Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | carboxylesterase | 0.0345 | 0.1455 | 0.1455 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0345 | 0.1455 | 0.138 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2039 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0345 | 0.1455 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0345 | 0.1455 | 0.1455 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0345 | 0.1455 | 0.138 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1455 | 0.1455 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0087 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2039 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2039 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0345 | 0.1455 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2039 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0345 | 0.1455 | 0.138 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2039 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0345 | 0.1455 | 0.138 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0345 | 0.1455 | 0.138 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0679 | 0.0597 |
Onchocerca volvulus | 0.0345 | 0.1455 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0345 | 0.1455 | 0.138 |
Echinococcus granulosus | neuroligin | 0.0345 | 0.1455 | 0.138 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0679 | 0.0597 |
Onchocerca volvulus | 0.0345 | 0.1455 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2039 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0345 | 0.1455 | 0.138 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0345 | 0.1455 | 0.138 |
Echinococcus granulosus | acetylcholinesterase | 0.2039 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0345 | 0.1455 | 0.138 |
Brugia malayi | hypothetical protein | 0.0345 | 0.1455 | 0.1455 |
Brugia malayi | Carboxylesterase family protein | 0.2039 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0191 | 0.0679 | 0.0597 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1455 | 0.1455 |
Echinococcus granulosus | geminin | 0.0191 | 0.0679 | 0.0597 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0087 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0345 | 0.1455 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2039 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2039 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0345 | 0.1455 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0345 | 0.1455 | 0.1455 |
Onchocerca volvulus | 0.0345 | 0.1455 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0345 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1455 | 0.1455 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0345 | 0.1455 | 0.138 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1455 | 0.1455 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0345 | 0.1455 | 0.138 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0345 | 0.1455 | 0.138 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0345 | 0.1455 | 0.138 |
Brugia malayi | Carboxylesterase family protein | 0.0345 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1455 | 0.1455 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2039 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0345 | 0.1455 | 0.138 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0345 | 0.1455 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2039 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1455 | 0.1455 |
Brugia malayi | Carboxylesterase family protein | 0.0345 | 0.1455 | 0.1455 |
Onchocerca volvulus | 0.0345 | 0.1455 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0345 | 0.1455 | 1 |
Onchocerca volvulus | 0.0345 | 0.1455 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.