008 0.0044
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0661 0.1892 0.1863
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0788 0.2276 0.3295
Mycobacterium leprae conserved hypothetical protein 0.0524 0.1478 0.2131
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0061 0.008 0.0043
Echinococcus granulosus tumor protein p63 0.2139 0.6353 0.934
Plasmodium vivax ferrodoxin reductase, putative 0.0061 0.008 0.0043
Brugia malayi Cathepsin L-like precursor 0.0051 0.0051 0.0075
Brugia malayi Cathepsin L-like precursor 0.0051 0.0051 0.0075
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0007 0.001
Schistosoma mansoni glutamate synthase 0.0061 0.008 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0061 0.008 0.0315
Onchocerca volvulus Mothers against decapentaplegic homolog 0.005 0.0047 0.0321
Loa Loa (eye worm) hypothetical protein 0.0524 0.1478 0.2173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Schistosoma mansoni peptidase Clp (S14 family) 0.2287 0.6802 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0061 0.008 0.0156
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0061 0.008 0.0541
Trichomonas vaginalis set domain proteins, putative 0.0517 0.1458 0.9868
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0061 0.008 0.0043
Schistosoma mansoni hypothetical protein 0.0047 0.004 0.0058
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0061 0.008 0.0043
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.1499 0.4423 0.6484
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0061 0.008 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0136 0.0307 0.0452
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0229 0.0588 0.0795
Entamoeba histolytica hypothetical protein 0.0875 0.2539 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.004 0.0048
Echinococcus granulosus mothers against decapentaplegic 6 0.005 0.0047 0.007
Trichomonas vaginalis glutamate synthase, putative 0.0061 0.008 0.0541
Trypanosoma cruzi cysteine peptidase, putative 0.0195 0.0486 0.2364
Schistosoma mansoni lamin 0.0259 0.068 0.0999
Onchocerca volvulus 0.0524 0.1478 1
Schistosoma mansoni ferritin 0.0046 0.0036 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Trypanosoma cruzi trypanothione reductase, putative 0.0661 0.1892 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0061 0.008 0.0044
Loa Loa (eye worm) Smad1 0.0112 0.0234 0.0345
Loa Loa (eye worm) ctsf protein 0.0051 0.0051 0.0075
Schistosoma mansoni ferritin 0.0046 0.0036 0.0053
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0061 0.008 0.0117
Mycobacterium tuberculosis Conserved protein 0.0524 0.1478 0.1447
Schistosoma mansoni hypothetical protein 0.0044 0.003 0.0044
Mycobacterium ulcerans lipase LipD 0.0524 0.1478 0.2131
Mycobacterium ulcerans ferredoxin reductase 0.0061 0.008 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0061 0.008 0.0043
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0229 0.0588 0.2916
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Brugia malayi PHD-finger family protein 0.0054 0.0058 0.0085
Schistosoma mansoni transcription factor LCR-F1 0.0875 0.2539 0.3732
Echinococcus granulosus mothers against decapentaplegic 5 0.0112 0.0234 0.0345
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0229 0.0588 0.0795
Plasmodium falciparum glutathione reductase 0.0661 0.1892 0.2726
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.004 0.0058
Echinococcus multilocularis cysteine protease 0.0051 0.0051 0.0065
Mycobacterium tuberculosis Probable hydrolase 0.0524 0.1478 0.1447
Toxoplasma gondii selenide, water dikinase 0.0061 0.008 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Echinococcus multilocularis tumor protein p63 0.2139 0.6353 0.9339
Trypanosoma cruzi cysteine peptidase, putative 0.0195 0.0486 0.2364
Echinococcus granulosus cathepsin l1 0.0051 0.0051 0.0075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0259 0.068 0.0999
Loa Loa (eye worm) hypothetical protein 0.0103 0.0206 0.0303
Schistosoma mansoni smad1 5 8 and 0.0112 0.0234 0.0345
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0061 0.008 0.0065
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0007 0.001
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0061 0.008 0.0156
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0125 0.0274 0.0393
Schistosoma mansoni smad1 5 8 and 0.0112 0.0234 0.0345
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0524 0.1478 0.2173
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.006 0.0013
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0061 0.008 0.0043
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0061 0.008 0.0065
Echinococcus granulosus peptidase Clp S14 family 0.1499 0.4423 0.6502
Brugia malayi hypothetical protein 0.0875 0.2539 0.3732
Schistosoma mansoni intermediate filament proteins 0.0259 0.068 0.0999
Schistosoma mansoni Smad4 0.0112 0.0234 0.0345
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0061 0.008 0.0043
Brugia malayi MH1 domain containing protein 0.0112 0.0234 0.0345
Brugia malayi Cathepsin L-like precursor 0.0051 0.0051 0.0075
Schistosoma mansoni smad 0.005 0.0047 0.007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.0051 0.0065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.004 0.0058
Trichomonas vaginalis esterase, putative 0.0524 0.1478 1
Schistosoma mansoni disulfide oxidoreductase 0.0061 0.008 0.0117
Echinococcus granulosus lamin dm0 0.0259 0.068 0.0999
Echinococcus granulosus GPCR family 2 0.0047 0.004 0.0058
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0229 0.0588 0.0816
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0229 0.0588 0.0816
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0051 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.0051 0.0346
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0061 0.008 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0229 0.0588 0.2883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Brugia malayi Smad1 0.0112 0.0234 0.0345
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0086 0.0126
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0788 0.2276 0.331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1508 0.4448 0.4428
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0061 0.008 0.0156
Echinococcus multilocularis zinc finger protein 0.0042 0.0023 0.0024
Echinococcus granulosus ferritin 0.0046 0.0036 0.0053
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Entamoeba histolytica thioredoxin reductase, putative 0.0061 0.008 0.0315
Brugia malayi hypothetical protein 0.0035 0.0002 0.0003
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0061 0.008 0.011
Schistosoma mansoni hypothetical protein 0.0047 0.004 0.0058
Schistosoma mansoni smad1 5 8 and 0.0112 0.0234 0.0345
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Plasmodium vivax thioredoxin reductase, putative 0.0661 0.1892 0.2726
Onchocerca volvulus 0.0051 0.0051 0.0346
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0061 0.008 0.0043
Loa Loa (eye worm) hypothetical protein 0.0082 0.0145 0.0213
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0229 0.0588 0.2916
Schistosoma mansoni zinc finger protein 0.0042 0.0023 0.0034
Echinococcus granulosus zinc finger protein 0.0042 0.0023 0.0034
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0061 0.008 0.0065
Echinococcus multilocularis microtubule associated protein 2 0.0751 0.2165 0.3176
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0061 0.008 0.0117
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0229 0.0588 0.0554
Echinococcus granulosus intermediate filament protein 0.0259 0.068 0.0999
Echinococcus granulosus TGF beta signal transducer SmadC 0.0112 0.0234 0.0345
Entamoeba histolytica disulphide oxidoreductase, putative 0.0061 0.008 0.0315
Schistosoma mansoni ferritin light chain 0.0046 0.0036 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0229 0.0588 0.2916
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0061 0.008 0.0315
Schistosoma mansoni Smad4 0.005 0.0047 0.007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1676 0.4956 0.4937
Treponema pallidum thioredoxin reductase (trxB) 0.0061 0.008 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Schistosoma mansoni ferritin 0.0046 0.0036 0.0053
Loa Loa (eye worm) glutathione reductase 0.0661 0.1892 0.2781
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0047 0.007
Trypanosoma cruzi NADH dehydrogenase, putative 0.0061 0.008 0.0156
Schistosoma mansoni Smad4 0.005 0.0047 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Loa Loa (eye worm) hypothetical protein 0.0524 0.1478 0.2173
Schistosoma mansoni tar DNA-binding protein 0.046 0.1284 0.1888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1676 0.4956 0.4937
Brugia malayi MH2 domain containing protein 0.0112 0.0234 0.0345
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0061 0.008 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Trypanosoma brucei NADH dehydrogenase 0.0061 0.008 0.011
Leishmania major hypothetical protein, conserved 0.0054 0.006 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0051 0.0075
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0229 0.0588 0.0816
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1676 0.4956 0.7271
Schistosoma mansoni hypothetical protein 0.0047 0.004 0.0058
Loa Loa (eye worm) TAR-binding protein 0.046 0.1284 0.1888
Plasmodium vivax SET domain protein, putative 0.0065 0.0093 0.0062
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0178 0.0435 0.2086
Loa Loa (eye worm) cysteine protease 0.0051 0.0051 0.0075
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0061 0.008 0.0541
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0229 0.0588 0.2916
Schistosoma mansoni ferritin light chain 0.0046 0.0036 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0051 0.0202
Echinococcus multilocularis Smad4 0.0112 0.0234 0.0335
Toxoplasma gondii thioredoxin reductase 0.0661 0.1892 0.2726
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0061 0.008 0.0541
Schistosoma mansoni ferritin 0.0046 0.0036 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0229 0.0588 0.2883
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0061 0.008 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.004 0.0058
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0229 0.0588 0.2883
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0229 0.0588 0.0864
Plasmodium falciparum glutathione reductase 0.0229 0.0588 0.0795
Plasmodium falciparum ferrodoxin reductase-like protein 0.0061 0.008 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0229 0.0588 0.2883
Echinococcus multilocularis thioredoxin glutathione reductase 0.0661 0.1893 0.2776
Schistosoma mansoni tar DNA-binding protein 0.046 0.1284 0.1888
Loa Loa (eye worm) fibroinase 0.0051 0.0051 0.0075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0061 0.008 0.0117
Mycobacterium ulcerans esterase/lipase LipP 0.0524 0.1478 0.2131
Schistosoma mansoni glutamate synthase 0.0061 0.008 0.0117
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0129 0.019
Echinococcus multilocularis peptidase Clp (S14 family) 0.1499 0.4423 0.6499
Schistosoma mansoni tar DNA-binding protein 0.046 0.1284 0.1888
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.1499 0.4423 0.4403
Loa Loa (eye worm) hypothetical protein 0.0125 0.0274 0.0403
Trypanosoma cruzi hypothetical protein, conserved 0.0524 0.1478 0.7752
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1508 0.4448 0.4428
Trichomonas vaginalis apoptosis inducing factor, putative 0.0061 0.008 0.0541
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0061 0.008 0.0117
Brugia malayi RNA recognition motif domain containing protein 0.046 0.1284 0.1888
Echinococcus granulosus tar DNA binding protein 0.046 0.1284 0.1888
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0093 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0051 0.0065
Brugia malayi MH1 domain containing protein 0.0062 0.0083 0.0123
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0524 0.1478 0.1447
Onchocerca volvulus 0.0524 0.1478 1
Echinococcus multilocularis glutamate synthase 0.0061 0.008 0.0107
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0112 0.0234 0.0335
Brugia malayi intermediate filament protein 0.0259 0.068 0.0999
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0229 0.0588 0.0795
Mycobacterium tuberculosis Probable dehydrogenase 0.1508 0.4448 0.4428
Echinococcus multilocularis cysteine protease 0.0051 0.0051 0.0065
Schistosoma mansoni bromodomain containing protein 0.0136 0.0307 0.0451
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0061 0.008 0.011
Loa Loa (eye worm) intermediate filament protein 0.0259 0.068 0.0999
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0139 0.0316 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0061 0.008 0.0541
Mycobacterium ulcerans glutamate synthase subunit beta 0.0061 0.008 0.0065
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0061 0.008 0.0044
Onchocerca volvulus 0.0051 0.0051 0.0346
Brugia malayi Cathepsin L-like precursor 0.0051 0.0051 0.0075
Trypanosoma brucei trypanothione reductase 0.0661 0.1892 1
Schistosoma mansoni apoferritin-2 0.0046 0.0036 0.0053
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0259 0.068 0.0999
Trichomonas vaginalis D-aminoacylase, putative 0.0524 0.1478 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0061 0.008 0.0541
Trichomonas vaginalis glutamate synthase, putative 0.0061 0.008 0.0541
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0061 0.008 0.0117
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0051 0.0346
Echinococcus multilocularis smad 0.0112 0.0234 0.0335
Trichomonas vaginalis ferritin, putative 0.0046 0.0036 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0061 0.008 0.0065
Brugia malayi glutamate synthase 0.0061 0.008 0.0117
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.2287 0.6802 1
Mycobacterium tuberculosis Conserved protein 0.0524 0.1478 0.1447
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0061 0.008 0.0117
Echinococcus multilocularis lamin 0.0259 0.068 0.099
Loa Loa (eye worm) hypothetical protein 0.0255 0.0665 0.0978
Brugia malayi Intermediate filament tail domain containing protein 0.0259 0.068 0.0999
Onchocerca volvulus 0.0051 0.0051 0.0346
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0229 0.0588 0.0795
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0061 0.008 0.0065
Loa Loa (eye worm) MH1 domain-containing protein 0.0112 0.0234 0.0345
Schistosoma mansoni thyroid hormone receptor 0.0136 0.0307 0.0452
Plasmodium vivax hypothetical protein, conserved 0.0524 0.1478 0.2113
Loa Loa (eye worm) beta-lactamase 0.0524 0.1478 0.2173
Schistosoma mansoni glutamate synthase 0.0061 0.008 0.0117
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0875 0.2539 0.3732
Brugia malayi cytoplasmic intermediate filament protein 0.0139 0.0316 0.0464
Schistosoma mansoni hypothetical protein 0.0875 0.2539 0.3732
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.0204 0.03
Brugia malayi Bromodomain containing protein 0.0082 0.0145 0.0213
Schistosoma mansoni cellular tumor antigen P53 0.0313 0.0841 0.1237
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.0051 0.0065
Loa Loa (eye worm) hypothetical protein 0.2287 0.6802 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0061 0.008 0.0541
Echinococcus granulosus mothers against decapentaplegic 2 0.005 0.0047 0.007
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.0051 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0524 0.1478 1
Mycobacterium ulcerans NADH dehydrogenase 0.0061 0.008 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Entamoeba histolytica hypothetical protein 0.0875 0.2539 1
Leishmania major hypothetical protein, conserved 0.0061 0.008 0.0156
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0277 0.0407
Schistosoma mansoni hypothetical protein 0.0047 0.004 0.0058
Loa Loa (eye worm) transcription factor SMAD2 0.1644 0.4859 0.7143
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0061 0.008 0.0044
Echinococcus granulosus glutamate synthase 0.0061 0.008 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0061 0.008 0.0065
Onchocerca volvulus 0.0259 0.068 0.4598
Echinococcus multilocularis mothers against decapentaplegic 5 0.0112 0.0234 0.0335
Loa Loa (eye worm) hypothetical protein 0.0087 0.0161 0.0236
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.006 0.0046
Schistosoma mansoni lamin 0.0259 0.068 0.0999
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0043 0.0063
Trypanosoma cruzi cysteine peptidase, putative 0.0195 0.0486 0.2364
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0229 0.0588 0.0864
Loa Loa (eye worm) hypothetical protein 0.0061 0.008 0.0117
Loa Loa (eye worm) hypothetical protein 0.012 0.026 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Leishmania major NADH dehydrogenase, putative 0.0061 0.008 0.0156
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.035 0.0514
Plasmodium falciparum thioredoxin reductase 0.0661 0.1892 0.2726
Onchocerca volvulus 0.0051 0.0051 0.0346
Mycobacterium tuberculosis Probable lipase LipE 0.0524 0.1478 0.1447
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0128 0.0283 0.0417
Toxoplasma gondii hypothetical protein 0.0788 0.2276 0.3295
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0128 0.0283 0.0407
Schistosoma mansoni tar DNA-binding protein 0.046 0.1284 0.1888
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0061 0.008 0.0065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0229 0.0588 0.0816
Echinococcus granulosus histone lysine methyltransferase setb 0.0102 0.0204 0.03
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0061 0.008 0.0117
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0277 0.0397
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0061 0.008 0.0065
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0061 0.008 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0455 0.1269 0.1865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0051 0.0346
Loa Loa (eye worm) hypothetical protein 0.0313 0.0841 0.1237
Schistosoma mansoni hypothetical protein 0.0126 0.0277 0.0407
Trichomonas vaginalis penicillin-binding protein, putative 0.0524 0.1478 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0061 0.008 0.0107
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0061 0.008 0.0107
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0061 0.008 0.0156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0093 0.0137
Brugia malayi Pre-SET motif family protein 0.0065 0.0093 0.0137
Loa Loa (eye worm) programmed cell death 8 0.0061 0.008 0.0117
Leishmania major trypanothione reductase 0.0661 0.1892 1
Schistosoma mansoni sulfide quinone reductase 0.0061 0.008 0.0117
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0061 0.008 0.0541
Brugia malayi Bromodomain containing protein 0.0161 0.0383 0.0563
Leishmania major hypothetical protein, conserved 0.0061 0.008 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0195 0.0486 0.2328
Entamoeba histolytica hypothetical protein 0.0875 0.2539 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0229 0.0588 0.0756
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.2287 0.6802 1
Echinococcus multilocularis ferritin 0.0046 0.0036 0.0042
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.004 0.0058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.046 0.1284 0.1888
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0206 0.0303
Loa Loa (eye worm) thioredoxin reductase 0.0661 0.1892 0.2781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0051 0.0346
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0229 0.0588 0.2916
Loa Loa (eye worm) hypothetical protein 0.0102 0.0204 0.03
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0061 0.008 0.0117
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1508 0.4448 0.4428
Treponema pallidum NADH oxidase 0.0229 0.0588 0.0816
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0229 0.0588 0.2916
Trypanosoma cruzi hypothetical protein, conserved 0.0524 0.1478 0.7752
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0061 0.008 0.0043
Onchocerca volvulus Cathepsin F homolog 0.0051 0.0051 0.0346
Loa Loa (eye worm) MH2 domain-containing protein 0.1644 0.4859 0.7143
Leishmania major cathepsin L-like protease 0.0195 0.0486 0.2364
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0061 0.008 0.0065
Schistosoma mansoni microtubule-associated protein tau 0.0751 0.2165 0.3183
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0168 0.0404 0.0594
Echinococcus multilocularis lamin dm0 0.0259 0.068 0.099

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 64 % Evaluated in rat PCA (passive cutaneous anaphylaxis) test administered at 60 mg/kg ip and the inhibition of PCA due to inhibition of IgE mediated release was determined ChEMBL. 2431144

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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