Detailed information for compound 1307698

Basic information

Technical information
  • TDR Targets ID: 1307698
  • Name: 7-chloro-N-[4-(4-methylpiperazin-1-yl)phenyl] quinolin-4-amine
  • MW: 352.861 | Formula: C20H21ClN4
  • H donors: 1 H acceptors: 1 LogP: 4.29 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1ccc(cc1)Nc1ccnc2c1ccc(c2)Cl
  • InChi: 1S/C20H21ClN4/c1-24-10-12-25(13-11-24)17-5-3-16(4-6-17)23-19-8-9-22-20-14-15(21)2-7-18(19)20/h2-9,14H,10-13H2,1H3,(H,22,23)
  • InChiKey: LJSIXDJBHLLWHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-N-[4-(4-methyl-1-piperazinyl)phenyl]-4-quinolinamine
  • (7-chloro-4-quinolyl)-[4-(4-methylpiperazin-1-yl)phenyl]amine
  • A2436/0103246
  • (7-Chloro-quinolin-4-yl)-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine
  • BAS 01835897
  • ChemDiv1_022005
  • Oprea1_750899
  • Oprea1_751580
  • MLS001203414
  • SMR000517023

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAD54-like (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax DNA repair protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Babesia bovis DNA repair and recombination protein RAD54-like, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni DNA repair and recombination protein rad54-related Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi recombination factor GdRad54 Get druggable targets OG5_127098 All targets in OG5_127098
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Plasmodium yoelii DNA repair protein RAD54-like-related Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Cryptosporidium hominis DNA repair protein RAD54-like Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica DNA repair protein, putative Get druggable targets OG5_127098 All targets in OG5_127098
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA repair and recombination protein rad54-related Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium falciparum DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination Get druggable targets OG5_127098 All targets in OG5_127098
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei gambiense DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania mexicana DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum DNA repair and recombination protein RAD54B, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis Get druggable targets OG5_127098 All targets in OG5_127098
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA-dependent ATPase required for x-ray damage repair and recombination Get druggable targets OG5_127098 All targets in OG5_127098
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Theileria parva DNA repair protein rad54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Entamoeba histolytica DNA repair protein, putative Get druggable targets OG5_127098 All targets in OG5_127098
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum ko:K01529 RAD54L, GdRAD54; RAD54-like [EC:3.6.1.-], putative Get druggable targets OG5_127098 All targets in OG5_127098
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania braziliensis DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Candida albicans Putative helicase similar to RAD54 Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania donovani DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus SPRY domain containing protein Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Cryptosporidium parvum RAD54 like SWI/SNF2 ATpase Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma brucei DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA repair and recombination protein RAD54-like, putative Get druggable targets OG5_127098 All targets in OG5_127098
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) type III restriction enzyme Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127098 All targets in OG5_127098
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna repair and recombination protein rad54 Get druggable targets OG5_127098 All targets in OG5_127098
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum IPR000299,Band 4.1,domain-containing Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma japonicum ATP-dependent RNA helicase DDX1, putative Get druggable targets OG5_127098 All targets in OG5_127098
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative Get druggable targets OG5_127098 All targets in OG5_127098
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Type III restriction enzyme, res subunit family protein Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Putative helicase similar to RAD54 Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus granulosus DNA repair and recombination protein RAD54B Get druggable targets OG5_127098 All targets in OG5_127098
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania major hypothetical protein, conserved RAD54-like (S. cerevisiae) 747 aa 633 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.042 0.8758 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0403 0.0403
Echinococcus multilocularis SPRY domain containing protein 0.001 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Schistosoma mansoni hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus GPCR family 2 0.0019 0.0264 0.0264
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0506 0.6846
Echinococcus multilocularis muscleblind protein 0.018 0.3684 0.3684
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Onchocerca volvulus 0.0025 0.0399 0.9902
Schistosoma mansoni hypothetical protein 0.0041 0.0733 0.0733
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0036 0.0079
Echinococcus granulosus dna repair and recombination protein rad54 0.001 0.0065 0.0065
Brugia malayi Blistered cuticle protein 3 0.0026 0.0403 0.0891
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0114 0.0252
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0399 0.5405
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Onchocerca volvulus 0.0025 0.0399 0.9902
Echinococcus multilocularis muscleblind protein 1 0.018 0.3684 0.3684
Brugia malayi Muscle positioning protein 4 0.0008 0.0036 0.0079
Brugia malayi hypothetical protein 0.0025 0.0399 0.0883
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0189 0.2555
Trypanosoma brucei DNA repair and recombination protein RAD54, putative 0.001 0.0065 0.0877
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.001 0.0065 0.0877
Schistosoma mansoni hypothetical protein 0.0205 0.4198 0.4198
Schistosoma mansoni notch 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.018 0.3684 0.3684
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0114 0.1544
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0025 0.0399 0.0399
Echinococcus granulosus protein jagged 1 0.0008 0.0036 0.0036
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0738 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.001 0.0065 0.0065
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0478 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0733 0.162
Echinococcus multilocularis neural cadherin 0.0008 0.0036 0.0036
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0114 0.0114
Plasmodium vivax DNA repair protein RAD54, putative 0.001 0.0065 0.0877
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Brugia malayi hypothetical protein 0.003 0.0506 0.1118
Schistosoma mansoni hypothetical protein 0.0019 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0065
Onchocerca volvulus Slit protein homolog 0.0008 0.0036 0.0887
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0403 0.0891
Echinococcus multilocularis dna repair and recombination protein rad54 0.001 0.0065 0.0065
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.0738 1
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0036 0.0036
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0399 0.0883
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0399 0.5405
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0399 0.5
Echinococcus granulosus protein jagged 2 0.0008 0.0036 0.0036
Brugia malayi notch-like transmembrane receptor 0.0008 0.0036 0.0079
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0114 0.0114
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0399 0.5405
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.2392 0.2677
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Echinococcus granulosus peroxidasin 0.0026 0.0403 0.0403
Echinococcus granulosus delta-like protein 1 0.0008 0.0036 0.0036
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0036 0.0887
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0264 0.0264
Brugia malayi EGF-like domain containing protein 0.0008 0.0036 0.0079
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0036 0.0079
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0399 0.7353
Brugia malayi hypothetical protein 0.022 0.4522 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0036 0.0887
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0403 1
Schistosoma mansoni hypothetical protein 0.0019 0.0264 0.0264
Echinococcus granulosus slit 2 protein 0.0008 0.0036 0.0036
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0506 0.6846
Brugia malayi EGF-like domain containing protein 0.0008 0.0036 0.0079
Onchocerca volvulus 0.0008 0.0036 0.0887
Schistosoma mansoni notch 0.0008 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.003 0.0506 0.6543
Loa Loa (eye worm) hypothetical protein 0.0146 0.2953 0.2953
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0475 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0189 0.2555
Onchocerca volvulus Putative cubilin 0.0008 0.0036 0.0887
Toxoplasma gondii EGF family domain-containing protein 0.0008 0.0036 0.0484
Onchocerca volvulus 0.0026 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0065
Onchocerca volvulus 0.0025 0.0399 0.9902
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0738 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1136 0.2513
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0189 0.0143
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0399 0.7353
Loa Loa (eye worm) hypothetical protein 0.0012 0.0114 0.0114
Onchocerca volvulus Peroxidase homolog 0.0026 0.0403 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0475 1
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0036 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0264 0.0264
Schistosoma mansoni hypothetical protein 0.0008 0.0036 0.0036
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0738 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0114 0.1544
Schistosoma mansoni hypothetical protein 0.0019 0.0264 0.0264
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0264 0.0264
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0506 0.6846
Echinococcus multilocularis 0.001 0.0065 0.0065
Echinococcus multilocularis 0.001 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0119 0.2392 0.2677
Echinococcus granulosus protein jagged 2 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) Notch2 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0399 0.4963
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.015 0.015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0264 0.0584
Brugia malayi Delta serrate ligand family protein 0.0008 0.0036 0.0079
Loa Loa (eye worm) hypothetical protein 0.0041 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.006 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus SPRY domain containing protein 0.001 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0114 0.009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0271 0.3669
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus muscleblind protein 0.018 0.3684 0.3684
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0738 1
Brugia malayi EGF-like domain containing protein 0.0008 0.0036 0.0079
Giardia lamblia DNA repair protein RAD52 0.042 0.8758 1
Echinococcus granulosus fibropellin Ia 0.0008 0.0036 0.0036
Loa Loa (eye worm) notch protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0399 0.0399
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0403 1
Echinococcus multilocularis dna repair and recombination protein rad54 0.001 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0399 0.0883
Schistosoma mansoni slit 0.0008 0.0036 0.0036
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0114 0.0114
Brugia malayi recombination factor GdRad54 0.001 0.0065 0.0143
Brugia malayi hypothetical protein 0.0026 0.0403 0.0891
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Schistosoma mansoni hypothetical protein 0.0014 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0114 0.1544
Loa Loa (eye worm) type III restriction enzyme 0.001 0.0065 0.0065
Onchocerca volvulus 0.0026 0.0403 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0403 0.0403
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0403 0.0891
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0399 0.5405
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0399 0.4963
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0036 0.0036
Onchocerca volvulus 0.0008 0.0036 0.0887
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0399 0.5405
Schistosoma mansoni cell polarity protein 0.0008 0.0036 0.0036
Echinococcus granulosus SPRY domain containing protein 0.001 0.0065 0.0065
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0189 0.184
Onchocerca volvulus 0.0008 0.0036 0.0887
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0399 0.4963
Schistosoma mansoni septate junction protein 0.0008 0.0036 0.0036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.015 0.015
Schistosoma mansoni peroxidasin 0.0026 0.0403 0.0403
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0399 0.5405
Echinococcus granulosus aminopeptidase N 0.0025 0.0399 0.0399
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0478 1 1
Schistosoma mansoni notch 0.0008 0.0036 0.0036
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0506 0.6846
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0276 0.3736
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0475 0.105
Schistosoma mansoni peroxidasin 0.0026 0.0403 0.0403
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0036 0.0079
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0036 0.0036
Brugia malayi Cadherin domain containing protein 0.0008 0.0036 0.0079
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0399 0.4963
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.001 0.0065 0.0877
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0399 0.5
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0399 0.5405
Schistosoma mansoni hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus geminin 0.0205 0.4198 0.4198
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0036 0.0036
Entamoeba histolytica aminopeptidase, putative 0.0025 0.0399 0.0385
Echinococcus multilocularis SPRY domain containing protein 0.001 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus neural cadherin 0.0008 0.0036 0.0036
Brugia malayi Peroxidasin 0.0026 0.0403 0.0891
Echinococcus granulosus notch 0.0008 0.0036 0.0036
Onchocerca volvulus 0.0008 0.0036 0.0887
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Schistosoma mansoni hypothetical protein 0.0019 0.0264 0.0264
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0399 0.5405
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0403 0.0891
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0399 0.5405
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0403 0.0403
Brugia malayi EGF-like domain containing protein 0.0008 0.0036 0.0079
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0403 0.0891
Schistosoma mansoni DNA helicase recq1 0.0012 0.0114 0.0114
Brugia malayi TATA binding protein associated factor 0.0025 0.0399 0.0883
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0036 0.0036
Echinococcus granulosus bloom syndrome protein 0.0029 0.0475 0.0475
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0036 0.0036
Echinococcus granulosus SPRY domain containing protein 0.001 0.0065 0.0065
Onchocerca volvulus 0.0026 0.0403 1
Echinococcus multilocularis protein jagged 2 0.0008 0.0036 0.0036
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0114 0.0252
Echinococcus multilocularis fibropellin Ia 0.0008 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0008 0.0036 0.0036
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.0738 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0478 1 1
Brugia malayi hypothetical protein 0.0025 0.0399 0.0883
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0475 0.0475
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0399 0.5405
Loa Loa (eye worm) hypothetical protein 0.0019 0.0264 0.0264
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.0738 0.0738
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0264 0.0264
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0036 0.0036
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0399 0.5405
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Brugia malayi EGF-like domain containing protein 0.0008 0.0036 0.0079
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0264 0.0584
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0403 0.0891
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0506 0.6846
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0403 0.0403
Leishmania major hypothetical protein, conserved 0.0041 0.0738 1
Plasmodium falciparum DNA repair and recombination protein RAD54, putative 0.001 0.0065 0.0877
Schistosoma mansoni notch 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0399 0.0399
Echinococcus multilocularis geminin 0.0205 0.4198 0.4198
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.04 0.542
Echinococcus multilocularis aminopeptidase N 0.0025 0.0399 0.0399
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0114 0.0114
Brugia malayi EGF-like domain containing protein 0.0008 0.0036 0.0079
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.001 0.0065 0.0065
Echinococcus multilocularis dna repair and recombination protein rad54 0.001 0.0065 0.0065
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0036 0.0036
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0036 0.0036
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.001 0.0065 0.0065
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1136 0.2513
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0036 0.0036
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0399 0.0399
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.0738 0.0738
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0399 0.5405
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0065
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0403 0.0403
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0399 0.5405
Loa Loa (eye worm) hypothetical protein 0.003 0.0506 0.0506
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0399 0.5405
Brugia malayi Augmenter of liver regeneration 0.0041 0.0738 0.1633
Onchocerca volvulus Peroxidase homolog 0.0026 0.0403 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0025 0.0399 0.0399
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0399 0.5405
Onchocerca volvulus 0.0008 0.0036 0.0887
Brugia malayi hypothetical protein 0.002 0.0277 0.0612
Loa Loa (eye worm) hypothetical protein 0.018 0.3684 0.3684
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0738 1
Brugia malayi GCC2 and GCC3 family protein 0.0008 0.0036 0.0079
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0399 0.0883
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Brugia malayi Type III restriction enzyme, res subunit family protein 0.001 0.0065 0.0143
Schistosoma mansoni notch 0.0008 0.0036 0.0036
Loa Loa (eye worm) RecQ helicase 0.0029 0.0475 0.0475
Echinococcus multilocularis protein jagged 1 0.0008 0.0036 0.0036
Brugia malayi EGF-like domain containing protein 0.0008 0.0036 0.0079
Trypanosoma cruzi Aminopeptidase M1, putative 0.0025 0.0399 0.5405
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Echinococcus granulosus protein jagged 1 0.0008 0.0036 0.0036
Loa Loa (eye worm) aminopeptidase N 0.0025 0.0399 0.0399
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0065
Echinococcus multilocularis protein jagged 1 0.0008 0.0036 0.0036
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0399 0.0399
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0506 0.6846
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0264 0.0264
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0399 0.5405
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0403 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.0399 0.0399
Echinococcus multilocularis peroxidasin 0.0026 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0026 0.0403 0.0403
Echinococcus multilocularis notch 0.0008 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0399 0.0399
Echinococcus multilocularis GPCR, family 2 0.0019 0.0264 0.0264
Brugia malayi Cadherin domain containing protein 0.0008 0.0036 0.0079
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1136 0.1136
Schistosoma mansoni notch 0.0008 0.0036 0.0036
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0738 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0506 0.6846
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0399 0.5405
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0399 0.7353
Loa Loa (eye worm) hypothetical protein 0.0025 0.0399 0.0399
Echinococcus multilocularis slit 2 protein 0.0008 0.0036 0.0036
Schistosoma mansoni DNA helicase recq5 0.0012 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0205 0.4198 0.4198
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0399 0.5405
Brugia malayi Muscleblind-like protein 0.018 0.3684 0.8146
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.0738 0.0738

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 2.47 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (binding) = 5.428 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
AC50 (functional) 6.94 uM PubChem BioAssay. Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AUC (ADMET) = 2.12 uM.hr AUClast in FVB mouse brain at 10 mg/kg, po qd ChEMBL. 24183589
EC50 (functional) = 2.8 uM Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay ChEMBL. 24602904
EC50 (ADMET) > 25 uM Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay ChEMBL. 24602904
EC50 (functional) > 260 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] ChEMBL. No reference
MTD (ADMET) = 10 uM Cytotoxicity against mouse N2A cells assessed as maximal tolerant concentration ChEMBL. 21531054
Potency (functional) 0.0262 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
RUmax (binding) = 165.4 % Binding affinity to truncated human PrP 121-231 at 50 uM by surface plasmon resonance method ChEMBL. 21531054

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23
Mus musculus ChEMBL23 24602904

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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